ライフサイエンスコーパス: clusterin

1 complement system proteins C3, factor B, and clusterin.

2 s insensitivity to the inhibitory effects of clusterin.

3 3, ECM-1, haptoglobin, serum amyloid A3, and clusterin.

4 ears to play a key role in the regulation of clusterin.

5 d with the plasma esterase, paraoxonase, and clusterin.

6 undergoing apoptosis expressed low levels of clusterin.

7 amyloid) deposits than PDAPP mice expressing clusterin.

8 as the inverse was evident for intracellular Clusterin.

9 25% were found to be a single gene product, clusterin.

10 acy of PDT using pharmacological inducers of clusterin.

11 larity with the multifunctional glycoprotein clusterin.

12 lume loss occurs in the presence of elevated clusterin.

13 hese include fibromodulin with 90% cleavage, clusterin (50%), ADAM9 (54%), vitronectin (54%), and alp

14 Converging evidence indicates that clusterin, a chaperone glycoprotein, influences Alzheime

15 nt study, we have examined the expression of clusterin, a protein expressed in aging neurons, in the

16 Clusterin, a widely expressed glycoprotein, is induced i

17 n had no effect on caspase-3 activation, and clusterin accumulation and caspase-3 activation did not

18 Clusterin affects inflammation, immune responses, and am

19 results establish a protective role of apoJ/clusterin against chronic glomerular kidney disease and

20 lin; and a two-fold decrease in glycosylated clusterin (all p < 0.05).

21 and fibromodulin) and of amyloid deposition (clusterin, alpha2-macroglobulin, and ADAM9).

22 ariety of partly unfolded, stressed proteins.Clusterin also binds to many different unstressed ligand

23 Studies have shown that clusterin (also called apolipoprotein J) can influence t

24 Clusterin, also known as apolipoprotein J, is a multifun

25 Clusterin, also known as apolipoprotein J, is a ubiquito

26 ubstrate) and the complement lysis inhibitor clusterin among the top 5 most abundant transcripts.

27 Apolipoprotein J/clusterin (apoJ/clusterin), an intriguing protein with unknown function,

28 gonucleotide that inhibits the production of clusterin, an antiapoptotic protein that is upregulated

29 t of deregulated genes included the cDNA for clusterin, an extracellular glycoprotein without a firml

30 ted insulin-like growth factor 1 (IGF-1) and clusterin, an extracellular stress protein, constitute t

31 Clusterin and alpha2-macroglobulin bound to PGPFs to sig

32 ct targets of miR-17 approximately 92 (e.g., clusterin and angiopoietin-like 4).

33 rying the same CADASIL mutations, identified clusterin and collagen 18 alpha1/endostatin as GOM compo

34 scle cells and implicate the accumulation of clusterin and collagen 18 alpha1/endostatin in brain ves

35 Clusterin and COMMD1 facilitated the degradation of ATP7

36 In this study, we confirmed that clusterin and COMMD1 interact to down-regulate both ATP7

37 Together these data indicate that clusterin and COMMD1 represent alternative and independe

38 Clusterin and COMMD1 were previously identified as inter

39 , endogenous ATP7B existed in a complex with clusterin and COMMD1, but these interactions were neithe

40 found a significant interaction between CSF clusterin and CSF Abeta1-42 on the entorhinal cortex atr

41 d, conversely, Abeta increased intracellular clusterin and decreased clusterin protein secretion, res

42 lation and downregulated renal expression of clusterin and EGF receptor.

43 At the same time, apical trafficking of gp80/clusterin and gp114/CEACAM becomes randomized, basal-lat

44 s, the interplay between cancer cell-derived clusterin and IGF-1 may dictate the outcome of cell grow

45 Both urinary clusterin and IL-18 are useful biomarkers and may allow

46 preoperative clinical variables and anuria, clusterin and IL-18 independently enhanced the clinical

47 tional characterizations suggested a reduced clusterin and increased apolipoprotein C-III content of

48 Apart from urine clusterin and interleukin-18, all other urinary biomarke

49 blishing abundant cell-surface expression of clusterin and intracellular expression of NGN.

50 CxCl11, Ccl5, Ifr7, Ifi27 Oas1b, Fcerg1,Mif, Clusterin and MHC class II) were upregulated as a result

51 e process and suggest independent effects of clusterin and p-tau on Abeta-associated volume loss.

52 resides on lipid-poor complexes dominated by clusterin and proteins implicated in host defense and in

53 nes of the loss-of-Nkx3.1 signature, such as clusterin and quiescin Q6, are highly expressed in prost

54 aches identified the multifunctional protein clusterin and tissue inhibitor of metalloprotease (TIMP)

55 induced apoptosis was inhibited by antisense clusterin and was found to be highly dependent on p21 bu

56 Stress-induced chaperones clusterin and YB-1 localize within TNTs, are transported

57 inity glutamate transporter (EAAT-2), apo-J (Clusterin), and peroxiredoxin-6) are selectively express

58 ing effect of either exogenous or endogenous clusterin, and parabiosis of db clusterin(-/-) double-mu

59 This behavior suggests that clusterin, and perhaps other extracellular chaperones, c

60 ipoprotein E (APOE), forkhead box class O3a, clusterin, and phosphatidylinositol binding clathrin ass

61 ing myc box-dependent-interacting protein 1, clusterin, and presenilin-1.

62 wn drusen components, including vitronectin, clusterin, and serum amyloid P, thus suggesting that spe

63 s of denaturation on the fluorescence of the clusterin-ANS complex were compared between proteins wit

64 Finally, we found that preincubation with clusterin antagonizes the toxic effects of Abeta1-42olig

65 remaining 162 non-ALCL cases marked with the clusterin antibody, including Hodgkin disease and primar

66 yloid A2], APOA4 [apolipoprotein A-IV], CLU [clusterin], ANTRX2 [anthrax toxin receptor 2], PON1 [ser

67 Moreover, clusterin, apoA-I, and apoE preserved the lipid-transfer

68 The most abundant proteins were clusterin (apoJ), PLTP itself, coagulation factors, comp

69 Apolipoprotein J/clusterin (apoJ/clusterin), an intriguing protein with u

70 Thus, clusterin appears to be an inhibitor of epithelial cell

71 This inhibitory function of clusterin appears to prefer IGF-1, as it fails to exert

72 tic genes encoding p53, BAK, IGFBP5 and SGP2/clusterin are not activated, while the anti-apoptotic ge

73 that Stat1, and its subsequent regulation of clusterin, are essential for docetaxel resistance in pro

74 tin complex from human plasma and identified clusterin as a major component of this leptin-containing

75 ute phase proteins have focused attention on Clusterin as a modifier of late-stage Alzheimer disease

76 Results of this study identify clusterin as a pivotal factor in the cell injury mechani

77 We previously identified clusterin as potentially involved in nephropathic cystin

78 Abeta accumulation in the absence of apoE or clusterin as well as in the absence of both proteins.

79 The cytoprotective secretory form of clusterin, as evaluated by Western blot analysis, was lo

80 t interactions between CSF Abeta1-42 and CSF clusterin, as well as CSF Abeta1-42 and CSF p-tau181p, o

81 We show that secreted clusterin associates with IGF-1 and inhibits its binding

82 l QconCATs were mixed with recombinant human clusterin at a 1:1 molar ratio and digested, and the act

83 We demonstrate that whereas the clusterin/ATP7B interaction was enhanced by oxidative st

84 It is unknown whether clusterin binds to all of these many ligands via one or

85 Here we report, that clusterin binds to apolipoprotein E receptor 2 (ApoER2)

86 It has been suggested that, in vivo, clusterin binds to toxic molecules in the extracellular

87 Clusterin bound ANS in a manner that was very similar to

88 In addition, we show that clusterin can function as a biological detergent that ca

89 Apolipoprotein E (apoE) and clusterin can influence structure, toxicity, and accumul

90 pregulated in the remote areas together with clusterin (CLU) and TNF-alpha.

91 ial-mesenchymal transition (EMT) and induces clusterin (CLU) expression, linking these genes to cance

92 The clusterin (CLU) gene is genetically associated with AD a

93 The C allele at the rs11136000 locus in the clusterin (CLU) gene is the third strongest known geneti

94 Expression of the clusterin (CLU) gene results in the synthesis of a conve

95 newly confirmed genetic risk allele C of the clusterin (CLU) gene variant rs11136000 is carried by ap

96 seq analysis revealed that expression of the Clusterin (CLU) gene, which is related to apoptosis, was

97 cellular and extracellular chaperone protein clusterin (CLU) interacts with MMP-9 both inside and out

98 disease (AD) GWAS variants identified at the clusterin (CLU) locus to identify a subset of likely cau

99 Since clusterin (CLU) production in reactive astrocytes may be

100 etic and biochemical evidence strongly links Clusterin (CLU) to Alzheimer disease (AD) pathogenesis,

101 for further analysis: osteopontin (OPN) and clusterin (CLU) which were upregulated in denervated mot

102 everal known platelet transcripts, including clusterin (CLU), glycoproteins IIb/IIIa (ITGA2B/3), lipo

103 Clusterin (CLU), or apolipoprotein J (ApoJ), is the thir

104 perones, including the extracellular protein clusterin (CLU), play a significant role in maintaining

105 Clusterin [CLU, a.k.a. TRPM-2, SGP-2, or ionizing radiat

106 Overexpression and knockdown of clusterin/COMMD1 decreased and increased, respectively,

107 ar Endothelial Growth Factor A (VEGF-A), and clusterin compared to the control group.

108 teractions between cerebrospinal fluid (CSF) clusterin, CSF Abeta1-42, and CSF p-tau at threonine 181

109 n (C5a and sC5b-9) and renal injury markers (clusterin, cystatin-C, beta2-microglobulin, and liver fa

110 itochondrial associated molecules, including clusterin, cytochrome C, and HTRA2/OMI.

111 The fibrotic response in Clusterin deficient (CLU-/-) mice persisted after bleomy

112 In young apoJ/clusterin-deficient animals, the development of immune c

113 complexes localized to the mesangium of apoJ/clusterin-deficient but not wild-type mice.

114 Up to 75% of glomeruli in apoJ/clusterin-deficient mice exhibited moderate to severe me

115 Clusterin-deficient mice had 50% less brain injury follo

116 In the apoJ/clusterin-deficient mice, immune complexes of immunoglob

117 To further elucidate how the clusterin-dependent induction of Dkk1 by Abeta mediates

118 Aging mice deficient in apoJ/clusterin developed a progressive glomerulopathy charact

119 Despite this, in vivo evidence that clusterin directly influences cell death is lacking.

120 ions where inhibition of aggregation occurs, clusterin does not bind detectably to the native or fibr

121 r endogenous clusterin, and parabiosis of db clusterin(-/-) double-mutant to WT mice still caused let

122 However, clusterin downregulation by miR-17 approximately 92 is i

123 d that exogenous purified astrocyte-secreted clusterin exacerbated oxygen/glucose-deprivation-induced

124 nd immunohistochemistry were used to analyze clusterin expression at a cellular level on a series of

125 The discovery of clusterin expression at the articular cartilage surface

126 36 cases of systemic ALCL, were surveyed for clusterin expression by immunohistochemistry and Western

127 t to HSF-1 as an important factor regulating clusterin expression in response to MX781, although AP-1

128 Our findings show increased clusterin expression in the aged S100B mice compared to

129 ly demonstrated that in organs such as skin, clusterin expression is restricted to differentiating bu

130 vity, but not HSF-1, and elicit no effect on clusterin expression levels.

131 Remarkably, inhibition of Stat1 or clusterin expression resulted in the re-sensitization of

132 Elevated clusterin expression was characterized within certain re

133 articular cartilage, where it was found that clusterin expression was confined to the articular surfa

134 Clusterin expression was not related to expression of an

135 he effects of genetically determined reduced clusterin expression, may help to achieve neuroprotectio

136 s the TGFbeta signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis a

137 ession, but it also caused the inhibition of clusterin expression.

138 The utility of clusterin for prediction of DGF (hemodialysis within 7 d

139 ese data support the hypothesis that nuclear clusterin function is proapoptotic when induced by APC o

140 136000 single nucleotide polymorphism in the clusterin gene (CLU) on longitudinal changes in resting

141 y docetaxel treatment, we observed Stat1 and clusterin gene expression heightened in the resistant ph

142 Silencing of the clusterin gene resulted in a significant increase in cel

143 Surprisingly, the absence of clusterin had no effect on caspase-3 activation, and clu

144 Apoliprotein J (apoJ)/clusterin has attracted considerable interest based on i

145 Although clusterin has been implicated in a broad spectrum of phy

146 Additionally, clusterin has been implicated in regulating complement a

147 Consistent with this last idea, clusterin has been shown to bind to a variety of molecul

148 hesis is supported by our demonstration that clusterin has discrete binding sites for LRP-2 and other

149 under different conditions demonstrated that clusterin has no effect on the elongation rate but mainl

150 Collectively, our results indicate that (i) clusterin has three independent classes of binding sites

151 is also presented for the tumor secretion of clusterin (HGMW-approved symbol CLU) and its possible ro

152 aracteristic analysis suggested that urinary clusterin, IL-18, kidney injury molecule-1, and NGAL con

153 induces gene expression of the glycoprotein clusterin in a variety of cell types via a consensus AP-

154 However, the precise role of clusterin in Alzheimer disease pathogenesis is still not

155 of the thrombospondin type 1 repeat protein clusterin in cells overexpressing c-Myc and miR-17 appro

156 Clusterin in cystinosis cells localized to the nucleus a

157 py revealed elevated levels of intracellular clusterin in cystinosis cells.

158 A novel finding was the high expression of clusterin in DM, which was confirmed by immunohistochemi

159 se-3 activation), as well as accumulation of clusterin in dying neurons.

160 ata support a potential therapeutic role for clusterin in enhancing chemotherapy-induced apoptosis an

161 This does not preclude an important role of Clusterin in late-stage disease, but it cautions against

162 d no difference in the circulating levels of Clusterin in late-stage prion disease when animals will

163 Absent of p21, clusterin in not induced, and apoptosis is significantly

164 e first time, demonstrate the involvement of clusterin in PDT-mediated cell death and during tumor re

165 Knockdown of clusterin in primary neurons reduced Abeta toxicity and

166 To clarify the functional role of clusterin in regulating apoptosis, we examined its expre

167 Here, we studied the expression of clusterin in renal proximal tubular epithelial cells obt

168 s implicate a potentially important role for clusterin in the earliest stages of the Alzheimer diseas

169 these issues, we expressed recombinant human clusterin in the yeast Pichia pastoris.

170 xpression using RNAi, we found that CAII and clusterin increase cell survival after doxorubicin treat

171 nted by an activated HSR or Hsp72 but not by clusterin, indicating a distinct mode of action of this

172 Clusterin-induced apoptosis was inhibited by antisense c

173 thione peroxidase 3 (GPX3), apolipoprotein J/clusterin, insulin-like growth factor-binding protein 2,

174 11, guanylate-binding proteins 1 and 2, ApoJ/clusterin, interferon (alpha and beta) receptor 2, decor

175 lass I, MHC class II, beta(2)-microglobulin, clusterin, interleukin-13 receptor alpha chain, ovotrans

176 Furthermore, the region(s) of clusterin involved in these many binding interactions re

177 Urinary clusterin is a biomarker of kidney injury but its utilit

178 Clusterin is a chaperone protein associated with treatme

179 Clusterin is a heterodimeric glycoprotein found in many

180 Clusterin is a highly conserved glycoprotein implicated

181 Clusterin is a multifunctional, secreted glycoprotein th

182 Therefore, clusterin is a secreted marker for a HIF-independent pVH

183 Clusterin is a widely expressed glycoprotein that has be

184 Northern hybridization was used to show that clusterin is expressed specifically in the superficial z

185 Clusterin is sensitive marker of glial reactivity in AID

186 Clusterin is the first identified extracellular mammalia

187 The function of clusterin is unknown, but it has been associated with ce

188 CLU (clusterin) is a tumor suppressor gene that we have previ

189 imarily found inside cells, while the other, clusterin, is predominantly located in the extracellular

190 Using a monoclonal antibody against clusterin, its differential expression was confirmed by

191 We asked if clusterin, known to be regulated by wnt, is part of an A

192 r results show that cellular localization of Clusterin leads to divergent effects on epithelial cell

193 The cells showing high clusterin levels generally lacked differentiation marker

194 h a maximum at 12 h after treatment, whereas clusterin levels in Pc 4-PDT-treated, apoptosis-resistan

195 inhibited by competitive binding with other clusterin ligands or by anti-clusterin monoclonal antibo

196 uct from the novel transcript has been named clusterin-like protein 1 (CLUL1).

197 ganization and protein sequence of a retinal clusterin-like protein and to identify conserved element

198 Using sequence analyses, we show that clusterin likely contains three long regions of natively

199 thelial cell apoptosis whereas intracellular Clusterin maintained epithelium viability during lung re

200 These findings demonstrate that clusterin markedly influences Abeta structure and neurit

201 These results indicate that clusterin may be a new therapeutic target to modulate no

202 neuron-derived exosomal alpha-synuclein and clusterin measurement predicted Parkinson's disease from

203 vels of brain Abeta deposition as did PDAPP, clusterin(+/+) mice.

204 apoE(-/-) and clusterin(-/-) mice accumulated similar Abeta levels but

205 In contrast, apoE(-/-)/clusterin(-/-) mice had both earlier onset and markedly

206 Both apoE(-/-) and apoE(-/-)/clusterin(-/-) mice had elevated CSF and brain interstit

207 lthough Abeta deposition was similar, PDAPP, clusterin(-/-) mice had significantly fewer fibrillar Ab

208 By 12 months of age, PDAPP, clusterin(-/-) mice had similar levels of brain Abeta de

209 genic mouse model of Alzheimer's disease, to clusterin(-/-) mice.

210 is not present but ApoER2, VLDLR, and Dab1, clusterin might be involved in maintaining neurogenesis

211 disease and support the hypothesis that apoJ/clusterin modifies immune complex metabolism and disposa

212 pithelial cell apoptosis while intercellular Clusterin modulated the expression of the DNA repair pro

213 to lysozyme ratios as low as 1:80 (i.e. one clusterin molecule per 80 lysozyme molecules).

214 ding with other clusterin ligands or by anti-clusterin monoclonal antibodies.

215 onist MX781 causes a substantial increase of clusterin mRNA and protein levels in prostate carcinoma

216 Induction of clusterin mRNA is associated with transcriptional activa

217 cell lines, TGFbeta induction of endogenous clusterin mRNA, as well as clusterin promoter transactiv

218 c agonists and antagonists show no effect on clusterin mRNA/protein levels.

219 Given this variety of ligands, clusterin must have specific structural features that pr

220 us as an approximately 55-kDa mature nuclear clusterin (nCLU) form.

221 Nuclear clusterin (nCLU) is an ionizing radiation (IR)-inducible

222 In the absence of clusterin, neuritic dystrophy associated with the deposi

223 These data suggest that clusterin not only suppresses epithelial cell proliferat

224 One gene, clusterin, not previously known to be expressed in lymph

225 ean number of papillomas/mouse was higher in clusterin-null animals.

226 as not altered, although those developing in clusterin-null mice were on average better differentiate

227 ic growth in vivo, we compared wild-type and clusterin-null mice with respect to their sensitivity to

228 The effect of clusterin on Abeta-associated brain atrophy is not confo

229 ngs demonstrate additive effects of apoE and clusterin on influencing Abeta deposition and that apoE

230 ts of the extracellular molecular chaperone, clusterin, on the in vitro aggregation of mutational var

231 so enhance TNT production and rescue loss of clusterin- or YB-1-repressed TNT formation.

232 (including AR, PSA, PAP2A, VEGF, NXK3, CLU [Clusterin]), or cancer incidence or severity.

233 loss of NKX3.1 expression and corresponding clusterin overexpression are co-localized at sites of pr

234 Furthermore, expression of clusterin overlapped with the expression of apoptotic pr

235 identified a pathway whereby Abeta induces a clusterin/p53/Dkk1/wnt-PCP-JNK pathway, which drives the

236 To determine whether endogenous clusterin plays a role in influencing Abeta deposition,

237 disease progression and in combination with clusterin predicts and differentiates Parkinson's diseas

238 ved that substoichiometric concentrations of clusterin prevent oligomer interaction with the antibody

239 tion antisense oligonucleotide that inhibits clusterin production.

240 Herein, we report that extracellular Clusterin promoted epithelial cell apoptosis whereas int

241 vivo studies demonstrated that extracellular Clusterin promoted epithelial cell apoptosis while inter

242 tation of the heat shock element site in the clusterin promoter completely abolishes MX781-induced tr

243 generated a reporter system using the human clusterin promoter fused to firefly luciferase (hCLUp-Lu

244 differentially affects the activation of the clusterin promoter in a cell type-specific manner.

245 ion of endogenous clusterin mRNA, as well as clusterin promoter transactivation are blocked.

246 iated with transcriptional activation of the clusterin promoter, which requires the proximal -218-bp

247 man c-Fos expressing plasmid together with a clusterin promoter/reporter construct or the artificial

248 tosolic Hsp72 or the extracellular chaperone clusterin protected against PrP(Sc)- or Abeta-induced to

249 Secretory clusterin protein (sCLU) is a general genotoxic stress-i

250 Stat1 and clusterin protein expression was induced upon docetaxel

251 from patients with nephropathic cystinosis, clusterin protein expression was mainly limited to the p

252 lowed by light application, led to increased clusterin protein expression, peaking 24 h after the tre

253 reased intracellular clusterin and decreased clusterin protein secretion, resulting in the p53-depend

254 d at the transcriptional level, the CAII and clusterin proteins were elevated after doxorubicin treat

255 etory isoform set (pre- and mature secretory clusterin proteins, psCLU/sCLU), as well as another set

256 ized some effects of the molecular chaperone clusterin, providing new and more detailed evidence of i

257 es of this recombinant product with those of clusterin purified from human serum.

258 nduced by the brain microenvironment-derived clusterin resulted in decreased GAD1 promoter methylatio

259 treatment with chemotherapy led to increased clusterin RNA and protein levels localizing to apoptotic

260 Clusterin RNA and protein levels were decreased in colon

261 We therefore sought to investigate apoJ/clusterin's role in kidney aging, as this may reveal the

262 Secretory clusterin (sCLU) is a stress-induced, pro-survival glyco

263 Secretory clusterin (sCLU), an extracellular molecular chaperone,

264 nd DTX was mediated by secretory/cytoplasmic clusterin (sCLU).

265 Decreased clusterin secretion by pVHL-defective tumors was confirm

266 A expression of c-myc, a proto-oncogene, and clusterin (SGP-2), a marker associated with immature col

267 Finally, recombinant human clusterin suppressed, in a dose-dependent manner, DNA re

268 of regulatory genes (lysyl oxidase-like and clusterin) that are involved in both the production and

269 ectively adsorbed a proinflammatory protein (Clusterin) that was not found on the surfaces of HA-CS N

270 molten globule-like binding site and provide clusterin the ability to bind to a variety of molecules.

271 We found that transient transfection of clusterin to colon cancer cell lines directly enhanced b

272 We also tested whether the binding of clusterin to ligands could be inhibited by competitive b

273 c variant I56T is inhibited significantly at clusterin to lysozyme ratios as low as 1:80 (i.e. one cl

274 Binding of clusterin to these receptors triggers a Reelin-like sign

275 hybridization was used to precisely localize clusterin transcripts in articular cartilage, where it w

276 on, yet a deficit in p21 can be subverted by clusterin transfection.

277 in cerebral vessels by secreting the factor clusterin upon binding of Abeta40 to the fibrinogen rece

278 utations via different degradation pathways, clusterin via the lysosomal pathway and COMMD1 via the p

279 ved in regulation of the complement pathway (clusterin, vitronectin, and fibromodulin) and of amyloid

280 Tissue metalloproteinase inhibitor 3, clusterin, vitronectin, and serum albumin were the most

281 in 1, latency-associated peptide, TGF-beta1, clusterin, von Willebrand factor, multimerin-1, protein

282 Cerebrospinal fluid clusterin was associated with the entorhinal cortex atro

283 Furthermore, clusterin was down-regulated in rapidly dividing human k

284 Exosomal clusterin was elevated in subjects with non-alpha-synucl

285 renal transplant recipients (N=81), urinary clusterin was measured serially between 4 hr and 7 days

286 the protease-sensitive disordered regions of clusterin was protected from trypsin digestion.

287 One prominent candidate biomarker, clusterin, was then subjected to a series of validation

288 CAII, Id2, p55PIK, and clusterin were not altered by doxorubicin in MCF-7 cells

289 , tentatively identified as ovoinhibitor and clusterin, were found to react with serum IgE from egg-a

290 zed by significantly increased extracellular Clusterin whereas the inverse was evident for intracellu

291 with respect to expression and secretion of clusterin, which does not behave like a HIF target.

292 and express high levels of the glycoprotein clusterin, which has been shown to demarcate immature ac

293 n the pipette of the extracellular chaperone clusterin, which is known to selectively bind oligomers,

294 lar zone (SVZ) explants are compromised when clusterin, which is present in the subventricular zone,

295 that cover seven tryptic peptides from human clusterin with a length of natural flanking sequences ra

296 PDT resulted in significant up-regulation of clusterin with a maximum at 12 h after treatment, wherea

297 s.These data substantiate the interaction of clusterin with biologically active regions exposed on nu

298 of a high-affinity (KD= 1 nm) interaction of clusterin with biologically relevant Abeta1-42oligomers,

299 All of the 36 ALCL cases marked for clusterin, with most cases showing moderate to strong st

300 in ALCL is unknown, the unique expression of clusterin within this category of lymphoma provides an a