ライフサイエンスコーパス: cocrystallize

1 a thermodynamically stable cocrystal do not cocrystallize.

2 ation of functionalities that do not readily cocrystallize.

3 een synthesized, biologically evaluated, and cocrystallized.

4 dynamically stable cocrystal, will it indeed cocrystallize?

5 We have cocrystallized a stable complex of recombinant N- and C-

6 es of supramolecular tessellations formed by cocrystallizing a chiral tris(naphthalenediimide) triang

7 Cocrystallizing a given molecule with another can be use

8 The cocrystallized actin-CD structure also revealed changes

9 questioned on the basis of the inability to cocrystallize Ad26 fiber with CD46.

10 en the corresponding homologous residues and cocrystallized ADP or nucleotide analogs.

11 ematic changes are made to the participating cocrystallizing agents.

12 Heterocyclic adenine nitrogens of cocrystallized agonist overlaid corresponding positions

13 Uncomplexed guest molecules cocrystallize alongside the threaded complexes in the so

14 trans-3(.+) ) is observed in solution, which cocrystallize and exist in the crystal phase.

15 ond cluster, Au(146)(SPh)(30)(PPh(3))(12) 2, cocrystallizes and is identified as having a closed elec

16 P) shape and specific ligand interactions to cocrystallize anisotropic and isotropic NPs, with order

17 l membrane environment have been obtained by cocrystallizing antiamoebin with n-octanol.

18 Pyruvate kinase from rabbit muscle has been cocrystallized as a complex with MgIIATP, oxalate, Mg2+,

19 We show here that human insulin can be cocrystallized at preselected ratios with the fully acti

20 ost combinations of molecules do not readily cocrystallize but form either one-component crystals or

21 In addition, we cocrystallized chlortetracycline and EphB1 receptor, whi

22 Cocrystallized complexes of the macrocyclic PIs and the

23 e demonstrate the establishment of FRET in a cocrystallized Cu(8)(p-MBT)(8)(PPh(3))(4)@Cu(10)(p-MBT)(

24 ccommodate a series of fatty acid analogs by cocrystallizing CYP2E1 with omega-imidazolyl-octanoic fa

25 er a 200 ms peracetic acid reaction with the cocrystallized enzyme-substrate microcrystal slurry, a f

26 e-uridine product complex prepared either by cocrystallizing enzyme with uridine or by diffusing cyti

27 ELISA, carbohydrate microarray analysis, and cocrystallized Fab 2G12 with four different oligomannose

28 wild-type transporter, with and without the cocrystallized Fab antibody fragment, to investigate the

29 omputational studies have used the closed or cocrystallized Hsp90 structures in an attempt to explore

30 lecular function of a mutational hotspot, we cocrystallized human HNF-1alpha 83-279 with a high-affin

31 ffraction studies show that both enantiomers cocrystallize in a single crystal, and the racemic mixtu

32 e structure of the PilZ adaptor protein MapZ cocrystallized in complex with c-di-GMP and its protein

33 nding interactions of pyrazine-based ligands cocrystallized in protein targets.

34 this study, the crystal structure of R-HPCDH cocrystallized in the presence of (S)-hydroxypropyl-coen

35 Starting from the cocrystallized intracellular CXCR2 antagonist 00767013 (

36 kynureninase inhibitor, 3-hydroxyhippurate, cocrystallized it with human kynureninase, and solved th

37 ding site at the very C terminus of KAT1 and cocrystallized it with tobacco (Nicotiana tabacum) 14-3-

38 rmed and the lock broken, whether or not the cocrystallized ligand is present.

39 none exchange cavities, allowing exchange of cocrystallized lipids with the bulk membrane and suggest

40 sthydrolysis state is presented, obtained by cocrystallizing MalK with ATP-Mg(2+).

41 rdered arrangement of polymers and unreacted cocrystallized monomeric conformers has been observed.

42 The molecules of cocrystallized octanol are found in two different areas

43 cocrystal and thus predict if molecules will cocrystallize or not.

44 pied by small molecule LFA-1 inhibitors when cocrystallized or analyzed by (15)N-(1)H HSQC (heteronuc

45 cy is assessed by redocking ligands from 282 cocrystallized PDB complexes starting from conformationa

46 A substructure analysis of the cocrystallized PDE ligands in combination with those in

47 ng enzyme inhibitor complexes is to start by cocrystallizing PI-PLC with the head group analogs.

48 rs (MMPs) to the atom environment within the cocrystallized protein-ligand complex.

49 A comprehensive nonredundant database of 475 cocrystallized protein-protein complexes was used to stu

50 We cocrystallized selected inhibitors with BACE1 to reveal

51 analysis of dihydrofolate reductase (DHFR) (cocrystallized separately with NADPH, dihydrofolate and

52 he binding affinity of the U2AF2 UHM for the cocrystallized SF3B1 ULM rivals that of a nearly full-le

53 hered phases (e.g., substrates, sorbates, or cocrystallized species), suggesting a methodology of eli

54 rotein conformation, complicating the use of cocrystallized structures for ligand screening.

55 nship analysis was performed for those whose cocrystallized structures with the enzyme were published

56 We cocrystallized Stx2a with P11 and defined their interact

57 binding sites, including those that did not cocrystallize, suggest a framework for explaining the di

58 into the structure-activity relationship, we cocrystallized SylA-GlbA in complex with the proteasome

59 and clotrimazole, and in the present work we cocrystallized the P450 with posaconazole at 2.5 A resol

60 bacterial pyruvate decarboxylase prepared by cocrystallizing the enzyme with pyruvate and a stable an

61 By cocrystallizing the enzyme with various combinations of

62 Hence, cocrystallizing the wild-type enzyme with phosphate resu

63 ible hydrophobic moieties to the analogs and cocrystallize these with the enzyme.

64 at TnsA and a slightly longer version of the cocrystallized TnsC fragment (residues 495-555) might co

65 rids, in which organic and metal halide ions cocrystallize to form neutral species, are a promising p

66 Benzoquinone and hydroquinone cocrystallize to form quinhydrone, a 1:1 complex with a

67 C, in a crystal lattice isomorphous with the cocrystallized undecamer 5'-AAAGATATCTT previously deter

68 ges in the intensity and the location of the cocrystallized water hydroxyl peaks (3200-3600 cm(-1)).

69 prior work, we have shown that both isoforms cocrystallize with d-glutamate as dimers, and the enzyme

70 , suitable derivatives of phosphangulene can cocrystallize with fullerenes or even bind them in solut

71 mplexes of phosphangulene are predisposed to cocrystallize with fullerenes, thereby yielding material

72 rs, capable of forming intermolecular bonds, cocrystallize with multiple structural arrangements.

73 ile succinic acid and fumaric acid were each cocrystallized with 1 to provide 2:1 cocrystals of fluox

74 -ray crystallography data obtained for MMP-3 cocrystallized with 20 gave detailed information on key

75 A structure of wild-type PurE cocrystallized with 4-nitroaminoimidazole ribonucleotide

76 An X-ray structure of NS5B protein cocrystallized with 49 revealed unique protein-inhibitor

77 determined crystal structures of the enzyme cocrystallized with 5'-deoxy-5'-dimethylthioadenosine an

78 CobT was cocrystallized with 5,6-dimethylbenzimidazole (DMB) in t

79 The PARP domain of TNKS2 was cocrystallized with 66, and the X-ray structure was dete

80 f excess nickel for both NikR alone and NikR cocrystallized with a 30-nucleotide piece of double-stra

81 of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex.

82 andida albicans RNA guanylyltransferase Cgt1 cocrystallized with a carboxy-terminal domain (CTD) pept

83 1 with high catalytic efficiency toward HNE, cocrystallized with a GSH-HNE conjugate analogue, demons

84 glycine and the oxamide of glycine were each cocrystallized with a series of four bipyridines, includ

85 Structure analysis of CD1a cocrystallized with a synthetic mycobactin lipopeptide a

86 Unfortunately only a few compounds have been cocrystallized with AcrB, and thus computational approac

87 Duplex DNA containing 2'-fluoro-m7dG (Fm7dG) cocrystallized with AlkA as a host-guest complex in whic

88 tion of intact BG cells (approximately 5 mg) cocrystallized with alpha-cyano-4-hydroxycinnamic acid.

89 published high-resolution structure of A(2A) cocrystallized with an antagonist.

90 s not require analytes to be incorporated or cocrystallized with an initiator.

91 ,3"-bi-1,2,4-triazole (DNBT) is successfully cocrystallized with AN to yield the cocrystal 2AN:DNBT.

92 selectivity toward the plant enzyme and was cocrystallized with Arabidopsis HPPD.

93 tallography data for selected lead compounds cocrystallized with arginases I and II.

94 the same DNA sequence (TATGGATCCATA) as that cocrystallized with BamHI.

95 Here we report the structure of human RFK cocrystallized with both MgADP and FMN.

96 ver, recent studies, including several GPCRs cocrystallized with bound ligands, suggest that the extr

97 Compound 3 was also cocrystallized with Brd4 for determining the ligand bind

98 Compound 32 was cocrystallized with BRD4, yielding a 1.56 A resolution c

99 We show that, in LeuT-E290S cocrystallized with bromide or chloride, the anion is co

100 RGS17 cocrystallized with Ca(2+) bound to conserved positions

101 crystal structure of a reversible inhibitor cocrystallized with Cathepsin S is also reported.

102 ucible and endothelial NOS oxygenase domains cocrystallized with chlorzoxazone and four nitroindazole

103 Leucettinib-21 was cocrystallized with CLK1 and modeled in the DYRK1A struc

104 widely used antidepressant fluvoxamine, was cocrystallized with CYP46A1.

105 S. stercoralis DAF-12 ligand-binding domain cocrystallized with dafachronic acids.

106 of MMOH from Methylococcus capsulatus (Bath) cocrystallized with dibromomethane or iodoethane, or by

107 We compare structures of capsids cocrystallized with different CpAMs and find that they a

108 cture of a presumably inactive form of SCLam cocrystallized with different oligosaccharides.

109 se structures, a new structure of the enzyme cocrystallized with DNA and calcium ions, and previously

110 By contrast, two structures of K38A cocrystallized with DNA and Mn(2+) ions in different lat

111 mpared to the performance on holo-structures cocrystallized with DNA.

112 1H-indolo[3,2-c]quinoline-6-carboxylic acids cocrystallized with DYRK1A confirmed the predicted bindi

113 Leucettines were cocrystallized with DYRK1A, DYRK2, CLK3, PIM1, and GSK-3

114 artial agonist and compared it to structures cocrystallized with either a full agonist or an antagoni

115 nd 1.95 A resolution in the unbound form and cocrystallized with either SO(4)(2)(-) or HCO(3)(-).

116 hydro-2-thiophenecarboxylic acid (SADTA) was cocrystallized with Escherichia coli aspartate aminotran

117 A simple heparin hexasaccharide that cocrystallized with FGF-1 and FGF-2 and protected both a

118 type-II ribosome-inactivating protein (RIP), cocrystallized with galactose is described.

119 ructure of the D-dimer from human fibrinogen cocrystallized with GHRPYam, the packing of which showed

120 lationship of the two active sites, CobU was cocrystallized with GTP and pyrophosphate.

121 y potent potentiator 32 (AM-3607), which was cocrystallized with human GlyRalpha3cryst to afford the

122 of several crystal structures of this enzyme cocrystallized with inhibitors, little was understood ab

123 t publication of structures of several GPCRs cocrystallized with ligands of differing activity offers

124 ragment screen identified hits that could be cocrystallized with LTA4H and inspired a fragment mergin

125 s with the recent structure of CCR5 receptor cocrystallized with Maraviroc.

126 The structure of MIF cocrystallized with NAPQI reveals that the NAPQI has und

127 gh-performance liquid chromatography (HPLC), cocrystallized with Ni-(octaethylporphyrin), and charact

128 l structure of retinal dehydrogenase type II cocrystallized with nicotinamide adenine dinucleotide (N

129 single-crystal X-ray diffraction on samples cocrystallized with NiII(octaethylporphyrin).

130 leoside hydrolase from Crithidia fasciculata cocrystallized with p-aminophenyliminoribitol reveals ti

131 This hit (1) was cocrystallized with PaTMK, and several potent PaTMK inhi

132 ross-react with both PFA1 and PFA2 and, when cocrystallized with PFA1, binds in an identical conforma

133 t revealed by the crystal structure of PheRS cocrystallized with Phe.

134 s of phospholipid binding further, GM2AP was cocrystallized with phosphatidylcholine (PC), known to i

135 led to a submicromolar inhibitor, which was cocrystallized with Plm II to produce an X-ray structure

136 X-ray crystal structures of wild-type HpMTAN cocrystallized with S-adenosylhomocysteine (SAH), Formyc

137 CYP8B was cocrystallized with S-tioconazole to yield the first X-r

138 ucture of an inactive variant (HpMTAN-D198N) cocrystallized with SAH.

139 n crystal structure of histone deacetylase 6 cocrystallized with SelSA-2 conclusively demonstrates th

140 X-ray crystal structures of MTAN cocrystallized with several inhibitors show them to bind

141 Three compounds were cocrystallized with Staphylococcus aureus KARI and yield

142 Representative compounds were cocrystallized with Streptococcus pneumoniae (Spn) ParE;

143 comes accessible only in structures that are cocrystallized with strong agonists.

144 ures of 19 of these enzymes, including seven cocrystallized with substrate analogs or products; and t

145 factor-independent epimerases and racemases, cocrystallized with substrates or substrate analogues, t

146 stal structures of fibrin double-D fragments cocrystallized with synthetic peptides corresponding to

147 o(2+)-substituted Bacillus subtilis LuxS was cocrystallized with the 2-ketone intermediate and the st

148 UNC8531 was cocrystallized with the 53BP1 TTD to guide further optim

149 ate constants in the structure of the mutant cocrystallized with the alternate substrate, 4-nitrobuty

150 Chicken smooth muscle alpha-actinin was cocrystallized with the beta1-integrin cytoplasmic domai

151 ive site of ligand-bound forms that had been cocrystallized with the bicyclic diketone substrate bicy

152 In addition, compound 9a was cocrystallized with the catalytic domain of FGF-R1 provi

153 Selected inhibitors were cocrystallized with the catalytic domain of human HDAC4.

154 s 2,2,6,6-tetramethylheptanedione-3,5), were cocrystallized with the chalcogen bond donors (4-NC(5)F(

155 midazole group by pyridylimidazole, has been cocrystallized with the dodecanucleotide sequence d(CGCG

156 itors, starting from an inhibitor previously cocrystallized with the enzyme (K(i) = 0.8 muM).

157 into their modes of binding, they were also cocrystallized with the extracellular domain of PSMA.

158 receptor positive allosteric modulators were cocrystallized with the GluA2 ligand binding domain in o

159 Recently, two crystal structures of BACE cocrystallized with the inhibitors OM99-2 and OM00-3 wer

160 uzi, etiologic agent of Chagas' disease, was cocrystallized with the inosine analogue Formycin B (FmB

161 conformation of PPH even when the enzyme was cocrystallized with the oxalate inhibitor.

162 (residues 118-424) of human PheOH (hPheOH), cocrystallized with the oxidized form of the cofactor (7

163 E4 inhibitor resembling the structure of 8a, cocrystallized with the PDE4.

164 The 89 kDa protein was cocrystallized with the peptide Gly-His-Arg-Pro-amide, w

165 The 180 kDa covalent dimer was cocrystallized with the peptide Gly-His-Arg-Pro-amide, w

166 However, when CYP8B1 was cocrystallized with the pyridine-containing compound wit

167 complex was obtained from enzyme aerobically cocrystallized with the substrate stachydrine (N,N-dimet

168 re analysis of the monopyrrolinone compounds cocrystallized with the wild-type HIV-1 protease provide

169 X-ray crystal structures of CYP2A6 cocrystallized with three furan analogues bearing methan

170 stal structure of compound 1m in this class, cocrystallized with unactivated p38 alpha protein, indic

171 crystal structures of bovine Arp2/3 complex cocrystallized with various bound adenine nucleotides an

172 t was supported by X-ray structures of BACE1 cocrystallized with various ligands and molecular modeli

173 was supported by X-ray structures of ERbeta cocrystallized with various ligands as well as molecular

174 ived from tRNATyr (supF) with glutamine were cocrystallized with wild-type tRNAGln and their structur

175 o TM0665 protein, and the mutant protein was cocrystallized with Zn(2+) to determine the structure by

176 s unreactive toward weak C-H donors and even cocrystallizes with a molecule of cyclohexadiene (CHD) i

177 tris(iodoethynyl)-2,4,6-trifluorobenzene (1) cocrystallizes with a variety of halide salts, namely, E

178 It cocrystallizes with AlMe(3) as [Sc(AlMe(4))(3)(Al(2)Me(6

179 trammonium (HMTA(+) , C(13) H(19) N(4) (+) ) cocrystallizes with PbBr(4) (2-) , MnBr(4) (2-) , and Sn

180 orless insulator where the dicarboxylic acid cocrystallizes with two of its monoanionic conjugated ba

181 though minocycline and doxorubicin have been cocrystallized within the large binding pocket in the pe

182 We cocrystallized ZnF8-12 of hPRDM9A with an oligonucleotid