ライフサイエンスコーパス: closed conformation

1 l death and Ucn1 maintains this channel in a closed conformation.

2 ite within the central ion channel pore in a closed conformation.

3 ATD clamshell transitions from an open to a closed conformation.

4 atalytic pocket that predominantly assumes a closed conformation.

5 DS-SOSIP in the vaccine-preferred prefusion-closed conformation.

6 its potential ability in stabilizing the LBD closed conformation.

7 is highly dynamic but predominantly adopts a closed conformation.

8 ATP analogue, RNA and Yra1-C, Sub2 assumes a closed conformation.

9 s a folding chaperone enabling E4 to adopt a closed conformation.

10 iquitin is transferred to substrate from the closed conformation.

11 odulates Cascade activity by stabilizing the closed conformation.

12 chain motions that already take place in the closed conformation.

13 g when bound to ADP and constrains TrkH to a closed conformation.

14 lently stabilized by a disulfide bond in the closed conformation.

15 sports Fe(III) by binding the metal ion in a closed conformation.

16 oro or bromo substituent engendered a second closed conformation.

17 uced apparent affinity, inducing a partially closed conformation.

18 helix that locks the active site in an over-closed conformation.

19 he transition of the clamp from an open to a closed conformation.

20 ttering analyses show that it locks IDE in a closed conformation.

21 own highly conserved C-terminus, inducing a closed conformation.

22 uces a conformational change from an open to closed conformation.

23 rs that lock the enzyme in the inactive over-closed conformation.

24 AS stabilizes integrins in the low-affinity, closed conformation.

25 center of the pore serve as the gate in the closed conformation.

26 t with stabilization of the voltage sensor's closed conformation.

27 in solution, but Merlin(S518D) remains in a closed conformation.

28 We found that individual Sed5 adopts a tight closed conformation.

29 y inhibits ligand binding by stabilizing the closed conformation.

30 y are separated widely (30.4 A apart) in the closed conformation.

31 between an active open state and an inactive closed conformation.

32 This rate enhancement is diminished in the closed conformation.

33 ithin lipids, in which both channels adopt a closed conformation.

34 n were more confined than Lck mutants in the closed conformation.

35 down RBDs, thereby locking the spike into a closed conformation.

36 ed part of gammaTuRC appear to stabilize the closed conformation.

37 drogen-bonding residues and induce a similar closed conformation.

38 ts or inhibitors, the resting ABCG2 adopts a closed conformation.

39 SNARE protein syntaxin-1 in an autoinhibited closed conformation.

40 disordered region, fixing the channel in its closed conformation.

41 plish the conformational change leading to a closed conformation.

42 d alphabeta-tubulins drive gamma-TuRC into a closed conformation.

43 t specifically interacted with Merlin in the closed conformation.

44 tional equilibrium of FeuA from an open to a closed conformation.

45 n intermediate energy state between open and closed conformations.

46 ell survival protein that exists in open and closed conformations.

47 e oscillates between open, intermediate, and closed conformations.

48 serve as alternatives to those in the cleft-closed conformations.

49 escribed the transition between the open and closed conformations.

50 usculus TASK2 in lipid nanodiscs in open and closed conformations.

51 f the cofactor-binding loop in both open and closed conformations.

52 l structures of human beta4GalT7 in open and closed conformations.

53 dergoes an ATP-driven cycle through open and closed conformations.

54 ows prolonged periods of cycling between two closed conformations.

55 exists on the surface of virions in open or closed conformations.

56 solution structure of a pLGIC) as a "locally closed" conformation.

57 keep its envelope glycoprotein (Env) in its "closed" conformation.

58 y crystallography to 3.9 A, revealing a new 'closed' conformation.

59 n be summarized as "open," "semi-open," and "closed" conformations.

60 ts strain-dependent "open," "semiopen," and "closed" conformations.

61 arrier between the apo 'open' and ATP-bound 'closed' conformations.

62 ADP in two distinctly different ('Open' and 'Closed') conformations.

63 ed that enhance presentation of the trimeric closed conformation across diverse HIV-1 strains.

64 he 99-, 148-, and 220-loop exist in open and closed conformations, allowing or preventing substrate a

65 ion of the intact nNOS-CaM complex reveals a closed conformation and a cross-monomer arrangement with

66 xtension and Ub that stabilize Cdc34~Ub in a closed conformation and are critical for Ub discharge.

67 at the bulky residues should destabilize the closed conformation and eliminate the approximately 3 kc

68 These interactions may lock the clamp to the closed conformation and enclose the DNA being transcribe

69 the stability of the dimer interfaces in the closed conformation and how clamp dynamics contribute to

70 yo-EM structures of CorA in the Mg(2+)-bound closed conformation and in two open Mg(2+)-free states a

71 d stabilize BG505 SOSIP.664 in its prefusion closed conformation and limit reactivity to weakly neutr

72 mRNA leader, with AUG recognition evoking a closed conformation and more stable P site interaction o

73 prothrombin wild type stabilized 70% in the closed conformation and of the mutant Y93A stabilized 80

74 ctions involving the eIF1A NTT stabilize the closed conformation and promote utilization of suboptima

75 complex around its RING domain, locking the closed conformation and promoting ubiquitin discharge.

76 ze the apex of the Env trimer in a prefusion-closed conformation and show antigenically, structurally

77 StBax1 keeps StXPB in a closed conformation and stimulates ATP hydrolysis by XPB

78 e structure, the cytoplasmic domain adopts a closed conformation and the ion conduction pore is also

79 Sly1 binds to both the closed conformation and the N-peptide of Sed5, suggestin

80 well-established to bind tightly to both the closed conformation and the N-peptide of syntaxin 1a, th

81 hat Munc18c, like Munc18a, binds to both the closed conformation and the N-peptide of Syx4.

82 fingers domain caused the enzyme to adopt a closed conformation and to become susceptible to the ant

83 oss-linking actually traps the LBDs in cleft-closed conformations and delineate semiclosed conformati

84 ling the uncoupling between ATP-PRT open and closed conformations and its functional state.

85 ound LBDs also stayed predominantly in cleft-closed conformations and made only infrequent excursions

86 chromatin make two-state transitions between closed conformations and open dumbbell conformations.

87 ctive site locked the activated enzyme in a "closed" conformation and revealed the positions of criti

88 l elements that block E2 Ub from adopting a 'closed' conformation and (2) participating in contacts t

89 ta6, alphaVbeta8 has a constitutive extended-closed conformation, and binding to pro-TGF-beta1 does n

90 domains are preferentially conserved in the closed conformation, and conformational diversity is fac

91 orable for the ligand-free AdK to access the closed conformation, and imply that ligand binding may p

92 mmetric, three of the protomers exhibiting a closed conformation, and one an open conformation.

93 ) that captured this permease in the outward-closed conformation, and we identified the extracellular

94 cross-linking immobilized the LBDs in cleft-closed conformations, and consequently concluded that th

95 in a dynamic equilibrium between "open" and "closed" conformations, and the extent to which the open

96 ical, is responsible for the PS1 pathogenic 'closed' conformation, and resulting increase in the Abet

97 neutralize viruses (tier 2) express Env in a closed conformation antigenic for broadly neutralizing a

98 hesive and that the extended-closed and bent-closed conformations are nonadhesive.

99 d crystal structures, but that both open and closed conformations are thermally accessible in the pre

100 hermore, the p53/Pol II cocomplex displays a closed conformation as defined by the position of the Po

101 UvrD monomer can rotate between an open and closed conformation as well as two highly populated inte

102 est that apo-GCGR can adopt both an open and closed conformation associated with extensive contacts b

103 ent a cryo-EM structure of mouse Piezo1 in a closed conformation at 3.7A-resolution.

104 canning, while impeding rearrangement to the closed conformation at non-AUG codons.

105 ity and histone modifications demonstrated a closed conformation at the human NOS2 locus and an open

106 has been established in its open and locally closed conformations at acidic pH.

107 aviruses revealed flexible loops in open and closed conformations at the m(7)GpppA-binding pocket.

108 ution, both Merlin and Merlin(S518D) adopt a closed conformation, but binding experiments indicate th

109 e Q32 loop in apo-HasA(yp) is already in the closed conformation, but no residue from the Q32 loop bi

110 e apoenzyme shows the C terminus locked in a closed conformation by a disulfide bond between Cys(972)

111 ajor component, and 3) Ca(2+) stabilized the closed conformation by a factor of two.

112 del where mambalgin-2 traps the channel in a closed conformation by precluding the conformational cha

113 ent and that S2M11 also locks the spike in a closed conformation by recognition of a quaternary epito

114 Mad2 adopts the closed conformation (C-Mad2) in a Mad1-Mad2 core complex

115 ope (Env) trimers, stabilized in a prefusion-closed conformation, can elicit humoral responses capabl

116 es that bind at the trimer apex stabilize a "closed" conformation characteristic of the most difficul

117 The nucleotide binding domains form a closed conformation containing two bound ATP molecules,

118 en proposed to act as a gate with an open or closed conformation controlling access to the active sit

119 k(off), the disulfide in M88 stabilizes the closed conformation, decreasing k(off) 260-fold relative

120 n cells, whereas inhibitors that stabilize a closed conformation do not.

121 the pleckstrin homology domain (PHD) from a 'closed' conformation docked near the stalk to an 'open'

122 ALIX is normally present in a closed conformation due to an intramolecular interaction

123 er-561 phosphorylation-dependent switch to a closed conformation during synaptic plasticity.

124 uestion is whether the Met(20) loop adopts a closed conformation during the chemical hydride transfer

125 pattern; in other words, E4 adopts the most closed conformation, E2 adopts the most open conformatio

126 o-EM structures of human TMEM175 in open and closed conformations, enabled by resolutions up to 2.6 a

127 The headpiece crystallizes in a closed conformation essentially identical to that seen p

128 are necessary for transition from an open to closed conformation fail to rescue evoked release defect

129 s its interactions with microtubules, with a closed conformation favouring oligomerization on microtu

130 reased with Ca (systole), suggesting rigidly closed conformations for the E1 (Ca-bound) enzymatic sub

131 he-87, Phe-144, and Phe-153 that support the closed conformation found in the crystal structure.

132 l domain) could induce a tendency toward the closed conformation greater than that for UL30 and expla

133 he activities are mutually exclusive, as the closed conformation has GTP binding/GTPase activity, and

134 ious reports showing that trapping P-gp in a closed conformation highly activated ATPase activity, he

135 accine development is therefore to mimic the closed conformation in a designed immunogen.

136 of ATP to MalK2 promotes an asymmetric, semi-closed conformation in accordance with the low ATPase ac

137 mplex with the CTR in an open apo form and a closed conformation in complex with a cofactor and a pse

138 annel is hindered by N139's preference for a closed conformation in situations with protonated E286.

139 nked DENV protease exists predominantly in a closed conformation in solution.

140 pen conformation in isolated SF3b(10), but a closed conformation in spliceosomes(11), which is requir

141 ents of the OB domain (~50 angstrom), from a closed conformation in the ATP complex to an open confor

142 ail of eIF1 in blocking rearrangement to the closed conformation in the scanning preinitiation comple

143 pen conformation emerges from an ensemble of closed conformations in a highly Na(+)-dependent manner,

144 trate a dynamic equilibrium between open and closed conformations in solution.

145 (A653T) mutation stabilizes the channel in a closed conformation, in contrast to Lurcher.

146 Vinculin can assume a closed conformation, in which the head and tail domains

147 The EBD crystallizes in a "closed" conformation, in contrast to the "open" structur

148 trate that LNAs which block formation of the closed conformation inhibit genome translation.

149 chical as removal of HVR1 fully destabilized closed conformations, irrespective of glycan status, con

150 ation and thioester transfer to E2s, while a closed conformation is associated with pyrophosphate rel

151 However, the closed conformation is likely destabilized by various mu

152 The same closed conformation is observed by NMR and crystallograp

153 The results show that the closed conformation is stabilized by intersubunit ion-io

154 al and EPR analysis suggests that this fully closed conformation is the major conformation for the AT

155 with excited normal modes confirmed that the closed conformation is the most stable for the CDK2/cycl

156 e stabilities of open, partially closed, and closed conformations is a prerequisite for enhancing the

157 RET state, which we attribute to a partially closed conformation, is also predominant in ternary comp

158 ormation with only part of the complex in a "closed" conformation matching the microtubule geometry.

159 K and show that MCAK in solution exists in a closed conformation mediated by an interaction between t

160 (ASPP2, also called Tp53bp2), that bound to closed-conformation Merlin predominately through the FER

161 The closed conformation minimized TCR dwell times and thereb

162 riant with acylated ceftazidime both favor a closed conformation not conducive for catalysis.

163 at the mammalian SC D2 domain stabilizes the closed conformation observed for hSC D1-D5.

164 ded PLC-beta exists in equilibrium between a closed conformation observed in crystal structures and a

165 The closed conformation, observed in a trapped phosphoryl tr

166 Neurogranin binds to the closed conformation of calmodulin and its impact on syna

167 At the closed conformation of CD81, however, EC2 disengages fro

168 IFN-alpha/beta treatment led to a closed conformation of CNS-1, as assessed by DNase I hyp

169 The closed conformation of CYP2B35 contained two molecules o

170 rmonomer interaction, which induces a firmly closed conformation of dimers and crucially involves the

171 mational dynamics in the DXPS mechanism: The closed conformation of DXPS is critical for stabilizatio

172 However the proposal that the RING dependent closed conformation of E2~Ub represents the active form

173 h slow unfolding, favoring the autoinhibited closed conformation of filamin's force-sensing domain pa

174 hobic core clusters to further stabilize the closed conformation of flaps, and the hydrogen bonding i

175 The prefusion-closed conformation of HIV-1 Env has been identified as

176 4) play an important role in maintaining the closed conformation of HIV-1 protease.

177 es in the kinetics for both the open and the closed conformation of Hsp90 in dependence on the number

178 the present study we have modeled the inward-closed conformation of LdNT1.1 using the crystal structu

179 g to 'gene end' RNA sequences stabilized the closed conformation of M2-1 leading to a drastic shift i

180 imulations revealed that BTZ adducts favor a closed conformation of MGL that occludes substrate recru

181 Here, we present a closed conformation of NaVAe1p, a pore-only BacNaV deriv

182 conditions, our simulations revealed a fully closed conformation of NS5B that may facilitate de novo

183 tes SNARE complex formation by loosening the closed conformation of Sed5.

184 und that single Munc18-1 proteins induce the closed conformation of syntaxin-1 not only in the free s

185 5 could perfectly bind either to the open or closed conformation of T1R3.

186 Here, we present a catalytically relevant, closed conformation of taxadiene synthase (TXS), the mod

187 where resistance occurs by destabilizing the closed conformation of the active site.

188 in an inactive state, which reveals a unique closed conformation of the ECD.

189 A-CTT from the P-site and rearrangement to a closed conformation of the entry channel with reduced mo

190 bridging sheet region further stabilized the closed conformation of the Env.

191 We also describe a novel closed conformation of the enzyme that may represent an

192 the mutation V478W in helix N to promote the closed conformation of the enzyme to make it susceptible

193 ce, respectively, inhibit, and stabilize the closed conformation of the headpiece.

194 two bound ATP molecules is known to favor a closed conformation of the Hsp90 dimer.

195 binding but involves destabilization of the closed conformation of the ion conduction gate.

196 s that stabilize the catalytically competent closed conformation of the polymerase.

197 nd presence of Ca(2+) define the ligand-free closed conformation of the protein and the structure of

198 he neuronal protein Munc18a interacts with a closed conformation of the SNARE protein syntaxin1a (Syx

199 Binding of Ecm29 to the proteasome induces a closed conformation of the substrate entry channel of th

200 tructure-guided mutagenesis corresponds to a closed conformation of the tandem U2AF2 RNA recognition

201 en conformation of the apoenzyme to a nearly closed conformation of the ternary complex entails a dis

202 Mg(2+) to the protein surface stabilizes the closed conformation of the ternary enzyme complex and re

203 ds, demonstrate how these molecules open the closed conformation of the transporter, and establish th

204 d TSR1 domains for proMIC2 and MIC2 reveal a closed conformation of the VWA domain and how it associa

205 cates that the substrate does not affect the closed conformation of this gate.

206 activity is controlled by distinct open and closed conformations of an active-site loop, with certai

207 ed by a pre-equilibrium between the open and closed conformations of helix alpha2 at the active site.

208 brane-associated lid domain of MGL to favour closed conformations of the enzyme that do not permit th

209 inal domain reveal several distinct open and closed conformations of the peptide linking N- and C-ter

210 d effect on the balance between the open and closed conformations of the TnC molecule, which provides

211 HIV-1 to evade immune responses against the "closed" conformation of Env expressed on HIV-1-infected

212 utralizing antibodies (bNAbs) targeting the "closed" conformation of Env induce its internalization f

213 The "closed" conformation of Env is resistant to nonneutraliz

214 n" conformation, which is distinct from the "closed" conformation of postfusion trimers.

215 phate (cGAMP) mimetic that induces the same "closed" conformation of STING.

216 structural stability of Env (i.e. induced a "closed" conformation of the trimer) increased virus resi

217 active site of the enzyme and requires the "closed" conformation of the zinc-binding loop on the sur

218 Electron microscopy demonstrated a "closed" conformation of WT ADAMTS13 and suggested a more

219 ly demonstrate that not only the "open" and "closed" conformations of the GT-B enzyme are largely pre

220 rotransmitter release requires opening of a 'closed' conformation of UNC-64/syntaxin.

221 A or mRNA stabilize first the open, and then closed, conformation of the PIC to influence the accurac

222 rystal form that show alternative, yet still closed, conformations of active site loops.

223 the secretory SM protein Munc18 binds to the closed conformation" of syntaxin 1, the ER-Golgi SM prot

224 ed that tTG adopts either a nucleotide-bound closed conformation or a transamidation-competent open c

225 its dwell time in an intrinsically occurring closed conformation or desensitized state.

226 stabilizes the assembly in either the active closed conformation or the inactive open conformation.

227 id residues 123-170), which exhibits open or closed conformations or structural disorder, depending o

228 in N-terminal extension that, by promoting a closed conformation, plays an autoinhibitory function an

229 ith shifts of a Phe residue between open and closed conformations plus an Asp residue carboxylate shi

230 mple a state where the V3 loop is not in its closed conformation position.

231 that SL9266/PK is dynamic, with 'open' and 'closed' conformations predicted to have distinct functio

232 The closed conformation predominates (70%) and features an u

233 PfRad50 complexes show that the ATP-induced 'closed' conformation promotes DNA end binding and end te

234 al analysis implied a mechanism in which the closed conformation recruits a cellular factor that woul

235 ly to the catalytic cysteine, the E1 is in a closed conformation required for thioester bond formatio

236 quilibrium may exist in CDK4/cyclin D1, with closed conformations resembling that captured for CDK2/c

237 ier 1 and tier 2/3 Env trimers have open and closed conformations, respectively, and CD4 opens the cl

238 up H5N1-NS1 exhibit "open," "semiopen," and "closed" conformations, respectively, suggesting that NS1

239 ly resembles the inhibited L-histidine-bound closed conformation, revealing the uncoupling between AT

240 fully model this loop in either its open or closed conformations, revealing the roles of specific re

241 The ligand-free, closed conformation reveals well-ordered lipids interact

242 In the presence of RyRp at high Ca(2+), the closed conformation shifts to a more compact conformatio

243 In the closed conformation state, polbeta appears to allow only

244 is in the ground state and the other in the closed conformation state.

245 Before engaging CD4, Env adopts a closed conformation (State 1) that is largely antibody r

246 aging CD4, Env adopts an antibody-resistant "closed" conformation (State 1).

247 The closed conformation structure is highly similar to the b

248 omain, which can adopt two conformations: a "closed" conformation, suitable for internal electron tra

249 The closed conformation supports catalysis by orienting the

250 y affected by Dvl mutants unable to form the closed conformation than by wild-type Dvl.

251 with Syntaxin-1 folded into a self-inhibited closed conformation that binds to Munc18-1.

252 The major intracellular form is the closed conformation that functions as a GTP-binding GTPa

253 rature and in a lipid bilayer, Aqy1 adopts a closed conformation that is globally better described by

254 dinator for holding the RNAP II complex in a closed conformation that is highly competent for transcr

255 te, thus attenuating the ATP binding-induced closed conformation that is required for phosphorylation

256 Strikingly, the Gpr126 ECR adopts a closed conformation that is stabilized by an alternative

257 The structures of unbound NEMO show a closed conformation that partially occludes the three bi

258 ct each other at their apical tips to form a closed conformation that presents epitopes recognized by

259 ubstituted phenylimidazoles give rise to two closed conformations that depend on the size of the para

260 n of TcdB is dynamic and can sample open and closed conformations that may facilitate modulation of T

261 a22 NTE has high plasticity, with a primary "closed" conformation that can adopt an open conformation

262 veloped, which was in equilibrium between a "closed" conformation that forms an intramolecular pi-sta

263 ls, forcing PDE6D to assume a predominantly "closed" conformation that impedes binding of lipids.

264 ps2PD(D24N)-T6P complex structures reveal a "closed" conformation that is effected by extensive inter

265 Our results show that even in the closed conformation, the His-E7 gate does not create a l

266 Ca(2+) ions per monomer and its pore is in a closed conformation; this probably reflects channel rund

267 In its inactive conformation, Shot adopts a "closed" conformation through interactions between its NH

268 complex, in which syntaxin-1 still adopts a closed conformation tightly bound to Munc18-1, whereas t

269 rolysis, P-gp transitions through a complete closed conformation to a complete open conformation in t

270 ransition of the FH2 ring from an inhibitory closed conformation to a permissive open conformation, s

271 The Hsp40 co-chaperone converts this fully closed conformation to an open conformation to initiate

272 Whereas the disulfide in M112 disrupts the closed conformation to increase k(off), the disulfide in

273 , PQS bent its hydrophobic side chain into a closed conformation to lower the energy barrier for pene

274 depends on its transition from an inactive, "closed" conformation to a potentially active, "open" con

275 utations at the ATPase site bias Get3 toward closed conformations, uncouple TA binding from induced G

276 We showed that apo-Pol lambda exists in the closed conformation, unprecedentedly with a preformed Mg

277 lymerase fingers subdomain from an open to a closed conformation upon binding of a complementary nucl

278 sette importers and switch from an open to a closed conformation upon substrate binding, providing sp

279 tering, that SaNanK is a dimer that adopts a closed conformation upon substrate binding.

280 To stabilize the trimer in its prefusion closed conformation, we complexed trimeric BG505 SOSIP.6

281 nformations, respectively, and CD4 opens the closed conformation, we conclude that SERINC5 selectivel

282 hate (PIP(2)) or that constitutively adopt a closed conformation, we confirmed a critical role for PI

283 In contrast, the enzyme favored a closed conformation when bound to ADP in solution, consi

284 receptor (SNARE) protein syntaxin-1 adopts a closed conformation when bound to Munc18-1, preventing b

285 tion when bound to the ribosome but are in a closed conformation when not bound to the ribosome.

286 FANCD2-FANCI adopts a closed conformation when the FANCD2 subunit is monoubiqu

287 rochemical and SAXS studies stating that the closed conformation, where the two domains are in close

288 e (E2~Ub) for catalysis by locking it into a closed conformation, where ubiquitin is folded back onto

289 ith complementary dNTPs adopt mainly a fully closed conformation, whereas a conformation with a FRET

290 by Src homology 3 (SH3) domain, leading to a closed conformation, whereas a non-phosphorylatable S561

291 We propose that ADAMTS13 circulates in a closed conformation, which is maintained by a CUB-spacer

292 Ribose binding induces the RBP "closed" conformation, which slows Xe exchange to a rate

293 validates the physiological relevance of the closed conformation, while electron microscopy (EM) and

294 We find that Slo2.2 exists in multiple closed conformations whose relative occupancies are inde

295 es at up to 3.4 A resolution, which reveal a closed conformation with base flipping and base-specific

296 The N-lobe consists of EF1 and EF2 in a closed conformation with either Mg(2+) or Ca(2+) bound a

297 onsistent with a model in which CFTR is in a closed conformation with two ATPs bound.

298 rimer variants were indeed stabilized in the closed conformation, with a reduced ability to undergo r

299 y causing accumulation of the complex in the closed conformation without release of Nrf2.

300 However, FeuA also rarely samples the closed conformation without the involvement of the ligan