ライフサイエンスコーパス: co-operative

1 ge excess of EnvZc, OmpR binding to EnvZc is co-operative.

2 the uptake of zinc and that metal binding is co-operative.

3 t LTX-stimulated exocytosis depends upon the co-operative action of external and intracellular Ca2+ i

4 rior elevation of free [Ca2+]i, supporting a co-operative action of free [Ca2+] and InsP3 in activati

5 up protein, Dichaete, in a manner suggesting co-operative activation.

6 six pairs of HLA class I alleles that have a co-operative additive effect in mediating HIV disease co

7 d to identify pairs of alleles that mediate 'co-operative additive' effects, either to improve diseas

8 The movement was highly co-operative and at any moment, most of the Soj in any c

9 our results indicate that RECQL5 plays both co-operative and complementary roles with WRN.

10 of p53 to different recognition elements was co-operative and the affinities varied by up to 50-fold.

11 Thus, the folding of CI2 is extremely co-operative, and interactions have to be made between s

12 Co-operative antitumor effect and in vivo persistence, w

13 to the RNA polymerase active site depends on co-operative ATP hydrolysis by the activator.

14 Biofilm formation is a co-operative behaviour, where microbial cells become emb

15 rol the production of public goods and other co-operative behaviours.

16 However, high affinity co-operative binding (K(d) ~ 0.4 microM) is evident for

17 Substitutions at Int position 47 also affect co-operative binding among Int proteins at arm-type DNA

18 usual among P450 enzymes in that it exhibits co-operative binding between the substrate camphor and a

19 minal domain mediates two alternate types of co-operative binding interactions.

20 application of nanoMIP beacons with a unique co-operative binding mechanism for the detection of meth

21 The co-operative binding mechanism, which relies on the stru

22 raction with RNA polymerase (RNAP); however, co-operative binding of a second dimer blocks this site.

23 This is the first demonstration of co-operative binding of an activator and IHF in a sigma5

24 The co-operative binding of aspartate in the E. coli enzyme

25 Our data are most consistent with a model of co-operative binding of BvgA dimers to this intervening

26 ncer cells and identify a mechanism in which co-operative binding of LRH-1 and ERalpha at oestrogen r

27 BRG1-Tbeta4 co-operative binding promotes optimal transcription of W

28 chniques including receptor decoys, multiple co-operative binding sites, and sequential positive feed

29 lts show that the POZ domain mediates strong co-operative binding to multiple sites but inhibits bind

30 Both catabolic operators show evidence for co-operative binding with respect to protein concentrati

31 The physiological mechanism of co-operative Ca(2+) regulation of cardiac contractility

32 r Ca(V) 1.2 channel clustering to facilitate co-operative channel interactions and elevate Ca(2+) inf

33 The co-operative control of the oxidative stress response by

34 essentially superimposable, consistent with co-operative denaturation.

35 ld-type cbEGF12-13 and cbEGF12-14 identify a co-operative dependence of domain folding where calcium

36 a negatively charged residue is required for co-operative DNA binding between Int and Xis, and sugges

37 Most PCPG have quiet genomes with some rare co-operative driver events, including EPAS1/HIF-2alpha m

38 hronization patterns and, thus, in nephrons' co-operative dynamics.

39 The technique is modular, meaning that the co-operative effect of dimerization is made explicit by

40 individual pentameric sequences or a global, co-operative effect of many pentamers within the beta-sp

41 LUSIONS/SIGNIFICANCE: These results identify co-operative effects between HLA Class I alleles in the

42 tion on the heterogeneous catalyst requiring co-operative effects between neighboring oxidized Ir cen

43 cular) to drive water oxidation without such co-operative effects is explained by the specific coordi

44 and abnormal cell proliferation is driven by co-operative effects of viral E6 and E7 genes.

45 negative binding co-operativity) mirror the co-operative effects seen in the ligand binding.

46 We have also screened for internal co-operative effects within the repertoire of p53 modifi

47 al genes toward cardiac genes, guiding their co-operative epigenetic and transcription activities.

48 abidopsis, like tomato, was found to exhibit co-operative ethylene and SA action for the production o

49 t role that reciprocity plays in maintaining co-operative exchange we know relatively little of when,

50 We assign co-operative functions to 2,578 proteins, enabling syste

51 y between channels permits Ca(2+) -dependent co-operative gating behaviour mediated by dynamic, physi

52 y between channels permits Ca(2+) -dependent co-operative gating behaviour mediated by physical inter

53 nnels are functional and contribute to overt co-operative gating behaviour of Ca(V) 1.2 channels in I

54 the presence of base, presumably due to the co-operative geometry of the hydrogen bonding motif.

55 This co-operative hierarchical binding model explains the dua

56 y acting EBPs, the evolution of the strictly co-operative HrpRS pair raises questions of potential be

57 Although co-operative ideology has often been emphasised as a dri

58 jacent to the high affinity site permits the co-operative incorporation of a second Rev molecule to t

59 ((R))-identified TFs (MYC and IRF1) leads to co-operative induction of APL differentiation, as does p

60 combined with MEK or BRD4 inhibitors causes co-operative inhibitory responses on cell growth.

61 ll coefficient of 2.7, suggesting a positive co-operative interaction among its catalytic sites.

62 r affinity humanized variants demonstrated a co-operative interaction between light chain framework r

63 n bacteria with elevated levels of EcoKI the co-operative interactions are obscured, consistent with

64 Optimal protein function often depends on co-operative interactions between amino acid residues di

65 ental regulation in embryos, suggesting that co-operative interactions between different factors medi

66 Co-operative interactions between pairs of truncated pro

67 d by in vitro experiments, but the predicted co-operative interactions between targets have not been

68 residues of XerD has no measurable effect on co-operative interactions with XerC in DNA-binding assay

69 erivative containing residues 1-268 retained co-operative interactions with XerC; nevertheless, it di

70 suggest that ToxR dimers might be capable of co-operative interactions.

71 hree-dimensional zipper-like structure via a co-operative interplay of hydrogen bonding, aromatic sta

72 seen in two-domain K+ channels delineated a co-operative intersubunit interaction between the Y and

73 ith the nucleoid, which can undergo dynamic, co-operative jumping from nucleoid to nucleoid in the pr

74 g to the DNA recombination intermediate in a co-operative manner.

75 inds multiple alpha(1D)-AR PDZ ligands via a co-operative mechanism.

76 as only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomage

77 that the wing is not involved in the highly co-operative nature of HSF binding, but may be important

78 arious monodeoxysucrose analogs revealed the co-operative nature of the hydroxyl groups in mediating

79 were aged at least 18 years, with an Eastern Co-operative Oncology Group performance status of 0-2, a

80 ade 1, 2, or 3a follicular lymphoma; Eastern Co-operative Oncology Group performance statuses of 0-2;

81 This enables the simulation of various co-operative or competitive mechanisms, where there is e

82 Co-operative oxygen binding by the vertebrate haemoglobi

83 ates the PcrA helicase activity by promoting co-operative PcrA binding onto its DNA substrate, RepD s

84 that F2-Ins(3,4,5,6)P4 imitated only the non-co-operative phase of inhibition by Ins(3,4,5,6)P4, and

85 of inhibition by Ins(3,4,5,6)P4, and not the co-operative phase.

86 t c-FLIPL/S binding to the DISC is instead a co-operative procaspase-8-dependent process.

87 d Ca(2+) activation as a fourth-order highly co-operative process ([Ca]i required for half-activation

88 luorescence spectroscopy, revealing a highly co-operative process that occurs with a Hill coefficient

89 bacteriorhodopsin from SDS into lipids is a co-operative process, it is nevertheless possible to obt

90 erate and boreal forests (ICP [International Co-operative Programme on Assessment and Monitoring of A

91 which may be important for understanding the co-operative properties of ALAD enzymes.

92 alpha synthesis on a translational level via co-operative regulation of both initiation factor 4E-bin

93 8) based on the RETICS (Thematic Network for Co-Operative Research in Health) classification system.

94 Recent evidence suggests a co-operative role for RAC1 activity in BRAF(V600E)-drive

95 opic ligands (CTP or CTP+UTP) re-establishes co-operative saturation kinetics.

96 types and intermediate cell types throughout co-operative signaling.

97 migration of carcinoma cells in part through co-operative signalling with the tetraspanin family of t

98 the extreme deformability of SSBs and drive co-operative, stepwise self-assembly of remaining PARP-1

99 mine, but not spermidine, showed evidence of co-operative stimulation of frameshifting and the existe

100 scale (ADAS-Cog) and the Alzheimer's Disease Co-operative Study-Activities of Daily Living Inventory

101 In contrast, Brn-3a and p53 co-operative to induce maximal activation of another p53

102 e have demonstrated that IRF6 functions as a co-operative transcriptional activator and that mutation

103 ts, their physical linkage in the genome and co-operative transcriptional regulation may play a signi

104 The co-operative transition between these states allows the

105 (n(H)) close to 3, consistent with a single co-operative transition controlled by Ca(2+) binding.

106 The absence of a co-operative transition could result from the denatured

107 the compact state occurs through a two-state co-operative transition following heteropolymer formalis

108 ration chromatography techniques indicated a co-operative transition only for B23-110.

109 periments, could be fit globally to a common co-operative transition.

110 beyond the species-repertoire and, (iv) in a co-operative turn-taking social setup.

111 previously isolated KorA mutants to act in a co-operative way in the presence of KorB in vivo or in v

112 rough detailed simulations how a competitive co-operative ('winner-take-all', WTA) network architectu

113 raction of NifA with the UAS is not strongly co-operative with holoenzyme or IHF, a result supportive

114 sponses at endplates, and that these are non-co-operative with respect to overall endplate depolarisa

115 necessary for sequence-specific DNA-binding, co-operative XerC/D interactions, synapsis and catalysis