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1 t (P = 0.007 in early and P = 0.0048 in late clinical stages).
2 tion drug candidates from the preclinical to clinical stage.
3 disease progression shown to correlate with clinical stage.
4 er at the target site, are mostly at the pre-clinical stage.
5 rogeneous among the patients with MF in each clinical stage.
6 aches are being pursued and have reached the clinical stage.
7 tate-specific antigen level, ISUP grade, and clinical stage.
8 er DFS (HR = 0.19; P = 0.011) independent of clinical stage.
9 cluding those unique to and abundant in each clinical stage.
10 036 was associated with N classification and clinical stage.
11 from mechanical tissue substrates among ARVC clinical stages.
12 y, the infection is chronic, with subsequent clinical stages.
13 ich side effect information for drugs at all clinical stages.
14 is, on the basis of the subclassification in clinical stages.
15 t differed considerably among treatments and clinical stages.
16 ne of these products has yet progressed into clinical stages.
17 nteritis that traverses both subclinical and clinical stages.
18 G was significantly associated with advanced clinical stages.
19 t from abnormal prenatal beginnings to early clinical stages.
20 phocytes of OSCC patients with early or late clinical staging.
21 World Health Organization classification and clinical staging.
22 gible for sphincter-sparing surgery based on clinical staging.
23 men included in the study, 363 (98%) had WHO clinical stage 1 disease, 364 (99%) had high functional
24 tre, prospective, cohort study patients with clinical stage 1 endometrial cancer of all histologies a
25 ll tolerated when given to children with WHO clinical stage 1 or 2 HIV disease along with high antire
27 on activity of most other HAP, including the clinical stage 2-nitroimidazole mustard TH-302, dinitrob
28 es were eligible if they reported death, WHO clinical stage 3 or 4 events, admittance to hospital, se
29 more advanced HIV (World Health Organization clinical stage 3 or 4) disease had lower mortality in cl
35 endpoint of death, World Health Organization clinical stage 4 disease, or CD4(+) counts of <200/mm(3)
36 s (54 died, 45 had World Health Organization clinical stage 4 events, and 49 had poor immunological r
37 d new or recurrent World Health Organization clinical stage 4 events, or had poor immunological respo
38 rom LRR at 5 years ranged from 86% to 97% by clinical stage, 86% to 97% by pathologic stage, and 71%
40 We compared the distribution of grade and clinical stage across the pre-PSA and PSA screening eras
41 c physiological and HRCT variables to form a clinical staging algorithm predictive of mortality in a
42 was significantly higher with more advanced clinical stage (Alzheimer's disease > mild cognitive imp
43 -to-lead and lead optimization campaigns and clinical stage and approved drugs, reflecting their incr
44 nitiation, cumulative time with NVL, and WHO clinical stage and CD4 cell count at ART initiation, rat
45 arian cancer patients present at an advanced clinical stage and develop resistance to standard of car
47 omarker of GI GVHD that can be combined with clinical stage and histologic grade to improve risk stra
51 pathways involved in preeclampsia at the pre-clinical stage and may be used for the prediction of pre
53 t its overexpression is correlated with late clinical stage and predicts poor prognosis in ESCC patie
55 ency of lymph node metastasis increased with clinical stage and was similar to that in historical sur
56 ifferences of clinical outcome in respective clinical stages and individual 'stage, size, grade and n
57 can progress over years through a series of clinical stages and lead to irreversible neurological or
58 grative topological measures correlated with clinical stages and prognosis, which was further validat
60 e findings may potentially contribute to the clinical staging and monitoring of Stargardt disease.
61 m prostate-specific antigen, tumor grade and clinical stage) and by treatment type (radical prostatec
64 ions were comparable for age, comorbidities, clinical stage, and elevated biomarkers of systemic infl
65 correlated with larger tumor size, advanced clinical stage, and low survival rate in OSCC patients.
68 ng centre, largest radiological tumour size, clinical stage, and prespecified chemotherapy regimen.
71 m SUV, performance status, T stage, N stage, clinical stage, and treatment type (surgery vs other) we
72 ultiple tumor niches, their association with clinical stages, and their potential use in cancer diagn
73 heir sample size, lack of clearly documented clinical staging, and lack of well-defined gold standard
75 s to address the mechanism of action of four clinical stage anti-Abeta antibodies, aducanumab, ganten
76 in structures of a large set of post-phase-I clinical-stage antibody therapeutics (CSTs) and calculat
77 like DZB, should be further evaluated at the clinical stage as targeted therapy for CCA treatment.
78 ty of Urological Pathology (ISUP) grade, and clinical stage as traditional risk stratification parame
79 ntification and treatment of AD in the early clinical stages as well as before cognitive symptoms eme
81 e, year of ART initiation, CD4 count and WHO clinical stage at ART initiation, retention in HIV care
83 therapy determines prognosis rather than the clinical stage before neoadjuvant chemotherapy, indicati
84 hibitor that is more potent than three major clinical stage BET inhibitors BMS-986158, OTX-015, and G
85 prognostic models: one with CD4 cell count, clinical stage, bodyweight, age, and sex (CD4 count mode
86 to improve the decision making at the early clinical stage by using innovation and the high-profile
93 ing for known survival covariates, including clinical staging criteria, the IHC panel remained an ind
94 nt chemotherapy on the basis of pretreatment clinical stage (CS), estrogen receptor status (E), grade
95 ating the American Joint Committee on Cancer clinical stage (CS), final pathologic stage (PS), estrog
96 ohort study of 1386 men with favorable-risk (clinical stage cT1 to cT2bN0M0, prostate-specific antige
97 en (</=80 years) diagnosed in 2011-2012 with clinical stage cT1-2, localized prostate cancer, with pr
98 te cancer and 619 men with unfavorable-risk (clinical stage cT2cN0M0, PSA of 20-50 ng/mL, or Grade Gr
99 n of CRT to surgical resection, adjusted for clinical stage, demographic information, and CRT regimen
100 strains and are constituents of vaccines in clinical-stage development, these findings will aid in r
101 sms in common, and then assesses the various clinical-stage diabetes drugs for their potential activi
103 in has made it a challenging target, with no clinical stage, direct small-molecule MYC inhibitors ava
106 have delivered inhibitors reaching advanced clinical stages due to several challenges in the discove
107 us knowledge, and linkage to care) and three clinical stages (eligibility for antiretroviral therapy
108 relation to Parkinson disease diagnoses at 3 clinical stages: established (cases diagnosed before 199
109 iding preclinical support for the use of the clinical stage FAK/PYK2 inhibitors for treatment of MM,
110 s after diagnosis, while currently available clinical staging for esophageal cancer is lacking necess
112 ls of p-IRAK-4 levels did not correlate with clinical stage, gender, or age, but attenuated IRAK-1,-4
113 found with estimated dose or type of statin, clinical stage, Gleason score, or with prediagnosis stat
114 , histologic type of the tumor, T stage, and clinical stage had no influence on relapse (P = 0.180, P
115 gence of resistance observed for the current clinical-stage hepatitis C virus (HCV) NS3 protease inhi
116 abnormalities included CD4 cell count nadir, clinical staging, history of AIDS-defining events, infec
117 n this study, we use BIVV009 (Sutimlimab), a clinical stage, humanized mAb that specifically inhibits
119 etrospective study including data from 2,483 clinical stage I (CSI) patients, 1,139 CSI nonseminoma a
120 n 1997 and 2002, 502 patients with suspected clinical stage I (T1-2N0M0) NSCLC were prospectively enr
121 y 1999, 636 women (age >/= 70 years) who had clinical stage I (T1N0M0 according to TNM classification
124 nd retroperitoneal lymph node dissection for clinical stage I disease in January 2010, which revealed
126 h seminoma and 257 with nonseminoma; 371 had clinical stage I disease, 201 had systemic disease, and
127 risk lung nodules (n = 4), and management of clinical stage I non-small cell lung cancer (n = 1) were
130 ber 1980 to December 2015, 580 patients with clinical stage I NSGCT were treated with AS, and 162 sub
131 ts and Methods Adult patients with resected, clinical stage I or II adenocarcinoma of the head of the
132 Results We identified 15,237 patients with clinical stage I or II resected pancreatic head adenocar
133 nce a relapse after adjuvant carboplatin for clinical stage I seminoma can be successfully treated wi
135 s) with limited-stage small-cell lung cancer clinical stage I to III who received CT or CRT were iden
136 isease in 1 of 20 (5%) patients with initial clinical stage I, 2 of 44 (5%) stage IIA, 8 of 47 (17%)
137 ive cohort study of patients <=85 years with clinical stage I-II PDAC in the 2004 to 2014 National Ca
139 ment resulted in fewer early progressions in clinical stage I/II HL, although early outcome was excel
141 is available concerning localized-stage FL (clinical stages I/II), which accounts for ~20% of newly
142 vival rates of patients with first, primary, clinical stage IA nonsmall cell lung cancer from a large
143 l study of 787 patients with newly diagnosed clinical stage IB or II melanoma, we estimated odds rati
147 2 trial of neoadjuvant therapy for high-risk clinical stage II or III breast cancer, evaluated multip
152 ts in the independent validation cohort (99% clinical stage II-III) who were predicted to be treatmen
154 lysis of patients with locoregional disease (clinical stage II/III) demonstrated that females receive
155 erapy achieves low local recurrence rates in clinical stages II to III rectal cancer, it delays admin
157 the role of FDG PET/CT in initial staging of clinical stage IIA and IIB and primary operable stage II
160 receiving CRT decreased with increasing age, clinical stage III disease, female sex, and the presence
163 variate analysis, an age less than 50 years, clinical stage III, grade 3, estrogen receptor (ER)-nega
164 re with risk factors (RFs) of early relapse, clinical stage III/IV, and anemia identified patients wi
165 icular lymphomas (FLs) diagnosed in advanced clinical stages III/IV, and which are frequently charact
167 ditional prognostic information over TLG and clinical staging in patients with advanced T-stage OPSCC
168 er MTV and TGA add prognostic information to clinical staging in patients with oral and oropharyngeal
170 ck of a suitable animal model, mimicking all clinical stages, in particular the healing process, rema
171 id sequences from 137 antibodies in advanced clinical stages, including 48 approved for therapeutic u
174 ted by FDG-PET in cervical cancer relates to clinical stage, is comparable to historical data, and st
177 n and their contribution to pathological and clinical stages leading to vision loss in diabetic retin
178 o detect MGA expression, especially in early clinical stage, low grade and lymph node metastasis-nega
179 ate cancer, as assessed by low-risk disease (clinical stage </=T2a, biopsy Gleason score </=6, and pr
180 n [PSA], <=15 ng/mL; Gleason score, <=3 + 4; clinical stage, <=T2c; lesion size at multiparametric MR
183 isting evidence, although scarce, supports a clinical staging model by which at-risk women are manage
184 morbidity Index, tumor type, tumor location, clinical stage, neoadjuvant treatment, and the hospital
185 NFL concentration is increased by the early clinical stage of AD and is associated with cognitive de
186 dysfunction and SR Ca(2+) leak depend on the clinical stage of AF or specific animal model studied.
187 eurogranin is increased already at the early clinical stage of Alzheimer's disease and predicts cogni
188 presence of these lesions did not change the clinical stage of any patient and did not affect treatme
190 onic liver failure (ACLF) is the most severe clinical stage of cirrhosis, there is lack of informatio
192 ET/CT has no impact in the definition of the clinical stage of disease and minimal impact in the trea
194 e of HCC patients, and which correlated with clinical stage of HCC, were NAA, dimethylglycine, 1-meth
197 ation carriers, in the later preclinical and clinical stages of ADAD, mutation-carrying children were
198 out the brain during asymptomatic as well as clinical stages of Alzheimer disease calls for precise l
208 these changes are present from the earliest clinical stages of multiple sclerosis; (ii) they occur i
210 relation between EPO serum concentration and clinical stages of PDR, suggest that erythropoietin repr
212 of 12-HETER1 positively correlates with the clinical stages of prostate cancers and Gleason scores.
213 rbation, is affected at the pre-clinical and clinical stages of spinocerebellar ataxia type 6 (SCA6),
214 entified as a good tumor-specific marker for clinical staging of cervical sentinel lymph nodes in hea
215 Specific IVCM-MF correlate with ACD and clinical staging of disease, and are prognostic indicato
219 terion that is currently lacking in the AJCC clinical staging of MPM.Supplemental material is availab
224 y of drugs encompassing approximately 12,000 clinical-stage or Food and Drug Administration (FDA)-app
225 ing iron availability by VIT-2763, the first clinical stage oral ferroportin inhibitor, ameliorated a
226 sion levels of KISS1 in PCas correlated with clinical stage (P < 0.01) and with KISS1R expression (P
229 omes derived from multivariate analysis were clinical stage (P<0.0001), location of the tumor (P=0.02
231 NMRP expression were evident at the earliest clinical stages (p < 0.05), which progressed significant
233 expression was significantly associated with clinical stage, pathologic tumor status, distant metasta
237 neoadjuvant chemotherapy using pretreatment clinical stage, posttreatment pathologic stage, estrogen
238 These results should improve MRI-guided clinical staging, presurgical planning, and intraoperati
239 rly clinical stage primary INS, whereas late clinical stage primary INS resembled the genetic profile
240 enetic profiles in normal pancreas and early clinical stage primary INS, whereas late clinical stage
241 iR levels were significantly associated with clinical stage, primary tumor size, and response to trea
243 nostic factors including high Gleason score, clinical stage, prostate-specific antigen (PSA) and exte
247 pproaching 25% depending on quantitative and clinical stage, sex and histological subtype and is bett
249 eral regions was correlated highly with FECD clinical stage (Spearman's rho = 0.813, 0.793, and 0.721
250 ed hazard ratio 0.21, 95% CI 0.17-0.27), WHO clinical stage (stages III-IV vs I-II; 3.45, 2.43-4.90),
251 ed system based on World Health Organization clinical staging, standardized first-line ART regimens,
252 ed, with the same number of patients in each clinical stage subgroup (12 stage I patients, 32 stage I
254 seventh edition tumor-node-metastasis (TNM) clinical staging system for OAL and followed every 6 to
255 sus-host disease (GvHD) is based on either a clinical staging system or histological or endoscopic fi
256 he American Joint Committee on Cancer (AJCC) clinical staging system, T3 and T2 lesions portended a h
257 86-19 ('Study 19') to examine the utility of clinical staging systems as end points in clinical trial
258 40 to 80 years with a GS between 2 and 6 and clinical stage T1 or T2 prostate cancer enrolled between
259 CI, 0.94-2.03), as did current smokers with clinical stage T1 through T3 (HR, 1.41; 95% CI, 0.80-2.4
260 CI], 1.11-2.32), as did current smokers with clinical stage T1 through T3 (HR, 1.80; 95% CI, 1.04-3.1
262 cohort study of Medicare beneficiaries with clinical stage T1a kidney cancer treated with partial or
263 ewly diagnosed LPCa with Gleason score <= 7, clinical stage T1b to T3a, and prostate-specific antigen
266 with esophageal adenocarcinoma histology and clinical stage T1bN1-N3 or T2-T4aN-/+M0 were divided int
267 t, 2 cm or greater in diameter by palpation, clinical stage T1c-3, cN0, cN1, or cN2a, without metasta
268 ed from 2004 to 2007 with low-risk prostate (clinical stage T1c/T2a; Gleason score, </=6; and prostat
270 a were for very-low-risk cancers, defined by clinical stage (T1c), prostate-specific antigen density
271 ery-low-risk (subset of the low-risk group) (clinical stage, T1c; Gleason score, </=6; prostate-speci
272 reated low-volume low-grade prostate cancer (clinical stage T2a or lower; Gleason score, 3+3; index t
274 otential advantage of extended resection for clinical stage T4b gastric adenocarcinoma with good long
275 adjuvant therapy, but limitations in current clinical staging techniques mean nodal metastases often
276 th higher odds of Parkinson disease at all 3 clinical stages: the odds ratios comparing long nappers
278 le across manifest HD from early to advanced clinical staging through metabolomic analysis by mass sp
279 related with histological subtype of OC, but clinical staging, TLG, and SUV(max) values were not rela
280 astasis suppressive activity of entolimod, a clinical stage TLR5 agonist that activates NF-kappaB-, A
282 , and we classified patients by tumour site, clinical stage (TNM system), and post-surgical stage (In
283 SA) concentration, biopsy Gleason grade, and clinical stage to classify patients as low, intermediate
284 y dismal clinical outcomes, independently of clinical stage, TP53 aberrations (deletion of chromosome
285 ected included demographics, diagnosis date, clinical stage, treatment, and outcome 1,082 patients me
286 th tGIV and pYGIV showed no correlation with clinical stage, tumor size, pathologic type, lymph node
287 epithelioid histology, T stage, quantitative clinical stage/tumor volume staging, adjuvant chemothera
288 (24%) had germline BRCA1 or BRCA2 mutations; clinical stage was I (13%), IIA (36%), IIB (36%), and II
297 utation status, CD38 or ZAP-70 cytogenetics, clinical stage) were significantly associated with time
298 ups (PSA concentration, Gleason grading, and clinical stage) were then used to sub-stratify within ea
299 e primarily associated with tumor burden and clinical stage, whereas tumor TLG is the best predictor
300 ic and prognostic tool for AD, regardless of clinical stage, which would be of great benefit in clini