ライフサイエンスコーパス: co-stimulation

1 roteins involved in antigen presentation and co-stimulation.

2 rials that are centered on modulating T-cell co-stimulation.

3 CD2 superfamily, NTB-A, important in T cell co-stimulation.

4 tigen is encountered in the presence of full co-stimulation.

5 umor activity is further enhanced by in vivo co-stimulation.

6 ell activation, but does not account for all co-stimulation.

7 mounts, was required for the effect of B7-H1 co-stimulation.

8 tokines together with cell contact-dependent co-stimulation.

9 and whether the interaction plays a role in co-stimulation.

10 ntigen 4-Ig, which blocks B7-mediated T-cell co-stimulation.

11 s and involves both antigen presentation and co-stimulation.

12 inhibited JNK responsiveness during CD3/CD28 co-stimulation.

13 ed in an immune-stimulatory environment with co-stimulation.

14 amplified activation induced by CD2 and CD28 co-stimulation.

15 their population size to the amount of local co-stimulation.

16 cquisition within the tumor after additional co-stimulation.

17 tive injury, antigen presentation and T cell co-stimulation.

18 ve T cells and with reduced requirements for co-stimulation.

19 g stimuli and produce IL-2 in the absence of co-stimulation.

20 mour cells, and could be further enhanced by co-stimulation.

21 ated antigen) is a critical event for T cell co-stimulation.

22 t antigen presenting cells or through direct co-stimulation.

23 gest that there are patients with vestibular co-stimulation already present at their everyday CI stim

24 Here we have shown that CD28 co-stimulation, an extracellular cue intrinsically requi

25 d by persistent antigen exposure, suboptimal co-stimulation and a plethora of hostile factors that da

26 Here we show that B7-CD28 co-stimulation and B7 expression by specific antigen-pre

27 antigen sensitivity and the impact of T cell co-stimulation and co-inhibition receptors.

28 and receptors play important roles in T-cell co-stimulation and co-inhibition.

29 uced expected patterns of T-cell activation, co-stimulation and co-inhibition.

30 l activation, that is, antigen presentation, co-stimulation and cytokine milieu.

31 In addition to providing T cell help through co-stimulation and cytokine production, CD4(+) T cells c

32 grin-mediated cellular hubs promote enhanced co-stimulation and cytokine signaling to drive Th2 diffe

33 urs that respond to soluble TME factors with co-stimulation and cytokine signals in T cells, called T

34 cell responses to antigen in the absence of co-stimulation and do so, in part, by repressing the exp

35 LRs recruiting lymphocytes, participating in co-stimulation and establishing an environment conducive

36 damaging effector responses, including CD28 co-stimulation and IL-2 signaling, constituting a negati

37 t from antigen recognition in the absence of co-stimulation and inflammation, and is associated with

38 We show that reducing CAR co-stimulation and modifying the endogenous T cell recep

39 ation and cytokine production following CD28 co-stimulation and normal morphology when migrating in a

40 These findings conceptually link co-stimulation and nutrient sensing and point to the mag

41 Abatacept modulates co-stimulation and prevents full T-cell activation.

42 Various signals ranging from antigen, co-stimulation and proinflammatory cytokines are require

43 inhibiting regulatory cells, boosting T-cell co-stimulation and using combinations of recombinant cyt

44 Excessive co-stimulation and/or insufficient co-inhibition can lea

45 signals, including T cell receptors (TCRs), co-stimulation, and cytokines, and metabolism-associated

46 Co-stimulation (ANP + SNAP) led to an additive response

47 addition to CD4 T-cell activation and T-cell co-stimulation are critical components in the developmen

48 cell-receptor triggering and the delivery of co-stimulation are essential events leading to T cell ex

49 et the mechanisms that enforce dependence on co-stimulation are incompletely understood.

50 er, the transcriptional consequences of CD28 co-stimulation are not completely understood.

51 These findings implicate negative co-stimulation as a key regulator and determinant of T c

52 g cells (APC) which are capable of providing co-stimulation as well.

53 contrast, treatment with cyclosporine A and co-stimulation blockade abolished T-cell proliferation a

54 se CD154 monoclonal antibody (mAb) to induce co-stimulation blockade leads to long-term murine islet

55 Treatment with rapamycin plus co-stimulation blockade resulted in massive apoptosis of

56 We found that co-stimulation blockade successfully prevented rejection

57 Hence, co-stimulation blockade targeting the CD30 and OX40 sign

58 Co-stimulation blockade with abatacept (CTLA4-Ig) will s

59 h CD28-B7 and CD40-CD40 ligand interactions (co-stimulation blockade) inhibited proliferation of allo

60 These results indicate that in synergy with co-stimulation blockade, CXCR3 is a viable therapeutic t

61 rejection and tolerance induction following co-stimulation blockade, providing new targets for immun

62 promote allograft rejection particularly in co-stimulation blockade-based immunosuppressive regimens

63 tes memory T cells and, when combined with a co-stimulation blockade-based regimen using cytotoxic T

64 dopted a short-term, systemically applicable co-stimulation blockade-based strategy using CTLA4-Ig an

65 ined after neutralization of LEA29Y-mediated co-stimulation blockade.

66 nfusion, chimerism, T cell depletion, and/or co-stimulation blockade.

67 Studies of a co-stimulation blocker (abatacept), tumor necrosis facto

68 Belatacept is a first-in-class co-stimulation blocker in development for primary mainte

69 ory cytokines inhibit DC maturation, whereas co-stimulation-blocking agents can also promote the indu

70 ross-presentation of associated peptides and co-stimulation by APCs that interact with alpha(2)M.

71 endritic cells (but not on tumour cells) and co-stimulation by B7-1&2 (a peripheral membrane protein

72 as dispensable, with TIGIT restricting CD226 co-stimulation by blocking interaction with their common

73 Moreover, co-stimulation by CXCL12 together with soluble VCAM-1 po

74 3 ligation alone, activation of JNK requires co-stimulation by the CD28 receptor.

75 nt findings, however, suggest that eliciting co-stimulation can also induce tolerance.

76 diac allograft survival with combined T cell co-stimulation (CD28-CD80/86 and CD154-CD40) blockade in

77 ence (%CD57+CD28-), exhaustion (%PD-1+), and co-stimulation (%CD57- CD28+) on CD4+ and CD8+ T cells.

78 However, BCR signaling without appropriate co-stimulation commits B cells to death rather than to d

79 Our data indicate that negative co-stimulation constrains the possible cell states that

80 TGF-beta and TCR co-stimulation converts thymic CD4+CD25+ T cells into CD

81 We found that spinal and muscle co-stimulation could be closely predicted as the linear

82 duration of antigenic stimulation, degree of co-stimulation, cytokine environment, and CD4(+) T-cell

83 In the presence of co-stimulation-deficient T cell activation, anergy is a

84 T-cell co-stimulation delivered by the molecules B7-1 or B7-2 t

85 l type I interferons (IFNs) directly inhibit co-stimulation-dependent T reg cell activation and proli

86 larly, induction of anergy in the absence of co-stimulation during activation was associated with red

87 ICOS-ligand (ICOS-L) are crucial for T-cell co-stimulation, effector cell differentiation and memory

88 Furthermore, co-stimulation enhanced production of CCL2 as well as ph

89 CB1R and IL-6R co-stimulation enhanced the differentiation of rat corti

90 g expression of optimal surrogate markers of co-stimulation/exhaustion signatures in independent data

91 ity LFA-1, only high affinity LFA-1 provides co-stimulation for CD8(+) T cell activation.

92 trispecific binds CD28, which serves as both co-stimulation for T-cell activation and an additional t

93 he difference between predicted and observed co-stimulation forces.

94 ls migrated into the tumor, where additional co-stimulation from antigen-presenting cells drove effec

95 evels of co-stimulation, with RA attenuating co-stimulation from interfering from FoxP3 induction.

96 new antigen affinities, and enhanced T cell co-stimulation further promoted new antigen recognition.

97 Historically, co-stimulation has been regarded as a prerequisite for T

98 6), anti-CD20 and those that modulate T-cell co-stimulation have consistently shown good efficacy in

99 pase 8 activation were not inhibited by IBOP co-stimulation, however, resulting in a 2.6-fold increas

100 D8(+) T cells can evoke cell-autonomous CD28 co-stimulation in cis in peripheral tissues, suggesting

101 f CTLA4Ig-induced blockade of CD28-B7 T-cell co-stimulation in conjunction with intrathymic immunomod

102 Much attention has focused on the role of co-stimulation in dictating tolerance versus immunity to

103 e roles of cytokines, antigenic signals, and co-stimulation in guiding T cell responses, data indicat

104 cs in response to dopamine and acetylcholine co-stimulation in living flies.

105 r findings thus reveal a function of B7-CD28 co-stimulation in shaping the T cell repertoire and limi

106 reinforces the key role of CD154-CD40 T-cell co-stimulation in the pathophysiology of liver I/R injur

107 We demonstrate here that CD27-CD70 co-stimulation in the thymus rescues developing Treg cel

108 en receptor-mediated death can be rescued by co-stimulation, in which the roles of protein kinase C a

109 ed IFN-gamma production; however, only MCP-1 co-stimulation increased IL-4 production, whereas MIP-1

110 educe Akt S473 phosphorylation and to reduce co-stimulation-independent IL-2 production in Dicer-defi

111 aggregation defects could be rescued by ADP co-stimulation, indicating that they are a consequence o

112 TCR ligation and co-stimulation induce cellular division; however, optima

113 ed here helps explain how G(i/o) and G(q/11) co-stimulation induces a faster activation of TRPC4 than

114 Co-stimulation is a prerequisite for pathogenic activity

115 mmune activation while suppression of T-cell co-stimulation is coincident with selective upregulation

116 Although co-stimulation is essential for boosting and shaping the

117 induce an immune reaction, probably because co-stimulation is missing.

118 y, we find that where evidence of CD4 T-cell co-stimulation is pronounced, that of CD8 T-cell exhaust

119 xhausted' T-cell state driven by CD2-induced co-stimulation is reduced by signals through the exhaust

120 ell receptor (TCR) stimulation together with co-stimulation is sufficient for the activation of both

121 Adoptive T-cell therapy using CD3/CD28 co-stimulation likely requires in vivo generation of ant

122 nt stimulation and the electrical vestibular co-stimulation measured by vestibular evoked myogenic po

123 Our findings demonstrate that GITR co-stimulation mediates antitumor immunity by promoting

124 T-cell co-stimulation modulation with abatacept for 12 months r

125 Co-stimulation modulation with abatacept slowed reductio

126 The selective co-stimulation modulator abatacept demonstrated efficacy

127 eating high risk individuals with the T-cell co-stimulation modulator abatacept.

128 Upon antigen engagement and proper co-stimulation, naive lymphocytes exit quiescence and un

129 raises the questions of whether and how CD28 co-stimulation occurs in peripheral tissues.

130 on, production of pathogenic antibodies, and co-stimulation of autoreactive T cells.

131 g G protein-coupled signaling profile, where co-stimulation of both receptors leads to strongly reduc

132 ed senescence of CD8+ T cells, and decreased co-stimulation of CD4+ and CD8+ T cells (all P < .05), a

133 igger activation of natural killer cells and co-stimulation of effector T cells, and may thus promote

134 These data demonstrate that co-stimulation of G(12/13) and G(i) pathways is sufficie

135 olishment of platelet aggregation induced by co-stimulation of G(q) and G(i) pathways, but not by G(1

136 nogen receptor antagonist was not rescued by co-stimulation of G12/13 pathways in the presence of Pyk

137 In addition, TxA2 generation induced by co-stimulation of Gi and Gz pathways, which is dependent

138 This effect is specific for the co-stimulation of IGFBP-3 with TGF-beta1 because a combi

139 ssion of IL-13Ralpha1 is more dependent upon co-stimulation of immunoglobulin and CD40 receptors.

140 ng is analogous to the activation of ICat by co-stimulation of M2 and M3 receptors.

141 utoimmune GWAS to cRE active during TCR-CD28 co-stimulation of naive human CD4+ T cells.

142 CARMIL2 is required for CD28-mediated co-stimulation of NF-kB signaling in T cells and its def

143 pression is regulated, we considered whether co-stimulation of NIH3T3 cells with RA and epidermal gro

144 se results were corroborated in vitro, where co-stimulation of norrin with VEGF or stimulation of nor

145 Co-stimulation of PBMCs with AQP4-IgG/AQP4 immunocomplex

146 In addition, co-stimulation of purified human T cells was significant

147 ting dendritic cells (DC) and is involved in co-stimulation of T cells by DC.

148 CD97 has been shown recently to mediate co-stimulation of T cells via CD55.

149 Although co-stimulation of T cells with agonist antibodies target

150 Membrane-bound ligands for stimulation and co-stimulation of T-cell receptors are presented via the

151 wever, antibody stimulation was dependent on co-stimulation of the FcgammaII receptor (CD32) since sp

152 f a vaccine targeting PSA that also enhances co-stimulation of the immune system did not seem to exac

153 Whereas co-stimulation of the T-cell antigen receptor (TCR) and

154 tive to a calcineurin inhibitor (CNI), while co-stimulation of TLRs and BCRs induced differentiation

155 In both, most fields elicited by co-stimulation of two laser beams were well explained by

156 4(+) T cell therapy in combination with OX40 co-stimulation or CTLA-4 blockade can eradicate melanoma

157 Blockade of ICOS:ICOSL co-stimulation or MHCII-expression on B cells is central

158 on a cluster of differentiation (CD)40/CD154 co-stimulation pathway blockade, (iii) the patient shoul

159 As the CD154-CD40 co-stimulation pathway provides essential second signal

160 These include blockade of co-stimulation pathways and agonism of coinhibitory path

161 CD40 co-stimulation prevents TFEB-driven cell death, while en

162 e that abatacept, a drug that blocks CD80/86 co-stimulation, produces changes at the systemic level t

163 e to T1D through their enhanced capacity for co-stimulation, proliferation, and inflammatory cytokine

164 s a key role in the mechanism by which LFA-1 co-stimulation promotes B-cell activation and IS formati

165 We also found that 4-1BB co-stimulation promotes lower PD-1 expression in B7-H3.C

166 Its biologic effects include T-cell co-stimulation, promotion of erythropoiesis, angiogenesi

167 tivation of CD8(+) T cells in the absence of co-stimulation provided by CD80 and CD86 molecules.

168 l antigen receptors and specific CD2-induced co-stimulation provided to human CD8 T cells in vitro, s

169 ry T cells, with increased expression of the co-stimulation receptors ICOS, CD28 and interleukin 18 r

170 Co-stimulation regulates T cell activation, but it remai

171 The consequence is a decrease in the co-stimulation required to develop an effective immune r

172 es in the thymic medulla, in which CD27-CD70 co-stimulation rescues developing Treg cells from apopto

173 be true, it would simplify the prediction of co-stimulation responses and the development of control

174 estern blot analysis showed that HU and IL-6 co-stimulation resulted in increased levels of Sp1 and S

175 ation and increased antigen presentation and co-stimulation, resulting in increased expansion of tumo

176 A lack of co-stimulation results in peripheral T-cell tolerance, w

177 timulatory signal, and dominance of negative co-stimulation results in T cell dysfunction(2).

178 ompatibility complex interaction (signal 1), co-stimulation (signal 2) and cytokine signaling (signal

179 by antigen/MHC (signal 1) and CD28-dependent co-stimulation (signal 2), resting CD4(+) T cells commit

180 Negative co-stimulation signaling by hepatic T-cells might be dev

181 nctions triggered by antigen recognition and co-stimulation signals are associated with a rapid and i

182 When combined with soluble co-stimulation signals, MHC II artificial APCs (aAPCs) e

183 h LNCaP cells are capable of this mode of AR co-stimulation, stable expression of mutant beta-catenin

184 However, co-stimulation studies show that Galphaq receptor agonis

185 der certain levels of TCR signal strength or co-stimulation, such as effector/memory (CD4(+)TEM and C

186 that "peripheral" blockade of CD28-B7 T-cell co-stimulation synergizes with the "central" immunosuppr

187 CD3/CD28 co-stimulation, therefore, generates T1 or T2 population

188 encounter foreign antigen along with proper co-stimulation they undergo rapid and extensive clonal e

189 The effects of B7-1 and B7-2 co-stimulation through CD28 depend on the strength of th

190 and can inhibit T cells by preventing CD226 co-stimulation through interactions in cis or through co

191 Augmented co-stimulation through NKG2D confers a high rate of surv

192 We demonstrate that augmented co-stimulation through NKG2D during priming paradoxicall

193 These findings demonstrate that augmented co-stimulation through NKG2D is effective in rescuing CD

194 T-cell activation requires co-stimulation through receptors such as CD28 and antige

195 our studies demonstrate the ability of CD28 co-stimulation to fine tune subset-specific responses by

196 to present tumor antigens in the context of co-stimulation to overcome tolerance and induce tumor-sp

197 amma upon antigenic stimulation, and require co-stimulation to proliferate to anti-CD3 stimulation.

198 a skewing of the TIGIT/CD226 axis from CD226 co-stimulation towards TIGIT-mediated inhibition of CD8(

199 ocytes, antigen recognition with appropriate co-stimulation triggers exit from G0 phase of the cell c

200 oped an autologous CART19 product with 4-1BB co-stimulation using a novel humanized chicken antibody

201 Co-stimulation via FcepsilonRI, using IgE/antigen, and C

202 Co-stimulation via the CD28 receptor is required for eff

203 the master transcription factor Bcl-6, ICOS co-stimulation was essential to maintain the phenotype b

204 onstrate that CD8 T cells require DNAM-1 for co-stimulation when recognizing antigen presented by non

205 TLA-4 Ig and anti-CD40L antibody) that block co-stimulation, which is essential for full T cell activ

206 rophage inflammation in the absence of H + L co-stimulation, while miR-210-3p inhibitor notably compr

207 reased IL-17 response to phytohaemagglutinin.Co-stimulation with A. fumigatus and M. avium leads to a

208 ss of synergistic TNF-alpha production after co-stimulation with A. fumigatus and M. avium.

209 fects of SIL, yet this was not restorable by co-stimulation with ANP.

210 ial cells exhibited synergistic responses to co-stimulation with AP and lipopolysaccharide.

211 Co-stimulation with ATP and either PTHrP (43-52) or PTHr

212 Co-stimulation with both MCP-1 and IL-6 did not elevate

213 1-mediated transcriptional activity, whereas co-stimulation with both Wnt3a and BMP-2 markedly reduce

214 Co-stimulation with carbachol and 8-pCPT-2'-O-Me-cAMP le

215 anced, whereas nuclear pSTAT3 was reduced by co-stimulation with CCK-8s.

216 Co-stimulation with CRH and AVP results in complex patte

217 Co-stimulation with CSE, IL-17A and aeroallergens furthe

218 Co-stimulation with CTS and pharmacological agents that

219 Co-stimulation with forskolin and acetylcholine promoted

220 tivation of AP-1:Luc observed in response to co-stimulation with growth factors and Ro-31-8220.

221 Upon co-stimulation with HCV-E2 and HIV-gp120, we observed a

222 on and function can be profoundly altered by co-stimulation with inhibitory receptors.

223 Co-stimulation with insulin does not affect the IL-1beta

224 ssive transcriptional activity of NFAT1 upon co-stimulation with ionomycin and phorbol 12-myristate 1

225 erferons in response to rhinovirus exposure, co-stimulation with rhinovirus and IFN-alpha upregulated

226 Co-stimulation with TGF-beta1 and TNF-alpha induced an a

227 eased the secretion of STC-1 but it required co-stimulation with the Adenosine-3', 5'-cyclic monophos

228 ne expression in human mesangial cells after co-stimulation with thrombin and tumor necrosis factor a

229 a moderate upregulation of preproET-1 mRNA, co-stimulation with TNFalpha resulted in a strong and pr

230 romoter (-4.4 kbp to 204 bp) was overcome by co-stimulation with TNFalpha, providing a possible mecha

231 ccurs even in the presence of high levels of co-stimulation, with RA attenuating co-stimulation from

232 SCO-100/Matrix-M (AbISCO), to assess if TLR9 co-stimulation would quantitatively or qualitatively mod