ライフサイエンスコーパス: clock

1 tor circadian locomotor output cycles kaput (CLOCK).

2 s veins and a flame shaped hemorrhage at 7 o'clock.

3 the spatiotemporal control of the molecular clock.

4 rived JA molecules in regulating Arabidopsis clock.

5 cted because it is the fastest known radical clock.

6 us timekeeping system known as the circadian clock.

7 ted at the transcriptional level by the cone clock.

8 ., [Formula: see text] states) and a Poisson clock.

9 itulate the oscillations of the segmentation clock.

10 luding 7 previously known to function in the clock.

11 ion state is essential for a functional root clock.

12 tant components of the Arabidopsis circadian clock.

13 ogical processes requires a robust circadian clock.

14 underlying COR regulation of host circadian clock.

15 ing induces directional shifts of the muscle clock.

16 ng that cisplatin can modulate the molecular clock.

17 ulates the pace of the Arabidopsis circadian clock.

18 altered aging in SZ manifests in these other clocks.

19 of magnitude over state-of-the-art microwave clocks.

20 ute the molecular "cogs" of these biological clocks.

21 lecular oscillator known as the segmentation clock(1,2).

22 and a core component of the plant circadian clock(2,3).

23 thesis(4), frequency division(5) and optical clocks(6).

24 t target the clock, and that a dysfunctional clock ablates this response.

25 at specifically bound to and interfered with CLOCK activity.

26 erences and demonstrating that the circadian clock affects posttranscriptional regulation.

27 idered when building and applying epigenetic clock algorithms to human epidemiological or disease coh

28 1 (OV) mice display enhanced islet circadian clock amplitude and augmented in vivo and in vitro GSIS

29 Molecular clock analyses suggested that GI1 was horizontally acqui

30 ibuted rates across sites is used in relaxed clock analyses, which assumes time-reversibility and sta

31 Molecular clock analysis indicated that the establishment of M-tro

32 w that CLK8 disrupts the interaction between CLOCK and BMAL1 and interferes with nuclear translocatio

33 ain of CRY1 interacts with distinct sites on CLOCK and BMAL1 to sequester the transactivation domain

34 , which is driven by the positive regulators Clock and Bmal1.

35 cyanobacteria is regulated by the circadian clock and can adapt to seasonal changes of day length.

36 +1G>A, that shows reduced affinity for BMAL1/CLOCK and causes an arrhythmic phenotype.

37 reflect the extensive interplay between the clock and cell physiology through the regulation of core

38 ection and a distance in which to move (the "clock and compass" model) [1-5].

39 Molecular clock and ecological niche modeling suggested that the h

40 ociation between the output of the circadian clock and external environmental cues is a major cause o

41 activity of SPY in modulating the circadian clock and implicate that O-glycosylation might play an e

42 ling pectin esterification regulate the root clock and lateral root initiation.

43 While obstruction and REL augmented CLOCK and NPAS2 expression above sham levels, rapamycin

44 The circadian clock and physical activity are both required to promote

45 rotein 1 (XBP1) disrupts the hepatic 12-hour clock and promotes spontaneous non-alcoholic fatty liver

46 RBalpha is a core component of the circadian clock and proposed to be a dominant regulator of hepatic

47 n the conserved nature of both the molecular clock and sleep across species.

48 oss kingdoms, is influenced by the circadian clock and the light-dark (diel) cycle in an opposite man

49 effects of O-glycosylation on the circadian clock and the underlying mechanisms remain largely unkno

50 hway beyond its classical interpretation in 'clock and wavefront' models(1).

51 An intimate link exists between circadian clocks and metabolism with nearly every metabolic pathwa

52 t-dark conditions is a function of circadian clocks and photic input pathways, but a mechanistic unde

53 pancreatic beta cells that are perturbed in Clock (-/-) and Bmal1 (-/-) beta-cell lines.

54 circadian system with drugs that target the clock, and that a dysfunctional clock ablates this respo

55 light sensitivity in the mammalian circadian clock are interrelated.

56 ome of the genes controlled by the circadian clock are oncogenes or tumor suppressors.

57 State-of-the-art atomic clocks are based on the precise detection of the energy

58 of mechanisms, time frames, and outputs, all clocks are built by calibrating or delaying the rate of

59 Genetically encoded biological clocks are found broadly throughout eukaryotes and in cy

60 Promising candidates for use in atomic clocks are highly charged ions(6) (HCIs) and nuclear tra

61 Studies show that beta-cell circadian clocks are important regulators of GSIS and glucose home

62 e show that these neurons and their cellular clocks are necessary and sufficient to gate and time nig

63 Importantly, such TTFL-based clocks are present in all major tissues across the organ

64 Whether pathogens modulate host circadian clock as a potential strategy to suppress host innate im

65 range is useful for applications in optical clock, astronomical calibration and biological imaging.

66 le of these clocks in adult airway diseases, clock biology is also likely to be important in perinata

67 re, but more recent insights into peripheral clock biology raise questions of clock emergence, its co

68 translation feedback loop (TTFL) composed of CLOCK-BMAL1 transcriptional activators and CRY-PER trans

69 data demonstrating PER removes CRY from the CLOCK-BMAL1-E-box complex.

70 and interferes with nuclear translocation of CLOCK both in vivo and in vitro Results from further exp

71 orylation plays a central role in timing the clock, but how this contributes to overt rhythms is uncl

72 an 12-h clock independent from the circadian clock, but its function and mechanism of regulation rema

73 demonstrate that perturbation of the 12-hour clock, but not the core circadian clock, is associated w

74 ainment of the Madeira cockroach's circadian clock, but the cellular nature of its entrainment pathwa

75 Most cells of the body contain molecular clocks, but the requirement of peripheral clocks for rhy

76 Furthermore, our molecular clock calculations suggest the branching of animal isola

77 Thus, the clock can be used to maximize the benefits and minimize

78 approximately) synchronized with a reference clock, can one distill synchronized clocks in pure state

79 ed a comprehensive analysis of 14 epigenetic clocks categorized according to what they were trained t

80 Disabling the circadian clock causes abnormal collagen fibrils and collagen accu

81 a fatal disease that disrupts the circadian clock, causes disordered temperature regulation, and ind

82 expression in adult neurons outside the core clock circuit and the mushroom body (MB) Kenyon cells (K

83 signaling peptide produced only by circadian clock circuit neurons.

84 e has been done to test the role of specific clock circuit output signals.

85 diurnal PDF release keeps both PDF-dependent clock circuits in antiphase.

86 CRY1 exhibiting higher affinity to the BMAL1/CLOCK complex than CRY2.

87 h nighttime expression of the core circadian clock component CRYPTOCHROME (CRY) in the NAc.

88 eal-time monitoring of the activity of these clock components and clock-driven cellular outputs.

89 EGULATOR 5 (PRR5), one of the core circadian clock components, as a new SPY-interacting protein.

90 Light-entrained circadian clocks confer rhythmic dynamics of cellular and molecula

91 The mammalian circadian clock consists of a transcription-translation feedback l

92 conserved translation initiation factor, is clock controlled in Neurospora crassa, peaking during th

93 Clock-controlled accumulation of P-eIF2alpha led to redu

94 ps among rhythmic chromatin modifications at clock-controlled genes (ccg) revealing circadian control

95 en by rhythmic transcriptional activation of clock-controlled genes.

96 utant to study their genetic relationship in clock-controlled growth and phase transition phenotypes.

97 eins are known to regulate the expression of clock-controlled plant genes by controlling their transc

98 ion of CPLX3 may be a mechanism by which the clock controls the cone synaptic transfer function to se

99 Throughout the body, such molecular clocks convey temporal control to the function of organs

100 Furthermore, molecular clock dating has suggested a Cambrian-Ordovician terrest

101 I-IL-10-epithelial barrier axis by circadian clock disarrangement, alterations in feeding time or con

102 Compared to control mice, circadian clock disruption significantly exacerbated post-IR systo

103 must be taken into account in models of the clock disruption-cancer connection.

104 g processes, we employed Levine's epigenetic clock (DNAm PhenoAge) to estimate DNA methylation age in

105 These included standalone tests (clock-drawing test, median sensitivity 0.79 and specific

106 isplayed reduced repressor activity on BMAL1/CLOCK driven transcription, which is explained by reduce

107 f the activity of these clock components and clock-driven cellular outputs.

108 This clock drives rhythmic repression of inflammatory arthrit

109 peripheral clock biology raise questions of clock emergence, its concordance with tissue-specific st

110 The mammalian circadian clock encodes time via rhythmic action potential activit

111 We also tested the effects of circadian clock-enhancing small-molecule nobiletin on GSIS in mous

112 k networks, focusing on the role of light in clock entrainment and known molecular players in this pr

113 ted Brillouin scattering laser and achieve a clock exhibiting short-term stability of 3.9 x 10(-14) o

114 A distinct 12-hour clock exists in addition to the 24-hour circadian clock

115 ory and relativity lies the possibility of a clock experiencing a superposition of proper times.

116 e approaches that do not require a molecular clock for estimating divergence times.

117 e overall strong-field dynamics: it sets the clock for the emission of electrons with a given rescatt

118 ar clocks, but the requirement of peripheral clocks for rhythmicity and their effects on physiology a

119 r (helplessness), we found altered circadian clock function and high nighttime expression of the core

120 d pectin states is essential for proper root clock function and the subsequent initiation of lateral

121 then focus on emerging data tying circadian clock function to immunologic activities within the resp

122 the idea that the NPC specifically modulates clock function, we found a strong enrichment in core clo

123 the self-assembling properties of circadian clock gene 2 hydrophobin chimera and homogeneity of the

124 ia AdipoR1-mediated upregulation of the core clock gene Bmal1.

125 acting in part through the NPC, alters core clock gene expression and/or mRNA accumulation in a way

126 However, rhythmic clock gene expression in other brain sites raises the po

127 donors show marked differences in circadian clock gene expression patterns, suggesting fundamental d

128 day resulted in differential changes of core clock gene expression, demonstrating an exercise and clo

129 temporal characteristics in core and noncore clock gene expression.

130 clock phase, likely through changes in core clock gene expression.

131 Core clock gene mRNA oscillations remained mostly unaffected

132 The 5 known circadian clock gene transcripts showed a strong circadian express

133 Here we show that deletion of BMAL1, a core clock gene, in paraventricular hypothalamic (PVH) neuron

134 tudies which have investigated the effect of clock genes and proteins on Myc transcription and MYC pr

135 ll physiology through the regulation of core clock genes and proteins.

136 the rhythmicity and phase coherence of core clock genes and the broader transcriptome after onset of

137 ustrated the roles of environmental cues and clock genes in regulating ILC3 biology and consider the

138 Core clock genes were analyzed for rhythmicity by cosinor fit

139 nction, we found a strong enrichment in core clock genes, as well as an increased nuclear to total mR

140 onomous circadian system, consisting of core clock genes, generates near 24-h rhythms and regulates t

141 c under all conditions, including many known clock genes, the period of gene expression lengthened fr

142 a circadian pattern and regulated hepatocyte clock-genes by neutrophil elastase (NE) secretion.

143 wo key elements of the Arabidopsis circadian clock, GIGANTEA (GI) and ZEITLUPE (ZTL), which likely ac

144 hemes and core design principles of cellular clocks, giving special consideration to the challenges a

145 Circadian (~24 hour) clocks have a fundamental role in regulating daily physi

146 Existing DNA methylation clocks have been shown to be highly accurate in blood bu

147 Peroxyl radical clocks have been used to determine the rate constants of

148 However, the best optical clocks have not seen their performance transferred to th

149 Microwave atomic clocks have traditionally served as the 'gold standard'

150 O-GlcNAc in regulating the animal circadian clock, here we report that nuclear-localized SPY, but no

151 Sectoral (clock hour) per directional radial GA progression rates

152 CoNV area showed good correlation to clock hours (r = 0.749, P < .001).

153 n about whether enhancement of the circadian clock in beta-cells will confer protection against beta-

154 mutation or overproduction on the circadian clock in comparison to their effects on cell cycle progr

155 r BMAL1 is a principal driver of a molecular clock in mammals.

156 nal macroscopic model for the core circadian clock in mammals.

157 etabolic-sensing function of skeletal muscle clock in partitioning nutrient flux between muscle and l

158 The circadian clock in plants temporally coordinates biological proces

159 s study aimed to generate a novel epigenetic clock in rats-a model with unique physical, physiologica

160 een proposed as a time cue for the circadian clock in rodents and humans.

161 ch is explained by reduced affinity to BMAL1/CLOCK in the absence of PER2 compared with CRY1.

162 eviously unsuspected roles of the hepatocyte clock in the physiological coordination of nutritional s

163 5) now shows a requirement for the intrinsic clock in the regenerative capacity of insulin-producing

164 ce in the sensitivity of the major circadian clock in the suprachiasmatic nucleus to a low dose of mo

165 portantly, exposure to hypoxia phase-shifted clocks in a tissue-dependent manner led to intertissue c

166 hile the focus has been on the role of these clocks in adult airway diseases, clock biology is also l

167 Circadian clocks in fungi and animals are driven by a functionally

168 molecular mechanisms underpinning circadian clocks in multicellular organisms are well understood.

169 ung development, and the possibility of lung clocks in priming the fetus for postnatal life.

170 eference clock, can one distill synchronized clocks in pure states, at a non-zero rate?

171 han answers, it is about time to investigate clocks in the developing lung.

172 SCN(VIP)) neurons, including their molecular clock, in generating the mammalian locomotor activity (L

173 aracterized a cell-autonomous mammalian 12-h clock independent from the circadian clock, but its func

174 This biological clock integrates multiple cues to modulate a myriad of d

175 ne expression, demonstrating an exercise and clock interaction, providing insight into potential mech

176 arge-scale genomic studies have expanded the clock into a complex network composed of thousands of ge

177 teractions that bind its individual cellular clocks into a coherent time-keeper.

178 live imaging, we show that the somitogenesis clock is active in gastruloids and has dynamics that res

179 The circadian clock is an intrinsic oscillator that imparts 24 h rhyth

180 ants of HAT reactions (k(H)), but no radical clock is available to measure the rate constants of PRA

181 The mammalian cell-autonomous circadian clock is built around a self-sustaining transcriptional-

182 We speculate that the 12-h clock is coopted to accommodate elevated gene expression

183 The molecular circadian clock is driven by interlocked transcriptional-translati

184 nes and crucially if lithium's effect on the clock is fundamental to its mood-stabilizing effects.

185 However, whether the molecular clock is involved in this coordination is largely unknow

186 Given that phase coherence between circadian clocks is considered favorable, we propose that hypoxia

187 he 12-hour clock, but not the core circadian clock, is associated with the onset and progression of t

188 The circadian clock itself has the potential for use as a target for t

189 Circadian clocks keep time via ~ 24 h transcriptional feedback loo

190 tion can be generated, particularly when the clock machinery is nearly identical in all tissues.

191 ll proliferation and biomass production, the clock may direct metabolic processes of cancer cells in

192 e hierarchy of the cell-intrinsic hepatocyte clock mechanism and the feeding environment.

193 uced steatohepatitis barely affects the core clock mechanism but leads to a reprogramming of circadia

194 lusion, our study has identified a circadian clock mechanism of protein homeostasis wherein a sacrifi

195 Consequently, clock-mediated photoperiod-responsive growth and develop

196 nt to the ciliary body between the 5 and 9 o'clock meridians as well as multiple nodules in the poste

197 mpullae were never observed in the 3- or 9-o'clock meridians.

198 ependent manner led to intertissue circadian clock misalignment.

199 in protein expression levels for a circadian clock model, we illustrate the adaptability of NERDSS.

200 these issues by constructing the first plant clock models based on the S-System formalism originally

201 ts relative simplicity, this approach yields clock models with comparable accuracy to the conventiona

202 s clearly superior and allows for around-the-clock molecular testing.

203 of the negative limbs of the core circadian clock, most notably REV-ERBalpha.

204 nchronous and rhythmic even in an arrhythmic clock mutant host.

205 efects in two classically derived Neurospora clock mutants each arise from disruption of ck-1a regula

206 ns between the light-signaling and circadian-clock networks, focusing on the role of light in clock e

207 PRL-1 knockdown in PDF clock neurons dramatically lengthens circadian period.

208 hannel as an important player in a subset of clock neurons of the fruit fly.

209 lize molecular rhythms in subtypes of master clock neurons to test principles of cell identity and ne

210 We conclude that the Arabidopsis circadian clock not only controls transcription of genes but also

211 ght represent false positives resulting from clocks not robustly calibrated to the tissue being teste

212 o the accessory medulla (AME), the circadian clock of the Madeira cockroach.

213 The developmental 'alarm clock' of speciation sounds off when sufficient divergen

214 ile the effects of ablation of the molecular clock on memory have been studied in many systems, littl

215 umans, we quantified parameters of molecular clocks operative in human T2D islets at population, sing

216 gnore repetitive stimuli (e.g., the tic of a clock) or detect meaningful repetition (e.g., consecutiv

217 Moreover, our data suggest that islet clocks orchestrate temporal profiles of insulin and gluc

218 The circadian clock orchestrates biological processes so that they occ

219 dentified WIDE AWAKE (WAKE) in Drosophila, a clock output molecule that mediates the temporal regulat

220 veal a key role for SCN VIP cells in central clock output.

221 L1/ARNTL is a non-redundant component of the clock pathway that regulates circadian oscillations of g

222 ch variations are dependent on the circadian clock per se or are secondary to circadian differences i

223 out of treadmill exercise on skeletal muscle clock phase changes.

224 hase that exactly tracks that of the optical clock phase from which it is derived, yielding an absolu

225 ences the directional response of the muscle clock phase in vivo and in vitro.

226 are sufficient to shift the muscle circadian clock phase, likely through changes in core clock gene e

227 of the dark phase, did not alter the muscle clock phase.

228 Hence, circadian clock-pituitary epigenetic pathway interactions form the

229 To examine whether compromised clocks play a role in the pathogenesis of T2D in humans,

230 The metal ball was located at the 7 o'clock position in all controls.

231 g the night-time when the internal circadian clock promotes sleep, in many cases resulting in impairm

232 Mutation of the core clock protein REVERBalpha in these cells exacerbated the

233 osophila, light-dependent degradation of the clock protein TIMELESS by the blue light photoreceptor C

234 s that specifically modulate regulatory core clock proteins may potentially enable better management

235 chemical and structural understanding of the clock proteins that constitute the molecular "cogs" of t

236 s a given proper time conditioned on another clock reading a different proper time is derived.

237 The probability that one clock reads a given proper time conditioned on another c

238 lar aging, including resetting of epigenetic clock, reduction of the inflammatory profile in chondroc

239 This form is preserved when changing clock reference frames, yielding physics covariant with

240 le-specific interactions with the light- and clock-regulated gene timeless (tim).

241 A detailed understanding of how the internal clock regulates cognition is critical for the developmen

242 Here, we show circadian clock regulation of endoplasmic reticulum-to-plasma memb

243 del to simulate HRV under decreased "coupled-clock" regulation.

244 R GTPase ACTIVATION PROTEIN DOMAIN3, as root clock regulators.

245 s as a pivotal interventional target against clock-related disorders.

246 COR preferentially suppresses expression of clock-related genes in high throughput gene expression s

247 Our work identifying the human segmentation clock represents an important milestone in understanding

248 C21C, presumably playing a dedicated role in clock resetting.

249 ween two times <= 0.1), counted by the decay clock, reveals saw-toothed fluctuations around a Phanero

250 hich affects the phase of the skin circadian clock, reverses the diurnal rhythm of IMQ-induced ISG ex

251 atin had a dose-dependent impact on cochlear clock rhythms only after treatment at nighttime suggesti

252 23: IOP, pattern standard deviation, and 7-o'clock RNFL thickness) and 2018 (1 of 23: vertical cup-to

253 Light is the clock's primary synchronizer.

254 l control mechanisms involving the circadian clock set rates of nighttime starch mobilization that ma

255 Adoption of these clocks should accelerate the identification of longevity

256 smission method while operating at megahertz clock speeds.

257 diel cycles via pathways independent of the clock, suggesting that the integration of circadian and

258 t are associated with the mouse segmentation clock, suggesting that this oscillator might be conserve

259 ochrome is considered the main mechanism for clock synchronization, although the visual system also c

260 c structure/function, the interdependence of clock synchrony and functionality in perinatal lung deve

261 A radical clock system was developed to investigate single-electro

262 y conserved role in modulating the circadian clock system, via O-GlcNAcylation in mammals, but via O-

263 rt's primary pacemaker), and by the "coupled-clock" system within the SAN cells.

264 redicted to bind closely to the interface in CLOCK that interacts with its transcriptional co-regulat

265 horylation of TIM is a core mechanism of the clock that sets period length and phase in darkness, ena

266 However, numerous epigenetic clocks that may capture distinct aspects of aging have b

267 tions such as neuromorphic computing, atomic clocks, thermometry, and sensing.

268 The sun rises at an earlier clock time in the eastern regions of a given time zone t

269 ore than 150,000 CPU hours and weeks of wall-clock time.

270 Day-to-day clock timing of caloric events had poor stability within

271 s nocturnal behaviors is driven by molecular clock timing, which cycles in anti-phase between day- ve

272 exists in addition to the 24-hour circadian clock to coordinate metabolic and stress rhythms.

273 roach on the linoleate-based peroxyl radical clock to enable the simultaneous measurement of both k(H

274 erty gated by specific neurons of the master clock to favor subsequent alertness prior to dawn (a cir

275 od mechanisms to synchronize their circadian clock to light.

276 sical mechanisms linking molecular circadian clocks to cardiac arrhythmogenesis are not fully underst

277 Honey bees are highly dependent on circadian clocks to regulate critical behaviors, such as foraging

278 umoral factors) and intrinsic (eg, circadian clocks) to cells.

279 rocesses of cancer cells in concert with non-clock transcription factors to control how nutrients and

280 obtained by applying microwave dressing to a clock transition of the ground-state electron spin of a

281 -lived engineered entanglement on an optical-clock transition(13) in tailored atom arrays.

282 will enable searches for further soft-X-ray clock transitions(8,12) in HCIs, which are required for

283 , and have led to advances in compact atomic clocks, ultrafast ranging, and spectroscopy.

284 ates that metabolic control by the circadian clock underpins specific hallmarks of cancer metabolism.

285 owed accelerations in SZ for the 3 mortality clocks up to 5 years, driven by smoking and elevated lev

286 ermosensory PNs in the lACA to the circadian clock via the accessory medulla.

287 ADIPOQ regulates MBH clocks via AdipoR1-mediated upregulation of the core clo

288 The fluorenylcyclopropyl radical clock was selected because it is the fastest known radic

289 The 2 mitotic clocks were decelerated in SZ related to antitumor natur

290 : Starting from many copies of noisy quantum clocks which are (approximately) synchronized with a ref

291 arkers of ageing, referred to as 'epigenetic clocks', which have been widely used to identify differe

292 e the AFRAID (Analysis of Frailty and Death) clock, which accurately predicts life expectancy and the

293 in feedback loops of the mammalian molecular clock, which provides sufficient detail to consider mult

294 ndogenously by genetically encoded molecular clocks, whose components cooperate to generate cyclic ch

295 O contains an unexpectedly robust autonomous clock with unusual spatiotemporal characteristics in cor

296 reveal that islets from T2D patients contain clocks with diminished circadian amplitudes and reduced

297 on cells (ipRGCs) synchronize our biological clocks with the external light/dark cycle [1].

298 ur cistrome to directly regulate the 12-hour clock, with a periodicity paralleling the harmonic activ

299 phenomena of epigenetic drift and epigenetic clock, with regard to its implication in cancer etiology

300 molecular workings of the cellular circadian clock work as building blocks of those properties.