ライフサイエンスコーパス: clinical research

1 s at risk remains limited despite decades of clinical research.

2 m the methods of pulmonary and critical care clinical research.

3 de an essential link between preclinical and clinical research.

4 Syndrome, and suggest future directions for clinical research.

5 assessment of areas with a need for further clinical research.

6 knowledge are most likely to translate into clinical research.

7 Missing data occur frequently in clinical research.

8 the major challenges for data integration in clinical research.

9 e frequency of undetermined deaths in future clinical research.

10 ers that either succeed or fail to influence clinical research.

11 easible and may find various uses for future clinical research.

12 d, urine, and saliva) is emerging in current clinical research.

13 ns aimed at advancing iCCA translational and clinical research.

14 d to address the presence of missing data in clinical research.

15 5 years) who had volunteered to take part in clinical research.

16 ective therapies and are in critical need of clinical research.

17 sequencing has revolutionized biological and clinical research.

18 l demands limit their use for biomedical and clinical research.

19 d will serve as a backbone for the future of clinical research.

20 thodologies can contribute to biomedical and clinical research.

21 on language and procedures are being used in clinical research.

22 ractical considerations in PRO assessment in clinical research.

23 ount of un-decoded information into usage in clinical research.

24 ry (LC/ESI-MRM-MS) are more commonly used in clinical research.

25 sed to diagnose celiac disease (CeD) and for clinical research.

26 brain, but also in pathological contexts in clinical research.

27 s increasingly being viewed as essential for clinical research.

28 Oncolytic viruses are an active area of clinical research.

29 ent at relapse offer ample opportunities for clinical research.

30 at is broadly revolutionizing biological and clinical research.

31 ut also transforming the way that we conduct clinical research.

32 innovations that will advance the conduct of clinical research.

33 or future clinical outcome prediction and in clinical research.

34 e in nearly all aspects of today's basic and clinical research.

35 ne use of nanoscale imaging in pathology and clinical research.

36 n will be essential for conducting optimized clinical research.

37 s could elevate clinical care and facilitate clinical research.

38 not obtained also impairs epidemiologic and clinical research.

39 l-world data that open new venues to conduct clinical research.

40 GS amplicon sequencing, increasingly used in clinical research.

41 to facilitate adoption of this technology in clinical research.

42 mans and 6 species commonly evaluated in pre-clinical research.

43 e stimulated a growing need for high-quality clinical research.

44 hat can improve the conception and design of clinical research.

45 uld compromise ethical principles that guide clinical research.

46 In an era of increased complexity of clinical research, a demand for personalized medicine, a

47 mproving equitable access to care, improving clinical research, addressing structural barriers, and i

48 and Kraepelin shared both a commitment to a clinical research agenda for psychiatry (to utilize meth

49 n is to develop, prioritize, and implement a clinical research agenda that addresses the public healt

50 a Gupta and colleagues discuss priorities in clinical research aimed at improving tuberculosis preven

51 he schizophrenia drug-protein interactome to clinical research - an important step, especially in the

52 trajectory of this line of translational and clinical research and address its possibilities and curr

53 roke dysphagia and is appropriate for use in clinical research and clinical service delivery.

54 s represents an important outcome measure in clinical research and clinical trials; further, survival

55 ing recent knowledge with the aim to support clinical research and drug development.

56 Additionally, this approach might advance clinical research and even clinical practice by accelera

57 d shows a high potential for applications in clinical research and histopathological diagnosis.

58 sitivity affects the way PET is used both in clinical research and in patient care.

59 gn and study reporting has helped to improve clinical research and in turn, the landscape of medical

60 t in accuracy and sensitivity/specificity in clinical research and medical management of patients wit

61 Data from clinical research and our previous study have suggested

62 their patients, for example, contributing to clinical research and outcomes research as well as healt

63 ated the potential impact dPCR could have on clinical research and patient management by earlier (tra

64 ive proteomics in molecular systems biology, clinical research and personalized medicine.

65 NAFLD and highlight opportunities for future clinical research and pharmacologic intervention, as wel

66 kinetics tools, making it adaptable to both clinical research and possible diagnostic applications.

67 ma on QoL that is suitable for use in asthma clinical research and potentially in clinical care.

68 with respect to its potential importance for clinical research and practice in mental health.

69 astatic castration-resistant prostate cancer clinical research and practice.

70 ts of antimalarial-related cardiotoxicity in clinical research and practice.

71 ection of patient-reported outcomes (PRO) in clinical research and routine care.

72 metabolite profiling as a valid technique in clinical research and routine medical care.

73 s and illustrates how they are being used in clinical research and the potential for their use in cli

74 ii) complexes have successfully been used in clinical research and their mechanisms of anticancer act

75 alues that can be universally implemented in clinical research and therapeutic trials.

76 ption-PCR (RT-qPCR) assays are being used by clinical, research and public health laboratories.

77 le with a wide range of bacterial species of clinical, research, and industrial interest, opening the

78 This burden has important clinical, research, and policy implications.

79 2) spurred a wave of basic, translation, and clinical research; and 3) provided an unprecedented inve

80 nd warrants further investigation for use in clinical research applications that rely on health-care

81 For most clinical research applications, the SUVR approach is app

82 ASCO organized its recommendations for clinical research around five goals to ensure lessons le

83 pain perception are of interest in basic and clinical research as altered pain sensitivity is both a

84 ifepristone based on any new developments in clinical research as best practices continue to be updat

85 significant recent developments in basic and clinical research as well as important future research d

86 cells that has emerged from experimental and clinical research as well as pathology investigations.

87 also examined to shed light on new basic and clinical research avenues that may lead to mitigating on

88 This year's Lasker Clinical Research Award honors H.

89 This year's Lasker Clinical Research Award honors H. Michael Shepard, Denni

90 osis, screening an international multicenter clinical research-based sample of 438 individuals affect

91 e decades of laboratory, epidemiological and clinical research, breast cancer incidence continues to

92 published his foundational paper "Ethics and Clinical Research," bringing to light unethical experime

93 vision requirements for feeding, is used for clinical research but has limited published validation i

94 iority design is used extensively in current clinical research, but its complex features may hamper t

95 Scientifically and ethically sound clinical research can be conducted during disease outbre

96 The study was conducted in a clinical research center with the use of a counterbalanc

97 t group or usual diet group at 2 US academic clinical research centers from August 2015 to July 2017;

98 es (hospital clinics, general practices, and clinical research centers) in 14 countries conducted bet

99 ial of the American Lung Association Airways Clinical Research Centers.

100 without hepatitis B aged 18-65 years at one clinical research centre in New Zealand (eight participa

101 olled, dose-escalation trial was done at one clinical research centre in the UK.

102 In part 2, adults aged 18-65 years at clinical research centres in New Zealand, Australia, the

103 s per month were enrolled at 59 headache and clinical research centres in North America and Europe, a

104 onic migraine, enrolled from 69 headache and clinical research centres in North America and Europe.

105 (FEV1) of at least 12% at screening, from 52 clinical research centres in six countries.

106 ience in mental health research using the UK Clinical Research Collaboration classification: underpin

107 leading the world in crafting new models of clinical research collaboration that hold the promise of

108 ctice was conducted across the network of UK Clinical Research Collaboration-registered trial units (

109 ve syndrome, and to facilitate international clinical research collaboration.

110 ce on best biopsy practices, focusing on the clinical research community.

111 ary use of electronic health record data for clinical research concerning allergy, asthma, and immuno

112 8) F-flortaucipir uptake in patients meeting clinical research criteria for PSP (n = 33) to normal co

113 lications for standardizing the reporting of clinical research data and for refining reimbursement gu

114 arge-scale integration of model organism and clinical research data can provide a breadth of knowledg

115 he primary focus in interpreting therapeutic clinical research data should be on the treatment ("oomp

116 Preclinical and clinical research developments in mechanical and pharmac

117 ome increasingly deployed in preclinical and clinical research due to its rapid and accurate readouts

118 g promise as therapeutics in a resurgence of clinical research during the past 10 years.

119 ding the conduct of clinical trials, and the clinical research ecosystem will need to adapt to this t

120 on of tailored and combined experimental and clinical research efforts will help to address remaining

121 l clinical challenges and help guide ongoing clinical research efforts.

122 placed a tremendous strain on sustaining the clinical research enterprise and will also likely affect

123 anding initiative for enhancing trust in the clinical research enterprise.

124 Materials and Methods The clinical research ethics board approved chart review, an

125 easurement Set is recommended for use in all clinical research evaluating ARF survivors after hospita

126 esenting four stakeholder groups relevant to clinical research evaluating postdischarge outcomes of a

127 utcomes that are essential to include in all clinical research evaluating the use of either venoarter

128 A significant body of clinical research evidence supports using a restrictive

129 We describe work from both basic and clinical research examining potential immune mechanisms

130 any; (e) optimization of trial design in AIT clinical research; (f) challenges planning and conductin

131 d 18 years and older were enrolled at two UK clinical research facilities, in an age-escalation manne

132 th care providers must know how to interpret clinical research findings and critically evaluate the s

133 provide a framework for critically assessing clinical research findings and highlight specific method

134 d opportunities in basic, translational, and clinical research focusing on the potential of mitochond

135 ls-(18)F-FDG and (18)F-NaF-have been used in clinical research for imaging coronary artery plaque, an

136 This finding is a strong sign to encourage clinical research for which quality protocols are alread

137 n Flanders/Fonds Wetenschappelijk Onderzoek, Clinical Research-Fund of the University Hospitals Leuve

138 In most epidemiologic studies and in clinical research generally, there are variables with a

139 ortion of the Acknowledgements section ("the Clinical Research Group CEDER of the German Research Cou

140 exchanges, we convened an interprofessional clinical research group, conducted a literature review o

141 Preclinical and clinical research has identified a set of treatment para

142 Clinical research has proven to be too slow, unreliable,

143 Clinical research has shown that chronic antipsychotic d

144 ng, diagnosis, and treatment of cancer.While clinical research has translated to longer survival and

145 Over the past decade, preclinical and clinical research have confirmed the essential role of i

146 Years of basic and clinical research have established the relationship betw

147 a, Association Leon Berard Enfant Cancereux, Clinical Research Hospital Program (French Ministry of H

148 alcohol use disorder.SIGNIFICANCE STATEMENT Clinical research identified cognitive deficits in alcoh

149 A synthesis of preclinical and clinical research identified three neuroprotective drugs

150 They must also be used in pre-clinical research if the excessive level of irreproducib

151 lch Center for Prevention, Epidemiology, and Clinical Research in 1989.

152 Decades of clinical research in acute respiratory distress syndrome

153 n amyloid-beta (Abeta) continues to dominate clinical research in AD, a deeper understanding of Abeta

154 areas of future international, collaborative clinical research in childhood glaucoma.

155 Clinical research in hepatology has had a rich tradition

156 of locus coeruleus integrity can be used for clinical research in neurodegenerative diseases.

157 tools should be further improved by specific clinical research in OA.

158 n varies, and potential platforms to advance clinical research in this area.

159 r damage and emphasizes the need for further clinical research in this area.

160 derstood biology, and dismal track record of clinical research in this field.

161 nd use of treatment guidelines and to enable clinical research (including clinical trials), cancer su

162 t challenges for the conduct of minimal-risk clinical research, including the very definition of mini

163 Clinical research increasingly utilizes objective biolog

164 Preclinical and clinical research indicates that excess corticosteroid i

165 Outcomes of neuroscience and clinical research into 5-Hydroxytryptamine 2A (5-HT2A) r

166 Substantial preclinical and clinical research into chronic graft-versus-host disease

167 Medicine committee report titled Integrating Clinical Research into Epidemic Response: The Ebola Expe

168 industry leaders to accelerate high-quality clinical research into neurotherapeutics and pain.

169 gs for daily practice and for the purpose of clinical research involving a core laboratory.

170 ns; 3) whether a regulatory framework(s) for clinical research involving human subjects might accommo

171 disciplines discussed current irAE basic and clinical research, irAE diagnosis and management, and th

172 clinical trials and promising new therapies.Clinical research is about saving and improving the live

173 The specific goals are: (1) ensure that clinical research is accessible, affordable, and equitab

174 Use of machine learning (ML) in clinical research is growing steadily given the increasi

175 sts' involvement in basic, translational and clinical research is needed for the development of new p

176 Further clinical research is needed to consolidate the findings

177 hus, timely, rigorous, relevant, and ethical clinical research is needed to improve the care and opti

178 However, clinical research is rapidly progressing, as shown by th

179 Clinical research laboratory.

180 tee of the NIH and the FDA.FUNDINGCenter for Clinical Research, NCI, NIH.

181 Diabetic Retinopathy Clinical Research Network (DRCR.net) investigators.

182 s Trials (CATT) and the Diabetic Retinopathy Clinical Research Network (DRCR.net).

183 ed forty multiethnic subjects from 12 Asthma Clinical Research Network and AsthmaNet trials were anal

184 , Lung, and Blood Institute-sponsored Asthma Clinical Research Network and AsthmaNet.

185 practice clinics were selected by the local clinical research network and invited to participate in

186 ity Score >=4, stage 2 or 3 fibrosis by NASH Clinical Research Network classification, and absolute l

187 ctivity score >= 4), fibrosis (F1-F3 by NASH Clinical Research Network criteria), and elevated liver

188 ts according to nonalcoholic steatohepatitis clinical research network criteria.

189 y and scored centrally according to the NASH Clinical Research Network criteria.

190 thin the nonalcoholic steatohepatitis (NASH) clinical research network from 2005 through 2015.

191 with biopsy-proven NASH, defined by the NASH clinical research network histologic scores.

192 assessed by the Nonalcoholic Steatohepatitis Clinical Research Network histologic scoring system.

193 lysis of biopsy data collected from the NASH Clinical Research Network Pathology Committee of Pioglit

194 ctively registered the pilot trial on the UK Clinical Research Network Portfolio Database (ID number:

195 The Diabetic Retinopathy Clinical Research Network Protocol S randomized clinical

196 NAFLD from the Nonalcoholic Steatohepatitis Clinical Research Network Scoring System) from October 2

197 Patients with advanced NASH (NASH Clinical Research Network stage F3 or F4) were enrolled

198 We used the NASH Clinical Research Network system to score the histology.

199 652 subjects previously enrolled in 2 Asthma Clinical Research Network trials.

200 entre, Thames Valley and South Midlands NIHR Clinical Research Network, and AstraZeneca.

201 ntre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca.

202 ntre, Thames Valley and South Midland's NIHR Clinical Research Network, and the German Center for Inf

203 uses PCORnet, the National Patient-Centered Clinical Research Network, for engagement of health syst

204 alian Ministry of Health, Fonds NutsOhra, UK Clinical Research Network, Perth Children's Hospital Fou

205 ational Institutes of Health's Rare Diseases Clinical Research Network, which consists of expert cent

206 d by the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network.

207 National Institutes of Health Rare Diseases Clinical Research Network.

208 and Blood Institute-sponsored Heart Failure Clinical Research Network.

209 d in the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network.

210 components of a rational approach to achieve clinical research objectives in shorter clinical trial t

211 ters to accelerate basic, translational, and clinical research of pathobiological mechanisms and trea

212 have seen translation to higher species and clinical research of previously inaccessible targets, wh

213 rmation, which should advance both basic and clinical research on Alzheimer's disease and membrane-as

214 ave important implications for diagnosis and clinical research on disease mechanisms for iNPH.

215 s provides additional opportunity to perform clinical research on disease progression and management

216 lopment discerned in this effort are guiding clinical research on disorders with an immune cell base.

217 ndependently selected manuscripts describing clinical research on stem cells, tissues, or solid organ

218 rspective, David Hyman and coauthors discuss clinical research on the application of genomic informat

219 nt of GFR needs to be for application to the clinical, research or public health setting.

220 Study teams from the sponsor and clinical research organisation, investigators, and patie

221 erated randomisation schedule, prepared by a clinical research organisation.

222 y systems for understanding maladaptive use, clinical research parsing what AUD patients remember fro

223 d these cells are now gradually entering the clinical research phase for the testing of heart regener

224 entified from linkages to the United Kingdom Clinical Research Practice Datalink in England and the P

225 licting mechanistic evidence, we propose key clinical research priorities necessary to clarify the ro

226 a management, and could bolster trust in the clinical research process and the ease at which regulato

227 The Malawi-Liverpool-Wellcome Trust Clinical Research Programme has done sentinel surveillan

228 ents or analyses and hence hinders basic and clinical research progress.

229 cousin of hearing science, with low-quality clinical research providing unreliable estimates of effe

230 ns for Diabetic Retinopathy as 91 answerable clinical research questions about intervention effective

231 Among the final list of 106 clinical research questions, 22 questions met our defini

232 published up to March 2016 to high-priority clinical research questions.

233 Pre-clinical research received $61.1 billion (58.2%) across

234 discuss the current state of preclinical and clinical research related to renal sympathetic denervati

235 ientific reporting guidelines for animal and clinical research, respectively).

236 broadly, to examine the implications of the clinical research response mounted.

237 as urine and blood are typically targeted in clinical research, saliva represents an interesting alte

238 tch and its impact on quality of life in the clinical research setting.

239 To make this possible, clinical research should be oriented by guidelines for m

240 While clinical research should be prioritized to advantage pat

241 Clinical research should conform to high standards of et

242 m trial done at The Aurum Institute (Tembisa Clinical Research Site, Tembisa, South Africa), with pha

243 articipants were enrolled in 6 United States clinical research sites affiliated with the HVTN between

244 ant tuberculosis (RR-TB) index cases from 16 clinical research sites in 8 countries, enrollees were i

245 The trial was conducted at 6 outpatient clinical research sites located in Haiti, Dominican Repu

246 12 clinical research sites of the HIV Prevention Trials Net

247 llaboration between funders, trial networks, clinical research sites, clinical and data coordinating

248 The treating physician, clinical research staff, and participants were masked to

249 core domains that should be assessed in all clinical research studies evaluating acute respiratory f

250 easures that are essential to include in all clinical research studies evaluating ARF survivors after

251 holders agree are essential to assess in all clinical research studies evaluating the outcomes of acu

252 re that might be useful in epidemiologic and clinical research studies for quantification of treatmen

253 ysis of CSR junctions is useful in basic and clinical research studies of B cell functions.

254 erits consideration in translational and pre-clinical research studies of micturition and LUT functio

255 Future separate clinical research studies specifically designed to addre

256 Here, we discuss basic, translational, and clinical research studies that provide insight into the

257 f acylcarnitine and amino acid metabolism in clinical research studies using relevant biofluids and t

258 and variability could be used effectively in clinical research studies, particularly in the evaluatio

259 l tool for individual patient management and clinical research studies.

260 cluding 418 participants was conducted at 49 clinical research study sites from January 27, 2014, to

261 record data to inform and complement future clinical research studying the effect of periodontal tre

262 Preclinical and clinical research suggest that hypofractionation-fewer t

263 eproducibility and reporting of ML models in clinical research suggesting the need for ML analyses to

264 Animal studies and recent clinical research suggests that B. caapi preparations sh

265 In contrast, pre-clinical research suggests that cannabis may affect dopa

266 Clinical research suggests that paediatric liver disease

267 Council, Swedish Heart and Lung Foundation, Clinical Research Support at Uppsala University, German

268 Clinical research supports that exercise-induced broncho

269 a more equitable, accessible, and efficient clinical research system that protects patient safety, e

270 ton fetus were invited to participate by the clinical research team.

271 nflammatory effects, and present the limited clinical research that has been published in this arena.

272 an hamper the recruitment of individuals for clinical research that involves genetic testing.

273 standardized methods for the conduct of TBM clinical research that were drafted at an international

274 In clinical research, the application of polygenic risk sco

275 will have important applications for future clinical research, the identification of disease modifie

276 te the importance of MAVE data for basic and clinical research, there is no standard resource for the

277 comparable systems are already available for clinical research, this approach could be readily transl

278 These multimodal tools can inform clinical research through identifying heterogeneity of t

279 iscussed, as well as the need for additional clinical research to best advance CICU care for the alre

280 s momentum and continue to advance basic and clinical research to develop improved tools and interven

281 This year's Lasker-DeBakey Prize for Clinical Research to Douglas Lowy and John Schiller cele

282 We also include recommendations for future clinical research to fulfill quality aims within cardiov

283 the brain, has been used in preclinical and clinical research to investigate neuroinflammation in vi

284 pandemic started, forcing those involved in clinical research to rethink their research strategy, in

285 the lupus community needs to refine existing clinical research tools and better adapt them to overcom

286 ars, BMI 20-35 kg/m(2)) from a database of a clinical research unit in the UK.

287 h meeting organized by the Oxford University Clinical Research Unit in Vietnam.

288 died in using modified constant routine in a clinical research unit.

289 recruited from hospitals, private practices, clinical research units, and academic medical centres.

290 th Africa, UK, and USA (including hospitals, clinical research units, and private offices).

291 is essential that scientists engaged in pre-clinical research use "Completely randomised" (CR), "Ran

292 el will facilitate multicenter collaborative clinical research using archival samples and permit the

293 New information derived from clinical research using molecular genetics and advanced

294 which placebo or sham treatments are used in clinical research, we consulted experts in trials of dru

295 technical advances and their application to clinical research, which has led to abundant evidence re

296 en partially investigated in preclinical and clinical research, while the development of IL-37 and IL

297 n comparison to uveal tract encourage future clinical research with larger patients' population.

298 er, such studies are maturing and may foster clinical research, with opportunities to enhance the sur

299 s, which might slow down creative biomedical clinical research without necessarily restricting abuses

300 recruit, retain, and support a well-trained clinical research workforce; and (5) promote appropriate