ライフサイエンスコーパス: clinical significance

1 ae (MRMp) occurs in the United States or its clinical significance.

2 rse events associated with smoking limit its clinical significance.

3 arched for terms relating to statistical and clinical significance.

4 recent advances in defining and quantifying clinical significance.

5 line, although the findings are of uncertain clinical significance.

6 unts of quantitative features with potential clinical significance.

7 inct mutational processes, and explore their clinical significance.

8 le size, some statistical differences lacked clinical significance.

9 n EE at the present GCG dose was of marginal clinical significance.

10 nd unremarkable changes in the brain without clinical significance.

11 n regarding their persistence, activity, and clinical significance.

12 ia after ibrutinib is an issue of increasing clinical significance.

13 tatistically significant but of questionable clinical significance.

14 -R breast cancer as well as evidence for its clinical significance.

15 dow the original natural product in terms of clinical significance.

16 s were benign polymorphisms with no apparent clinical significance.

17 to replicate these findings and assess their clinical significance.

18 the overemphasis on statistical rather than clinical significance.

19 proved downstream annotation and analysis of clinical significance.

20 asic scientific interest, but also of direct clinical significance.

21 3%]) participants had results with potential clinical significance.

22 h the magnitude of change was on the cusp of clinical significance.

23 ith cryptococcal meningitis to determine its clinical significance.

24 l processes, and their modulation is of high clinical significance.

25 rus (LCMV), is a neglected human pathogen of clinical significance.

26 with modest short-term benefit of uncertain clinical significance.

27 s aeruginosa is a Gram-negative bacterium of clinical significance.

28 and the BRAF(V600) activating mutation have clinical significance.

29 erapy and bone marrow transplantation, is of clinical significance.

30 The transition of AKI to CKD has major clinical significance.

31 adiotherapy, but the changes are of marginal clinical significance.

32 uch as those involving PP2A, assumes greater clinical significance.

33 , and positive results were often of unclear clinical significance.

34 ng surveillance programs and were of limited clinical significance.

35 of cytokine heterogeneity and its potential clinical significance.

36 mprehensive genome sequencing and might have clinical significance.

37 These small changes were unlikely to be of clinical significance.

38 h additional neurological signs of uncertain clinical significance.

39 xpert round-table sessions to validate their clinical significance.

40 he remaining 25 KCNQ1 mutations with unknown clinical significance.

41 luded in neurologic monoclonal gammopathy of clinical significance.

42 date genes is a key step in evaluating their clinical significance.

43 e same as in children, likely limiting their clinical significance.

44 ronic inflammatory conditions highlights its clinical significance.

45 al tests are reported as variants of unknown clinical significance.

46 difficulty of experimentally evaluating its clinical significance, a large number of variants genera

47 osomal aberration predicted to be of unknown clinical significance and another one predicted to be li

48 e the impact of transient IOP elevation, the clinical significance and associated risks of these inte

49 atients are dyslipidemic, this finding is of clinical significance and indicates that self-lipid-reac

50 Here we show the clinical significance and metastatic mechanism of NIFK i

51 cations in these patients, such changes have clinical significance and might become targets for fetal

52 Here, we focus on the clinical significance and potential mechanisms underlyin

53 We explored the clinical significance and predictive value of trans-ethn

54 management of cancer; however, to date, the clinical significance and regulatory mechanisms of PD-L1

55 th IU can occur though bearing no functional clinical significance and spontaneously resolving within

56 As such, the clinical significance and therapeutic utility offered vi

57 Here, we review the epidemiology, clinical significance, and diagnostic and treatment stra

58 to replicate these findings, determine their clinical significance, and identify the underlying mecha

59 ture on observed deviations from guidelines, clinical significance, and initiatives to improve timely

60 xplores the existing data on the prevalence, clinical significance, and management of subclinical atr

61 a focus on the characterization, prevalence, clinical significance, and pathobiology derived from ani

62 kers of numerous diseases, lipoproteins have clinical significance, and this workflow can be used at

63 effects of multiple testing, inattention to clinical significance, and under-reporting of effect siz

64 eal (non-OPSCC), but its pathogenic role and clinical significance are unclear.

65 However, its prevalence and clinical significance are unknown.

66 This novel application holds promising clinical significance as it could be used to differentia

67 significant signal changes at levels of high clinical significance as well as sensitivity to sub-leth

68 unction, this new mechanism is of particular clinical significance, as it may provide additional targ

69 Such differences may have clinical significance, as therapeutic targeting of a sig

70 tive LA mechanical assessment has proven its clinical significance beyond volume measures; however, t

71 ical significance should not be equated with clinical significance, but the topic of clinical signifi

72 -2.67 to -1.68; P < 0.001; threshold met for clinical significance, defined as WMD >1.2 units), and m

73 erview covers both group-level indicators of clinical significance (e.g., effect size indexes), and i

74 can be considered a normal variation without clinical significance, especially in younger populations

75 were used as the gold standard criterion of clinical significance for comparison against the partici

76 These findings have potential clinical significance for older osteopenic patients unde

77 potentially actionable mutations could have clinical significance for targeted therapy and the enrol

78 se parameters has been proven to be of great clinical significance for the diagnosis, prognosis and t

79 ance (grade 4) in 19% of cases, and of great clinical significance (grade 3) in 44% of cases.

80 rest in conceptualizing and operationalizing clinical significance has been a "hot topic" in other he

81 ection in MAC lung disease (MAC-LD), but its clinical significance has not been investigated.

82 with clinical significance, but the topic of clinical significance has not received much attention in

83 describe the extent to which developments in clinical significance have penetrated the nursing litera

84 The clinical significance hereof requires further investigat

85 These lesions have clinical significance; hyperdiploidy or the presence of

86 cible with ICCs that correspond to excellent clinical significance (ICC > 0.9), are not related to ch

87 nd only very modestly raises TSH levels, the clinical significance, if any, of the rise in TSH is unc

88 results establish a correlation between the clinical significance, immunosuppressive potential, and

89 Temporal and nasal telangiectasias may have clinical significance in a patient's risk for retinal he

90 everal cancers, but PD-L1 expression and its clinical significance in basal cell carcinoma (BCC) are

91 Missense variants of uncertain clinical significance in CHEK2 were evaluated using an i

92 mechanisms of CNTFRalpha regulation and its clinical significance in glioma remain largely unknown.

93 Retn in blocking LPS function with important clinical significance in helminth-induced immunomodulati

94 f multiple circRNAs in HCC tissues and their clinical significance in hepatitis B-related HCC patient

95 rosis; however, its presence, frequency, and clinical significance in non-cystic fibrosis bronchiecta

96 enwrapment behavior has important basic and clinical significance in not only understanding how nich

97 ed to improve the visibility and salience of clinical significance in nursing science.

98 and identified SOX9-related genes and their clinical significance in patients with PDAC.

99 age of bleeding (hemostasis) is of paramount clinical significance in prophylactic, surgical, and eme

100 esults indicate that S. maltophilia may have clinical significance in respiratory infections.

101 nsights regarding mechanisms and outcomes of clinical significance in sleep and circadian research.

102 pathy in several patients may have potential clinical significance in spite of low risk of malignancy

103 ignaling in early-onset PCas, implying their clinical significance in the disease.

104 (epidermal growth factor receptor) may be of clinical significance in the treatment of epithelial tum

105 Clinical significance is calculated for the aggregate re

106 utcome in pneumonia clinical trials, but its clinical significance is incompletely understood.

107 ome Variation Society) expressions; however, clinical significance is reported directly from submitte

108 of DAs should be viewed with caution as its clinical significance is still uncertain.

109 Although the clinical significance is still under investigation, prec

110 Its clinical significance is unclear.

111 titers as 3 doses for 6 years, although the clinical significance is unknown.

112 Most of these variants of uncertain clinical significance lead to amino acid changes in the

113 However, despite growing biological and clinical significance, little is known about the structu

114 e continuum, allowing improved evaluation of clinical significance, management, and precision medicin

115 ves: To establish a novel assay and test its clinical significance.Methods: A prospective cohort of 3

116 An inherent consequence is that a variant's clinical significance might be reinterpreted over time a

117 Despite their clinical significance, molecular mechanisms leading to t

118 Belinostat is of clinical significance not only as a candidate drug for A

119 and harmonized interpretations of potential clinical significance, observing an increase from an ave

120 eless, this study is the first to report the clinical significance of a BL-BGC in S. mutans.

121 The trial independently confirms the clinical significance of a novel, minimal residual disea

122 irst study that evaluates the functional and clinical significance of a signaling molecule, Pak1, in

123 ghly sensitive to HER2-targeted therapy, the clinical significance of acquired HER2 heterogeneity dur

124 Clinical significance of aging-associated Nox2 activatio

125 First, the clinical significance of AHR in neuroblastoma was examin

126 renal function seem dissociated; hence, the clinical significance of albuminuria in this setting is

127 The clinical significance of Alloscardovia omnincolens in th

128 The clinical significance of altered lung bacteria in critic

129 ience imaging markers may help determine the clinical significance of Alzheimer's disease pathology a

130 To support the actionability and clinical significance of AR RTK fusions we present all a

131 standing of AR-V7 biology and to confirm the clinical significance of AR-V7.

132 e highlighted, as well as the mechanisms and clinical significance of arrhythmias in the setting of L

133 Data regarding the prevalence and clinical significance of asymptomatic bacteriuria (AB) i

134 Further studies need to determine the clinical significance of asymptomatic CMV shedding.

135 The clinical significance of asymptomatic respiratory viral

136 The potential clinical significance of B7-H4 is supported by the high

137 Despite the clinical significance of balanced chromosomal abnormalit

138 Altogether, our study has revealed the clinical significance of BMP10 in HCC, and suppression o

139 g as an ideal alternative for annotating the clinical significance of cancer-associated PTEN variants

140 Here we aimed to evaluate the clinical significance of circulating LDN in lung cancer

141 tand drug-resistant mechanisms; however, the clinical significance of co-occurring genetic alteration

142 Here, we review the clinical significance of CSCs and results of potential C

143 The emergence and clinical significance of daptomycin-resistant enterococc

144 We aimed to assess the clinical significance of DDI between the regular outpati

145 Quantifying this risk would clarify the clinical significance of delayed paternity.

146 We studied the clinical significance of detecting EBV DNA in the plasma

147 lt Lake City, UT), we aimed to determine the clinical significance of detecting HHV-6 in order to ide

148 The unclear clinical significance of device-detected AF, potential c

149 We investigated the frequency and clinical significance of diagonal earlobe crease (DELC)

150 RATIONALE: The clinical significance of diaphragm weakness in criticall

151 urther studies are necessary to evaluate the clinical significance of differences between the results

152 However, the frequency and clinical significance of direct infection in COVID-19 is

153 Although questions about the clinical significance of DRM discordance remain, in the

154 Approach to interpretation of the clinical significance of drug interactions during target

155 Although the clinical significance of DSA and antibody-mediated rejec

156 ion is a key event in tumor progression, and clinical significance of DTCs and CTCs are controversial

157 Prevalence and clinical significance of dual pathology are unknown.

158 This study reveals the biological and clinical significance of dysplastic hematopoiesis in new

159 component, does not distinguish the relative clinical significance of each, and counts only the first

160 Our study may also imply the clinical significance of early detection and prophylacti

161 cognitive function, or quality of life, the clinical significance of embolic protection devices has

162 Prevalence and clinical significance of emerging postapproval, vaccine-

163 his study, we evaluated the pre-clinical and clinical significance of eradicating pancreatic cancer s

164 Additionally, the clinical significance of even the highest scoring nuclea

165 of this study was to describe and assess the clinical significance of extravascular lung water variat

166 To date, the mechanistic, functional, and clinical significance of FDPS in cancer remains unexplor

167 Furthermore, we evaluated the clinical significance of FO-enriched nutrition and clari

168 o understand the cellular, evolutionary, and clinical significance of genetic variants.

169 olated to include other viruses to study the clinical significance of genotype-specific variations in

170 e challenge of interpreting the biologic and clinical significance of germline TP53 mutations in fami

171 (ages 12-30) and examined the functional and clinical significance of GWAS variants.

172 prospectively the incidence, predictors, and clinical significance of HCV reactivation during cancer

173 -regulation abilities may help determine the clinical significance of hippocampal hyperactivity throu

174 a defining the virologic characteristics and clinical significance of human rhinoviruses, human coron

175 hermore, we review available evidence on the clinical significance of hyperfiltration in diabetes and

176 by-specialty understanding of the nature and clinical significance of informatics variability and ado

177 ationships, and physiological mechanisms and clinical significance of kiwifruits.

178 echnical and clinical detection cutoffs, and clinical significance of LA-DRVs in antiretroviral drug-

179 The mechanism and clinical significance of low circulating 25-hydroxyvitam

180 The clinical significance of low-titer cryptococcal antigen

181 Future studies should attempt to clarify the clinical significance of lower VMAT2 in cocaine abusers,

182 METHODS AND To assess the clinical significance of measured cardiopulmonary hemody

183 The clinical significance of measurement discrepancies was e

184 NDM may evolve into MVP, highlighting the clinical significance of mild MVP expression.

185 We determined the clinical significance of minimal residual disease (MRD)

186 In the present study, the clinical significance of miR-424-3p expression in PC tis

187 We investigated the clinical significance of monocytic MDS-PA in a larger se

188 itional surveillance is needed to assess the clinical significance of MRMp and to monitor changes in

189 The clinical significance of MYC and BCL2 genetic alteration

190 regenerative medicine including the current clinical significance of NDs, as well as the challenges

191 To investigate the clinical significance of neutrophils in the response to

192 ion, we present our current knowledge of the clinical significance of NF-kappaB and its involvement i

193 The clinical significance of Nox2-derived ROS in aging-relat

194 Clinical significance of only 9.56% of the SNVs is known

195 ty of these communities and the ecologic and clinical significance of oral fungal commensals.

196 Studies are needed to understand the clinical significance of our findings.

197 Despite the clinical significance of P. aeruginosa, modeling P. aeru

198 Here we show the clinical significance of PD-L1 in meningioma as a marker

199 The clinical significance of peripheral lesions in AMD remai

200 The incidence and clinical significance of persistent T2 hyperintensity af

201 teractions within the urinary tract, and the clinical significance of polymicrobial bacteriuria is no

202 The clinical significance of polymicrobial interactions, par

203 ture of ambulatory monitors and the variable clinical significance of recorded data in patients.

204 However, the clinical significance of Rig-G and the underlying mechan

205 vement of RPS15A in HCC pathogenesis and the clinical significance of RPS15A expression remain unclea

206 We aimed to determine the prevalence and clinical significance of S aureus small-colony variants

207 ere retrospectively reviewed to evaluate the clinical significance of S. lugdunensis isolation, the a

208 ificantly reducing the time to interpret the clinical significance of sequence variants.

209 c basis for understanding the biological and clinical significance of SIRT2 mutations in genome maint

210 Determination of the clinical significance of such interactions between PrP(C

211 : To characterize the incidence, course, and clinical significance of symptom exacerbations (spikes)

212 o replicate these findings and determine the clinical significance of the association.

213 options for newly infected individuals, the clinical significance of the detection of minority DRM r

214 The aim of this study was to examine the clinical significance of the expression of MTA1 and its

215 Uncertainty about the incidence and clinical significance of the findings is the basis of 2

216 or on parent-reported outcomes, although the clinical significance of the improvement is unclear.

217 Given this research attention and the clinical significance of the issue, this article analyze

218 However, the clinical significance of the kidney's clearance of tubul

219 The long-term clinical significance of the lipid changes noted with th

220 The clinical significance of the long pharmacokinetic tail o

221 However, the clinical significance of the MHC class II Ag presentatio

222 While promising, the clinical significance of the newer mapping techniques wi

223 We sought to evaluate the prevalence and clinical significance of the newest immune checkpoint, H

224 Despite eminent clinical significance of the obesity led gut barrier abn

225 -vaccine-matched antigens, and the uncertain clinical significance of the observed immunological effe

226 investigate HIV prevention efficacy, and the clinical significance of the observed immunological effe

227 To justify the clinical significance of the proposed methodology, the C

228 Furthermore, the clinical significance of the retained gadolinium in the

229 The clinical significance of the small benefit of medication

230 We evaluated the clinical significance of the spontaneous histamine relea

231 This study underlines the clinical significance of the VWFpp assay in the diagnosi

232 side rare syndromes, the nature, extent, and clinical significance of their genetic origins are not k

233 To investigate the clinical significance of these altered pathways, we perf

234 tional studies are needed to investigate the clinical significance of these findings and the generali

235 The clinical significance of these findings has been substan

236 Although the clinical significance of these findings is yet to be det

237 The clinical significance of these findings needs further in

238 Clinical significance of these findings was validated by

239 To translate the clinical significance of these findings, WDR1 expression

240 he need for further studies to determine the clinical significance of these findings.

241 neity of HCC may identify the biological and clinical significance of these imaging subtypes.

242 The clinical significance of these motors emphasizes the imp

243 The clinical significance of these potential biomarkers was

244 and open new avenues of exploration into the clinical significance of these profiles with respect to

245 be a bilateral, asymmetric process, but the clinical significance of these subtle findings is not kn

246 However, the clinical significance of this change in mortality should

247 To assess the clinical significance of this change, TURQUOISE-I, Part

248 nd etoposide-based chemotherapy, pointing to clinical significance of this chemoresistance mechanism.

249 y observed after endurance exercise, but the clinical significance of this increase is unknown.

250 Finally we highlight the clinical significance of this pathology by demonstrating

251 als report conflicting results regarding the clinical significance of this pharmacological interactio

252 The clinical significance of this small decrease remains to

253 The clinical significance of this warrants further investiga

254 However, the clinical significance of troponin elevation in the setti

255 the Merkel cell polyomavirus (MCPyV) and the clinical significance of tumor viral status.

256 ely available archive for interpretations of clinical significance of variants for reported condition

257 terVar to help human reviewers interpret the clinical significance of variants.

258 evidence for the direct impact and potential clinical significance of VCSL on the generation of "sele

259 However, the biological and clinical significance of VGLL dysregulation in human bre

260 The clinical significance of viruses detected in patients wi

261 Background The clinical significance of visually evident emphysema on C

262 r to demonstrate higher absorption rate, the clinical significance of which warrants further evaluati

263 Despite their biological and clinical significance, only the IRAK4 kinase domain stru

264 etions, ERG deletions, PAX5(AMP), which have clinical significance or are associated with novel subty

265 limited by intermediate outcomes of unclear clinical significance or narrow eligibility criteria tha

266 By contrast, the term "clinical significance" or related surrogate terms were f

267 Of clinical significance, patients diagnosed with Chagas di

268 ormalities and their incidence, time course, clinical significance, predisposing factors, optimal ima

269 BRAF(V600E) mutation occurs frequently, but clinical significance remains to be determined.

270 detection of respiratory viruses, but their clinical significance remains unclear in pediatric lower

271 Their clinical significance remains unclear, and available ass

272 th S. maltophilia have poorer diagnoses, its clinical significance remains unclear.

273 D) and intellectual disability; however, its clinical significance remains unclear.

274 However, the clinical significance, reproducibility, and causality of

275 ard in self research, but also has important clinical significance, resonating recent efforts in comp

276 Raising consciousness about clinical significance should be an important priority am

277 This is of fundamental and clinical significance since dysregulation of intracellul

278 In addition, some of our findings may have clinical significance, such as the utility of the pyrimi

279 phocyte exhaustion/suppression showed higher clinical significance than those related to activation o

280 the positions of myosin variants of unknown clinical significance that were identified in patients w

281 Despite the potential clinical significance, the mechanism by which stress mod

282 Because of its clinical significance, the molecular and cellular mechan

283 Despite their frequency and clinical significance, there is a paucity of randomised,

284 Of clinical significance, these data have led to the start

285 Therefore, it is of a great biological and clinical significance to dissect the molecular mechanism

286 te variants were reclassified from uncertain clinical significance to likely pathogenic.

287 To impart functional and clinical significance to MTA1, we analyzed MTA1 and TH l

288 n incidental asymptomatic finding of limited clinical significance to multiple painful episodes of ur

289 OLG but also affect ORF-Y provides potential clinical significance to this finding.

290 ever, these differences are unlikely to have clinical significance until the density decreases to bel

291 gnoses, some of whom had variants of unknown clinical significance (VUS) in the related genes.

292 Clinical significance was assessed by American Thoracic

293 Clinical significance was investigated by using saphenou

294 ally significant difference, but with little clinical significance, was observed in gingival conditio

295 al locations to stratify variants of unknown clinical significance, we showed that the variants that

296 ce of MYC/BCL2 genetic alterations and their clinical significance were largely dependent on COO subt

297 s on the concept of monoclonal gammopathy of clinical significance, which can have a large spectrum o

298 antigen (ZIKV NS1) coincides with levels of clinical significance with detection of antigen in buffe

299 ral Lobe Epilepsy (TLE), and correlate their clinical significance with respect to postsurgical outco

300 linical relevance (amber flagged) or of weak clinical significance (yellow flagged).