ライフサイエンスコーパス: co-regulate

1 evelopmental stages that the clustered genes co-regulate.

2 quence, one might expect that they should be co-regulated.

3 er core and spindle pole are independent and co-regulated.

4 ow processes in muscle and myeloid cells are co-regulated.

5 share activity profiles and may therefore be co-regulated.

6 al antisense transcripts (NATs) are possibly co-regulated.

7 ests that clusters of adjacent CpG sites are co-regulated.

8 in polycistronic arrays but not necessarily co-regulated.

9 ntation of the underlying processes that are co-regulated.

10 er transcytosis and paracellular leakage are co-regulated.

11 th correlated expression profiles may not be co-regulated.

12 of genes that are 'functionally' related or co-regulated.

13 grouping together genes that are putatively co-regulated.

14 al processes, including cAMP metabolism, are co-regulated.

15 NBAS act in concert with core NMD factors to co-regulate a large number of endogenous RNA targets.

16 The two Mmp classes co-regulate a Wnt trans-synaptic signaling pathway modul

17 and U2AF65, revealing that JMJD6 and U2AF65 co-regulated a large number of alternative splicing even

18 transcription in MCF7 cells and with TRIM28 co-regulates a set of genes associated with stem cell ma

19 to identify probe pairs that are positively co-regulated across the samples.

20 multiple (rather than single) intermixed and co-regulated actions, even though many species' signal t

21 could account for, at least partially, their co-regulated alternative splicing events, suggesting bot

22 d ChIP-seq, we determined that H-NS and LuxR co-regulate and co-occupy 28 promoters driving expressio

23 In conclusion, Hox11 genes co-regulate and coordinate the development of zeugopod s

24 The numbers of identified co-regulated and anti-regulated pairs were higher than e

25 ses or defining given cell types are usually co-regulated and co-expressed, forming expression networ

26 tal-biased allelic expression are frequently co-regulated and enriched in common biological pathways.

27 Here, we present methods to robustly detect co-regulated and functionally enriched gene communities

28 d genes, the conditions under which they are co-regulated and sequence-level regulatory motifs.

29 ion changes over time; such molecules may be co-regulated and thus involved in similar biological pro

30 co-expressed microRNA target genes are often co-regulated, and different groups of target genes of th

31 dentify a module of 137 highly variable, yet co-regulated, antiviral response genes.

32 named pcuABCDE, which are co-transcribed and co-regulated as an operon.

33 ries would thus incorporate tissue-specific, co-regulated as well as housekeeping genes based only on

34 t have related functions and are potentially co-regulated, as well as proteins that are associated wi

35 s (i.e. "co-binding changes") can affect the co-regulating associations between TFs (i.e. "rewiring t

36 Do functionally associated genes tend to be co-regulated at the transcription level?

37 or components of specific complexes are also co-regulated at the transcriptional level, and share com

38 re we found that miR-19, miR-101 and miR-130 co-regulate ataxin1 levels and that their inhibition enh

39 wo major isoforms of Pfn (Pfn1 and Pfn2) are co-regulated by a common mechanism involving the action

40 t the member DEGs within a module tend to be co-regulated by a common pathway.

41 r markers of terminal motor neuron fate, are co-regulated by a shared cis-regulatory signature and a

42 genes that form modules that are potentially co-regulated by a small group of transcription factors.

43 ize orthology assignments for pairs of genes co-regulated by bidirectional promoters to map the ances

44 Meanwhile, the expression of IL-6 is co-regulated by both pathways.

45 dicating the ribA gene and T4SS operon 1 are co-regulated by both wBmxR1 and wBmxR2.

46 , as a healthy adult cardiac fibroblast gene co-regulated by cardiogenic transcription factors Gata4

47 nar positioning of cortical neurons are also co-regulated by cell type- and layer-specific transcript

48 erferes with PcG silencing at genes that are co-regulated by cohesin and PcG proteins.

49 d that a significant proportion of genes are co-regulated by DHX34, NBAS and core NMD factors in thes

50 and microarray analyses, to identify targets co-regulated by Eyeless and Hedgehog, Decapentaplegic or

51 show that full expression of somitic Fgf10, co-regulated by GLI3, is required for the anteroposterio

52 o our model of how this central NE system is co-regulated by opioids and stress-related peptides.

53 ntrolled by promoters methylated by CcrM and co-regulated by other global cell cycle regulators, demo

54 a small proportion of targeted events being co-regulated by PTB.

55 e that T6SS-dependent secreted effectors are co-regulated by RpoN.

56 if that is present in the promoters of genes co-regulated by SciP and CtrA.

57 encodes relationships between genes that are co-regulated by shared biological mechanisms.

58 In addition, ARGs in specific clusters are co-regulated by the cAMP-response element-binding protei

59 uential reactions in a metabolic pathway are co-regulated by the same TFs.

60 Expression of dsx in the sex comb is co-regulated by two enhancers with distinct spatial and

61 angioblasts and the adjacent heart field are co-regulated, by transcription factors previously associ

62 CaGPI19 also co-regulates CaERG11, the target of azoles while CaGPI2

63 anisms, genes are arranged in units that are co-regulated (called operons).

64 Phalanx number, although co-regulated, can be uncoupled from joint specification.

65 GA prostate tumour RNA-sequencing identifies co-regulated cancer genes associated with 2-oxoglutarate

66 phatases (PTPs) and protein-tyrosine kinases co-regulate cellular processes.

67 the positioning of microbial genes that are co-regulated, co-expressed or evolutionarily correlated.

68 in shuttling between DNA and RNA ligands to co-regulate COL2A1 expression at the level of transcript

69 We show that two genes in a co-regulated DGP have higher expression covariance compa

70 found that hypermethylation of MITF and its co-regulated differentiation pathway genes corresponded

71 the zinc-finger transcription factor Sp1 to co-regulate Drd2 expression.

72 functions at genes whose transcription they co-regulate during mouse T helper 17 (Th17) cell differe

73 shion in both nucleus and cytoplasm, and are co-regulated during mechanotransduction.

74 Target genes were collectively co-regulated during normal hematopoietic differentiation

75 tyl-D-glucosamine-utilization genes that are co-regulated during productive symbiosis.

76 Moreover, we demonstrate that genes co-regulated during the cell cycle tend to associate wit

77 set of protein complexes for which genes are co-regulated during the cell cycle.

78 associations and chromosome territories are co-regulated during the cell cycle.

79 microRNA sponges - they communicate with and co-regulate each other by competing for binding to share

80 show that STAT3 and betaA3/A1-crystallin may co-regulate each other in astrocytes.

81 PPM1A and PTEN, therefore, co-regulate each other's relative abundance, identifying

82 10 of its established targets identified as co-regulated 'ECM organisation' genes and miR-22-3p whic

83 The CSBs of co-regulated enhancers share a large number of sequence

84 ly conserved sequences that are shared among co-regulating enhancers.

85 ations and orientations within the different co-regulating enhancers; these elements contain either k

86 logically relevant subset of BRG1 and ARID1A co-regulated epithelial identity genes.

87 RGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory and inhibitory synapse developmen

88 Our data indicate that co-regulated expression of neuron subtype-specific and p

89 er, the data suggest that the Wld(S) protein co-regulates expression of a consistent subset of genes

90 Mn(II), and antagonized by Fe(II), PerR may co-regulate Fe(II) homeostasis by modulating BsFur level

91 A co-regulated five-gene cluster has been identified and p

92 These were also universally co-regulated following other bacterial basal resistance

93 A co-regulated fraction of specific wall-modifying protein

94 and 3D chromatin structure, which ultimately co-regulate functionally linked genes.

95 TWAS power over PrediXcan when >=1% cis-SNPs co-regulate gene expression and gene expression heritabi

96 Interdependent binding serves not only to co-regulate gene expression but also to prevent TFs from

97 Baf60c and Baf170 co-regulate gene expression with Brg1 in CPs, and in CMs

98 meiosis-expressed gene 1 (MEIG1) and Parkin co-regulated gene (PACRG) interact, and that sperm-assoc

99 found that MEIG1 associates with the Parkin co-regulated gene (PACRG) protein, and that testicular P

100 combined with motif conservation upstream of co-regulated gene clusters allowed the construction of p

101 The ANN model also predicts specific co-regulated gene clusters associated with differential

102 Genes within the co-regulated gene clusters tend to have relevant functio

103 ion piggybacking, which consequently created co-regulated gene clusters.

104 We confirmed co-regulated gene expression using P-element mutants.

105 ults in increased expression of the Hha/H-NS co-regulated gene hilA without affecting the expression

106 ning and user-friendly platform for building co-regulated gene modules and the tools necessary for th

107 nisms from diverse phylogenetic clades (4678 co-regulated gene modules, 3466 regulators and 9291 cis-

108 he discovery of co-expressed and potentially co-regulated gene modules.

109 enriched biological processes and discovered co-regulated gene networks and transcription factors pre

110 s are required, capable of discovering large co-regulated gene networks.

111 Sox2 and Pax6 co-regulate genes in neural lineages and the lens by for

112 We identified discrete groups of co-regulated genes (i.e., co-expression modules) and tes

113 Subsequently, 428 highly co-regulated genes (|CC| >/= 0.8) were clustered unsuper

114 goal of these analyses is to define sets of co-regulated genes and identify patterns of gene express

115 ne expression paradigm, implying that active co-regulated genes and their regulatory factors cooperat

116 such as the detection of co-expressed genes, co-regulated genes and transcription factor binding moti

117 Co-regulated genes are likely to reveal themselves by sh

118 Co-regulated genes are not identified in traditional mic

119 y by binding to the same enhancer regions of co-regulated genes as Gli1.

120 Identifying groups of co-regulated genes by monitoring their expression over v

121 ine biosynthetic genes and define a group of co-regulated genes called the A-B regulon.

122 Co-regulated genes consistent between the human and mous

123 Transcriptome analyses identify clusters of co-regulated genes during NC specification and migration

124 silico tool to identify physical clusters of co-regulated genes from gene expression data.

125 Combinatorial sequence analysis of these co-regulated genes generated a hypothetical regulatory c

126 In fact, all three co-regulated genes have the potential to interact not on

127 correlated biological pathways in humans and co-regulated genes in a humanized mouse model.

128 cose represses transcription of a network of co-regulated genes in Saccharomyces cerevisiae, ensuring

129 Identification of modules of co-regulated genes is a crucial first step towards disse

130 ted method to date for identifying conserved co-regulated genes is a two-step approach.

131 transcriptional patterning model is that the co-regulated genes knirps (a short gene) and knirps-rela

132 ression changes, we demonstrate a cluster of co-regulated genes known to have impact in the extracell

133 Furthermore, modules of co-regulated genes may only show tight co-expression acr

134 ression dataset by looking for enrichment of co-regulated genes relative to an empirical null distrib

135 A major subnetwork containing 61 closely co-regulated genes showed highly significant enrichment

136 l model for biclustering to infer subsets of co-regulated genes that covary in all of the samples or

137 xamined the phenotypes of mutations in seven co-regulated genes that had no published role in chemota

138 model for interrogating the contribution of co-regulated genes to in vivo phenotype as its multinucl

139 nd developmental stages revealed clusters of co-regulated genes with shared cis promoter elements, wh

140 ntly challenging problem is that of defining co-regulated genes within those gene lists.

141 DS but instead result from the clustering of co-regulated genes, a function of mammalian genome organ

142 Importantly, at co-regulated genes, aberrantly methylated bases accumula

143 gulatory modules governing the expression of co-regulated genes, Creme 2.0; and a dynamic portal to m

144 uced well-defined modules of region-specific co-regulated genes, in contrast to standard coexpression

145 1-ICD-overexpressing BS149 cells revealed 42 co-regulated genes, including glycoprotein non-metastati

146 roaches have focused on inferring modules of co-regulated genes, linking these modules with regulator

147 To identify co-regulated genes, MicrobesOnline can search for genes

148 asizing common features of large clusters of co-regulated genes, our results highlight the extent to

149 ative positioning of either co-functional or co-regulated genes, stems from two main approaches.

150 tocyte genes reveal two distinct clusters of co-regulated genes, suggesting that male and female game

151 deled as a collection of regulatory modules: co-regulated genes, the conditions under which they are

152 transcription cofactors p300/HDAC1 to these co-regulated genes, thereby altering the host gene expre

153 popular technique used to identify groups of co-regulated genes, to infer unknown gene functions.

154 To identify virB co-regulated genes, we searched the Brucella suis 1330 a

155 For a given set of co-regulated genes, WGRV returns statistically enriched

156 p- and down- regulation of several groups of co-regulated genes, with ADR1-dependent genes being the

157 cing experiments further reveals clusters of co-regulated genes, with in situ hybridization confirmin

158 e at a subset of known BDR4, JMJD6, and CHD4 co-regulated genes.

159 (TFs) and associated target genes in sets of co-regulated genes.

160 ave opposing effects on the transcription of co-regulated genes.

161 association, identifying a large spectrum of co-regulated genes.

162 vary greatly among the elements of different co-regulated genes.

163 catter plots, and dissection into cliques of co-regulated genes.

164 ond step, thus difficult to detect conserved co-regulated genes.

165 y with Kismet throughout the ISC genome, and co-regulates genes in ISCs, including Cbl, a negative re

166 ing classifies co-expressed, and potentially co-regulated, genes into biologically informative catego

167 de insights into how competing behaviors are co-regulated.Genes and circuits involved in sleep and se

168 re, we show that Set1 and Jhd2 predominantly co-regulate genome-wide transcription.

169 vailability of free PRC2 at the proximity of co-regulated genomic loci.

170 cero-phosphorylcholine), was identified in a co-regulated group of genes enriched for components of t

171 transcriptional control circuits that affect co-regulated groups of genes: a key to understanding how

172 wild-type p53 and hypoxia-inducible factor 1 co-regulate hDBR1 expression, and insufficient hDBR1 lea

173 ribe an approach to comprehensively identify co-regulated, heterogeneously expressed genes among cell

174 st to reveal functional associations between co-regulated human proteins from ProteomeHD, a compilati

175 analyses show that Nup153 and Sox2 bind and co-regulate hundreds of genes.

176 We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and systemic g

177 y binding sites in upstream regions of genes co-regulated in embryonic stem cells.

178 In agreement, EZH2 and Lat1 expression are co-regulated in models of cancer cell differentiation an

179 lin-dependent protein kinase II (CaMKII) are co-regulated in nucleus accumbens (NAc), a brain reward

180 oral fate and progenitor decommissioning are co-regulated in protracted neuronal lineages.

181 y common biochemical processes; how they are co-regulated in response to specific stressors; and how

182 Ube2S and UbcH10 are tightly co-regulated in the cell cycle by APC/C-dependent degrad

183 n and the Pi stress response are intricately co-regulated in the soil bacterium Agrobacterium tumefac

184 urons into different subtypes and discovered co-regulated injury-response genes including novel regen

185 Whatever the molecular mechanism by which CO regulates ion channels, endogenous production of this

186 our understanding of how their expression is co-regulated is limited.

187 ough heritable genetic polymorphisms or as a co-regulated mediator of the pathology, and may play a r

188 neurons, upregulated miRNA target genes are co-regulated members of prosurvival pathways associated

189 that TrmB transduces a growth rate signal to co-regulated metabolic pathways including amino acid, pu

190 in mice over its related, co-transcribed and co-regulated miRNA, miR-212.

191 t the network hub gene Bcat1 and seven other co-regulated MMnet genes out of 13, regulate bone functi

192 lustering algorithm identifies conditionally co-regulated modules of genes (biclusters).

193 h ASD and controls and identified miRNAs and co-regulated modules that were perturbed in ASD.

194 mprove discovery of biologically informative co-regulated modules.

195 roteins, indicating the possible presence of co-regulated mRNA cohorts.

196 Translationally co-regulated mRNA subsets share common upstream regulato

197 n is that RNA-binding proteins and microRNAs co-regulate mRNAs.

198 red that the three genes IPL1, DAM1 and KIP3 co-regulate MT dynamics.

199 transcription factors (TF) that as a group, co-regulate multiple, functionally related genes.

200 iry, and clockwork orange) were predicted to co-regulate nearly half of the genes that were upregulat

201 is unique switch arrangement of overlapping, co-regulated NES/NLS sequences is vital to delineating t

202 d co-methylation network analyses identified co-regulated networks in maternally inherited Ube3a dele

203 were clustered unsupervised to obtain small co-regulated networks.

204 cal for maintenance of the ES cell state and co-regulated on differentiation.

205 point receptors), which are co-expressed and co-regulated on dysfunctional or 'exhausted' T cells in

206 arch for conserved overrepresented motifs in co-regulated operons identified likely -35 and -10 promo

207 each consists of a set of transcriptionally co-regulated operons.

208 nia oxidizer community and ambient substrate co-regulate optimum temperatures (T(opt)), generating di

209 ering groups of correlated genes potentially co-regulated or associated to the disease or conditions

210 The new concept of a cluster of co-regulated orthologous operons allows the user to dist

211 Finally, we identify clusters of co-regulated ovary genes flanked by Su(Hw)(f) bound site

212 We show that the expression of a set of co-regulated ozone-induced genes is Ca(2+)-dependent and

213 pression are generally correlated within the co-regulated pairs and are anti-correlated within the an

214 nalysis showed that most of the genes in the co-regulated pairs participate in biological regulation.

215 alogs of testis-biased genes, we identified "co-regulated" paralogous pairs in which both genes are t

216 ant for revealing the related mechanisms and co-regulated pathways involved in the development of agi

217 beginning to understand the microbiota-host co-regulated pathways underlying these processes, paving

218 thereby preventing elaboration of the toxin co-regulated pilus (TCP) and cholera toxin in vitro and

219 teria by host immune defences, and the toxin co-regulated pilus (TCP) required for colonization.

220 s encoding cholera toxin (ctx) and the toxin co-regulated pilus (tcp), as well as accessory colonizat

221 of virulence factors cholera toxin and toxin-co-regulated pilus.

222 genes including cholera toxin and the toxin co-regulated pilus.

223 ation of specific glycans are organized into co-regulated polysaccharide utilization loci, with the a

224 All three were co-regulated post-transcriptionally by hnRNP K, as hnRNP

225 ted, Mot1 was found to control TBP levels at co-regulated promoters.

226 type VI secretion system (T6SS), haemolysin co-regulated protein (Hcp), binds directly to effectors,

227 Hemolysin co-regulated protein 1 (Hcp1) and O-polysaccharide (OPS)

228 f secreted proteins, specifically haemolysin co-regulated protein and an RTX toxin-like membrane fusi

229 d procedure yields a 50.9-fold enrichment of co-regulated protein candidates and a 2.5-fold improveme

230 and the founding substrate of the haemolysin co-regulated protein secretion island II T6SS (H2-T6SS).

231 lex interactions are strongly enriched among co-regulated proteins and transcription factors.

232 ur discovery of highly localized operon-like co-regulated regions of chromatin modification is unprec

233 oratory has demonstrated that the haemolysin co-regulated secretion island I (HSI-I)-encoded type VI

234 factor required for germline maintenance, to co-regulate select target genes.

235 s, analysing expression profiles in terms of co-regulated sets of genes or in terms of higher-order e

236 ght into determining functionally related or co-regulated sets of genes, suggest annotations of previ

237 llular functions of POU3F2 and TRIM8 as they co-regulate several pathways related to neural developme

238 rs participate in dense interactions between co-regulated subnetworks and contribute to therapy resis

239 Analysis of the co-regulated subunits of a stage-specific enzyme is ther

240 Some endocytic pathways may be co-regulated such that disruption of one pathway leads t

241 defined by Oamb and Octbeta3R respectively, co-regulate sugar consumption according to changes in en

242 and several blocks of duplicated genes were co-regulated, suggesting some type of epigenetic or posi

243 lycan biosynthesis and cellular behavior are co-regulating systems.

244 ivity of the enhancer in vivo MIST1 and PTF1 co-regulate target genes synergistically or additively,

245 iments have initially validated about 30% of co-regulated target genes identified by ChIP-BIT as bein

246 el sRNA seed regions and sets of potentially co-regulated target mRNAs.

247 y influence expression and middle-level ones co-regulate targets to mitigate information-flow bottlen

248 SUZ12 resulted in upregulation of TBX2/EGR1 co-regulated targets accompanied by a dramatic inhibitio

249 3 RIP-seq library, suggesting that PTBP2 may co-regulate TDP-43 RNA targets.

250 GAP2A and its human-specific paralog SRGAP2C co-regulate the development of excitatory and inhibitory

251 le, miR-18a-3p, -320a, -193b-3p, and -92b-3p co-regulate the glycolysis/gluconeogenesis and focal adh

252 functional modules where different microRNAs co-regulate the same functional process.

253 s into how climate change and human land use co-regulate the vegetation and carbon cycles of a tropic

254 articles, we demonstrated that PlpA and MglA co-regulated the direction of gliding motility through d

255 Here we reported that GATA-1 and GATA-2 co-regulated the expression of two microRNA genes, micro

256 as a novel IBP cofactor, which specifically co-regulates the chromatin accessibility of hundreds of

257 We found that MKL co-regulates the expression of Pfn isoforms indirectly b

258 NRF-2 is of special significance because it co-regulates the expressions of mediators of energy meta

259 g those with undetectable plasma HIV-1 RNA), co-regulates the glucocorticoid receptor and PPARgamma a

260 knock-out rat model, we show that GalNAc-T2 co-regulates the metalloproteinase-mediated limited prot

261 lex is a component of a genetic pathway that co-regulates the stability of the p53 and E2F-1 transcri

262 y, CRC factors exhibit prominent capacity of co-regulating the epigenome in cooperation with EWS-FLI1

263 53 maintains plasticity of imaginal discs by co-regulating the maintenance of genome integrity and di

264 ar, if the core genes for a trait tend to be co-regulated, then the effects of peripheral variation c

265 hat leptin and TRH, acting in the hindbrain, co-regulate thermogenesis.

266 The mechanisms by which CO regulates these ion channels are still unclear and re

267 ied within the highly compacted 3D genome to co-regulate thousands of genes.

268 anscytosis and paracellular permeability are co-regulated through a signaling pathway linking dynamin

269 n, CrMYC2 is capable of activating ORCA3 and co-regulating TIA pathway genes concomitantly with ORCA3

270 hreonine kinase (Stk1) and a TCS (CovR/CovS) co-regulate toxin expression in GBS.

271 positively correlated with RNA 63 suggesting co-regulated transcription during latency.

272 insights into the mechanisms by which Atxn1 co-regulates transcription.

273 e patterned tissue specification, in part by co-regulating transcription.

274 Significant over-representation of co-regulated transcripts encoding leucine rich repeat re

275 However, whether active deubiquitination co-regulates ubH2A levels in ESCs and during differentia

276 al role in flagellar assembly and evolved to co-regulate various cellular processes with motility.

277 ndependent contribution of the three H1-T6SS co-regulated vgrG genes, vgrG1abc, to bacterial killing.

278 d identified gene sets that are likely to be co-regulated via shared regulatory motifs.

279 proteins with similar abundance profiles are co-regulated, we clustered the proteins with abundance p

280 identified several groups of genes that are co-regulated with characterized marker genes.

281 hierarchical clustering identified 426 genes co-regulated with ENHO in liver, ileum, kidney medulla,

282 mplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus

283 acterium salinarum that is transcriptionally co-regulated with genes of the aerobic physiologic state

284 ne generated in which the ICS1:luc fusion is co-regulated with ICS1.

285 We show that Nctc1 is co-regulated with Igf2 and H19 and physically interacts

286 an intestinal copper transporter (Atp7a) was co-regulated with iron transport-related genes by a hypo

287 stinct mouse strains to identify transcripts co-regulated with itch behavior.

288 These analyses identified novel targets co-regulated with Maspin in human short-term cultures de

289 Finally, TRAIL and CCL2 are co-regulated with MDSC/M2 markers in lung adenocarcinoma

290 ng key enzymes of the C4 pathway are already co-regulated with photosynthesis genes and are controlle

291 Flotation and motility can be co-regulated with production of a beta-lactam antibiotic

292 eam of the neighbouring gene Map17, which is co-regulated with Scl in haematopoietic cells.

293 The closely related protein Dichaete is co-regulated with SoxN and has a partially redundant fun

294 transcription factor binding on one side and co-regulated with the Mediator complex recruitment and H

295 ch to identify genes, pathways and processes co-regulated with the query.

296 t proteins translocated by the T4SS would be co-regulated with the virB operon.

297 yeast, we discovered that most RBP genes are co-regulated with their target genes, but the RBPs tend

298 find that Set2 has a short half-life and is co-regulated, with RNAPII CTD phosphorylation levels, du

299 any UC risk genes are cell type specific and co-regulated within relatively few gene modules, suggest

300 the balance of its receptors Neo1 and Unc5B co-regulate Wnt and MAPK pathways in both mouse and huma