ライフサイエンスコーパス: cobblestone

1 present in year 5 versus year 10 as follows: cobblestone, 19% versus 30%; and reticular pigmentary ch

2 olithic communities inhabit the underside of cobblestones and pebbles in diverse desert biomes.

3 Superficial hemangiomas with a cobblestone appearance or rough surface left more severe

4 proliferate on the SF and denuded AM with a cobblestone appearance, abundant microvilli on the surfa

5 Amot was sufficient to restore an epithelial cobblestone appearance, Yap1 localization, and growth co

6 Epithelial sheets often present a "cobblestone" appearance, but the mechanisms underlying t

7 w stromal cell lines: HS-27a, which supports cobblestone area formation by early hematopoietic progen

8 of primitive hematopoietic cells, using the cobblestone area forming cell (CAFC) assay, in marrow of

9 The frequency of cobblestone area forming cells (CAFC) was used as a mean

10 tion of 45% of primary CFU-Cs, 33% of week-5 cobblestone area forming cells (CAFCs), and 18% of week-

11 ic progenitor cells (PHP), as defined by the cobblestone area-forming cell (CAFC) assay, and for bone

12 ed in eight strains of inbred mice using the cobblestone area-forming cell (CAFC) assay.

13 tive transplantation and quantitative week-5 cobblestone area-forming cell (CAFC) assays.

14 sigma-deficient BM cells displayed increased cobblestone area-forming cell (CAFC) capacity and augmen

15 -forming units (CFUs) in methylcellulose and cobblestone area-forming cell (CAFC) subsets in stromal-

16 tion between colony-forming cell (n = 10) or cobblestone area-forming cell (n = 9) numbers and clinic

17 m repopulating ability and day 28 and day 35 cobblestone area-forming cell [CAFC] frequencies).

18 topoietic stem cells as measured in vitro by cobblestone area-forming cell assays and in vivo by comp

19 (BU; 30 micro M) for 6 h also inhibited the cobblestone area-forming cell frequency but failed to ca

20 on were assessed for colony-forming cell and cobblestone area-forming cell potential, and multilineag

21 itro hematopoiesis as evidenced by continued cobblestone area-forming cells (CAFC) activity for at le

22 The frequency of cobblestone area-forming cells (CAFC) day-35 in DBA feta

23 FU-GM), and a 12-fold to 17-fold increase of cobblestone area-forming cells (CAFC) over input.

24 Sorted cells were highly enriched in cobblestone area-forming cells (CAFC), but their frequen

25 weeks and examined the migratory activity of cobblestone area-forming cells (CAFCs) and long-term cul

26 ion of the frequency of various day types of cobblestone area-forming cells in association with the i

27 tors, but enhanced the growth of stem cells (cobblestone area-forming cells), resulting in a profound

28 These surviving cells (1) are enriched for cobblestone area-forming cells, (2) repopulate fragments

29 LEC-1 and 5-FUBMC cocultures showed cobblestone-area formation and the presence of hematopoi

30 In MS-5 stromal cocultures, numerous early cobblestone areas (CAs) were generated within 10 to 14 d

31 ivity in vitro, but lost the ability to form cobblestone areas after 5 to 6 weeks in culture.

32 found to increase the size and frequency of cobblestone areas at 4 weeks in stromal cultures in the

33 cloning efficiency and a lower frequency of cobblestone areas compared with normal granulocyte colon

34 These cobblestone areas contain both primitive high-proliferat

35 ed stem cells by promoting the formation of "cobblestone areas" of proliferation.

36 Cobblestone brain malformation (COB) is a neuronal migra

37 cal defects such as lissencephaly type II or cobblestone brain.

38 to endothelial-like cells characterized by a cobblestone cell morphology, expression of endothelial m

39 , elongated morphology to an epithelium-like cobblestone clustering.

40 omal-dependent, cytokine-driven formation of cobblestone colonies on secondary plating.

41 oncentrations of colony-forming unit spleen, cobblestone colonies, and long-term colony-initiating ce

42 ic electrodiagnostic changes, brain MRI with cobblestone complex, and mutation in the fukutin gene.

43 g finding typically seen in combination with cobblestone cortex and congenital muscular dystrophy in

44 re four crucial events in the development of cobblestone cortex, namely defective pial basement membr

45 Cortical dysplasia resembling cobblestone cortex, with basement membrane breakdown and

46 drusen, senile reticular pigmentary changes, cobblestone degeneration, and FAF abnormalities.

47 c retinal tuft, meridional fold, lattice and cobblestone degeneration, retinal hole, retinal tear, rh

48 retinal tuft, meridional fold, lattice, and cobblestone degenerations.

49 n of EGCG and U0216 resulted in cells with a cobblestone epithelial phenotype.

50 mammalian target of rapamycin (mTOR) rescues cobblestone formation in myr-AKT-expressing bone marrow

51 ongly impaired primary AML cell survival and cobblestone formation in stromal cocultures.

52 row was obtained for determination of early (cobblestone forming cells) and late (granulocyte-macroph

53 Bone marrow cellularity, cobblestone forming cells, granulocyte-macrophage colony

54 ressing bone marrow cells are unable to form cobblestones in long-term cocultures.

55 ure undergo a commitment stage, during which cobblestone-like cells grow to high density past conflue

56 rons beyond the pial basement membrane and a cobblestone-like cortical malformation similar to the ph

57 o neuronal ectopia in the cerebral cortex, a cobblestone-like cortical malformation.

58 l pigment epithelium (RPE) is a monolayer of cobblestone-like epithelial cells that accomplishes crit

59 king reversion from poorly differentiated to cobblestone-like epithelial morphology, indicating a cru

60 normal osteocytes that were more rounded and cobblestone-like in shape and were aligned in irregular

61 al cells (DMVEC) transforms the cells from a cobblestone-like monolayer to foci-forming spindle cells

62 Stem-cell-derived RPE cells exhibit cobblestone-like morphology, transcripts, proteins and p

63 ques without affecting the contact-inhibited cobblestone-like phenotype of adjacent uninfected DMVEC.

64 Heterotopias resembling those found in cobblestone lissencephalies in which neuroepithelial cel

65 pathways are involved in the pathogenesis of cobblestone lissencephalies.

66 Cobblestone lissencephaly (COB) is a severe brain malfor

67 matrix (ECM) are frequently associated with cobblestone lissencephaly and mental retardation.

68 l form of congenital muscular dystrophy with cobblestone lissencephaly and structural eye defects to

69 nd gliosis also occurred, similar to type II cobblestone lissencephaly as seen in congenital muscular

70 the functions of TMTCs provide insight into cobblestone lissencephaly caused by deficiency in TMTC3.

71 Analysis of TMTC3 mutations associated with Cobblestone lissencephaly found that three of the varian

72 previously established Drosophila model for cobblestone lissencephaly was used to understand how Dg

73 ortex in both humans and mice that resembles cobblestone lissencephaly, which is characterized by ove

74 nized laminin in meningeal fibroblasts and a cobblestone lissencephaly-like phenotype in the developi

75 ation, as well the basis of TMTC3-associated Cobblestone lissencephaly.

76 cits, 2 phenotypes that frequently accompany cobblestone lissencephaly.

77 o neuronal cell migration diseases including Cobblestone lissencephaly.

78 sembling the cerebral cortex malformation in cobblestone lissencephaly.

79 some features resembling defects in type 2 (cobblestone) lissencephaly or congenital muscular dystro

80 play severe cortical phenotypes that feature cobblestone malformations.

81 om neighboring cells and lost their original cobblestone monolayer pattern when CsA was added.

82 bsence of any effect on cells present in the cobblestone monolayer.

83 othelial cells retained their characteristic cobblestone morphology and expression of tight junction

84 cells assume the characteristic endothelial cobblestone morphology and form tubes.

85 WNT5A expressing cells demonstrated cobblestone morphology and reduced in vitro migration re

86 Cell monolayers exhibited cobblestone morphology and were immunopositive for corne

87 he cortex, and cell shapes were altered from cobblestone morphology to irregular shape.

88 he epithelial cells stayed in their original cobblestone morphology with treatment of TGF-beta1 inhib

89 ells, immature cells differentiated, assumed cobblestone morphology, and labeled with the epithelial

90 Immortalized hVFE across passages have cobblestone morphology, express epithelial markers cytok

91 ial cells, as indicated by the appearance of cobblestone morphology, induction of E-cadherin expressi

92 ike shape replaced characteristic epithelial cobblestone morphology.

93 fining characteristics of ECFCs such as (i) 'cobblestone' morphology of cultured cell monolayers; (ii

94 ithelial morphology with a less well-defined cobblestone pattern than the parental line.

95 ndrome presented with skin-colored to yellow cobblestoned plaques to the neck and bilateral antecubit

96 nsively, and can redifferentiate into stable cobblestone RPE monolayers.

97 VEC) in culture results in the conversion of cobblestone-shaped cells to spindle-shaped cells, a char

98 in vivo, including phenotypic maturation of cobblestone-shaped osteoblasts into stellate-shaped oste

99 uggest that tonal GSK3beta repression at the cobblestone stage of osteoblast differentiation permits

100 n DMVECs was associated with a change from a cobblestone to a spindle shape, LANA expression, and an

101 Cobblestone (type II) lissencephaly and mental retardati

102 evere cortical lamination defects resembling cobblestone (type II) lissencephaly.

103 iodical measurements of the water content of cobblestone undersides were carried out.

104 sulting in wet-dry cycles and wetting of the cobblestone undersides.

105 show that two ileal IBD-stereoenterotypes ('cobblestones' versus 'villous mini-aggregation') cluster

106 vapor condensation on the undersides of the cobblestones, with the daily wet phase lasting for sever