ライフサイエンスコーパス: closed state

1 product release (open state), or catalysis (closed state).

2 S6(T) interaction stabilizes the gate in the closed state.

3 at barbiturates preferentially stabilize the closed state.

4 tRNAi, mRNA, or 18S rRNA exclusively in the closed state.

5 face of the plasma membrane and stabilizes a closed state.

6 ding and in stabilising the nucleotide-bound closed state.

7 en state at the expense of a substrate-bound closed state.

8 al and internal dynamics properties of Hsp90 closed state.

9 open state is energetically higher than the closed state.

10 luded ground state and a low population of a closed state.

11 a T4P molecular machine in the open and the closed state.

12 cleavage to fold efficiently into the mature closed state.

13 from an immature uncleaved state to a mature closed state.

14 cture that traps the channel in a presumably closed state.

15 MP-PNP was only observed when trapped in the closed state.

16 ion and the L1 stalk is positioned in a half-closed state.

17 robability of the channel by stabilizing its closed state.

18 scopy indicated these to resemble the mature closed state.

19 lecular chaperone, in a catalytically active closed state.

20 nactivated state then slowly deactivate to a closed state.

21 eptides stabilize the channel in the open or closed state.

22 he two other beta subunits in the completely closed state.

23 channels, and their formation stabilized the closed state.

24 d by an inhibitor that traps HSP70-1A in its closed state.

25 usly shown to cross between protomers in the closed state.

26 y base-pairing dNTP, it re-equilibrates to a closed state.

27 ate and rewinds during the transition to the closed state.

28 s Ac in the position that corresponds to the closed state.

29 ibitor, NS2B complexes with NS3pro to form a closed state.

30 d radicals, demonstrating the existence of a closed state.

31 scape to drive actuation towards the open or closed state.

32 the formation of the catalytically competent closed state.

33 tion, indicating propofol stabilizes a novel closed state.

34 nfiguration of syntaxin 1a is dominated by a closed state.

35 r charge distribution as that of the high-pH closed state.

36 it from a high-water-permeability state to a closed state.

37 transporter in a transport-inactive outward-closed state.

38 the open complex that should destabilize the closed state.

39 elerated channel opening and compromised the closed state.

40 y in many homologous channel structures in a closed state.

41 terminal part, S6(T)) and stabilizes it in a closed state.

42 state before pyrophosphate release or in the closed state.

43 e dynamics and shorten the dwell time in the closed state.

44 gating via stability of a novel inactivated closed state.

45 bilizes Env in the vaccine-desired prefusion-closed state.

46 ndicating inappropriate rearrangement to the closed state.

47 ts BK channels by selective interaction with closed states.

48 d on structural transitions between open and closed states.

49 The structures correspond to two distinct closed states.

50 dues to the ion channel pore in the open and closed states.

51 t that gates may in fact contain two or more closed states.

52 e transition state between the activated and closed states.

53 losed-pore/desensitized and antagonist-bound/closed states.

54 erminal bundles equilibrate between open and closed states.

55 ements as they switch between their open and closed states.

56 lution models of the channel in the open and closed states.

57 analyses indicate one open and two distinct closed states.

58 DNA origami hinges actuated between open and closed states.

59 on the partitioning of PICs between open and closed states.

60 icant energy barrier separating the open and closed states.

61 d by switching the tweezers between open and closed states.

62 residues to the channel pore in the open and closed states.

63 ed that is intermediate between the open and closed states.

64 tein by internal and external gates in their closed states.

65 3 partition of the template between open and closed states.

66 py structures of human TRPV6 in the open and closed states.

67 the channel is able to open from all (five) closed states.

68 le conformational states, including open and closed states.

69 e phosphorylated state, and on toward ligand-closed states.

70 which the enzyme is in either an "open" or "closed" state.

71 C conformation resembling the active, "fully closed" state.

72 t domains that move Env from a functionally "closed" State 1 to more "open" conformations, but the mo

73 isms for stabilization of Slo2 channels in a closed state: (1) dewetting and collapse of the inner po

74 ver conditions, Grp94 populates two distinct closed states, a relatively static ATP/ATP closed state

75 MYO1C(C) favored the actomyosin closed state (AM(C)), MYO1C(16) populated the actomyosin

76 that MYO1C(35) populated the actomyosin.ADP closed state (AMD(C)) 5-fold more than the actomyosin.AD

77 introduce a sharp free-energy minimum at the closed state and a broad energy barrier between open and

78 structures of human PAC in a high-pH resting closed state and a low-pH proton-bound non-conducting st

79 transition between a single 5-fold symmetric closed state and an ensemble of low Mg(2+), open, asymme

80 y two of three distinct structural states, a closed state and an open state, that are adopted by the

81 um channel form an occlusion for ions in the closed state and are splayed open on activation.

82 tension-induced gating, both stabilizing the closed state and coupling the channel to the membrane.

83 gate operates between the open state and the closed state and exhibits a residual conductance.

84 he Arg327 residue in stabilizing the channel closed state and explicate for the first time the struct

85 nce that strongly support the existence of a closed state and its analogue-dependent transition to th

86 channel function by locking channels into a closed state and that endogenous CFTR in HBEs is affecte

87 uggest that the ligand itself stabilises the closed state and that SBP closure is triggered by physic

88 and a broad energy barrier between open and closed states and how changes in ionic conditions modula

89 ed that NPA binding stabilized NMDA receptor closed states and increased the energy barriers toward o

90 eling suggests concurrent destabilization of closed states and low-affinity open channel block.

91 e, the coupled relationship of both open and closed states and their role in recapitulating macroscop

92 The absence of FHF2 accelerates the rate of closed-state and open-state sodium channel inactivation,

93 ML1: a 3.72-A apo structure at pH 7.0 in the closed state, and a 3.49-A agonist-bound structure at pH

94 te is antigenically distinct from the mature closed state, and cleavage has been reported to be essen

95 rable gate that fills and seals pores in the closed state, and creates a non-fouling, liquid-lined po

96 or Escherichia coli show the channel in its closed state, and indicate that ribosome binding per se

97 isrupted binding to Sba1, which prolongs the closed state, and promoted N-M undocking and lid opening

98 oscillating between active/open and inactive/closed states, and is regulated in part by phosphorylati

99 We describe stable wetted/open and dewetted/closed states, and uncover conformational changes in the

100 mmed PRE complexes, which sampled the hybrid/closed state approximately once before undergoing transl

101 ion of the HIV-1 Env trimer to its prefusion-closed state as this state is recognized by most broadly

102 to its redox partner, putidaredoxin, is in a closed state at ambient temperature in solution.

103 IC) from an open, scanning conformation to a closed state at AUG codons, from which Pi is released fr

104 ons of 48S PICs from yeast in these open and closed states, at 6.0 A and 4.9 A, respectively.

105 cted pore; this is likely to correspond to a closed state, because a CaCC with a single Ca(2+) occupa

106 Glu167 and Arg290 when the channel is in the closed state, but not in the ATP-bound open state.

107 o DNA exists in equilibrium between open and closed states, but predominantly in an open conformation

108 The pores are locked in a closed state by a hydrogen bond network at the C terminu

109 t the inhibitors stabilize the AMPA receptor closed state by acting as wedges between the transmembra

110 for an HIV-1 Env trimer captured in a mature closed state by antibodies PGT122 and 35O22.

111 open-closed channel equilibrium towards the closed state by outcompeting lipids critical for activat

112 The receptor was stabilized in a closed state by the binding of alpha-bungarotoxin.

113 optically determined conformational open and closed states by FRET, and binding-unbinding states of t

114 contrast, blocking palmitoylation increases closed-state channel inactivation and reduces myocyte ex

115 perturbing uS7-eIF2alpha interaction in the closed state, confer the opposite phenotypes of hyperacc

116 pocket and promoting the stabilization of a closed state conformation.

117 this vestibule hairpin is consistent with a closed-state conformation of the Kv channel in the plasm

118 intracellular [Au(CN)2](-) in both open and closed states, corroborating the conclusion that the int

119 A closed-state crystal structure is not available.

120 DEER measurements in the closed state demonstrate that eTRPV1 reports distances i

121 open state than the bent-closed and extended-closed states demonstrates profound regulation of affini

122 a high degree of selectivity, coupled with a closed-state dependent mechanism of action is required f

123 luded that BK channel C-type inactivation is closed state-dependent and that its extents and rates in

124 rtion of the riboswitch may adopt an open or closed state depending on the presence of metabolite.

125 1 kinase at cell poles converts Cdc15 to its closed state, destabilizes the actomyosin ring, and thus

126 , conformational change between the open and closed states did not affect stimulation of ATP hydrolys

127 The cross-linking thus favors a unique closed state distinct from the resting and longest-lived

128 gest that LBDs are semiclosed in the channel-closed state during stationary gating.

129 ormational status of the LBDs in the channel-closed state during stationary gating.

130 resolution structures of the human PIC in a closed state (engaged with duplex DNA), an open state (e

131 th inhibited enzyme function, whereas in the closed state, enzyme is activated by the close proximity

132 cale conformational transitions, whether the closed state exists in the absence of ligand, is controv

133 a flip in the asymmetry while remaining in a closed state for the second hydrolysis.

134 structure of an Hv1 construct in a putative closed state has been reported, and structural models fo

135 are conducive for sliding, and the populated closed state has stronger interactions with the phosphat

136 es of detergent-solubilized rat TRPV6 in the closed state have previously been solved.

137 inding correlates with the stability of the 'closed-state' helicase core, a complex with nucleotide a

138 tein Rps5/uS7 and eIF2alpha between open and closed states; however, its importance was unknown.

139 allosteric modulator, and in a desensitized/closed state in complex with fluorowilliardiine.

140 ce in open probability is caused by one long closed state in KcvS.

141 w that opening of these promoters from their closed state in precursor cells requires function of the

142 flexible, semiopen state and a rigid, fully closed state in situ and reversibly.

143 open state is unstable and reverts toward a closed state in the absence of the pEF Ca(2+) ion.

144 in solution mainly adopts the known open and closed states in exchange at 4 us.

145 t flickers rapidly between multiple open and closed states in non-deactivating bursts at positive mem

146 Sampling both open and closed states in their respective pH range, where they a

147 rmational transition between an ultra-stable closed state (in the free hormone) and an active open st

148 intact GluA2 AMPA receptor in an apo resting/closed state, in an activated/pre-open state bound with

149 the kinetics and structural determinants of closed-state inactivation (CSI) in Kv4.2 channels, consi

150 at this gate is additionally responsible for closed-state inactivation (CSI) in Kv4.x channels.

151 moving voltage-gated Na+ channels (VGSCs) to closed-state inactivation (CSI) without first opening.

152 induces a significant enhancement of channel closed-state inactivation and ablates sensitivity to dep

153 We conclude that Kv4.1 closed-state inactivation modulates pore blockade by QA

154 Further, the effect of the mutation on closed-state inactivation was evident in the presence of

155 g depolarized steady-state fast-, slow-, and closed-state inactivation, faster repriming, and larger

156 y depolarizes steady-state fast-, slow-, and closed-state inactivation.

157 tions, including the catalytically competent closed state independent of the UBA domain.

158 en state and a more fibrillar pattern in the closed state, indicating that cellulose microfibrils und

159 transition between fully open and (multiple) closed states involves global changes in structure of th

160 In the presence of GTP, a closed state is adopted by the SRP-FtsY complex.

161 table conformational states, of which an apo-closed state is dominant, consistent with previous exper

162 sition of release channels from an open to a closed state is identical to the phase transition associ

163 hange of the SBP and it is thought that this closed state is recognised by the transporter, triggerin

164 contrast to the wild-type enzyme, where the closed state is significantly more stable than the open

165 The closed state is stabilized by a tripartite salt bridge i

166 Although the transition between the open and closed states is critical for the switching process, its

167 e ability of RbmA to switch between open and closed states is important for V. cholerae biofilm forma

168 suggests that transition to a hypothetical "closed"-state is required to bring the cofactors adenosy

169 active site is similar between the open and closed states, it is unexpectedly different at the regul

170 411-S4 interactions destabilizes these early closed states, leaving hERG channels able to activate at

171 uced channel transition between the open and closed states measured on multichannel membranes also sh

172 d JNJ63955918 as a potent, highly selective, closed-state Nav1.7 blocking peptide.

173 atomistic molecular dynamics studies of the closed-state, non-conducting C1C2 structure and protonat

174 sequestrin2 is a protein that stabilizes the closed state of calcium release channels, i.e. the ryano

175 losely mimicked the vaccine-preferred mature closed state of Env could be obtained.

176 T, we discover novel dynamic behavior in the closed state of Grp94, the Hsp90 family member resident

177 inding sites with values around 10 mM in the closed state of KcsA.

178 mperature stabilized the open state over the closed state of Kv11.1a/1b channels and exerted the oppo

179 disrupts the characteristic long interburst closed state of reconstituted KirBac1.1 in giant liposom

180 otif domain interface likely destabilize the closed state of RyR2, resulting in enhanced basal channe

181 iological solution conditions, we identify a closed state of the ATP-binding pocket that correlates w

182 and oxidation of the protein destabilize the closed state of the channel, resulting in a pathological

183 dicate that Hi1a binds to and stabilizes the closed state of the channel, thereby impeding the transi

184 if of RyR2 are important for stabilizing the closed state of the channel.

185 ion conduction pathway, consistent with the closed state of the channel.

186 ydrated around a central Phe residue, to the closed state of the channel.

187 ilayers at high pH, which corresponds to the closed state of the channel.

188 ta indicate that although MDIMP binds to the closed state of the channels, it has more preference for

189 sfer (smFRET) method to observe the open and closed state of the DNA gate and to measure dwell times

190 Subsequently, the second Mg(2+) binds to the closed state of the enzyme-DNA-Mg.dNTP complex (K(d) = 3

191 rs to stabilize first the open, and then the closed state of the PIC to promote accurate AUG selectio

192 ATP fulfills a dual role: to destabilize the closed state of the receptor and to promote the ionic co

193 to form the fully collapsed metabolite-bound closed state of the SAM-I riboswitch.

194 in the absence of uracil, and resulted in a closed state of the transporter, due to relative movemen

195 Equally represented open and closed states of a back door channel, associated with al

196 Transitions between open and closed states of CFTR are regulated by ATP binding and h

197 conformational equilibrium between open and closed states of CYP3A4 that involves a pronounced chang

198 The combined studies reveal the open/closed states of GCGR and suggest that glucagon binds to

199 Homology models of the open and closed states of P2X2 indicate that pore opening is asso

200 high-resolution reconstructions of open and closed states of RyR1 were obtained from the same sample

201 o generate structural models of the open and closed states of RyR1.

202 highlighted the strong influence of the open/closed states of the Box moieties on their emission prop

203 nel for the activated, open and deactivated, closed states of the channel under depolarizing and hype

204 D411 with lower S4 residues stabilizes early closed states of the channel, and that disruption of the

205 ate, high-resolution models of both open and closed states of the channel.

206 in cAMP binding energy between the open and closed states of the channel.

207 not significantly different in the open and closed states of the channel.

208 cated in the transition between the open and closed states of the Cys-loop receptors.

209 vation accompanies transitions through early closed states of the hERG activation pathway, and that t

210 nds to both the activated closed and resting closed states of the Hv1 channel, thereby inhibiting bot

211 gh atomic resolution models of both open and closed states of the proteasome have been elucidated, th

212 pathway is presented to bridge the open and closed states of the TL.

213 hes for the activated, open and deactivated, closed states of three different voltage-gated K(+) chan

214 conformational sampling between the open and closed states of Tiam1 contributes to Rac1 dissociation.

215 lie the fluctuations between the "open" and "closed" states of the lid-like NCT with respect to a hyd

216 nsitions between active (open) and inactive (closed) states of the hMGL lid domain in controlling sub

217 iT from P. mirabilis in the outward-open and closed states on the corresponding structures of the rel

218 n the PA translocase, gates as either a more closed state or a more dilated state.

219 lays in blocking myosin tight binding in the closed-state position.

220 imer structure is similar to other reported "closed" state prefusion trimer structures.

221 This ATP-bound 'closed' state promotes binding to DNA, tethering DNA end

222 atic interactions between TM segments in the closed state pull hydrophobic residues together to form

223 ns in the pore-lining helix to stabilize the closed state (Q4947N, Q4947T, and Q4947S), which we also

224 photoswitched between its ring-open and ring-closed states quantitatively with excellent fatigue resi

225 with TRPV4 mutants indicate that the resting-closed state remains stable while the bond is substitute

226 ations between the classical/open and hybrid/closed states, respectively, in the presence of EF-G bef

227 d F57Bpa KCNE1 were cross-linked in open and closed states, respectively, which suggests that their a

228 B conformation of the labeled UvrD to a more closed state resulting in activation of helicase activit

229 Cryo-EM structures in the open and closed states reveal a dynamic tunnel lining, with impli

230 tly published crystal structure of its dark (closed) state revealed that the photoactive retinylidene

231 The cryo-EM structure of the closed state reveals an ordered SRP RNA and SRP M domain

232 oid inhibited binding of [(3)H]tetracaine, a closed-state selective channel blocker, or of [(3)H]acet

233 ds to the GPCR; the second conformation, the closed state, shows no interaction with the receptor.

234 nt accessibility to the amide oxygen with a "closed state" steric barrier compared to an "open state"

235 While the closed state structure is a symmetric pentamer, the open

236 Comparison of this structure with the closed-state structure in complex with competitive antag

237 Here we report the closed-state structure of the 2.3-megadalton complex of

238 with four conformations of the channel: two closed state structures, an intermediate state, and an o

239 We compare open- and closed-state structures developed previously with a rece

240 onsistent with those inferred from open- and closed-state structures of prokaryotic sodium channels.

241 sodium ions stabilize the TRPV1 channel in a closed state, such that removing the external ion leads

242 mt6 is unable to transition between open and closed states, suggesting that the regulation of RNA or

243 The closed state supports a model of catalysis in which the

244 50 (F182A), 35:65 (P188A), and predominantly closed states (T177A and P188A).

245 re that less active mutants have less stable closed states than their open states, in marked contrast

246 t closed states, a relatively static ATP/ATP closed state that adopts one conformation, and a dynamic

247 trasubunit interactions were observed in the closed state that are weakened upon desensitization and

248 opts one conformation, and a dynamic ATP/ADP closed state that can adopt two conformations.

249 ves toward the active site, where it forms a closed state that orients the C-As bond for dioxygen add

250 ed with formin homology 2 domains toward the closed state that precludes polymerization, but that pro

251 The periplasmic domain of BamA was in a closed state that prevents access to the barrel lumen, w

252 pen state that permits ion conductance and a closed state that prevents permeation.

253 s in a minor ( approximately 10 %) partially closed state that rapidly exchanges with a predominantly

254 s a conformational change to an intermediate closed state that shows increased effectiveness of pyrim

255 zyme I which exists in a variety of open and closed states that are sampled at various points in the

256 where c1 and c2 are initial-closed and deep-closed states that both close the channel fully, whereas

257 e to enter the active center and a "folded"/"closed" state that holds the NTP substrate in the active

258 iate a transition from an 'open' state to a 'closed' state that tightly binds nucleotide and DNA, and

259 rin can bind a number of ligands, but in the closed state the ligand-binding sites are inaccessible.

260 ere "normal" gating produces a nonconducting closed state, the channel leaked protons.

261 For the KcsA channel in the closed state, the distribution of water is peaked in the

262 In the closed state, the FMN domain closely contacts the FAD do

263 In the closed state, the lagging strand does not pass through t

264 This protein, FKBP12, promotes the RyR1 closed state, thereby inhibiting Ca(2+) leakage in resti

265 nal domains observed in the structure of the closed state, thereby promoting the resulting conformati

266 In the rigid, fully closed state, these interactions are prevented by steric

267 Extreme hyperpolarization produced a deeper closed state through a weakly voltage-dependent transiti

268 an autoinhibitory domain that maintains the closed state through electrostatic interactions, and adj

269 The strap stabilizes the closed state through trans-protomer interactions.

270 , can be switched in situ from a rigid fully closed state to a flexible semiopen state via Cl(-) indu

271 ch of Rpn11's Insert-1 loop from an inactive closed state to an active beta hairpin.

272 e begins with transitions from a ligand-free closed state to glutamate-bound active and desensitized

273 changes to switch between distinct open and closed states to tighten the active site and avail catal

274 te of syntaxin-1 during its transition from "closed" state to the SNARE complex formation.

275 Our findings imply hHsp90alpha occupies the closed state too long to function effectively in yeast,

276 crystallography to investigate the open- to closed-state transition of VcSiaP, the SBP of the sialic

277 fully assembled efflux pump is observed in a closed state under conditions of antibiotic challenge an

278 -activated Slo2 potassium channels are in a closed state under normal physiological conditions, alth

279 -activated Slo2 potassium channels are in a closed state under normal physiological conditions, alth

280 ility to "gate" between an open and several "closed" states under applied voltage.

281 tance K(+) -selective Slo2 channels are in a closed state unless activated by elevated [Na(+) ]i .

282 tance K(+) -selective Slo2 channels are in a closed state unless activated by elevated [Na(+) ]i .

283 m that normally holds the transporter in the closed state when cellular Mg(2+) levels are high.

284 s of the actin-tropomyosin interface in the "closed state" where tropomyosin binds to actin in the ab

285 we provide a snapshot of GRK5 in a partially closed state, where structural elements of the kinase do

286 inding, correct dNTPs are transported to the closed state, whereas incorrect dNTPs are delivered to t

287 odel could correspond to a commonly occupied closed state, whereas the McjD-based model could represe

288 These regions associate to produce a closed state, which is generally thought to suppress ass

289 Ca(2+), we obtained a single structure in a closed state, which was shown by atomistic simulations t

290 upled with the analogue-based radical in the closed state while odd-numbered analogues could trigger

291 ) channel activity by destabilizing the long closed states while facilitating closed-to-open state tr

292 alyze a Friedel-Crafts reaction in the fully closed state, while the semiopen state shows no reactivi

293 occurrence and the dwelling time of the long closed states whilst increasing the frequency of channel

294 rangement from an open PIC conformation to a closed state with more tightly-bound Met-tRNAi (PIN stat

295 complex (PIC) from an open conformation to a closed state with more tightly-bound Met-tRNAi.

296 emichannel but rather promoted gating to the closed state with transitions characteristic of the intr

297 ysis steps allow Grp94 to transition between closed states with different dynamic and structural prop

298 ly switched between its ring-opened and ring-closed states with high fidelity over multiple cycles.

299 he open conformation, and indicates that the closed state, with a high ( approximately 13 kcal/mol) f

300 analyses show we successfully shut S in the closed state without otherwise altering its architecture