ライフサイエンスコーパス: club

1 each other and are referred to as the "rich club".

2 tributed across the network, form a "diverse club".

3 were in turn strongly inter-connected (rich-club).

4 n the ventral surface of the female antennal club.

5 pression in the ventral half of the antennal club.

6 in hub regions, implicating the brain's rich club.

7 are found most frequently traverse the rich club.

8 and between the periphery and a central rich club.

9 normal for the breed by the American Kennel Club.

10 an important role for a highly central rich club.

11 ottish Paediatric Club and Scottish Glaucoma Club.

12 ate to the formation of the fully functional club.

13 :1 to a clinic- or community-based adherence club.

14 highly connected regions (hubs) forming rich-clubs.

15 tructural byproducts of hierarchies and rich clubs.

16 ected, such as topological and weighted rich clubs.

17 actical activities delivered by coaches at 2 clubs.

18 igher from 13 Scottish professional football clubs.

19 raging children to join out of school sports clubs.

20 etween community- and clinic-based adherence clubs.

21 sed clubs and 399 (51%) into community-based clubs.

22 nfections in the previous year, and 10% were clubbed.

23 molecular platform to prepare various novel clubbed 1,2,3-triazole hybrids using click chemistry.

24 domized 775 eligible adults into 12 pairs of clubs-376 (49%) into clinic-based clubs and 399 (51%) in

25 Within 3 days of advertising at each club, 426 men registered interest; 306 (72%) were eligib

26 ly connected cortical hubs that form a "rich club"--a high-cost, high-capacity backbone thought to en

27 iomineralization of the mantis shrimp dactyl club-a model bioapatite-based mineralized structure with

28 Aniline joins the club: A beta-diketiminato copper(I) catalyst enables C-H

29 The Zambian urban adherence club (AC) is a health service innovation designed to imp

30 g of patients who miss visits, and Adherence Clubs (ACs) and Decentralized Medication Delivery (DMD)

31 themes and discussions into resident journal club activities, clinical practice, quality improvement

32 s these commentaries during resident journal club activities.

33 ed during most dermatology residency journal club activities.

34 bs than among those assigned to clinic-based clubs (adjusted hazard ratio 1.38, 95% CI 1.02-1.87, p =

35 82; 95% CI, 1.30 to 2.54), attending pubs or clubs (adjusted odds ratio, 1.54; 95% CI, 1.28 to 1.86),

36 Low performing students try to engage in the club after it has been initially formed, and fail to pro

37 ican Journal of Ophthalmology, the IOL Power Club (along with a statistician) published an editorial

38 The rich-club also revealed lower diffusivities over time with co

39 pairs were found to travel through the rich club and a large proportion of these communication paths

40 s developed lumens lined with differentiated club and ciliated cells.

41 d the American College of Physicians Journal Club and Evidence-Based Medicine online.

42 piratory airways depends on secretory cells (club and goblet) and ciliated cells to produce and trans

43 icularly highly interconnected regions (rich club and hubs within it) form a topologically continuous

44 onsultant members of the Scottish Paediatric Club and Scottish Glaucoma Club.

45 until the formation of the fully functional club and unveil an unusual development mechanism.

46 hich included membership in a public fitness club and weekly meetings with a health promotion coach,

47 2 pairs of clubs-376 (49%) into clinic-based clubs and 399 (51%) into community-based clubs.

48 of genetic labeling and ablation of airway (club) and alveolar cells with exposure to environmental

49 nd more frequent use of vehicles through car clubs) and for a range of embodied and use-phase intensi

50 club connections, linking nodes of the rich club, and feeder connections, linking non-rich club node

51 Rich-club architecture appears to be a persistent feature of

52 ural networks in the human brain have a rich-club architecture comprising both highly inter-connected

53 These results provide evidence that rich-club architecture is one of the bases of functionally ef

54 n many different networks, the nodes of this club are assumed to support global network integration.

55 Among these, rich clubs are a functionally important property of a variety

56 Community health clubs are multi-session village-level gatherings led by

57 ether forming a densely interconnected "rich club," are noted to display a high level of neuronal com

58 Our findings highlight the role of the rich club as a substrate for the structural connectivity loss

59 d modules, hubs, module hierarchies and rich clubs as structural hallmarks of these wiring diagrams.

60 d in calcium phosphate mineralization of the club, as indicated by in vitro studies using recombinant

61 motor function measured by the Amended Motor Club Assessment (AMCA) score at week 36, analysed in the

62 volution, MUA graphs were found to form rich-clubs at an early stage in development (14 DIV).

63 Sports/physical activity club attendance (B = 0.6, 95% confidence interval (CI):

64 ntical sets of 13 hubs, small-world and rich club attributes, and 4 top-level subsystems.

65 on of focus was known to congregate, such as clubs, bars, community centers, and low-income housing.

66 Among those who were lost from club-based care (n = 367), the most common reason was mi

67 occurred in 13% of those lost from community club-based care and 21% of those lost from clinic-based

68 omized controlled trial to compare loss from club-based care between community- and clinic-based adhe

69 in clinic-based care within 90 days of their club-based care discontinuation date.

70 cipants, the cumulative proportion lost from club-based care was 52% (95% CI 47%-57%), compared to 43

71 The risk of loss to club-based care was higher among participants assigned t

72 ty occurred in 3% overall of those lost from club-based care, and was not different by arm (p = 0.816

73 16); no deaths occurred in either arm during club-based care.

74 experienced the primary outcome of loss from club-based care.

75 connectivity loss selectively affected rich club brain regions in premanifest and manifest Huntingto

76 althy human brains, where specific hub 'rich club' brain regions are more highly connected to each ot

77 lexible membrane initially folded within the club cavity expands to form the new club's envelope.

78 Lung-specific IL-13 transgenic (Club cell 10-kDa protein [CC10]-IL-13 Tg) mice and wild-

79 a novel molecular link between HIF2alpha and Club cell biology that can be regarded as a new HIF2alph

80 ding decreased basal cell number, precocious club cell differentiation, and increased secretoglobin e

81 e, whereas WNT signaling promoted a proximal club cell fate, thus implicating both signaling pathways

82 induce epithelial damage in lungs and alter club cell proliferation and morphology.Objectives: To de

83 y intratracheal FITC-dextran tracking, serum Club Cell protein 16 measurement, and other approaches.

84 ere the strongest predictors of progression; club cell protein was found to be a potential biomarker

85 Lower levels of circulating club cell secretory protein (CC16) in childhood are also

86 ork by transgenic overexpression of Vegfc in club cell secretory protein (CCSP)/VEGF-C mice reduced m

87 Club cell secretory protein (Clara) (CC16) is produced m

88 CC16 (club cell secretory protein-16), a member of the secreto

89 suppression of the DNA MMR pathway prevented club cell survival and increased the severity of viral d

90 smatch repair (MMR) pathway is essential for club cell survival of IAV infection.

91 tracing in mice, we have shown recently that club cells also give rise to alveolar type 2 cells (AT2s

92 Instead, ACE2 was detected in airway Club cells and endothelial cells at birth, and then AT2

93 ra) (CC16) is produced mainly by bronchiolar club cells and has been shown to have protective effects

94 l hyperoxia stimulated expression of ACE2 in Club cells and in AT2 cells by 2 months of age.

95 inocytes, olfactory epithelial cells, airway club cells and respiratory ciliated cells as potential r

96 transcriptomic analysis of freshly isolated club cells and their cultured progeny.

97 Increasing numbers of club cells are found in the alveoli with aging and after

98 Hence club cells are important in alveolar maintenance and car

99 Club cells are known to function as regional progenitor

100 Club cells are principally involved in protection and ma

101 d, anatomically and phenotypically confirmed club cells are seeded in 3-dimensional culture either in

102 Club cells are shown to survive KRAS mutations and to fo

103 nstrate that bronchioalveolar stem cells and club cells are the likely cells-of-origin for SCC transi

104 sal cultures with SARS-CoV-2 and identifying club cells as a target population.

105 xpressing IAV, we have previously shown that club cells can survive direct viral infection.

106 Thus, club cells detect junction damage as mechanical stress,

107 propose a model in which infected, surviving club cells establish a proinflammatory environment aimed

108 Freshly isolated club cells express Sca-1 and integrin alpha6, markers co

109 for the first time isolated highly purified club cells for in vitro study and demonstrated club cell

110 eckstoff has been proposed to be produced by club cells in the skin, several observations indicate th

111 ly reported that a subset of lung epithelial club cells is able to intrinsically clear the virus and

112 ium flux signaled through calcineurin within club cells of the bronchioles, inciting inflammation.

113 Ablation of club cells prevents chemical lung tumors and causes alve

114 The presence of bacteria inside club cells raises the possibility that the alarm substan

115 itiated by the rapid response of bronchiolar club cells to Alp1.

116 analyses demonstrate a direct conversion of club cells to ciliated cells without proliferation, meet

117 TRPV4 is also necessary and sufficient for club cells to sensitize mice to Alp1.

118 ub cells for in vitro study and demonstrated club cells' capacity to differentiate into alveolar epit

119 on of Il17ra or Il17rc in Scgb1a1-expressing club cells, a major component of the murine bronchiolar

120 n, OPN expression was confined to goblet and club cells, and was absent from ciliated and basal cells

121 e transported from the external surface into club cells, by cytoplasmic transfer or invasion of cells

122 We demonstrate that these cells, known as club cells, elicit a robust transcriptional response to

123 tive potential of alveolar type II cells and club cells, increased cellular senescence and DNA damage

124 pe Braf also induces transdifferentiation of club cells, which leads to the rapid development of leth

125 de induces a rapid and near-complete loss of club cells, with a concomitant gain in ciliated cells, u

126 fewer multiciliated cells and an increase in club cells.

127 FoxM1, a recognized proliferative factor of Club cells.

128 differentiation of NE-associated secretory (club) cells.

129 Club (Clara) cell protein 16 (CC-16) is a protein that i

130 helial cell proliferation mainly confined to Club (Clara) cells.

131 lated by a circadian clock within epithelial club (Clara) cells.

132 as performed varying H3N2v prevalence in the club cohort.

133 brain hubs that formed parts of a wider rich-club collective.

134 y, it was worse in community-based adherence clubs compared to those based at the clinic.

135 The "flexible club," comprising brain regions with neural flexibility

136 b organization, connectivity density of rich club connections and connections linking peripheral regi

137 nts, together with a reduced density of rich club connections predominantly comprising the white matt

138 Rich club connections were found to be more costly than predi

139 Second, rich club connections, linking nodes of the rich club, and fe

140 We hypothesized that selective loss of rich club connectivity might represent an organizing principl

141 rmore, the reduction in the strength of rich-club connectivity was significantly associated with the

142 l areas, as well as atypical long-range rich-club connectivity.

143 ronization revealed that the identified rich-club consisted of neurons that were synchronized in the

144 with functional connections within the rich-club core exhibiting the greatest stability over time.

145 d the American College of Physicians Journal Club databases for experimental and analytical studies o

146 This reduction in rich club density was found to be associated with lower level

147 ybridization and the development of triazole clubbed dibenzo[b,d]thiophene-based lead candidates to t

148 POSE OF REVIEW: To evaluate the incidence of club drug use in pediatric patients, especially those ag

149 ifetime DUD, based on amphetamine, cannabis, club drug, cocaine, hallucinogen, heroin, nonheroin opio

150 Use of club drugs by adolescents and emerging adults contribute

151 Robust data exists linking the use of club drugs by the men who have sex with men population w

152 Use of club drugs in emerging adult populations contributes to

153 r- versus intra-module connections, and rich club edge types.

154 particularly enhances the synchrony of rich-club edges.

155 -tie local edges rather than strong-tie rich-club edges.

156 Rich clubs emerge when nodes that are somehow prominent or 'r

157 imental evidence shows that gap junctions at Club endings are subject to dynamic regulatory control b

158 tic contacts on the Mauthner cells, known as Club endings, constitute a valuable model for the study

159 Failure to engage in the rich club eventually decreases these students' communication

160 The diverse club exhibits, to a greater extent than the rich club, p

161 descended testes (1.9%), breast mass (1.2%), club foot (1%), hypospadias (0.6%), hydrocephalus (0.6%)

162 e conditions (breast mass, cleft lip/palate, club foot, hernia or hydrocele [adult and paediatric]),

163 ias, hydrocephalus, cleft lip or palate, and club foot.

164 ge football training twice weekly at a local club (football group [FG]) (n = 109) or usual care (usua

165 observation of non-monotonicity in the rich club formation suggested the importance of intermediate

166 ully combines modular organisation with rich-club forming hubs.

167 The dactyl clubs from one species, Odontodactylus scyllarus, exhibi

168 m March 2008 through May 2012 among 4 soccer clubs from the Puget Sound region of Washington State, i

169 First, rich club hub nodes were found to be mostly present at the bo

170 Rich club hub nodes were present in all functional networks,

171 rowth, we identified a category named "fight-club hubs" characterized by a marked negative correlatio

172 hat these leading universities formed a rich club (i.e., a cohesive core through their close ties) an

173 controlled trial in 15 professional football clubs in England, the Netherlands, Norway, and Portugal.

174 ing culture through seminars, workshops, and clubs in which knowledge and practices are continually r

175 centrality) and was a component of the "rich club" in the control network but ranked low in connected

176 INTERPRETATION: Community health clubs, in this setting in western Rwanda, had no effect

177 ogically central collective called the "rich club." In parallel, studies of intrinsic brain activity

178 h the British Veterinary Association/ Kennel Club/ International Sheep Dog Society (BVA/KC/ISDS) eye

179 onstrate that overall loss from an adherence club intervention was high in this setting and that, imp

180 The identification of rich clubs is non-trivial, especially in weighted networks, a

181 The 'rich club' is a pattern of organization established in health

182 foster intellectual growth, such as journal clubs, lab meetings, and philosophy of science retreats.

183 we define a distinct subpopulation (~5%) of club-like lineage-negative epithelial progenitors (LNEPs

184 ity flow, confirming that hub nodes and rich-clubs may play an important role in coordinating functio

185 these interactions are hosted within a "rich-club", mediated by persistent interactions among high pe

186 volved LPUs in all sensory centers, and rich-club members formed a putative motor center of the brain

187 it to data from a cohort of 100 agricultural club members reporting swine contact to estimate transmi

188 with a health promotion coach, or to fitness club membership alone.

189 d improved fitness compared with the fitness club membership only group (N=106).

190 football proved to be acceptable, even when club membership was not subsidised.

191 ], most recent CD4 count) and retention (ART club membership, baseline CD4) after adjustment were sim

192 proteomic data, we identified and sequenced Club Mineralization Protein 1 (CMP-1), an abundant mildl

193 fect of two versions of the community health club model on child health and nutrition outcomes.

194 ine A (HUP-A), an alkaloid isolated from the club moss Huperzia serrata, that is a potent reversible

195 rborescent vascular plants related to living club mosses (Lycophytes), ferns (Monilophytes), horsetai

196 E, ACE2 is expressed in basal, intermediate, club, mucus, and ciliated cells; 3) ACE2 is upregulated

197 number of highly connected neurons as a rich club (N = 11) interconnected with high efficiency and hi

198 d connectivity amongst highly-connected rich-club network hubs, which integrate processing from diver

199 esembled those observed for a synthetic rich club network, but were less similar to those seen in a s

200 the community structure of a social (karate club) network and the mouse brain connectome.

201 We find that for scale-free and rich-club networks there exist specific nodes that are critic

202 The rich club neurons are born early in development, before visib

203 The rich club neurons are connector hubs, with high betweenness c

204 Rich club neurons comprise almost exclusively the interneuron

205 fferent modules or between an activated rich-club node and a deactivated peripheral node.

206 ub or feeder edges and thus traversed a rich club node.

207 ub, and feeder connections, linking non-rich club nodes to rich club nodes, were found to comprise 86

208 Later on, rich-club nodes were a consistent topological feature of MUA

209 Rich-club nodes were also found to be crucial for MUA dynamic

210 Rich-club nodes were traversed by a majority of short paths b

211 r-RSN connections were found to involve rich club nodes, and these connections participated in a disp

212 ections, linking non-rich club nodes to rich club nodes, were found to comprise 86% of the intermodul

213 , and HRS-1 (based on the 2007 International Club of Ascites criteria of rapidly deteriorating renal

214 results indicate a critical role of the rich club of hub nodes in dynamic aspects of global brain com

215 It also included a rich club of hub nodes, located in parietal and prefrontal co

216 sassortative star-like structure with a rich-club of interconnected broadcasting hubs, and the neurop

217 We demonstrate that a rich club of interconnected cortical hubs is already present

218 wiring cost of the globally integrative rich club of neurons in the C. elegans connectome is justifie

219 d in the hypermineralized hammer-like dactyl clubs of the stomatopods, a group of highly aggressive m

220 global communication was mediated by a "rich club" of hub regions: a sub-graph comprised of high-degr

221 ormation of a densely connected neural "rich club" of hubs is of particular interest, because brain h

222 analytical approach) to constitute the "rich-club" of the C. elegans connectome.

223 in this network, whereas no high-degree rich club or clear small-world features were detected.

224 sequence or "path motif" that involved rich club or feeder edges and thus traversed a rich club node

225 fibrosis, whereas mutation of REVERBalpha in club or myeloid cells had no effect on the bleomycin phe

226 tion of aberrant and spectacular structures (clubs or galls).

227 ng (TD) individuals showed increases in rich-club organisation and inferred network functionality, wh

228 ore, our findings suggest that immature rich-club organisation might be associated with some neurodev

229 erty, whether age-associated changes in rich-club organisation occur during human adolescence remains

230 ster follows a small-world, modular and rich-club organisation that facilitates information processin

231 er, this typical age-related changes in rich-club organisation were characterised by progressive invo

232 Rich club organization between high-degree hub nodes was sign

233 n physical cost and behavioral value of rich club organization in a cellular connectome confirms theo

234 eak evidence of small-world attributes, rich club organization is absent, and multiresolution consens

235 Furthermore, when rich club organization is destroyed, the energy cost associat

236 Rich club organization is present well before the normal time

237 Though rich-club organization remains intact following premature bir

238 Rich-club organization was present in this network and involv

239 raphic assignments, assortative mixing, rich club organization, and network resilience.

240 Measures of rich club organization, connectivity density of rich club con

241 PBD connectomes have fewer hubs, weaker rich club organization, different modular fingerprint and int

242 show that while both networks display a rich-club organization, in which a small set of microbes comm

243 tween weaker connectivity and decreased rich-club organization, indicating that whole-brain simple co

244 , compromising the brain's modular and "rich-club" organization and, simultaneously, the perceptual b

245 ected to each other, indicating robust "rich-club" organization.

246 cal network of the human brain shows a "rich-club" organization.

247 Among community-based club participants, the cumulative proportion lost from c

248 5% CI 38%-48%, p = 0.002) among clinic-based club participants.

249 nical examination did not reveal cyanosis or clubbing, peripheral pulses were normal, and blood press

250 yers of two levels of expertise (novices and club players).

251 Finally, these two clubs potentially evolved via distinct selection pressur

252 ith aging, but inferred rates of bronchiolar club progenitor cell self-renewal and differentiation we

253 exhibits, to a greater extent than the rich club, properties consistent with an integrative network

254 ctivity deficits of the brain's central rich club (RC) system relative to both control subjects and B

255 Second, rich club regions attracted the most signal traffic and likew

256 affic and likewise, connections between rich club regions carried more traffic than connections betwe

257 e show that the set of pathways linking rich club regions forms a central high-cost, high-capacity ba

258 Third, a number of rich club regions were significantly under-congested, suggest

259 n compared to the functional hub and diverse club regions.

260 re traffic than connections between non-rich club regions.

261 embership in the highly interconnected "rich club." RESULTS: Marked differences in centrality (connec

262 thin the club cavity expands to form the new club's envelope.

263 Our findings suggest that the brain's rich club serves as a macroscopic anatomical substrate to cro

264 intervention; n=50), or 20 community health club sessions (Classic intervention; n=50).

265 tion (control; n=50), eight community health club sessions (Lite intervention; n=50), or 20 community

266 cal morphology at elevated temperatures: the club-shaped particle (clubSP), which contains a cylindri

267 However, in all three cases (whisky and club soda; rum with cola; gin and tonic water), MEC was

268 sure activities including attending concerts/clubs/sporting events (odds ratio = 1.82, 95% confidence

269 d programme delivered by coaches in football club stadia in 12 weekly 90-minute sessions.

270 A rich-club structure has been found previously in large-scale

271 find that hierarchical organisation and rich-club structure of the cortical connectivity are largely

272 sent novel evidence suggesting that the rich club structure plays a central role in cross-linking mac

273 randomized controls, different kinds of rich-club structures can be detected, such as topological and

274 e undergone epilepsy surgery, revealing rich-club structures within the obtained functional networks.

275 dular organisation, and strong core and rich-club structures.

276 ong participants assigned to community-based clubs than among those assigned to clinic-based clubs (a

277 e interconnectivity, forming a core or "rich club" that integrates information across anatomically di

278 Besides bilateral clubbing, the physical examination findings were normal.

279 nectome by its back-bone, known as the 'rich-club', these network changes were driven by the 'periphe

280 Building a transcriptome of the club tissue and probing it with proteomic data, we ident

281 ings provide evidence of the structural rich club to form a central infrastructure for intermodule co

282 of an important role of the structural rich club to interlink functional domains.

283 lock size 2-9) in a 1:1 ratio, stratified by club, to a weight loss programme delivered by community

284 They were randomised, stratified by club, to either the EuroFIT intervention or a 12-month w

285 es Company, AstraZeneca, The Bentley Drivers Club (UK).

286 clinic-based standard care if they missed a club visit and did not pick up ART medications within 5

287 = 367), the most common reason was missing a club visit and the associated ART medication pickup enti

288 better when a greater proportion of the rich club was removed, in agreement with our theoretical pred

289 Increased time spent in out of school sports clubs was significantly associated with decreased %SB (p

290 een groups, adjusted for baseline weight and club, was 4.94 kg (95% CI 3.95-5.94) and percentage weig

291 each other than chance, thus forming a "rich club." We found similar results in networks recorded in

292 d the American College of Physicians Journal Club were searched from inception through April 2014.

293 receiving the intervention, community health clubs were established, community health workers were tr

294 Clubs were held every other month.

295 Adherence clubs, where groups of 25-30 patients who are virally su

296 ribe a unifying framework for detecting rich clubs which intuitively generalizes various metrics into

297 then traversed, and finally exited the rich club, while passing through nodes of increasing and then

298 upervised and performed mostly at a coronary club with periodic control sessions twice yearly at the

299 ll dogs annually registered by the UK Kennel Club, with in excess of a quarter having an EBV for elbo

300 and densely interconnected, forming a "rich club" within the human brain.