ライフサイエンスコーパス: clinically

1 n a patient has demonstrated chemoresistance clinically.

2 neal elasticity ex vivo, they cannot be used clinically.

3 ction), which are used to treat infected PUs clinically.

4 are cumbersome and challenging to translate clinically.

5 tifungal therapy and 22 (81%) responded well clinically.

6 The proposed 3D LA LGE method produced clinically acceptable image quality with 1.5 mm x 1.5 mm

7 Axial curvature zone averaging yielded clinically acceptable repeatability only in eyes with Km

8 sting in a CDI mouse model, auranofin at low clinically achievable doses (0.125 mg/kg and 0.25 mg/kg)

9 rucaparib inhibit DYRK1s, CDK16 and PIM3 at clinically achievable, submicromolar concentrations.

10 d DNA methylation profiling to determine the clinically actionable genomic and epigenomic landscapes

11 sh MET(N375S) as a biologically distinct and clinically actionable molecular subset of SCCs that are

12 ub in primary bone cancer metastasis that is clinically actionable.

13 Clinically, active versus passive lifestyle intervention

14 izumab-based inhibition of VEGF has been the clinically adopted strategy to treat colorectal and brea

15 on low-molecular-weight carriers offer many clinically advantageous attributes relative to macromole

16 o fear and anxiety disorders transmission in clinically affected families.

17 patology have ample opportunities to partner clinically and academically.

18 Most patients improve clinically and at imaging on follow-up, particularly fol

19 on-deficit/hyperactivity disorder (ADHD) are clinically and biologically heterogeneous neurodevelopme

20 Uveitis activity was assessed clinically and by ICGA.

21 at a multifaceted implementation package was clinically and cost-effective for targeting prescribing

22 , and examine the efficacy in subgroups with clinically and genetically defined risk.

23 e contrast was not present and may provide a clinically and laboratory relevant, relatively inexpensi

24 cal syndromes of frontotemporal dementia are clinically and neuropathologically heterogeneous, but pr

25 mentia and amyotrophic lateral sclerosis are clinically and pathologically overlapping disorders with

26 metastasis poses a challenging problem both clinically and scientifically, as the stochastic nature

27 res on clones long before the development of clinically apparent chronic lymphocytic leukaemia.

28 tion can occur and consists of a spectrum of clinically apparent syndromes from mild symptoms to tiss

29 ported using genetically modified pigs and a clinically applicable drug treatment regimen.

30 well with the profiles of the corresponding clinically approved ADC Kadcyla.

31 Intrinsic or acquired resistance to clinically approved CDK4/6 inhibitors has emerged as a m

32 tage-gated potassium channels (K(V)1 family) clinically approved for the symptomatic treatment of pat

33 Here, we use the clinically approved MEK inhibitor Trametinib to investig

34 Furthermore, clinically approved PCSK9-neutralizing antibodies synerg

35 bioactive compounds, including a variety of clinically approved therapies.

36 cer (SCLC) is a neuroendocrine tumor treated clinically as a single disease with poor outcomes.

37 tant prostate cancers, and this may manifest clinically as transformation from a prostate adenocarcin

38 However, 10 patients were clinically assessed as having possible PTLDS.

39 egression to assess the associations of each clinically assessed marker of earlier puberty with self-

40 However, clinically available drugs have been limited until recen

41 Beyond these clinically available imaging tools, attempts have been m

42 Despite the variety of clinically available therapeutic molecules, medical inte

43 uman tumors, no inhibitor of mutant KRAS was clinically available until recently.

44 reasing drug resistance and the absence of a clinically available vaccine, there is an urgent need fo

45 They are clinically beneficial in autoimmune diseases such as mul

46 pH-activatable optical imaging agent may be clinically beneficial in differentiating previously unex

47 s an observational component of the trial, a clinically blinded coronary CTA was conducted prior to I

48 tumors, a metabolic process that is observed clinically by (18)F-fluorodeoxyglucose positron emission

49 reversible airflow obstruction characterised clinically by wheezing, shortness of breath, and coughin

50 Individuals clinically classified as AD dementia but having negative

51 ce for patients with esophageal cancer and a clinically complete response (cCR) after neoadjuvant che

52 Seventy-seven pediatric patients with clinically confirmed fish allergy underwent skin prick t

53 only partially overlaps with the genetics of clinically defined AUD.

54 p<0.001) and 14.4 (4.99, 41.69; p<0.001) for clinically defined chronic pulmonary disease, moderate-s

55 al outcome trajectories were associated with clinically defined dysmature and disorganised EEG patter

56 mingly complex forms of CKD across different clinically defined subgroups and are characterized by hi

57 Sixty-nine patients with a 'clinically defined' diagnosis of FMD were genotyped for

58 ration of a placebo, the local delivery of a clinically deployable formulation of the two drugs reduc

59 enhancing RGS protein function is often more clinically desirable but presents a challenge.

60 istently found to have a lower prevalence of clinically detected atrial fibrillation (AF) than whites

61 biopsies from a total of 883 nonmetastatic, clinically detected cancers of the colorectum, esophagus

62 The model was trained using clinically diagnosed Alzheimer's disease and cognitively

63 tion studies were conducted among cases with clinically diagnosed diabetes.

64 lity risks are increased in individuals with clinically diagnosed hereditary hemochromatosis, but ris

65 and a specificity of 0.82 in differentiating clinically diagnosed PTB cases from non-TB disease contr

66 Clinically diagnosed pulmonary tuberculosis (PTB) patien

67 ishing asymptomatic from symptomatic stones, clinically diagnosed symptomatic stone episodes from sel

68 lassified as bacteriologically-confirmed TB, clinically diagnosed TB, or other diseases.

69 164 patients with clinically diagnosed uveitis of the posterior segment.

70 dent cases of alpha-synucleinopathy, 86 were clinically diagnosed with RBD (19.8%), including 30 (35%

71 hemia, defined as any new choroidal ischemia clinically diagnosed within 35 days after an IAC injecti

72 rowth factor-beta-induced (TGFBI) gene cause clinically distinct types of corneal dystrophies.

73 Providing clinically effective blockade of CGRP signaling required

74 These findings demonstrate that clinically effective deep brain stimulation of the subth

75 d pediatric cancers and are some of the most clinically-effective therapeutic targets, yet low consen

76 lipophilicity coupled with a low anticipated clinically efficacious plasma exposure for migraine also

77 evated degree of molecular specificity, many clinically employed and experimental targeted anticancer

78 erstanding how pharmacologically diverse and clinically essential drugs act through overlapping and d

79 Posterior wounds were left undisturbed to clinically evaluate healing (using photographs and Heali

80 computed tomography scan and were thereafter clinically evaluated every 2-4 months (years 1-2), then

81 st twice as high in aggressive compared with clinically favorable tumors (median Simpson index of div

82 asures with tumor-to-blood ratios provides a clinically feasible approach to human imaging.

83 reatment warrants further investigation as a clinically feasible therapy for ICH.

84 xamer hydrogels currently being investigated clinically for hearing loss.

85 It is most commonly used clinically for the treatment of Gram-positive skin and s

86 Influenza is difficult to distinguish clinically from other acute respiratory infections.

87 mples from 30 dogs that sustained RCCL and 9 clinically healthy dogs were analyzed.

88 ld extend the generalizability to the broad, clinically heterogeneous ED population under conditions

89 l17ra) reversed the development of psoriasis clinically, histologically, and transcriptionally in imi

90 However, it is not clear which of the clinically identified RNF43 mutations affect its functio

91 cipients was lower, but differences were not clinically important (56.6 vs. 57.5 mL/min/1.73m for ide

92 istance mechanisms, and biosynthesis of this clinically important antimicrobial agent.

93 hat calcium supplementation does not provide clinically important benefits for BMD in lactating women

94 ed measurement is sensitive enough to detect clinically important changes in disease status or effect

95 s] to 24 points [most symptoms]; the minimal clinically important difference for change in scores was

96 was underpowered to find a statistically and clinically important difference in the primary outcome.

97 core (range, 0 [best] to 90 [worst]; minimal clinically important difference, 5.7 points).

98 ale (range, 0 [worst] to 184 [best]; minimal clinically important difference, 9 points) and symptoms

99 We aim to increase the understanding of this clinically important disease entity through a genome-wid

100 e could not rule out the presence of smaller clinically important effects.

101 In order to achieve this clinically important goal, the approach necessarily brea

102 k-modeling approaches are likely to identify clinically important HTE, methodological aspects of risk

103 CBD-dominant cannabis may not have excluded clinically important impairment, and the doses tested ma

104 The clinically important MAM blood group antigen is present

105 odiesterases exist, and certain families are clinically important modulators of vasodilation.

106 y variable; the pooled result did not show a clinically important or statistically significant associ

107 dimensional measures of adherence may ignore clinically important patterns of medication-taking behav

108 ture to a nucleic acid target representing a clinically important sexually transmitted infection (STI

109 Clinically important Staphylococcus aureus obtains iron

110 ll-cause death or to characterise effects in clinically important subgroups.

111 ZVV's feasibility was assessed clinically in five human patients with acute lung injury

112 of vessels, even in patients with apparently clinically inactive disease; acute blindness is rare dur

113 en 25 to 65 years of age who were undergoing clinically indicated colposcopy at two medical centers i

114 ontinuation of ACEI/ARB medications that are clinically indicated in the context of the COVID-19 pand

115 ein angiography (FA) was also performed when clinically indicated.

116 red at baseline, 6-month intervals, and when clinically indicated.

117 rts to reduce elective CS rates that are not clinically indicated.

118 agent immune modulators have thus far proven clinically ineffective, and multi-modal therapies target

119 ning and the increased diagnosis of possibly clinically insignificant disease might have a role in ce

120 In summary, LIRICAL provides accurate, clinically interpretable results for phenotype-driven ge

121 Furthermore, an intuitive and clinically interpretable summary of treatment efficacy b

122 endothelial corneal dystrophy was classified clinically into early-stage (without edema) and late-sta

123 ver, basal-like breast cancer (BLBC) remains clinically intractable.

124 Most are clinically irrelevant and possess intrinsic antagonist o

125 , two, or even three antibiotics against two clinically isolated multi-drug-resistant bacteria strain

126 was relatively specific to schizophrenia (HC-clinically isolated syndrome for multiple sclerosis BAC

127 that further intervention may be required to clinically justify rapid AST implementation.

128 weeks in vivo, the localized activity of the clinically licensed growth factor BMP-2.

129 e of neoadjuvant CHT and RP in patients with clinically localized, high-risk PC at this time.

130 Men with clinically localized, high-risk PC were assigned to RP a

131 Clinically, LUBAC activity is consistently elevated in m

132 sal tissues and skin, can become pathogenic, clinically manifesting most commonly as oropharyngeal ca

133 EV was generally well tolerated and provided clinically meaningful and durable responses in patients

134 We found no evidence of clinically meaningful benefits of serum urate reduction

135 No clinically meaningful between-group difference in the in

136 failed to meet established thresholds for a clinically meaningful change.

137 Clinically meaningful changes were defined a priori and

138 potential solutions by attempting to obtain clinically meaningful conclusions at the end or during a

139 rs, rucaparib maintenance treatment led to a clinically meaningful delay in starting subsequent thera

140 differentially abundant microbial species is clinically meaningful for finding disease-related pathog

141 umab to trastuzumab emtansine did not show a clinically meaningful improvement in progression-free su

142 In addition, clinically meaningful improvements were seen in child-re

143 D; however, the at-risk pool is large, and a clinically meaningful metric for risk stratification to

144 hours after the procedure, NSAIDs provide a clinically meaningful reduction in pain relative to a co

145 rves (AUC) and partial AUC for the region of clinically meaningful specificity (85%-100%) were used t

146 Tazemetostat monotherapy showed clinically meaningful, durable responses and was general

147 b demonstrated effective antitumor activity; clinically meaningful, durable responses; and acceptable

148 tral neck dissection (pCND) in patients with clinically node negative (cN0) papillary thyroid cancer

149 In clinically node negative patients (cN0), 97.7% (432/442)

150 -PRF) + autogenous bone graft (ABG) may be a clinically "non-inferior" treatment modality as compared

151 T1) in a large, well-characterized cohort of clinically normal elderly who were followed longitudinal

152 emplate generated from 30 neurologically and clinically normal non-brachycephalic dogs, tissue segmen

153 Animals were evaluated clinically on a daily basis during a 20-day experimental

154 included major bleeding (fatal, critical, or clinically overt bleeding or bleeding at the surgical si

155 Its steep rise up to 72 hours before clinically overt deterioration has the potential for phy

156 Clinically, patients presenting with symptoms of gastrit

157 (2)(SNP) = 0.035, p = 7.12 x 10(-4)) and the clinically predicted phenotype from VUMC (h(2)(SNP) = 0.

158 review of patient medical records, including clinically prescribed antibiotics, revealed the potentia

159 it cellular cholesterol biosynthesis and are clinically prescribed to patients with hypercholesterole

160 iers in the general population or in various clinically presenting patient groups remains poorly defi

161 imuli (<-1.8 log cd . s/m(2)) occur prior to clinically recognized DR.

162 Frailty is a clinically recognized syndrome of decreased physiologica

163 The locally preferred clinically reconstructed images were blindly reviewed by

164 In addition, these clinically reconstructed images were used for semiquanti

165 -onset, with a positive predictive value for clinically relapsing disease of only 20%.

166 se were categorized into different groups of clinically related disorders.

167 Here, we show that clinically relevant antagonists used for treating autoim

168 We reasoned that clinically relevant antifungal resistance could derive f

169 CDK4/6 activity is clinically relevant as mutations, deletions, and amplifi

170 s of six prospective cohort studies found no clinically relevant association between subclinical thyr

171 a limited number of combinations demonstrate clinically relevant benefits, which remain concentrated

172 iation was seen between high aFXa and 90-day clinically relevant bleeding (4.8% vs. 2.9%, p = 0.34) o

173 l site leading to intervention) and nonmajor clinically relevant bleeding.

174 ially available compounds against a panel of clinically relevant BLs: class A CTX-M-15 and KPC-2, sub

175 ns of different geometries and under various clinically relevant boundary conditions.

176 offset restoration ROM did increase but not clinically relevant by offset overcorrection for all dir

177 lls and their protein-level responses to two clinically relevant cancer drugs.

178 .ConclusionExpert-level models for detecting clinically relevant chest radiograph findings were devel

179 sion of FLIP(L) using siRNA or entinostat (a clinically relevant class-I HDAC inhibitor) efficiently

180 Clinically relevant CMV infection was defined as either

181 This inhibition occurs at clinically relevant concentrations and may contribute to

182 The dynamic range covers the whole range of clinically relevant concentrations of the autoantibodies

183 gues, suppressed RyR2-mediated Ca release at clinically relevant concentrations.

184 as been used in research studies to identify clinically relevant copy number abnormality (CNA) profil

185 promising DST solution for rapidly providing clinically relevant data to manage complex DR-TB cases.

186 enetic and phenotypic changes that determine clinically relevant delamanid resistance to help develop

187 mary outcomes were the risk of depression or clinically relevant depressive symptoms (total of incide

188 Toxicity over Time analyses provided clinically relevant descriptions of neutropenia and fati

189 as well as the diversity and distribution of clinically relevant determinants of pathogenicity and an

190 lyses are required to determine if there are clinically relevant differences with respect to RD confi

191 Finite, short-duration treatment with a clinically relevant dose of GS-9688 is well tolerated an

192 (NSCLC) explant models after treatment with clinically relevant doses of cisplatin.

193 ere, we propose the term atrial failure as a clinically relevant entity, defined as any atrial dysfun

194 duce a miniature stimulator that operates at clinically relevant high frequencies.

195 These findings suggest a clinically relevant impact of IVIg on monoclonal antibod

196 gy in detecting Prostate Specific Antigen in clinically relevant levels (ng/ml), paving the way towar

197 and BAT rMal d 3 (0.001 ug/mL) can identify clinically relevant Mal d 3 sensitization (sensitivity o

198 L-6 during homeostatic T cell expansion in a clinically relevant model of lymphoablation.

199 unbiased genetic screenings combined with a clinically relevant model system is a practical approach

200 Using Bruton's tyrosine kinase (BTK) as a clinically relevant model system, we show efficient degr

201 Here, we present a method for predicting clinically relevant motion parameters from an ordinary v

202 g CCR2 and PD-1 blockade extends survival in clinically relevant murine glioma models and provides th

203 molecular pharmacology of a diverse range of clinically relevant NAMs.

204 , and the principal safety outcome, major or clinically relevant non-major bleeding (assessed in part

205 nding oligogenic inheritance that results in clinically relevant OFT malformations.

206 decision-making depends on identification of clinically relevant organisms present in a sample.

207 nd the percent of sites positive for select, clinically relevant pathogens.

208 on of super-resolved microvascular images at clinically relevant penetration depths, which can be pot

209 of a newly identified TCR in complex with a clinically relevant peptide derived from the cancer test

210 systems, including the ability of affecting clinically relevant phenotypes such as virulence, host c

211 ere disease in aged mice, and exhibited more clinically relevant phenotypes than those seen in Hfh4-A

212 nificantly increase survival are observed in clinically relevant platinum and acquired PARPi-resistan

213 Here, we tested their role in the clinically relevant polysaccharide conjugate vaccine aga

214 Clinically relevant precursors and early cancers were to

215 model utilizing the PaO(2)/FiO(2)-ratio as a clinically relevant primary outcome criterion.

216 the level at which minority variants become clinically relevant remains unclear.

217 treatment in E. coli-induced myositis and a clinically relevant S. aureus wound infection murine mod

218 iosensor for detecting biomarkers for AIV in clinically relevant samples such as chicken serum.

219 = .04) and with an alternative definition of clinically relevant serrated polyps (12.3%; 95% CI, 9.3-

220 There are clinically relevant sex differences in acute and chronic

221 of snake venom metalloproteinases from five clinically relevant species of snakes.

222 ly, ES24 shows antibacterial activity toward clinically relevant strains.

223 Here, we report the identification of two clinically relevant subtypes of post-traumatic stress di

224 onal cohort showed no evidence for a severe, clinically relevant systemic immunodeficiency.

225 Here, using chlamydia DNA as a clinically relevant target and high-throughput sequencin

226 Photodynamic therapy (PDT) is an important clinically relevant therapeutic modality that has proven

227 t clinical trials using L-AZM as a novel and clinically relevant therapeutic target to improve cardia

228 and nonspecific for response monitoring in a clinically relevant time frame.

229 or change in type of a hiatal hernia may be clinically relevant to help understand changing or worse

230 There were no clinically relevant treatment-related serious adverse ev

231 strategies are being pursued for predicting clinically relevant tumour behaviours, such as treatment

232 This is clinically relevant.

233 acteristics to identify lncRNA signatures in clinically-relevant co-expression lncRNA-mRNA networks r

234 mixed-effects regression models adjusted for clinically-relevant confounders and including a random-e

235 ates of death or serious morbidity (DSM) and clinically-relevant fistula (CR-POPF) were 19.5% and 17.

236 mployed to achieve the targeted synthesis of clinically-relevant molecules in the presence of specifi

237 Clinically-relevant radiotherapy induces aberrant comple

238 Whilst it is impossible to clinically separate observed behavior of cells from thei

239 Four participants (14%) in the DS group had clinically significant age-related cataracts, but there

240 Consequently, the AM group had clinically significant BCSVA (> 3 lines) (81.8% vs 38.4%

241 s, adverse 90-day outcomes, the incidence of clinically significant CA-AKI is very low.

242 -target biopsies had been performed, 8.8% of clinically significant cancers (grade group >=3) would h

243 ced from plasma collected from subjects with clinically significant CMV infection (CS-CMVi).

244 All patients had clinically significant comorbidities, the most common be

245 29 patients experienced 36 clinically significant deteriorations.

246 ing original and generic PGAs did not show a clinically significant difference in IOP-lowering effect

247 n for active surveillance, identification of clinically significant disease, choice of postprostatect

248 Hg) at 24 months, whereas the proportions of clinically significant IOP increases were 5.6% and 8.8%,

249 t is challenged by the low concentrations of clinically significant nucleic acids and their sequence

250 t surgery was associated with lower rates of clinically significant posterior capsule opacification c

251 emperature was associated independently with clinically significant QT shortening of 2.80 millisecond

252 dical records of the patients diagnosed with clinically significant retrocorneal membranes associated

253 male and 4 female) were identified to have a clinically significant retrocorneal membranes at the tim

254 s for the identification of biologically and clinically significant subsets in the data.

255 urement discrepancies between modalities are clinically significant with respect to diagnosis of LVH,

256 e subtypes: early onset (EO), lethal, and/or clinically significant.

257 s suggest that inherited NOS2 deficiency was clinically silent in this patient until lethal infection

258 Hemodynamics were clinically similar between grafts and control aortic roo

259 accuracy of all four modelling methods were clinically similar, the optimal modelling method may be

260 adox of severe asthmatic children, whom when clinically stable can have an FEV(1) >100% of predicted,

261 sequencing was performed on sputum from 253 clinically stable COPD patients (4-year median follow-up

262 Although clinically superior to ICS, mechanisms underlying the ef

263 tic management study involving patients with clinically suspected acute recurrent ipsilateral DVT.

264 ngiography are the first-line modalities for clinically suspected endocarditis given their ability to

265 he study population, comprising 124 patients clinically suspected for PTB with smear and culture repo

266 in patients referred for ileocolonoscopy for clinically suspected inflammatory bowel disease (IBD) is

267 68 (31.6%) episodes of clinically suspected MK were classed as recurrent.

268 We examine both clinically tested vaccines as well as nascent approaches

269 with massive hypertrophic cardiomyopathy as clinically the most prevalent symptom caused by bialleli

270 y stimulating factor (pegfilgrastim) is used clinically to accelerate immune reconstitution following

271 clinical tool in both situations and is used clinically to assess the inflammatory component of the d

272 review the main approaches that are applied clinically to calculate the absorbed dose.

273 C-reactive protein (CRP) is a biomarker used clinically to measure systemic inflammation and is repro

274 n a proof-of-concept approach, we explored a clinically translatable intronic CRISPR (clustered regul

275 activity data of PDX tumors in developing a clinically translatable predictive cancer biomarkers for

276 Finally, few of these findings have yet been clinically translated, leaving ample opportunity for fut

277 Clinically, tumour SLC43A2 correlated negatively with T

278 To achieve robust inhibition of MAOA/B, the clinically used antidepressant tranylcypromine (TCP) was

279 EPA can be clinically used by pathologists, as a complementary devi

280 , including a one-step radiosynthesis of the clinically used compounds [(11)C]UCB-J and [(11)C]PHNO.

281 r pressure-lowering action comparable to the clinically used dorzolamide.

282 Compared to clinically used indocyanine green, the QDs show superior

283 In contrast, a clinically used S1P(1) functional antagonist, siponimod,

284 minireview, we review one of the most common clinically used sepsis biomarkers, procalcitonin, and it

285 In this ex vivo modeling system, clinically used valve-sparing aortic root replacement co

286 As clinically useful autophagy inhibitors are elusive, our

287 the systematic understanding of potentially clinically useful genomic and molecular targets for a su

288 whether these changes are large enough to be clinically useful.

289 cer (18)F-JK-PSMA-7 was found to be safe and clinically useful.

290 We conclude that it is feasible to collect clinically valid physiological data wirelessly for 50% o

291 rs, and scientists to emergently develop and clinically validate new swabs for immediate mass product

292 in determining PCT in blood plasma with the clinically validated electrochemiluninescent immunoassay

293 elopmental disorder characterized by common, clinically variable symptoms, such as typical facial dys

294 een individuals that were ascertained for FH clinically versus genetically.

295 we propose an efficient hardware design for clinically viable iBCIs, and suggest that the circuit de

296 The identification of clinically viable strategies for overcoming resistance t

297 trasound (US) enhanced delivery to develop a clinically viable therapeutic strategy for tumours overe

298 Clinically, videoendoscopy is applied to assess the symm

299 cularly in the late stages of syphilis, with clinically well-characterized samples.

300 Comparable events are observed clinically, with the levels of cf-mt-DNA elevated in old