ライフサイエンスコーパス: cochaperone

1 fer process requires Jac1, a J-protein Hsp70 cochaperone.

2 mplex is rescued by Sec17, a universal SNARE cochaperone.

3 A is a DnaJ homolog that functions as a DnaK cochaperone.

4 model that trehalose functions as a chemical cochaperone.

5 r J-domain protein, Hdj-2, a recognized CFTR cochaperone.

6 ment, thus revealing novel functions of this cochaperone.

7 TTI2 (Tel2-interacting protein 2) molecular cochaperone.

8 more gp93 biology by identifying CNPYb as a cochaperone.

9 ATP hydrolysis on Hsp90 and the Hop and p23 cochaperones.

10 network of protein-protein interactions for cochaperones.

11 l for their interactions with substrates and cochaperones.

12 ces dissociation of the client and remaining cochaperones.

13 ds of client proteins with the assistance of cochaperones.

14 expansive network that includes a variety of cochaperones.

15 d by the integrated expression of regulatory cochaperones.

16 culum (ER), is believed to be independent of cochaperones.

17 functions of Hsp70 chaperones and associated cochaperones.

18 dified the association of hsp90 with several cochaperones.

19 ewly identified member of the DnaJ family of cochaperones.

20 nst Hsp90 may be enhanced in the presence of cochaperones.

21 ed proteins, including Hsp90 and most of its cochaperones.

22 Ec but retained the ability to act with DnaK cochaperones.

23 ctions with the Hsp70 chaperone and numerous cochaperones.

24 chaperone, DnaK, but is independent of Hsp90 cochaperones.

25 strategies targeting multiple chaperones and cochaperones.

26 ochondrial Hsp70 (mtHsp70) and its J protein cochaperone [2].

27 metazoan protein BCL2-associated athanogene cochaperone 6 (Bag6) forms a hetero-trimeric complex wit

28 BCL2-associated athanogene cochaperone 6 (Bag6) plays a central role in cellular ho

29 haperone functions and interactions with the cochaperone 78-kDa glucose-regulated protein (binding im

30 ble to bind to this site, and that these two cochaperones act competitively, through Hsp90, to modula

31 Here, we find that the cochaperone, activator of Hsp90 ATPase homolog 1 (Aha1),

32 Furthermore, we show that the cochaperone activity of auxilin is required for constric

33 gi structure formation is independent of its cochaperone activity or Hsc70, rather, through DjA1-GRAS

34 h expression level, isoform specificity, and cochaperone activity.

35 he Hsp90 chaperone system is mediated by the cochaperone adaptor protein Cdc37, which acts as a scaff

36 s of the Hsp90 cycle-for example, by various cochaperones-affects the activation of different clients

37 onship between Hsp90 oligomers and the Hsp90 cochaperone Aha1 (activator of Hsp90 ATPase).

38 adenosine triphosphatase (ATPase)-activating cochaperone Aha1 and, unexpectedly, the binding of Hsp90

39 37) and recruitment of the ATPase activating cochaperone AHA1, but the molecular regulation of this c

40 the activation of its ATPase activity by the cochaperone Aha1.

41 yeast cytosolic Hsp90 can be relieved by the cochaperone aha1.

42 ne function and impacts interaction with the cochaperones Aha1 and Cdc37.

43 R, whereas nearly twice as much of the Hsp90 cochaperone, Aha1, associated with DeltaF508 CFTR.

44 sruption of the excessive association of the cochaperone, Aha1, with DeltaF508 CFTR is associated wit

45 ck cognate B), which encodes a mitochondrial cochaperone, also known as HSC20 (heat shock cognate pro

46 ions in conjunction with Hsp70 and the Hsp70 cochaperones, an Hsp40 (J-protein) and a nucleotide exch

47 s site conserved among Hsp70 proteins alters cochaperone and client interactions.

48 ) is an immunoglobulin-binding protein (BiP) cochaperone and component of the endoplasmic reticulum-a

49 n that they can bypass the requirement for a cochaperone and result in the recovery of client protein

50 a protein family including a tubulin folding cochaperone and the retinitis pigmentosa protein RP2, in

51 As both a cochaperone and ubiquitin ligase, the C-terminal Hsp70 (

52 enables them to be modulated by ligands and cochaperones and "tuned" through evolution.

53 In concert with cochaperones and accessory proteins, heat shock proteins

54 the assembly of multiprotein complexes with cochaperones and clients.

55 tein 70 (HSP70) acts in concert with several cochaperones and nucleotide exchange factors and plays a

56 conformational changes that are regulated by cochaperones and numerous posttranslational modification

57 lamp' interactions between Hsp90 and its TPR cochaperones and show that they block binding between Ho

58 association between HSP70 and several of its cochaperones and substrate proteins.

59 involved, although acetylation affects ATP, cochaperone, and client protein binding to hsp90alpha, a

60 Among these were Bag1, encoding a Hsp70 cochaperone, and Csde1, encoding an RNA-binding protein,

61 shown conclusively to hydrolyze ATP or bind cochaperones, and both activities, by contrast, result i

62 d insight into molecular mechanism of Hsp90, cochaperones, and clients' structure and function.

63 ting a functional interplay among DnaK, DnaK cochaperones, and Hsp90Ec.

64 way, which revealed a network of chaperones, cochaperones, and targeting factors that together drive

65 Molecular chaperones and cochaperones are the most abundant cellular effectors of

66 DNAJC14, a heat shock protein 40 (Hsp40) cochaperone, assists with Hsp70-mediated protein folding

67 rocess, multiple Hsp70- and Hsp90-associated cochaperones associate with receptor-chaperone complexes

68 as a "flag" for Hsp90 dependence and stable cochaperone association.

69 ated by partial siRNA silencing of the Hsp90 cochaperone ATPase regulator Aha1.

70 te that BNRF1 substitutes for the repressive cochaperone ATRX to form a ternary complex of BNRF1-Daxx

71 icated GARRPR motif at the N terminus of the cochaperone Bag-1L functions through the BF-3 pocket.

72 ere we show that the AR AF-1 is bound by the cochaperone Bag-1L.

73 We further provide evidence that the cochaperone BAG2 contributes to HSP70 stabilization in t

74 t mechanism of Tau degradation involving the cochaperone BAG2.

75 STIM1 interacts with the cochaperone BAG3 and localizes to autophagosomes in mito

76 ylase Usp7, the ubiquitin ligase Parkin, the cochaperone Bag6, and the protein phosphatase UBLCP1-sti

77 ncompassing exon 4 of the heat shock protein cochaperone BCL2-associated athanogene 3 (BAG3), was fou

78 formation also relies on the stress-induced cochaperone Bcl2-associated athanogene 3.

79 Many important cochaperones bind Hsp90 through their tetratricopeptide

80 and FKBP4 for efficient RNAi and that these cochaperones bind to hAgo2, we predict that loading of h

81 These findings reveal a new cochaperone binding site near the N terminus of hsp90, a

82 s a strong determinant of client protein and cochaperone binding.

83 rone whose activity is regulated not only by cochaperones but also by distinct posttranslational modi

84 malian gp96 was further found to require the cochaperone canopy 3 (CNPY3) for proper folding and expr

85 It suggests that the cochaperone Cdc37 aids Hsp90 to activate kinase clients

86 Here, we report that the Hsp90 cochaperone Cdc37 directly interacts with IRE1alpha thro

87 at its activation is ATP-dependent, with the cochaperone Cdc37 increasing the efficiency.

88 PP5-mediated dephosphorylation of the cochaperone Cdc37 is essential for activation of Hsp90-d

89 The cochaperone CDC37 promotes the association of HSP90 with

90 Hsp90 requires cochaperone Cdc37 to load its clients to the Hsp90 super

91 ar factor kappa-B kinase (IKK) together with cochaperone Cdc37, which is critical for the activity of

92 3 ligases for interaction with HSP90 and its cochaperone CDC37.

93 kinases to Hsp90 is actively mediated by the cochaperone Cdc37.

94 mportant subset of clients requiring the key cochaperone CDC37.

95 blishment of the heat-shock protein 90/Hsp90 cochaperone Cdc37/Hsp90-Hsp70-organizing protein chapero

96 Here we show that the Hsp90 cochaperones Cdc37, Aha1, FKBP4, and p23 are required fo

97 e molecular chaperone by the kinase-specific cochaperone cell division cycle 37 (Cdc37).

98 MHC I was also inhibited by knockdown of the cochaperone CHIP that interacts with heat shock proteins

99 gnition of the altered nNOS by Hsp70 and its cochaperone CHIP, an E3-ubiquitin ligase, has been propo

100 -translational degradation in the ER through cochaperone CHIP, Hsp105 has a primary role promoting CF

101 binding EEVD domain and association with the cochaperone CHIP, resulting in ubiquitination and protea

102 to systematically characterize the chaperone-cochaperone-client interaction network in human cells.

103 WDR92 associates with a prefoldin-like cochaperone complex and known dynein assembly factors.

104 ith the PIH1D1 adaptor component of the R2TP cochaperone complex, we examined the requirement of ECD

105 osis and also to be part of a prefoldin-like cochaperone complex.

106 s, delineate their participation in specific cochaperone complexes, and establish a surprisingly dist

107 which come from crystal structures of Hsp90 cochaperone complexes.

108 shock proteins (HSPs), molecular chaperones/cochaperones constituting a major component of the cell

109 e authors' findings reveal that the Hop/Sti1 cochaperone could act as a cell-intrinsic restriction fa

110 gs indicate that the TPR-containing Hop/Sti1 cochaperone could act as a cell-intrinsic virus restrict

111 (RGL) neural stem cells express the synaptic cochaperone cysteine string protein-alpha (CSP-alpha).

112 The cochaperone cysteine-string protein (Csp) is located on

113 f translocating proteins delayed at Sec61 is cochaperone dependent.

114 rotein activity at the same time as delaying cochaperone dissociation from inhibited HSP90-client com

115 Dominant mutations in the HSP70 cochaperone DNAJB6 cause a late-onset muscle disease ter

116 show that overexpression of the ER-resident cochaperone DNAJC14 affects YFV polyprotein processing a

117 by down-regulation of the antagonistic Hsc70 cochaperone DNJ-13, implying that the severe phenotype i

118 Hsc70 with its cochaperone, either auxilin or GAK, not only uncoats cla

119 led degradation, with degradation-inhibiting cochaperones exerting essential prosurvival functions.

120 he ER lumen where its putative function as a cochaperone explains the stress-sensitivity phenotype of

121 ombination of pharmacological inhibition and cochaperone expression reveals that, in vivo, cytosolic

122 are stabilized by the TTT (Tel2, Tti1, Tti2) cochaperone family, whose actions are mediated by CK2 ph

123 Here, we show that the Hsp90 cochaperone, FK506-binding protein 51 (FKBP51), which po

124 The steroid-induced immunophilin cochaperone FKBP51 inhibits PR- and GR-mediated transcri

125 Here, we report that the Hsp90 cochaperone FKBP51 is upregulated in LAPC-4 AI tumors gr

126 ptors is potentiated by the Hsp90-associated cochaperone FKBP52, although not by the closely related

127 has thus established CNPY3 as a TLR-specific cochaperone for gp96.

128 V replication assay and identified the Cns1p cochaperone for heat shock protein 70 (Hsp70) and Hsp90

129 ring protein alpha (CSPalpha), a presynaptic cochaperone for Hsc70, is required for synapse maintenan

130 Here we identify Sgt1, a cochaperone for Hsp90, as a novel Plk1 substrate during

131 he Tel2-Tti1-Tti2 complex is a PIKK-specific cochaperone for Hsp90.

132 Deletion of Fkbp52, an immunophilin cochaperone for PR, results in uterine-specific P(4) res

133 dc37) is a key heat shock protein 90 (Hsp90) cochaperone for protein kinase clients, and Akt/Hsp90 in

134 cm3(HJURP), indicating that Yta7(ATAD2) is a cochaperone for Scm3(HJURP) The absence of Yta7 causes d

135 erichia coli DnaJ homolog, can function as a cochaperone for the DnaK/Hsp70 chaperone system, and its

136 ed, along with its ATPase cycle and relevant cochaperones, for Ubr1-mediated ubiquitination.

137 degeneration in mice, presumably because the cochaperone function of CSPalpha is essential for neuron

138 ion and that YFV probably utilizes DNAJC14's cochaperone function to modulate processing at the NS3/4

139 , heat shock protein 70 (Hsp70), and several cochaperones functionally colocalize with this protein c

140 es, which encode the GroEL chaperone and its cochaperone GroES, responded to heat shock.

141 enes that encode the chaperone GroEL and its cochaperone, GroES, including all of the fully sequenced

142 machinery: heat shock protein 70 (Hsp70) and cochaperone heat shock organizing protein (HOP).

143 The Hsp90 molecular chaperone and its Cdc37 cochaperone help stabilize and activate more than half o

144 manner to peptides derived from the histone cochaperones HirA and CAF-I.

145 Thus Rad53 competes with histones H3-H4 and cochaperones HirA/CAF-I for binding to Asf1.

146 on substrate, histone H3, in addition to its cochaperone, HIRA.

147 We identified four Hsp70 genes and two GrpE cochaperone homolog genes (CGE) in moss that encode chlo

148 he molecular chaperones Hsp70 and Hsp90, the cochaperone HOP, and ubiquitin ligase, CHIP.

149 ultaneously, which is also a property of the cochaperone Hop.

150 The cochaperone HOP/Sti1p also participates in VHL quality c

151 endoplasmic reticulum to the nucleus via the cochaperone Hsp40 pathway.

152 sence of excess Cur1 are counteracted by the cochaperone Hsp40-Sis1 in a dosage-dependent manner, and

153 otein-specific kinase, directly binds to the cochaperones Hsp40/DNAjc8 and Aha1, which mediate dynami

154 iated with cellular chaperones (HSP70) and a cochaperone (Hsp40) which can be coimmunoprecipitated wi

155 nits Rpb1 and Rpb8 associated with the HSP90 cochaperone hSpagh (RPAP3) and the R2TP/Prefoldin-like c

156 te and analyze transgenic mice that lack the cochaperone HSPBP1, a nucleotide-exchange factor of HSP7

157 Two ER chaperone families and their cochaperones, immunoglobulin binding protein (BiP) and c

158 in yeast or knockdown of the orthologous Hop cochaperone in plants leads to increased CIRV replicatio

159 cation, and knockdown of the orthologous Hop cochaperone in plants results in a 3-fold increase in CI

160 mice for a potential role of an immunophilin cochaperone in the etiology of human endometriosis.

161 Cytosolic HSP90 requires multiple cochaperones in folding client proteins.

162 nases after screening several chaperones and cochaperones in gene deletion mutant strains.

163 Given the number and diversity of cochaperones in mammals, it is likely that combinatorial

164 er tetratricopeptide repeat (TPR)-containing cochaperones in regulating Hsp90 activity, the Hsp90-TPR

165 e core chaperone HSC70, assisted by specific cochaperones, in particular class B J-domain proteins an

166 The TPR binding site of Hsp90 cochaperones includes a shallow, positively charged groo

167 multiprotein complex enriched in chaperones/cochaperones including Hsc70.

168 The ATPase cycle is regulated by cochaperones, including DnaJ proteins that accelerate AT

169 resembles a cellular J-protein/HSP40 family cochaperone, interacting specifically with Hsc70.

170 Our results indicate that a hierarchy of cochaperone interaction controls different aspects of th

171 that linker sequence affects Hsp90 function, cochaperone interaction, and conformation.

172 e mechanism of client protein binding or how cochaperone interactions modulate Hsp90 conformational s

173 ha1 stimulates the ATPase activity, restores cochaperone interactions, and compensates for the functi

174 forms stable complexes through a multidomain cochaperone interface.

175 rexpressing AtHSCB, encoding a mitochondrial cochaperone involved in [Fe-S] cluster biosynthesis, and

176 , binding of the B-Raf protein kinase to the cochaperone is conserved between mammals and nematodes.

177 tive regulation of the MAL activator by Aha1 cochaperone is proposed.

178 cyclophilin and the Ttc4 oncogene-like Cns1 cochaperone, is a strong inhibitor of CIRV replication.

179 he BAG family of heat shock protein (HSP) 70 cochaperones, is expressed in response to stressful stim

180 on that ICP22 functions as a virally encoded cochaperone (J-protein/Hsp40) functioning together with

181 Hsp70s work together with their cochaperones, J domain proteins and nucleotide exchange

182 kdown of expression levels of the identified cochaperones leads to disruption of purinosomes.

183 we show that MCJ is a type II transmembrane cochaperone localized in the Golgi network and present o

184 p23 is a heat shock protein 90 (Hsp90) cochaperone located in both the cytoplasm and nucleus th

185 Interestingly, viral cochaperones LT and ST were essential for stable interac

186 Tid1 (DNAJA3), a DnaJ cochaperone, may promote degradation of oncogenic kinase

187 Thus, although both nucleotides and J cochaperones modulate Hsp70 NBD:linker and NBD:SBD inter

188 s (the CFTR interactome), we show that Hsp90 cochaperones modulate Hsp90-dependent stability of CFTR

189 ostulated that CNPYb would be a TLR-specific cochaperone of gp93.

190 DjA1 is a cochaperone of Heat shock cognate 71-kDa protein (Hsc70)

191 Dimeric yeast Mge1, the cochaperone of heat shock protein 70 (Hsp70), is essenti

192 e in [RNQ(+)] propagation, Sis1, a J-protein cochaperone of Hsp70 Ssa, is also specifically required

193 Zuo1 functions as a J-protein cochaperone of its partner Hsp70.

194 AHA1 (activator of HSP90 ATPase) is a cochaperone of the ATP-dependent molecular chaperone, HS

195 ovel susceptibility gene, ST13, coding for a cochaperone of the glucocorticoid receptor, is associate

196 Aha1 is a ubiquitous cochaperone of the Hsp90/Hsp70 chaperone machine.

197 ir composition by inducing the attachment of cochaperones of HSP70, such as the mitotic-phase phospho

198 J-proteins are obligate cochaperones of Hsp70s and stimulate their ATPase activi

199 roteins are structurally diverse, obligatory cochaperones of Hsp70s, each with a highly conserved J d

200 J proteins are obligate cochaperones of Hsp70s, stimulating their ATPase activit

201 characteristic of proteins acting either as cochaperones of Hsp90 or as independent small heat shock

202 inally, we combined the Hsp70-NEF pairs with cochaperones of the J protein family (DnaJA1, DnaJA2, Dn

203 s various HSPs, chaperones, and at least one cochaperone on their cell surfaces; and that HSPs may be

204 s coding sequences of a homolog of the HSP90 cochaperone p23 (p23(H)) to those of AlaXp, to create p2

205 Overexpression of the hsp90 cochaperone p23 also promotes AR112Q degradation, and in

206 d 17-AAG-mediated attenuation of ATP and the cochaperone p23 binding to hsp90.

207 To delineate why Hsp90 and its cochaperone p23 interact with a mature structure, we foc

208 rm-selective inhibitors of Hsp90(alpha/beta)/cochaperone p23 interactions, we developed a dual-lucife

209 The cochaperone p23 plays an important role in estrogen rece

210 ow that FKBP51 stimulates recruitment of the cochaperone p23 to the ATP-bound form of Hsp90, forming

211 sp90 and loss of complex formation with AhR, cochaperone p23, and XAP-2.

212 ly(ADP ribose) polymerase 1 (PARP) and Hsp90 cochaperone p23, despite a lower intrinsic activity.

213 a Pro-Xaa-Leu-Glu (PXLE) motif in the HSP90 cochaperone p23, thereby recruiting PHD2 to the HSP90 pa

214 a ternary complex with kinase client and the cochaperone p50(Cdc37), Hsp90 proceeds through a cycle o

215 dly enhanced by haploinsufficiency of the ER cochaperone p58(IPK).

216 teracting protein (CHIP), a ubiquitin ligase/cochaperone, participates in protein quality control by

217 aining TCP-1 (CCT; also called TRiC) and its cochaperone phosducin-like protein 1 (PhLP1).

218 stance of the cytosolic chaperonin CCT and a cochaperone, phosducin-like protein 1 (PhLP1) for dimer

219 J-domain proteins (JDPs), obligatory Hsp70 cochaperones, play critical roles in protein homeostasis

220 ients by the Hsp90 system is mediated by the cochaperone protein Cdc37.

221 tetratricopeptide repeat (TPR) domains, the cochaperone protein Hop/Sti1 has been proposed to play a

222 ractions with a chaperone protein HscA and a cochaperone protein HscB.

223 f the JCI, Dickey and colleagues show that a cochaperone protein, carboxyl terminus of Hsp70-interact

224 endent molecular chaperone Hsp90 and partner cochaperone proteins are required for the folding and ac

225 w nucleotides affect Hsp90 interactions with cochaperone proteins, we monitored assembly of wild-type

226 conformational changes and interactions with cochaperone proteins, which facilitate activation of Hsp

227 sp90 dimer and interaction with a network of cochaperone proteins.

228 es have dramatic effects on interaction with cochaperone proteins.

229 h PIH1D1, a subunit of heat-shock protein 90 cochaperone R2TP complex, which is required for the asse

230 cognition is modulated by its ribosome-bound cochaperone, RAC.

231 unity, as well as HSP90 chaperones and their cochaperones RAR1 and SGT1B, are required for the DFPM-i

232 We show that the role of Cdc37 cochaperone reaches beyond that of an adaptor protein an

233 ET1A, an H3K4 methyltransferase, and BAT3, a cochaperone recruiter, as binding partners for BORIS, an

234 ependent conformational dynamics and clients/cochaperones recruitment remain elusive.

235 However, how these cochaperones regulate protein folding and whether they h

236 This Hsp70 cochaperone regulates binding between CTA and the ER Hsp

237 recipitated with p97/VCP indicating that the cochaperones remain associated with the misfolded propro

238 g ER stress requires specific chaperones and cochaperones residing in both the ER and the cytosol.

239 ults identify distinct functions for the Hop cochaperone, revealing an asymmetric mechanism for Hsp90

240 to better understand the abundant yeast p23 cochaperone Sba1.

241 We have discovered that Hsp90 and the cochaperone Sba1/p23 accumulate in the nucleus of quiesc

242 Hsp70-type chaperone Kar2 and the Hsp40-type cochaperone Scj1 bind to Hrd3KR.

243 The HSP40 cochaperone SEC63 is associated with the SEC61 transloco

244 -inducible phosphoprotein 1 (STI1), an Hsp90 cochaperone secreted by astrocytes, binds to PrP(C) in t

245 Hop-like stress-inducible protein 1 (Sti1p) cochaperone selectively inhibits the mitochondrial membr

246 Hop-like stress-inducible protein 1 (Sti1p) cochaperone selectively inhibits the mitochondrial membr

247 nt and animal innate immunity depends on the cochaperone Sgt1 and, at least in plants, on a cysteine-

248 The essential cochaperone Sgt1 recruits Hsp90 chaperone activity to a

249 y the small glutamine-rich tetratricopeptide cochaperone Sgt2.

250 sp70) chaperone pair Ssa1/Ssa2 and the Hsp40 cochaperone Sis1 are essential for degradation.

251 Finally, we show that the HSP-90 cochaperone spaghetti protein (SPAG) antagonizes DBT aut

252 such analysis, we establish that NUDC family cochaperones specifically associate with structurally re

253 f Hsp104 to hexamerize, to interact with the cochaperone Sti1, and to bind protein aggregates.

254 in and the J-domain of its stimulatory Hsp40 cochaperone, suggest that PfHsp70-x is highly similar to

255 ults demonstrate a role of the ISC HscA/HscB cochaperone system in facilitating efficient [2Fe-2S] cl

256 role of the Azotobacter vinelandii HscA/HscB cochaperone system in ISC-mediated iron-sulfur cluster b

257 Molecular chaperone Hsp90 and its cochaperone Tah1 are required for the stability of Pih1

258 and mammals, TTI2 associates with two other cochaperones, TEL2 (Telomere maintenance 2) and TTI1 (Te

259 BAG1 is a Hsp70/Hsc70-regulating cochaperone that also interacts with glucocorticoid rece

260 n translational control, encodes a cytosolic cochaperone that associates with the ER protein transloc

261 hilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR)

262 FKBP5 is a molecular cochaperone that contributes to the functional status of

263 bly, as well as by Jac1, the J-protein Hsp70 cochaperone that functions in cluster transfer from Isu.

264 re of J proteins to evolve a multifunctional cochaperone that functions with Hsc70 to promote lytic i

265 re of J proteins to evolve a multifunctional cochaperone that functions with Hsc70 to promote lytic i

266 turation of the kinase and identify SIP as a cochaperone that is critical to the HSP90-mediated activ

267 hsp90, but this can be reversed by FKBP52, a cochaperone that is thought to act later in the pathway.

268 Here, we identify MCJ/DnaJC15 as a distinct cochaperone that localizes at the mitochondrial inner me

269 suggest that UBQLN is a polyubiquitin-TDP-43 cochaperone that mediates the autophagosomal delivery an

270 Hsp40 is a cochaperone that regulates Hsp70 chaperone activity.

271 Sti1 is an Hsp70 cochaperone that regulates the spatial organization of a

272 aracterized as an Hsp70 and Hsp90-associated cochaperone that specifically regulates androgen recepto

273 s be functionally similar to J-protein/Hsp40 cochaperones that function together with their HSP70 par

274 mily is an evolutionarily conserved group of cochaperones that modulate numerous cellular processes.

275 FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of st

276 FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of st

277 90 and Hsp70 are highly regulated by various cochaperones that participate in the activation of stero

278 ionarily conserved, multifunctional group of cochaperones that perform diverse cellular functions ran

279 s determined by the balance of activities of cochaperones that regulate Hsc70 and Hsp90 functions.

280 hieved through a diverse family of J-protein cochaperones that select substrates for Hsp70.

281 e with a large and diverse set of cofactors (cochaperones) that regulate their specificity and functi

282 In addition, two cochaperones, the C terminus of Hsp70-interacting protei

283 ese processes, the chaperone cooperates with cochaperones, the presequence translocase, and other cha

284 signal transduction, was reduced, while the cochaperone, TID1, was increased.

285 Immunophilin FKBP52 serves as a cochaperone to govern normal progesterone (P(4)) recepto

286 e we report that initial recruitment of this cochaperone to Hsp90 is markedly enhanced by phosphoryla

287 insight into the interplay between CCT and a cochaperone to orchestrate the folding of a protein subs

288 import by recruiting Ssc1 and its J protein cochaperone to the translocon and coordinating their int

289 ouples an aspartyl protease with a molecular cochaperone to trigger autophagy and plant defense, prov

290 se (GAK) are homologous proteins that act as cochaperones to support the Hsc70-dependent clathrin unc

291 F1- and HSF2-mediated expression patterns of cochaperones, transcriptional regulators, and signaling

292 of Hsp70 relies on the interaction with the cochaperone ubiquitin ligase carboxyl terminal of Hsp70/

293 the presence of tau was able to recruit the cochaperone ubiquitin ligase CHIP, which is known to fac

294 Cochaperones were also involved in Hsp90-mediated remova

295 he ATP-hydrolyzing Hsp70s are regulated by J cochaperones, which contain J domains that stimulate Hsp

296 ly, we describe the roles of the plethora of cochaperones with which Hsp90 cooperates and growing ins

297 However, yeast with a deletion of the Hsp70 cochaperone YDJ1 showed a dramatic reduction in FHV RNA

298 ants indicated that SWI/SNF, Gcn5, the Hsp70 cochaperone Ydj1, and chromatin-associated factor Yta7 a

299 ditions, do not associate in vivo with Hsp40 cochaperones Ydj1 and Sis1, and do not catalyze refoldin

300 o the 'Chord and Sgt1' domain of known Hsp90 cochaperones, yet Shq1p does not interact with the yeast