ライフサイエンスコーパス: clonogenicity

1 ell invasiveness, and in OPCN2-enhanced cell clonogenicity.

2 poxia is paralleled by a twofold increase in clonogenicity.

3 a reduction in tumor cell proliferation and clonogenicity.

4 ncided with a dramatic increase in soft-agar clonogenicity.

5 gnificantly inhibit glioma cell survival and clonogenicity.

6 ells' proliferation, migration, invasion and clonogenicity.

7 assays for intracellular ROS, apoptosis, and clonogenicity.

8 ssing cells and induced a pronounced loss of clonogenicity.

9 mitochondrial injury, cell death, or loss of clonogenicity.

10 cterization of colony forming efficiency and clonogenicity.

11 hondrial dysfunction, apoptosis, and loss of clonogenicity.

12 s, sphere formation capacity and single cell clonogenicity.

13 le causing only small decreases in long term clonogenicity.

14 e more sensitive than KB in terms of loss of clonogenicity.

15 aling and inhibited Jurkat proliferation and clonogenicity.

16 inhibition and 4-fold higher with respect to clonogenicity.

17 ed by a substantial decline in leukemic cell clonogenicity.

18 end, however, cause a loss of suppression of clonogenicity.

19 growth retardation, cell death and decreased clonogenicity.

20 orrelated with growth inhibition and loss of clonogenicity.

21 ny formation, a measure of LTC-IC number and clonogenicity.

22 tion and is strongly correlated with loss of clonogenicity.

23 reatment resistance, migratory capacity, and clonogenicity.

24 emature chromosome condensation, and loss of clonogenicity.

25 d the cellular viability, proliferation, and clonogenicity.

26 hifts in transcriptional states, and reduced clonogenicity.

27 YAP/TAZ and PI3K synergistically suppresses clonogenicity.

28 exhibit unlimited ex vivo expandability with clonogenicity.

29 ns with recombinant DPT protein improved HSC clonogenicity.

30 e proliferation, cell cycle progression, and clonogenicity.

31 and 22Rv1 resulted in significantly reduced clonogenicity.

32 cterized by Kdr/Flk1, Cdh5, CD31 and lack of clonogenicity.

33 nticancer drug-induced apoptosis and greater clonogenicity.

34 enhancing Slug nuclear accumulation and MaSC clonogenicity.

35 lymphoid progenitors exhibit enhanced serial clonogenicity.

36 In the epidermis, the highest clonogenicity, a feature of stem cells (SCs), is found i

37 shed cell size that correlated with a higher clonogenicity, a longer-term proliferative potential, an

38 Significantly reduced clonogenicity, a proxy for tumor growth inhibition by io

39 educed apoptosis and enhanced proliferation, clonogenicity, adhesion, and migration.

40 bsence of drug treatment caused some loss of clonogenicity, although the magnitude of this cytotoxic

41 Compound 2 irreversibly inhibited clonogenicity, although this required at least 4 h of ex

42 y, siRNA targeting FGFR3 and kdFGFR3 reduced clonogenicity, anchorage-independent growth, and disinte

43 N-Cadherin and vimentin expressions, higher clonogenicity and ALDH positive expression of cancer cel

44 sfection resulted in reduced cell growth and clonogenicity and an approximately 2.0-fold increase in

45 This effect is characterized by elevated clonogenicity and an increased proportion of human prima

46 -mediated in vitro suppression of tumor cell clonogenicity and analyzed the sequence of the gene clon

47 HER2 reduces both receptors with diminished clonogenicity and augmented phagocytosis.

48 f aberrant progenitors with unlimited serial clonogenicity and blocked differentiation.

49 SP status predicts clonogenicity and cardiogenic gene expression (Gata4/6,

50 Naive IFP-MSC exhibit increased clonogenicity and chondrogenic potential compared with B

51 suggesting that DCLK1 overexpression induces clonogenicity and dedifferentiated phenotypes in hepatom

52 a progressive proliferation defect, loss of clonogenicity and diminished tissue regenerative ability

53 or of BMP type I receptor kinases, represses clonogenicity and diminishes the cancer stem cell-enrich

54 ation resulted in increased survival, higher clonogenicity and enhanced invasiveness of these cells.

55 Lymphoma SP cells exhibited autonomous clonogenicity and exported Wnt3a via exosomes to neighbo

56 MECs also showed increased invasiveness and clonogenicity and formed more free-floating spheroids an

57 Analysis of the viability, differentiation, clonogenicity and function of human stem/progenitor cell

58 methacin, and PB alone or in combination] on clonogenicity and HCCs recovery from 5-fluorouracil (FUr

59 enicity, whereas miR-215 knockdown increases clonogenicity and impairs differentiation in CDX1-high c

60 macologic inhibition decreased male GBM cell clonogenicity and in vivo tumorigenesis while increasing

61 Knockdown of IL1RAP decreased clonogenicity and increased cell death of AML cells.

62 patients with AML-inhibited cell growth and clonogenicity and induced apoptosis.

63 led that LLY-283 could reduce the viability, clonogenicity and invasion of DMG cells in vitro, repres

64 d AR activity as well as increased survival, clonogenicity and invasiveness.

65 to PTHrP+ cells, FoxA2+ cells exhibit higher clonogenicity and longevity.

66 ion-mediated drug resistance, and suppressed clonogenicity and lymphoma growth ex vivo and in vivo.

67 ratoma formation by Lu-iPSCs, and diminished clonogenicity and malignant growth of SCLC cells in vivo

68 leus-targeted SOD2 (NLS-SOD2) have increased clonogenicity and metastatic potential.

69 ndent effects upon growth factor dependence, clonogenicity and migration.

70 s at single-cell resolution and demonstrated clonogenicity and multipotency of the Gli1-expressing pr

71 Clonogenicity and multipotentiality of normal bovine SF

72 xpression of CDX1 in HCT116 leads to reduced clonogenicity and production of differentiating crypt-co

73 an lung SCC cell lines suppressed tumor cell clonogenicity and proliferation in culture and in vivo A

74 hosphorylates checkpoint kinase 2 to promote clonogenicity and proliferation of cancer cells.

75 CRISPR systems severely impaired cancer cell clonogenicity and proliferation.

76 g cancer cell viability, Ki-67 intensity and clonogenicity and promoted lung cancer cell migration.

77 45 treated cells counteracted the effects on clonogenicity and replicative senescence.

78 oresistance genes and demonstrated increased clonogenicity and resistance to chemo- and radiotherapy

79 Overexpression of TERT Delta 2-4 enhanced clonogenicity and resistance to cisplatin-induced cell d

80 enous TERT Delta 2-4 in Calu-6 cells reduced clonogenicity and resistance to cisplatin.

81 scavengers in CSCs markedly decreases their clonogenicity and results in radiosensitization.

82 that EGR2 knockdown inhibited proliferation, clonogenicity and spheroidal growth in vitro and induced

83 nockdown decreases proliferation, migration, clonogenicity and the size of the metastasis-initiating

84 hymal stem cell features (PMSCs), i.e., high clonogenicity and trilineage differentiation potential,

85 YY1-promoted cell proliferation, migration, clonogenicity and tumor growth.

86 lial to mesenchymal transition and inhibited clonogenicity and tumor initiation.

87 stablished through demonstration of enhanced clonogenicity and tumor-forming capacity of this cell su

88 l expression concomitant with a reduction in clonogenicity and tumorigenesis accompanied by an increa

89 nhibition, and suppression of both soft agar clonogenicity and tumorigenicity in nude mice.

90 Serine355, is required for maintaining both clonogenicity and tumorigenicity.

91 perties: decreased doubling times, increased clonogenicity and viability, facilitated S-phase entry,

92 ression, leading to increased proliferation, clonogenicity, and anchorage-independent growth.

93 it.ed proliferation, migration and invasion, clonogenicity, and anchorage-independent growth.

94 lular activities for inhibiting cell growth, clonogenicity, and cellular glutamate production, (2) ex

95 SCR130 in combination with IR on cell death, clonogenicity, and DNA damage is limited and highly cell

96 as associated with decreased MaSC expansion, clonogenicity, and expression of Slug, a master regulato

97 properties of cell adhesion, cell migration, clonogenicity, and in vitro life span.

98 r capacity for sphere formation, single cell clonogenicity, and in vivo tumorigenicity.

99 phoma stromal cells confers drug resistance, clonogenicity, and induction of histone deacetylase 6 (H

100 rests cell cycle at G(0)-G(1) phase, reduces clonogenicity, and inhibits cell growth of murine and hu

101 h shRNA slows leukemia cell growth, inhibits clonogenicity, and leads to increased sensitivity to ima

102 V617F AML cell lines disrupts proliferation, clonogenicity, and leukemic engraftment.

103 ell lysates and inhibited the proliferation, clonogenicity, and motility of U251 cells in a PTP-zeta-

104 d demonstrate long-term self-renewal, serial clonogenicity, and multigerm layer differentiation poten

105 ferative capability, stem cell proteins, and clonogenicity, and prevents the acquisition of senescenc

106 ances spontaneous differentiation, decreases clonogenicity, and reduces in vivo tumor growth.

107 r, such as increased cell growth, migration, clonogenicity, and self-renewal capacity.

108 ASXL3 silencing inhibited proliferation, clonogenicity, and teratoma formation by Lu-iPSCs, and d

109 the regulation of NSCLC cell proliferation, clonogenicity, and tumor growth, suggesting that IGFBP-3

110 tion of PRL-3 reduced myeloma cell survival, clonogenicity, and tumorigenesis, and detailed mechanist

111 where it functions to inhibit proliferation, clonogenicity, and tumorigenesis.

112 ML significantly suppressed the growth rate, clonogenicity, and tumorigenicity of breast cancer cells

113 The effect of vitamin C on viability, clonogenicity, apoptosis, P-glycoprotein, reactive oxyge

114 Induction of apoptosis and loss of clonogenicity are 3-5-fold lower under pulse treatment c

115 ridol and imatinib synergistically decreased clonogenicity as evaluated by the median-effect method.

116 ermined by an apoptosis assay at 72 h, and a clonogenicity assay at 12 days, after the initial treatm

117 In an anchorage-independent clonogenicity assay, MCF7/caspase-3 cells stably express

118 In vitro clonogenicity assays have demonstrated that the CD34(+)A

119 termined by peripheral blood cell counts and clonogenicity assays of hematopoietic progenitors, did n

120 used cell contact-dependent cell growth and clonogenicity assays, which showed that knockdown of TGF

121 se-dependent reduction of cell viability and clonogenicity at a single-digit micromolar level, along

122 al 6 beta-OOH, producing a 50% loss of L1210 clonogenicity at approximately 1/5 the concentration of

123 deleted for the two genes possess increased clonogenicity at late stages of stationary phase surviva

124 D47 and HER2 dual knockouts not only inhibit clonogenicity but also enhance macrophage-mediated attac

125 radiation dose sufficient to reduce cellular clonogenicity by 1 log in cells expressing functional p5

126 Inhibition of cancer cell clonogenicity by Chk1 inhibition could be rescued in vit

127 ereas prior exposure decreased inhibition of clonogenicity by paclitaxel.

128 in a dose-dependent manner, cell viability, clonogenicity, cell cycle progression and migration, and

129 cells in vitro for proliferation, survival, clonogenicity, cell cycle, and p53 expression.

130 tumorigenic properties of MPM cells, such as clonogenicity, cell migration and resistance to pemetrex

131 the cell cycle, and dramatically increasing clonogenicity, colony size and motility.

132 xerted greater inhibition of cell growth and clonogenicity compared to a single gene.

133 ockdown of HIF1-alpha abolished the enhanced clonogenicity during hypoxia.

134 ng single cell-derived multiple-cell clones (clonogenicity) during development.

135 g single cell-derived, multiple-cell clones (clonogenicity) during tissue maintenance.

136 rvivin mRNA and protein levels, reduced cell clonogenicity, enhanced paclitaxel activity), but lost i

137 tures of bone marrow-derived MSCs, including clonogenicity, expression of certain markers, and follow

138 ligand HGF further sustained proliferation, clonogenicity, expression of self-renewal markers, migra

139 pressed ovarian cancer cell spheroid growth, clonogenicity formation, and migration activity.

140 F decreased pancreatic cancer cell survival, clonogenicity, formation of pancreatospheres, invasive c

141 2 in the AML cell line U937 leads to loss of clonogenicity, G1 arrest and partial differentiation.

142 emonstrate that PROX1 is needed for RMS cell clonogenicity, growth and tumor formation.

143 e transferred to adherent dishes to evaluate clonogenicity; growth-controlled spheroids also failed t

144 addition to growth arrest and suppression of clonogenicity, HMBA induces apoptosis both in freshly is

145 isplays long-term colony-forming efficiency, clonogenicity, immunosuppression, and panmesodermal pote

146 fragmentation and condensation, and loss of clonogenicity in 3 MM cell lines (U266, RPMI-8266, and N

147 type gene, this mutant has no effect on cell clonogenicity in agar.

148 nd small molecule PRMT5 inhibition, reducing clonogenicity in an MTAP-dependent manner.

149 + cells from PNH patients had markedly lower clonogenicity in both primary colony cultures and in the

150 bilizer in suppressing the proliferation and clonogenicity in cancer cells harboring the p53Y200C mut

151 estinal crypts, as well as stemness and high clonogenicity in colon cancer cells, depend on Wnt signa

152 genous EPHB6 resulted in inhibition of their clonogenicity in culture.

153 d migratory capacity in transwell assays and clonogenicity in limiting dilution analyses.

154 knockdown markedly reduced proliferation and clonogenicity in MOLM-13, MV4-11 and THP-1 acute myeloid

155 tic cellularity and stem and progenitor cell clonogenicity in mouse BM.

156 decreased cell proliferation, viability and clonogenicity in mutant p53 cell lines.

157 They also showed reduced growth and clonogenicity in plating efficiency and soft agarose ass

158 asis suppression correlated with a decreased clonogenicity in soft (0.3%) and hard (0.9%) agar.

159 m cell marker, CD44, and displayed increased clonogenicity in soft agar and broad drug-resistance in

160 CF or the MyCF proteins exhibited decreased clonogenicity in soft agar and increased sensitivity to

161 with decreased rates of cell proliferation, clonogenicity in soft agar, changes in the actin cytoske

162 reduced rate of tumor growth and a decreased clonogenicity in soft agar.

163 Menin overexpression reduced the RAS-induced clonogenicity in soft agar.

164 heir anoikis susceptibility and blocks their clonogenicity in the absence of adhesion to the ECM.

165 sing L-buthionine sulfoxamine eliminated MSC clonogenicity in the presence of Ag(+), which was rescue

166 n suppressed MDS92 and MDS-L cell growth and clonogenicity in vitro and in vivo and decreased JAK2/ST

167 ed its ability to inhibit tumor cell-induced clonogenicity in vitro, to induce apoptosis in lung tumo

168 logeneic HSCs in vivo and do not enhance HSC clonogenicity in vitro.

169 first time that FC significantly enhance HSC clonogenicity, increase the proportion of multipotent pr

170 y degrades R-loops, rescued the reduction in clonogenicity induced by TOP1 deficiency, demonstrating

171 C-B or C-I inhibited proliferation, clonogenicity, induced G(2)/M cell-cycle arrest and casp

172 fter a dose of PDT producing a 99.9% loss of clonogenicity, LY-R cells responded by an increased prod

173 he ALK-centric RNAi therapy prohibits cancer clonogenicity, migration, and invasion and induces poten

174 and recurrent glioblastoma, in reducing the clonogenicity, migration, and invasion of endocrine-resi

175 onal studies, depletion of YY1 inhibited the clonogenicity, migration, invasion, and tumor formation

176 ed to significantly decreased proliferation, clonogenicity, migration, spheroid formation, and G1 cel

177 formation, including attenuated cell growth, clonogenicity, mobility, and anchorage-independent growt

178 f H460 cells greater than PMX; PMX inhibited clonogenicity more than C1 or C2 at pH 7.2, which favors

179 universal stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity.

180 significant impairment of proliferation and clonogenicity occurs.

181 e, ground-state ISCs marked by a single-cell clonogenicity of 70% and a corresponding 250-fold prolif

182 O1 inhibited the long-term proliferation and clonogenicity of AE cells and t(8;21) AML cell lines.

183 fering (si)RNA, decreased cell viability and clonogenicity of ALK+ ALCL cells.

184 Further, GANT61 treatment abolished the clonogenicity of all six human colon carcinoma cell line

185 iRNA-knockdown of Nrf2 significantly reduced clonogenicity of AML patient cells and improved their ch

186 osure, these NPs more efficiently reduce the clonogenicity of bone marrow cancer cells from patients

187 , this treatment combination yielded reduced clonogenicity of bone marrow-resident 5TGM1 cells, reduc

188 ing units/cell) resulted in 100% loss of the clonogenicity of breast tumor cells.

189 antisense LDH-A expression reduces soft agar clonogenicity of c-Myc-transformed Rat1a fibroblasts, c-

190 dent manner and suppressed proliferation and clonogenicity of cancer cells harboring the p53Y220C mut

191 gnificantly suppressed the proliferation and clonogenicity of cancer cells.

192 r to c-Myc, JPO1 overexpression enhances the clonogenicity of CB33 human lymphoblastoid cells in meth

193 Furthermore, hypoxia enhanced the clonogenicity of CML cells, as well as their efficiency

194 -terminally truncated version can rescue the clonogenicity of CRD-BP knockdown breast cancer cells, s

195 that, compared with controls, frequency, and clonogenicity of DBA, EEP and LEP are significantly decr

196 ng unit assays further demonstrate decreased clonogenicity of FLT3/ITD(+) cells upon treatment with A

197 GA was a potent inhibitor of the clonogenicity of four glioma cells lines with IC(50)s ra

198 reversible growth inhibition and decrease in clonogenicity of FUra-treated HCC are prolonged by subse

199 SON knockdown inhibits proliferation and clonogenicity of GBM cells in vitro and significantly su

200 less potent derivative of GA, inhibited the clonogenicity of glioma cells with IC(50) values of 13 n

201 We also found that the clonogenicity of H1299 cells in soft agar was markedly r

202 hich favors PCFT uptake, C1 and C2 inhibited clonogenicity of H460 cells greater than PMX; PMX inhibi

203 human colon cancer cells leads to increased clonogenicity of HCA-7, but not HCT-116 cells.

204 elped preserve the HSC/MPP pools and promote clonogenicity of hematopoietic progenitor cells.

205 CREB regulates hematopoietic engraftment and clonogenicity of hematopoietic progenitors, and is depen

206 ion, DCLK1 regulates oncogenic signaling and clonogenicity of hepatocytes by a novel non-canonical/at

207 hannel inhibitor glibenclamide decreased the clonogenicity of HepG2 cells without inducing cytotoxici

208 PB than on BM CD34+ cells, do not affect the clonogenicity of human and murine HSPCs, and increase ad

209 ready in clinics, exhibit reduced growth and clonogenicity of human and murine PCa cells (P < 0.01) a

210 encing or deletion reduces proliferation and clonogenicity of human keratinocytes and SCC-derived cel

211 nockdown of IQGAP1 blocked proliferation and clonogenicity of human leukemia cell-lines.

212 aling molecule Smoothened (Smo) promoted the clonogenicity of human SCLC in vitro and the initiation

213 te that FTY720 induces apoptosis and impairs clonogenicity of imatinib/dasatinib-sensitive and -resis

214 Inhibition of HLX reduces proliferation and clonogenicity of leukemia cells, overcomes the different

215 These agents abrogate the clonogenicity of leukemic cells but have minimal effects

216 ry CFC numbers after 5 weeks of culture, and clonogenicity of LTC-ICs was determined by limiting dilu

217 trate that erlotinib treatment increases the clonogenicity of lung cancer cells in a sphere-forming a

218 and ATRA were synergistic in inhibiting the clonogenicity of MCF-7 and T-47D cells that expressed es

219 ibit proliferation, migration, invasion, and clonogenicity of MM cells.

220 ages mimicks disease progression by reducing clonogenicity of myeloid cells, blocking granulopoiesis

221 1R levels and inhibits the proliferation and clonogenicity of neuroblastoma cells in vitro but not th

222 breast cancer cells, but did not affect the clonogenicity of nontumorigenic cells.

223 MEX3A overexpression enhanced the growth and clonogenicity of OCCC cell lines.

224 kdown by RNA interference (RNAi) reduced the clonogenicity of Panc1 pancreatic cancer cells 4-fold an

225 ly, in single-cell assays, Nov increases the clonogenicity of phenotypic HSCs without increasing thei

226 In this study, we show that the clonogenicity of several human tumor cell lines and prim

227 y, lenalidomide decreased the percentage and clonogenicity of SP cells, and also induced phosphorylat

228 GR overexpression led to a reduction in the clonogenicity of the follicular epithelial SCs.

229 e marrow-derived CD34+ cells to maintain the clonogenicity of the primitive progenitors.

230 in soft agar were performed to evaluate the clonogenicity of the sorted cells.

231 a specific pSTAT3 inhibitor, suppressed the clonogenicity of the stem-like cells in patients with hi

232 at5 on either the developmental potential or clonogenicity of this population.

233 1 per 11 cells on PA6, thus showing the high clonogenicity of this primitive stem cell population.

234 Our findings that self-renewal and clonogenicity of TICs were suppressed by pharmacological

235 s was demonstrated by inhibiting the loss in clonogenicity of TS(-) cells by anti-FasL and in enhance

236 vivo as well as the self-renewal ability and clonogenicity of tumor-derived stem cells.

237 exosomes that increase the proliferation and clonogenicity of tumor-initiating glioma stem-like cells

238 For each passage, clonogenicity on 3T3 fibroblasts feeder layers was compa

239 ng, decreased cell proliferation and reduced clonogenicity on plastic and in soft agar.

240 ot accompanied by an increased inhibition of clonogenicity over that induced by SN-38 alone.

241 atment also impairs growth, self-renewal and clonogenicity potential of cancer stem cells and reduced

242 damage, as shown by enhanced cell survival, clonogenicity, proliferation, and differentiation.

243 ession stimulated in vitro proliferation and clonogenicity properties and favored tumor development i

244 s, hypoxia enhances tumor cell viability and clonogenicity relative to normoxia.

245 t phenotypes: whereas S780A-STAT5a decreased clonogenicity, S726A-STAT5a decreased proliferation in r

246 enchymal stem cells (GMSCs), which exhibited clonogenicity, self-renewal, and multipotent differentia

247 Progenitor cells have clonogenicity, self-renewal, and multipotential capacity

248 dult progenitor cells presumably demonstrate clonogenicity, self-renewal, and multipotentiality, and

249 Clonogenicity significantly declined from P1 to P3 for t

250 TBD-BMSCs exhibited reduced clonogenicity, spontaneous differentiation into adipocyt

251 of p17 variants (vp17s) endowed with B-cell clonogenicity, suggesting a role of vp17s in lymphomagen

252 limited replicative expansion and maintained clonogenicity, suggests certain advantages for their use

253 markedly less cell adhesion, spreading, and clonogenicity than did control cells.

254 radiation resulted in a greater reduction of clonogenicity than either treatment alone in cells with

255 nes, CPA-LLP resulted in significantly lower clonogenicity than free CPA (p<0.05).

256 to apoptosis, DNA fragmentation, and loss of clonogenicity than HL-60/pCEP4 cells.

257 A also caused a reduction in both growth and clonogenicity that was associated with restoration of re

258 (-/-) NPCs results in reduced glycolysis and clonogenicity, thus depleting the embryonic NPC pool and

259 ro proliferation assays, direct cell counts, clonogenicity under anchorage-dependent and anchorage-in

260 Generally, an effective reduction of clonogenicity was detected in tumor cells treated with a

261 urthermore, the effect of DDR1 inhibition on clonogenicity was evaluated using a clonogenic assay, an

262 This clonogenicity was higher in lesion-free ApoE(-/-) mice a

263 Clonogenicity was highest in cells with high Wnt activit

264 IC(50) of 3.59 +/- 1.23 micromol/L although clonogenicity was inhibited at concentrations of 75 to 1

265 These data suggest that the reduced clonogenicity was predominantly due to intrinsic deficie

266 er cell lines by Ad-IGF-Ir/as, the soft agar clonogenicity was reduced by 84%.

267 chondria after 18 hours of IL-3 deprivation, clonogenicity was unaffected when IL-3 was replenished a

268 mage processing, cell-cycle progression, and clonogenicity were unique to cells transformed by mutant

269 osis), and colony formation in 0.2% agarose (clonogenicity) were measured.

270 L1210 cells exhibited a progressive loss of clonogenicity when irradiated with broad-band visible li

271 fferentiated cell lines causes a decrease in clonogenicity, whereas miR-215 knockdown increases clono

272 hich is essential for cell proliferation and clonogenicity, with immediate therapeutic implications.

273 akaryocyte-erythroid progenitors show higher clonogenicity, with increased megakaryocyte, megakaryocy