ライフサイエンスコーパス: coco

1 n approach termed Codon Consequence Scanner (COCOS).

2 tor to generate Ra(COCO)(2-)((aq)) (log K(Ra(COCO)2-) = 5.97 +/- 0.01), a rare example of a molecular

3 eprotonated COCO(4-) chelator to generate Ra(COCO)(2-)((aq)) (log K(Ra(COCO)2-) = 5.97 +/- 0.01), a r

4 elators with high negative charge [-4 for Ra(COCO)(2-)((aq))] and many donor atoms [>=11 in Ra(COCO)(

5 (2-)((aq))] and many donor atoms [>=11 in Ra(COCO)(2-)((aq))] provided a framework for stable complex

6 The experiments based on MS COCO 2017 and self-made datasets show that, compared wit

7 3)Ra(2+) reacted with the fully deprotonated COCO(4-) chelator to generate Ra(COCO)(2-)((aq)) (log K(

8 the slow pyrolysis carbonization of nata de coco, a renewable resource.

9 A gain-of-function cDNA screen reveals that Coco, a secreted antagonist of TGF-beta ligands, induces

10 re, we demonstrate a vital role for maternal Coco, a secreted antagonist of TGFbeta signalling, in th

11 We find that Coco, a Xenopus DAN family member, and two TGF-beta liga

12 al changes were observed for PTU binding to [CoCo(AAP)] and [CoZn(AAP)] but not for [ZnCo(AAP)], whil

13 c absorption spectra, recorded at pH 7.5 of [CoCo(AAP)], [CoZn(AAP)], and [ZnCo(AAP)] upon addition o

14 he electronic absorption and EPR spectra of [CoCo(AAP)], [CoZn(AAP)], and [ZnCo(AAP)] were recorded i

15 of the catalytically competent [Co_(AAP)], [CoCo(AAP)], and [ZnCo(AAP)] enzymes recorded in the pres

16 EPR spectra of [CoCo(AAP)]-1c, [ZnCo(AAP)]-1c, and [CoZn(AAP)]-1c were a

17 aramagnetic resonance (EPR) spectrum of the [CoCo(AAP)]-bestatin complex exhibited no observable perp

18 Thus, Coco acts as both an inhibitor and an enhancer of signal

19 logical activity, we have renamed this clone Coco, after the Spanish word meaning head.

20 using standard benchmarks, specifically the COCO and CIFAR10 datasets.

21 plate (GRP), and aberrant expression of both Coco and Pitx2c were associated with abnormal LR symmetr

22 holds true for all the beak shapes of Tree, Cocos, and Warbler Finches (three distinct genera).

23 y identified the BMP/Activin/Nodal inhibitor Coco as an enhancer of TGFbeta1 signaling.

24 damental importance for the effectiveness of CoCos as a financial stability enhancing mechanism.

25 Molecularly, Coco binds to TGFbeta1 and enhances TGFbeta1 binding to

26 In contrast, di-Co(II) Bla2 (CoCo-Bla2) is substantially more active than the mono-Co

27 e found 18-crown-6-tetracarboxylic acid (H(4)COCO) bound Ra(2+), Ba(2+), and Sr(2+) to form M(H(x)COC

28 der some network structures, the presence of CoCos can increase (and not reduce) financial fragility,

29 , the OpenMonkeyPose dataset) and on humans (COCO) can.

30 sembl variant effect predictor (VEP) plugin, COCOS captures amino acid sequence alterations stemming

31 , together with inhibitors such as Lefty and Coco/Cerl2, have been shown to provide the signals that

32 COCO-CL can be used as a semi-independent method to deli

33 We propose a new method, COCO-CL, for hierarchical clustering of homology relatio

34 sorption and EPR spectra of [Co_(DapE)] and [CoCo(DapE)] indicate that the first Co(II) binding site

35 interaction between the two Co(II) ions in [CoCo(DapE)] is very weak.

36 We conclude that derriere, Xnr1, and Coco define a posttranscriptionally regulated signaling

37 for normal levels of Xnr1 expression, while Coco directly inhibits both ligands.

38 ferent from that observed for L-Met binding [CoCo(EcMetAP-I)].

39 Whereas Coco enhances the manifestation of traits associated wit

40 et, the latest clinical trial reported by Lo-Coco et al in the New England Journal of Medicine is a p

41 nstrated that left-right patterning requires Coco exclusively on the right side, and Xnr1 and derrier

42 Mechanistic studies indicate that Coco exerts this effect by blocking lung-derived BMP lig

43 by DFT computation was CO2 -->*COOH-->*CO-->*COCO-->*COCH2 OH-->*CH2 OCH2 OH-->CH3 CH2 OH.

44 ctionalized macrocyclic oligo(cyclooctene)s (cOCOEs) in high purity and high yield by exploiting the

45 dy the role of contingent convertible bonds (CoCos) in a complex network of interconnected banks.

46 Coco induces a discrete gene expression signature, which

47 equential suboptimal conversions that damage CoCos investors.

48 We show that Coco is required to prevent Activin and Nodal signals in

49 es, inhabiting the Galapagos archipelago and Cocos Island, constitute an iconic model for studies of

50 the El Nino-Southern Oscillation (ENSO), at Cocos Island, Costa Rica, the site of multiple marine he

51 and Wolf drift primarily towards Malpelo and Cocos Islands, some reaching Costa Rica and Colombia.

52 s them a potentially optimal choice for both CoCos issuers and buyers.

53 ron paramagnetic resonance (EPR) spectra of [CoCo(MetAP)] also indicated that the Co(II) geometries a

54 EPR studies on [CoCo(MetAP)] also revealed that at pH 7.5 there is no si

55 ersea Hunter Group that operates in Isla del Coco National Park, Costa Rica, to (1) determine the fre

56 Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as

57 the Zn2 site (ZnCo-NDM-1), as well as both (CoCo-NDM-1).

58 phases (BOAP) derived from the pyrolysis of Cocos nucifera (coconut), Syagrus coronata (licuri), and

59 ted to the real sample application in honey, cocos nucifera and egg white.

60 teristics of oil bodies from mature coconut (Cocos nucifera L.) fruit.

61 ine the biochemical constituents in coconut (Cocos nucifera L.) haustorium, a spongy tissue formed du

62 Coexpression of a coconut (Cocos nucifera) 12:0-coenzyme A-preferring lysophosphati

63 ocarpus heterophyllus), and mature coconuts (Cocos nucifera) from different Brazilian regions (3 lots

64 Coconut water (Cocos Nucifera) is shown to be a source of essential ele

65 ste stream from food crops, such as coconut (Cocos nucifera) shell, which is nonedible, not of use fo

66 m size) within a minute from tender coconut (Cocos nucifera) water.

67 ion of the commonly introduced coconut palm, Cocos nucifera, interrupts the flow of allochthonous mar

68 arnauba [Copernicia prunifera], and coconut [Cocos nucifera]) endocarps contain lignin polymers deriv

69 natae, Tuber curcumae and Scletrotium poriae cocos) on the cytotoxic action of Abeta(1-40) were teste

70 lina hepatica, Serpula lacrymans, Wolfiporia cocos or Dacryopinax sp.

71 from four wheat varieties grown using soil, coco-peat with nutrient solution (CNS) and water (soaked

72 he bridging water molecule, observed in the [CoCo(PfMetAP-II)] structure, is absent.

73 est anomaly next to the boundary beneath the Cocos Plate and the Caribbean Plate.

74 Many of the natural frequencies of the Cocos Plate are closely associated with the frequencies

75 ductivity of the LAB beneath the edge of the Cocos plate at the Middle America trench offshore of Nic

76 However, subduction of the Cocos plate at the Middle American subduction system has

77 Subduction of the central Cocos plate encounters a thick high-velocity feature ben

78 aves that traverse the deep mantle under the Cocos plate resolve structures above the core-mantle bou

79 Finite element modeling of the Cocos Plate reveals normal modes which appear consistent

80 present images of the D'' region beneath the Cocos plate using Kirchhoff migration of horizontally po

81 ns of widespread intraplate magmatism on the Cocos Plate where a thin partial melt channel was imaged

82 data sensitive to a LAB channel beneath the Cocos Plate(9).

83 The northern and southern segments of the Cocos plate, including the Mexican flat slab subduction,

84 Our expectation is that future work using COCO-Search18 will far surpass these initial efforts, fi

85 We thoroughly characterize COCO-Search18, and benchmark it using three machine-lear

86 We introduce COCO-Search18, the first dataset of laboratory-quality g

87 We benchmarked CoCo-ST against ten state-of-the-art spatial-domain-dete

88 CoCo-ST also effectively distinguishes cell clusters and

89 ng a target sample with a background sample, CoCo-ST detects both high-variance, broadly shared struc

90 CoCo-ST is accessible at GitHub.

91 mpare and contrast spatial transcriptomics' (CoCo-ST), a graph contrastive feature representation fra

92 Coco synergizes with TGFbeta1 in both cell culture and X

93 In the absence of Coco, the TGF-beta signal is bilateral.

94 To highlight its significance, COCOS was applied to data from the 1000 Genomes Project.

95 und Ra(2+), Ba(2+), and Sr(2+) to form M(H(x)COCO)(x-2).

96 lactamase NDM-1, heterodimetallic analogues (CoCo-, ZnCo-, and CoCd-) of the enzyme were generated an