ライフサイエンスコーパス: codelete

1 t/non-codeleted, and 37(35%) were IDH-mutant/codeleted.

2 The gene encoding MTAP, MTAP, is frequently codeleted along with the tumor suppressor gene p16 in ma

3 Patients with 1p/19q codeleted anaplastic oligodendroglial tumors who partici

4 ting 60 of 127 patients, virtually all 1p19q codeleted and IDH mutated (59 of 60).

5 3; HR, 0.21; P = .029) in the IDH-mutant/non-codeleted and IDH-mutant/codeleted subgroups, respective

6 IDH-wild type, 43 (41%) were IDH-mutant/non-codeleted, and 37(35%) were IDH-mutant/codeleted.

7 pe; oligodendroglioma, IDH-mutant and 1p/19q codeleted; and astrocytoma, IDH-mutant.

8 nt; oligodendroglioma, IDH mutant and 1p/19q codeleted; and glioblastoma, IDH wild type.

9 For the subset of patients with 1p/19q codeleted AO/AOA, PCV plus RT may be an especially effec

10 isocitrate dehydrogenase (IDH)-mutant, 1p19q codeleted CNS WHO grade 2 and 3 should be offered radiat

11 diagnosed astrocytoma, IDH-mutant, 1p19q non-codeleted CNS WHO grade 2 should be offered RT with adju

12 or either astrocytoma, IDH-mutant, 1p19q non-codeleted CNS WHO grade 3 or glioblastoma, IDH-wildtype,

13 ople with astrocytoma, IDH-mutant, 1p19q non-codeleted CNS WHO grade 3 should be offered RT and adjuv

14 showed reduced survival, compared with their codeleted counterparts with weaker EGFR expression.

15 ma [AOA]), are chemosensitive, especially if codeleted for 1p/19q, but whether patients live longer a

16 n region in TgPWS mice, with 2 nonimprinted, codeleted genes reduced twofold.

17 d to isocitrate dehydrogenase-mutant, 1p/19q-codeleted glioma patients, while a lower excitation/inhi

18 arnofsky Performance Status, particularly in codeleted glioma patients.

19 and poorer outcome in patients with a 1p19q codeleted glioma.

20 iomas (56 of 135), 53% of IDH-mutant and non-codeleted gliomas (79 of 149), and 74% of IDH-mutant and

21 79 of 149), and 74% of IDH-mutant and 1p/19q-codeleted gliomas (94 of 127).

22 -14.2]; P = .02), but not IDH-mutant and non-codeleted gliomas (aHR for PFS, 1.19 [95% CI, 0.67-2.12]

23 CI, 0.98-2.91]; P = .06) and IDH-mutant and codeleted gliomas (aHR for PFS, 2.99 [95% CI, 1.44-6.21]

24 ocitrate dehydrogenase (IDH) 1-mutant 1p/19q codeleted gliomas and their noncodeleted counterparts me

25 CIC mutant grade II codeleted gliomas spontaneously grew faster than WTs.

26 e levels were detected in IDH1-mutant 1p/19q codeleted gliomas than in their noncodeleted counterpart

27 In the 1p19q codeleted gliomas, CIC mutations were associated with a

28 utant/1p19q intact, and 101 IDH mutant/1p19q codeleted gliomas.

29 Patients with IDH-mutant 1p/19q-codeleted grade 3 oligodendroglioma (O3(IDHmt/Codel)) be

30 eleted [IDH(m-noncodel)], and 16 with mutant codeleted [IDH(m-codel)]).

31 c carcinoma cell lines were p16(-), MTAP was codeleted in all five cases.

32 located 15 kb from APC and is almost always codeleted in these tumors.

33 Patients with codeleted mutated tumors (14.7 v 6.8 years; HR, 0.49; 95

34 Cystathionine concentration was higher in codeleted (n = 13) than noncodeleted (n = 18) gliomas wh

35 ); (2) astrocytoma, IDH-mutant and 1p19q non-codeleted (n = 54); (3) astrocytoma, IDH-wildtype (n = 2

36 HG concentration decreased rapidly in 1p/19q codeleted oligodendrogliomas and with a slower time cour

37 tcome in IDH-wildtype astrocytomas and 1p19q-codeleted oligodendrogliomas but not in IDH-mutant astro

38 itrate dehydrogenase (IDH)-mutant and 1p/19q-codeleted oligodendrogliomas with the best prognosis; ID

39 tomas, class II tumors are similar to 1p/19q codeleted oligodendrogliomas, and class III represents i

40 ic astrocytomas, a second grouped the 1p/19q codeleted oligodendrogliomas, and the mixture of remaini

41 rocytomas and grade 2 or 3 IDH-mutant, 1p19q-codeleted oligodendrogliomas.

42 s, when available) to predict 1p/19q status (codeleted or noncodeleted) and provided a prediction con

43 Genes in the frequently codeleted region 17p13 and 18q21/22 were associated with

44 the IDH-mutant/non-codeleted and IDH-mutant/codeleted subgroups, respectively.

45 mutant/1p19q intact, and 19 IDH mutant/1p19q codeleted), the classification accuracy was 40 of 49 gli

46 sin II in glioblastoma, and we now show that codeleting these myosins markedly impairs tumorigenesis

47 1p/19q-codeleted tumors derive more benefit from adjuvant PCV c

48 Patients with codeleted tumors lived longer than those with noncodelet

49 Although patients with codeleted tumors lived longest, patients with noncodelet

50 .001), and the median survival of those with codeleted tumors treated with PCV plus RT was twice that

51 tients with IDH-wild-type and IDH-mutant and codeleted tumors.

52 ompare metabolite concentrations obtained in codeleted versus noncodeleted gliomas, accounting for mu

53 The INK4A-exon 1beta and the INK4B gene were codeleted with INK4A in all of the homozygously deleted

54 tromeric of tumor protein p53 (Tp53), and is codeleted with Tp53, we propose that loss of miR-3676 ca