ライフサイエンスコーパス: clonal cell

1 on of IL-2 increases the numbers of dividing clonal cells.

2 odorant receptors may be expressed by these clonal cells.

3 ynamic diversity in populations of nominally clonal cells.

4 sity to homozygosity for the MPL mutation in clonal cells.

5 media, both primary keratocytes and selected clonal cells aggregated to form attachment-independent s

6 In this study, we use live cell imaging and clonal cell analyses to evaluate the fidelity of chromos

7 ed to Cys-S-OH in situ, moreover, using both clonal cells and a human airway epithelial cell line end

8 t prevention model (single-target-expressing clonal cells) and two tumor regression models.

9 ribution of responses within a population of clonal cells, and the number of outliers.

10 ed and eosinophils are considered to be "non-clonal" cells, and idiopathic HE and HES in which neithe

11 Clonal cells are genetically homogenous and derived from

12 The median percentage of clonal cells as determined by ASO-PCR was 0.02 for MGUS,

13 combinant receptors selectively expressed in clonal cells as the dependent variable in QSAR presents

14 combinant receptors selectively expressed in clonal cells as the dependent variable in three-dimensio

15 approach by sourcing bacterial strains from clonal cell banks and has demonstrated a similarly favor

16 This study shows that, by using ASO-PCR, clonal cells can be found at very low levels in the bloo

17 Nevertheless the clonal cells compete successfully with normal memory CD8

18 Using clonal cell culture combined with long-term time-lapse v

19 Clonal cell culture is crucial for experimental protocol

20 We have established a clonal cell culture system that supports the proliferati

21 Using a clonal cell culture system, we show that SOX10 inhibits

22 ion and global histone acetylation levels in clonal cell cultures from a female RTT patient with the

23 notypic variation is the phenomenon in which clonal cells display different traits even under identic

24 invasion by affecting immune cell function, clonal cell evolution, and drug resistance.

25 The selected clonal cells exhibited normal karyotype and underwent re

26 However, little is known about clonal cell expansion in vitro and persistence of the AC

27 tions characterised by the presence of small clonal cell expansions in individuals without symptoms o

28 acteristic of biased repertoires seen during clonal cell expansions, implying that strong T-cell resp

29 ERG lineages, indicating earlier or separate clonal cell expansions.

30 e idea that drug affinity data obtained from clonal cells expressing recombinant receptors may be sup

31 lar compartments and cannot be propagated in clonal cells for longitudinal studies or used for in viv

32 m Pseudomonas aeruginosa and discovered that clonal cells form striations that are packed lengthwise

33 The clonal cell fraction of normal clones was always higher

34 form lesions harbor mutations permissive for clonal cell growth.

35 (UV) radiation-exposed skin, mutations fuel clonal cell growth.

36 of the c-subunit in the PTP, we generated a clonal cell, HAP1-A12, from near-haploid human cells, in

37 unit b and the OSCP in the PTP by generating clonal cells, HAP1-Deltab and HAP1-DeltaOSCP, lacking th

38 different blastomeres but is independent of clonal cell heritage and of whether the blastomere is wi

39 e different methods to detect and quantitate clonal cells, ie, immunofluorescence microscopy (IM) for

40 These results indicate that the clonal cells in MGUS differ from those in myeloma and su

41 Using time-lapse imaging of clonal cells in rat cortex over several generations, we

42 Using ASO-PCR, we were able to detect clonal cells in the blood in 13 of 16 patients with MGUS

43 However, the number of clonal cells in the blood of MGUS patients is less than

44 However, identifying clonal cells in the blood of patients with monoclonal ga

45 Clonal cells in the blood should be quantified in future

46 Posterior-localized clonal cells in the follicle cell layer of developing ov

47 % to 51%) and PCR estimates of the number of clonal cells in the peripheral blood (range, .009% to 3.

48 While the small number of circulating clonal cells is not incompatible with their proposed rol

49 Here we used whole-genome sequencing of clonal cell isolates that developed chemotherapeutic res

50 Here, we use clonal cell labeling with multicolor reporters to charac

51 sion within and between functional zones and clonal cell layers.

52 zed beta-adrenergic receptors (beta-AR) in a clonal cell line (C1) immortalized from cerebral cortica

53 racteristic of terminal differentiation in a clonal cell line (clone C) of rabbit kidney intercalated

54 ntiation, we established a novel P19-derived clonal cell line (designated A404) harboring a smooth mu

55 One clonal cell line (MUTM-NEI/1) was characterized in nonpe

56 From the TM of the H-2Kb-tsA58 mouse, a clonal cell line (MUTM-NEI/1) was established.

57 yotubes within neuroblastoma X glioma hybrid clonal cell line (NG108-15) increased nPKC theta express

58 ings of human MiRP3 and Kv4.2 expressed in a clonal cell line (tsA201) reveal MiRP3 to modulate Kv4.2

59 An apoE4-expressing clonal cell line and a non-expressing clonal control cel

60 We generated a clonal cell line constitutively expressing GCaMP6s; high

61 Unexpectedly, a clonal cell line contained heterogeneously sized network

62 eptides selected for their ability to bind a clonal cell line derived from hPS cells would bind early

63 n of variant alleles below 0.1% frequency in clonal cell line DNA and in cell-free plasma DNA.

64 The rat phaeochromocytoma PC12 clonal cell line expresses an O2-sensitive voltage-depen

65 Our indicator cell line, SupT1-CCR5 cells (a clonal cell line expressing CD4, CXCR4 and CCR5) provide

66 A clonal cell line expressing prorenin was generated and g

67 d populations of cells from all donors and a clonal cell line from 1 donor expressed telomerase activ

68 In opossum kidney cells, a clonal cell line in which the PTHR1 and NPT2a are endoge

69 old more galectin-3 than mucin purified from clonal cell line LS-C, which produces mucin lacking peri

70 Therefore, the 1H91 clonal cell line may provide an in vitro model for study

71 More dramatically, the anion exchanger of a clonal cell line of intercalated cells derived from the

72 A clonal cell line of rat embryonic hippocampal origin (H1

73 However, only one clonal cell line overexpressing the protein but not prev

74 ceptor internalization was investigated in a clonal cell line stably transfected with the 5-HT2A rece

75 This approach identified a clonal cell line that exhibited approximately 10-fold re

76 HL-60 A2 is a clonal cell line that is defective for sialylation and a

77 l interfering RNA against GIPC to generate a clonal cell line that is deficient in GIPC.

78 A clonal cell line was selected from cells that formed foc

79 Using a rat CNS clonal cell line with neuronal progenitor properties, we

80 se findings are the first demonstration of a clonal cell line with primitive and definitive hematopoi

81 ND7/23 cells (a dorsal root ganglion-derived clonal cell line) and rat primary cerebrocortical neuron

82 cells, cultures of N-18 cells (neuroblastoma clonal cell line) are treated for 30 min in serum-free m

83 separate lineages using a well-characterized clonal cell line, 2T3, derived from the mouse calvariae.

84 mmortalized human dorsal root ganglion (DRG) clonal cell line, HD10.6, with a tetracycline-regulatabl

85 A clonal cell line, L-S1, has been identified from transfe

86 (ix) A novel HEp-2 clonal cell line, termed IkappaBalphaDN, was generated w

87 romocytoma (PC12) cells, an oxygen-sensitive clonal cell line.

88 ne synthesis, in the pheochromocytoma (PC12) clonal cell line.

89 hotopic tumors initiated from a biphenotypic clonal cell line.

90 specific gene expression that varies between clonal cell lineages.

91 mal integration efficiency approached 40% of clonal cell lines (essentially 50% of infected cells), o

92 in thousands of single cells and hundreds of clonal cell lines and found that longer circadian period

93 c transcription of about 4000 human genes in clonal cell lines and found that more than 300 were subj

94 of alpha4beta2 levels and responses in both clonal cell lines and midbrain neurons, and the regulati

95 We show that clonal cell lines and polyclonally activated normal T ce

96 fferently processed in neurons compared with clonal cell lines and that farnesylation does not accoun

97 ent provirus from different lymphocyte-based clonal cell lines as well as from latently infected prim

98 within as little as 1-2 weeks, and modified clonal cell lines can be derived within 2-3 weeks.

99 Long-term studies on CHO ldlr(-/-) a7 clonal cell lines carrying iBAC-S/MAR-LDLR demonstrated

100 We generated human clonal cell lines carrying the two vectors using site-sp

101 MOI of 100 or greater, however, 35 to 40% of clonal cell lines contained integrated AAV DNA.

102 h 80% of cells are infected, less than 5% of clonal cell lines contained integrated AAV DNA.

103 Clonal cell lines containing human CFTR were identified

104 We developed isogenic clonal cell lines containing the TERTp mutations and uti

105 d [Asp218,Asp222]Mek immunoprecipitated from clonal cell lines could phosphorylate kinase-inactive Er

106 Experimental clonal cell lines demonstrate an average of 33+/-4.4% (P

107 The CHO-K1 clonal cell lines demonstrated a wide range of luciferas

108 the growth and differentiation properties of clonal cell lines derived from 32Dcl3 which harbor myb t

109 rays to assess allele-specific expression in clonal cell lines derived from heterozygous mouse strain

110 SUIT-2 and clonal cell lines derived from it show spontaneous metas

111 Clonal cell lines derived from latent populations showed

112 Clonal cell lines derived from stable transfection with

113 Embryonic stem (ES) cells are clonal cell lines derived from the inner cell mass of th

114 is transient and viral DNA is not present in clonal cell lines derived from the transformed foci.

115 not all, tumor cells, and examination of the clonal cell lines derived from the tumor population show

116 promoter, to generate by infection 34 Jurkat clonal cell lines each containing a single integration o

117 umors, transplanted primary tumor cells, and clonal cell lines established from tumors.

118 expressed receptor mRNA, but only 14% of the clonal cell lines expressed receptor protein.

119 A431 clonal cell lines expressing non-phosphorylated dominant

120 on of stably transfected cell populations or clonal cell lines expressing specific amounts of a desir

121 First, using transduced clonal cell lines expressing varying levels of ABCG2, we

122 -induced chondrogenesis was used to identify clonal cell lines for articular chondrocyte and hypertro

123 Clonal cell lines from four mixed cell populations were

124 lone picking and produces genetically stable clonal cell lines from hPSCs in a safe and cost-efficien

125 However, establishing clonal cell lines from these tumors enabled the generati

126 o-EJ) and mito-ScaI, we generated a panel of clonal cell lines harboring a ~3.5 kb mtDNA deletion acr

127 e-cell dissociation and the establishment of clonal cell lines have been long-standing challenges.

128 or constitutively active mutants of Rac1 in clonal cell lines have established that Rac1 plays a key

129 pigmented and non-pigmented murine melanoma clonal cell lines in vitro.

130 n of NIH/3T3 cells with human L1 resulted in clonal cell lines in which L1 adhesion was consistently

131 HBX lines as well as clonal cell lines of cells transfected with 246p53 (246

132 We have developed clonal cell lines of human bronchial smooth muscle origi

133 We developed clonal cell lines of human bronchial smooth muscle origi

134 h factor-I (IGF-I) signaling, we established clonal cell lines overexpressing wild type or inactive m

135 effects of EGF on integrin function, whereas clonal cell lines overexpressing wild-type FLNa were mor

136 ciencies for the development of stable human clonal cell lines ranging from 5 x 10(-7) to 8.8 x 10(-5

137 Clonal cell lines reflect an independent choice to expre

138 Clonal cell lines representing early cardiomyocytes woul

139 e expression of temperature-sensitive p53 in clonal cell lines results in ALT-specific, transactivati

140 Analysis of multiple independent clonal cell lines revealed that expression of either Ets

141 sing RNA from proband dermal fibroblasts and clonal cell lines showed the mutant cDNA was about 15% o

142 either step is mediated by MTP, a series of clonal cell lines stably expressing apoB-53 and MTP was

143 trol of tetracycline (Tc) initially requires clonal cell lines stably expressing the tetracycline act

144 on were greater in ethanol-sensitive NIH/3T3 clonal cell lines than in their ethanol-insensitive coun

145 Clonal cell lines that contained a conserved approximate

146 h cells transfected with vector and with two clonal cell lines that each expressed different amounts

147 Clonal cell lines that overexpressed three times more Tb

148 Clonal cell lines that stably expressed HBx messenger RN

149 was inhibited by U1 anti-GFP in the various clonal cell lines was assessed by fluorescence-activated

150 The fraction of accessible sites in clonal cell lines was quantitated using restriction endo

151 Clonal cell lines were challenged with recombinant Sindb

152 Thirty-two AT6.1-12 clonal cell lines were established and the region(s) of

153 and metabolism, ADFP null and wild type (wt) clonal cell lines were established from ADFP null and wt

154 n fluorescent protein, and stably transduced clonal cell lines were generated by serial dilution in t

155 Clonal cell lines were isolated by fluorescence-activate

156 in cell spreading, several NIH-3T3- derived clonal cell lines were isolated that overexpress the bio

157 Clonal cell lines were selected with an antibiotic resis

158 xpressed with wild-type receptor, and stable clonal cell lines were selected.

159 A series of transient transfection assays in clonal cell lines which do not express ARPP-21 identifie

160 To demonstrate the technique's utility, clonal cell lines with siRNA knockdown of Coronin 1B wer

161 Using isogenic, clonal cell lines with variable copy numbers of an EGFP

162 s and the generation of edited cell pools or clonal cell lines, reducing the number of clones that ne

163 Compared with single-cell organisms or clonal cell lines, the biological environment and medica

164 intercellular circadian period variation in clonal cell lines, thereby revealing a previously unreco

165 ene expression profiles in hundreds of mouse clonal cell lines, we identified and validated multiple

166 -derived growth factor (PDGF) receptors, all clonal cell lines, with either type of chimera, showed s

167 mooth muscle cells and generate a variety of clonal cell lines.

168 l kinase (JNK) activity in insulin-secreting clonal cell lines.

169 metabolism that mirror those observed in the clonal cell lines.

170 e pattern of methylation is constant between clonal cell lines.

171 e [Asp218]- and [Asp218,Asp222]Mek1-infected clonal cell lines.

172 mutant overexpression approaches in various clonal cell lines.

173 n A partially rescued transgene silencing in clonal cell lines.

174 pha and beta-type mRNAs were co-expressed in clonal cell-lines.

175 Clonal cells (N18) of the mouse neuroblastoma C-1300 can

176 many of the genetic aberrations found in the clonal cells of myeloma.

177 We tested for these abnormalities in the clonal cells of WM patients.

178 ry resulted in the generation of rare, large clonal cell patches that were associated with stem cell

179 bserved intercellular heterogeneity within a clonal cell population can be mapped as dynamical states

180 A clonal cell population exhibiting a uniform vector integ

181 Cell cycle variability in clonal cell population is caused by stochastic processes

182 ity can lead to 'variations on a theme' of a clonal cell population, often with each cell within a tu

183 ry greatly within similar cells, even within clonal cell populations [1].

184 on, the uniformity of gene expression within clonal cell populations and the reproducibility of gene

185 l-to-cell variations in protein abundance in clonal cell populations are ubiquitous in living systems

186 iptome-wide analyses of allelic imbalance in clonal cell populations based on sequence polymorphisms,

187 Flo11-dependent phenotypic heterogeneity in clonal cell populations by modulating recruitment of key

188 owever, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastable

189 g boosting with different vectors, and these clonal cell populations could be detected for as long as

190 tions, both parental and single-cell-derived clonal cell populations differentiated to the chondrocyt

191 Heterogeneity within clonal cell populations remains a critical bottleneck wi

192 Immunostaining of clonal cell populations showed MIWC expression at the pl

193 c heterogeneity of circadian oscillations in clonal cell populations to investigate the underlying me

194 Clonal cell populations were analyzed for deletions by u

195 mporal association of the detection of these clonal cell populations with infection and the dominance

196 These mechanisms include direct selection of clonal cell populations with the capacity to rapidly upr

197 how that normal human endometrial glands are clonal cell populations with total mutation burdens that

198 protein 1, and Biglycan were examined within clonal cell populations, comprising either part of, or m

199 etuses (15 to 21 weeks postconception) using clonal cell populations.

200 that ParE(1) toxicity is not uniform within clonal cell populations.

201 ation doublings in the absence of hormone in clonal-cell populations, and the silent transgenes in th

202 We have analyzed clonal cell proliferation in the ventricular zone (VZ) o

203 ded into primary forms where eosinophils are clonal cells, reactive forms where an underlying reactiv

204 The same clonal cells seeded at high density targeted these prote

205 ow peaks, which could be a characteristic of clonal cell selection, clonal expansion, or both.

206 t studies have employed these tools to track clonal cell states in cancer progression and treatment r

207 contributes to the eradication of resistant clonal cell subpopulations.

208 Clonal cells that inducibly expressed caPKA enhanced the

209 also identified a minor subpopulation of non-clonal cells that were classified as metastable, pseudod

210 In all cases in which IM or FC detected clonal cells, the ASO-PCR was positive.

211 of micro-CT imaging, molecular profiling and clonal cell tracing.

212 isolation of the ST3GAL5 and SLC35A2 mutant clonal cells uncover a previously unappreciated differen

213 Perhaps the clonal cells use IL-15 more effectively or are more resi

214 + blood cells in relationship to circulating clonal cells was done in 13 myeloma patients using a clo

215 h MGUS with blood involvement, the number of clonal cells was very small ( < 0.04% of the BMNCs).

216 In clonal cells, we observed a negative correlation for the

217 lls with U1 ribozyme-encoding vector, stable clonal cells were selected in which the expression of al

218 We validate our technique in clonal cells with previously defined integration sites a