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1 0) hydroxoaquocobinamide (hereinafter called cobinamide).
2 e of all three variants and the intermediate cobinamide.
3 gh binding affinity for the cobalamin analog cobinamide.
4 ile method to measure cyanide in blood using cobinamide.
5  a facile method for producing and purifying cobinamide.
6 wn de novo intermediate, and did not salvage cobinamide.
7 ll depended on the assimilation of exogenous cobinamide.
8 ilar effects observed using the NO scavenger cobinamide.
9 everal commercially available cobalamins and cobinamide.
10 d for cob(II)alamin, base-off cobalamins, or cobinamides.
11                         Cobalamin (1.4%) and cobinamide (1.8%) (an incomplete corrinoid) represented
12                                              Cobinamide, 5', 6'-dimethylbenzimidazole, and 2-aminopro
13 is in Drosophila melanogaster, we found that cobinamide, a B(12) analog and an effective NO scavenger
14                    We showed previously that cobinamide, a cobalamin (vitamin B12) precursor, binds N
15  on the electronic properties of Cbls is Ado-cobinamide (AdoCbi(+)), an AdoCbl derivative that lacks
16 s increased by Deta-NONOate and decreased by cobinamide and ablation of mTORC2 activity.
17 er preformed B(12) or two of its precursors, cobinamide and DMB.
18 acteria predicted to be capable of salvaging cobinamide and synthesizing only the activated lower lig
19 appeared to convert most of the cobalamin to cobinamide and the 4 analogues that contain the bases-2-
20                                              Cobinamide appeared to act via scavenging NO because it
21 inity, and we now evaluated the potential of cobinamide as a NO scavenger in biologic systems.
22  human HC in complex with cyanocobalamin and cobinamide at 2.35 and 3.0 A resolution, respectively.
23                                              Cobinamide augmented the effect of an antibiotic and was
24                  The vitamin B(12) precursor cobinamide binds cyanide with high affinity, changing co
25 ossible to detail the activities of purified cobinamide biosynthesis (Cbi) proteins CbiF, CbiG, CbiD,
26 ux through the 5,6-dimethylbenzimidazole and cobinamide (Cbi) activation branches of the nucleotide l
27 owing conversion of the incomplete corrinoid cobinamide (Cbi) into AdoCbl.
28                                              Cobinamide (Cbi) salvaging is impaired, but not abolishe
29 nents of two distinct pathways for salvaging cobinamide (Cbi), a precursor of adenosylcobalamin (AdoC
30 se distinct pathways for salvaging exogenous cobinamide (Cbi), a precursor of adenosylcobalamin (coen
31 importing an "incomplete" corrinoid, such as cobinamide (Cbi), and adding appropriate alpha- and beta
32 d cobalamin (Cbl) as a substrate better than cobinamide (Cbi; a Cbl precursor); the beta phosphate of
33 terest, we also studied reactions of NO with cobinamide [Cbi] in the 2+ and 3+ oxidation states.
34  A novel cyanide analyzer based on sensitive cobinamide chemistry relies on simultaneous reagent and
35  present a new method for the preparation of cobinamide (CN)2Cbi, a vitamin B12 precursor, that shoul
36 also utilize the incomplete corrinoid Co (1+)cobinamide (Co (1+)Cbi) as an alternative substrate.
37 tronic excited states of Co(2+)Cbl and Co(2+)cobinamide (Co(2+)Cbi(+), a cobalamin derivative that la
38  (2-pic) and pyridine (py) adducts of Co(II) cobinamide (Co(II)Cbi(+)), adducts thought to have long
39 ee radical-neutralizing vitamin B(12)-analog cobinamide completely prevents age-related aortic wall d
40                                              Cobinamide could be a treatment for aortic aneurysms whe
41                                              Cobinamide did not inhibit the in vitro activity of eith
42                   In rodent and human cells, cobinamide exhibited toxicity at concentrations > or =50
43 t CobU requires a nucleoside upper ligand on cobinamide for substrate recognition, with the nucleosid
44 e assimilation of exogenous unphosphorylated cobinamide from its environment.
45  paper reports evidence that archaea salvage cobinamide from the environment by using a pathway diffe
46 osynthesis pathway, but efficiently salvaged cobinamide from the environment, suggesting the existenc
47              The auxotrophic requirement for cobinamide-GDP was corrected when a wild-type allele of
48  allele of the cobY gene was auxotrophic for cobinamide-GDP, a known intermediate of the late steps o
49                     Combining cobalamin with cobinamide had no effect on the ability of cobinamide to
50            The ability of archaea to salvage cobinamide has been under question because archaeal geno
51 dative stress in cells and tissues, and that cobinamide has promise as a first specific treatment for
52                              Given that aryl cobinamides have many side chains that increase their co
53  are consistent with a salvaging pathway for cobinamide in which an amidohydrolase enzyme cleaves off
54 ongly support the proposal that the relevant cobinamide intermediates during de novo adenosylcobalami
55                             We conclude that cobinamide is an effective intra- and extracellular NO s
56 noid substrates that are believed to include cobinamide, its precursor cobyric acid and probably othe
57                       Compared to cobalamin, cobinamide lacks the tethered 5,6-dimethylbenzamidazolyl
58                      Moreover, feeding flies cobinamide markedly attenuated subsequent NO-induced inc
59                                              Cobinamide on the filter changes color from orange (lamb
60                                     Alkaline cobinamide (orange, lambda(max) = 510 nm) changes to vio
61                                We found that cobinamide reversed NO-stimulated fluid secretion in Dro
62                       The vitamin B12 analog cobinamide reversed the cellular toxicity of sulfide, an
63                                              Cobinamide's mechanism of action appeared to be from red
64          The latter activity is required for cobinamide salvaging in bacteria.
65 B mutants suggested that the entry point for cobinamide salvaging is adenosylcobyric acid.
66  of color change increases 10 times when the cobinamide solution for filter impregnation is prepared
67 sphate guanylyltransferase needed to convert cobinamide to adenosylcobinamide-GDP during the late ste
68 modeling of pseudocobalamin and salvaging of cobinamide to produce cobalamin.
69 h cobinamide had no effect on the ability of cobinamide to scavenge NO.
70  not presence, of cobalamin, suggesting that cobinamide toxicity was secondary to interference with c
71 ded to analyze structural properties of aryl cobinamides using cryogenic ion vibrational predissociat
72                                              Cobinamide was taken up efficiently by cultured rodent c
73  the cobalt in the lower axial position, and cobinamide, which lacks the dimethylbenzimidazole nucleo
74                   Lastly, an RNA aptamer for cobinamide, which was originally selected in the presenc
75 yme B(12) de novo and from Cby, but not from cobinamide, which was the expected phenotype for an L-th
76                                              Cobinamides, with the B(12) 5,6-dimethylbenzimidazole lo
77                                              Cobinamide worked through two distinct mechanisms: direc
78   Here we show that adding sodium nitrite to cobinamide yields a stable derivative (referred to as ni