ライフサイエンスコーパス: coding

1 ng speed (Trail Making Test and Digit Symbol Coding).

2 ll, and therefore may not affect information coding.

3 cal layers, and rhythms implement predictive coding.

4 n induced a switch from absolute to relative coding.

5 eading frames from being regarded as protein-coding.

6 inforcing loop to generate reward prediction coding.

7 evealing fundamental principles of olfactory coding.

8 d thematically using deductive and inductive coding.

9 nt subset of neurons than experiential value coding.

10 on and its rather distant cousin, predictive coding.

11 Both Poisson frameworks preserve the coding accuracy and robustness to neuron loss of the ori

12 DNA is a threat to the genomic integrity and coding accuracy of the chromosomes of all living organis

13 d noise patterns is a greater determinant of coding accuracy than is absolute noise strength(12-14).

14 the implications of our findings for neural coding and for brain-controlled bionic hands.

15 ies, which can be used for genome editing of coding and non-coding genomic regions effectively.

16 ogical processes had variable proportions of coding and non-coding mutations, with chromatin remodeli

17 ys, including Wnt and Notch, altered by both coding and non-coding mutations.

18 y deliver more meaningful prediction in both coding and non-coding regions of the cancer genome.

19 For somatic point mutations in coding and non-coding regions of the genome, we propose

20 ed for processing and/or degradation of both coding and non-coding RNAs.

21 MRX restricts transcription of coding and noncoding DNA by a mechanism that does not re

22 NA, while conversely most studies of protein-coding and noncoding genes frequently ignore any intron-

23 e report that positive epistasis between the coding and noncoding regions of the viral genome combine

24 res from neutrality across the locus in both coding and noncoding regions.

25 ly recruits the Set3 complex to both protein-coding and noncoding RNA (ncRNA) genes via a SUMO-intera

26 refore enables cells to selectively regulate coding and noncoding RNAs.

27 late the stability and, hence, expression of coding and noncoding RNAs.

28 provides a blueprint for dissection of their coding and noncoding roles.

29 These variants were mainly non-coding and reached at least nominal significance in clas

30 We designed a 20.5 Mb array targeting coding and regulatory regions of genes with a known role

31 e of genome rearrangements among the protein-coding and ribosomal RNA genes could be inferred across

32 In particular, using Freedom House's coding and terminological classifications, the proportio

33 sting a role for cross-frequency coupling in coding and transmitting retrieved spatial information.SI

34 ciation studies (GWAS) are predominantly non-coding and typically attributed to altered regulatory el

35 result from difficulties related to landmark coding, and predict recovery of allocentric strategies i

36 Overall, this work demonstrates that non-coding AR binding sites are frequently mutated in prosta

37 g approach derived from principles of neural coding as a framework to understand working memory limit

38 :DNA hybrids and RNAPII are detected at gene-coding as well as at intergenic areas when double-strand

39 ticularly, the knowledge learnt from protein-coding ASD risk genes was transferred to the prediction

40 Then, signals are reformatted to reduce the coding biases inherent in peripheral mechanics, and wind

41 HGNC) guidelines for naming not only protein-coding but also RNA genes and pseudogenes, and outline t

42 rial transcriptomic data commonly ignore non-coding but functional elements e.g. small RNAs, long ant

43 Disruption of this stem abolishes the non-coding, but not the coding, function of the endogenous x

44 oci and to separate transcripts with protein coding capability from other sources of LINE-1 RNA.

45 for HCMV is hampered by the immense protein coding capacity of this betaherpesvirus.

46 these maps collectively harboured sufficient coding capacity to approximately reconstruct objects.

47 decreased correlations increased information coding capacity.

48 ion from gene addition studies using protein-coding cDNAs to the modulation of gene expression using

49 he homeodomain protein Matalpha2) evolved by coding changes in this ancient regulator, followed milli

50 reveal how expression variation through non-coding cis variation at FLC has enabled Arabidopsis acce

51 ge N = 320K), conditioning on a broad set of coding, conserved and regulatory annotations.

52 o identify 1776 other genes enriched for non-coding constraint mutations with likely regulatory poten

53 eplication, require transcription across the coding CTG strand and arise by blocking repair of CAG sl

54 l cortex: the Allen Brain Observatory Visual Coding dataset.

55 support more and larger genes, far more non-coding DNA, greater regulatory complexity, and thousands

56 omic regions or de novo, from previously non-coding DNA.

57 performed to determine the contributions of coding DNMs to an individual's OFC risk.

58 least as high as that observed for damaging coding DNVs.

59 Recent advances in optical coding, drug delivery, diagnostics, tissue engineering,

60 tune base pairing specificity and affect the coding efficiency and fidelity during gene replication.

61 uction hypothesis, a theory of retinal color coding emerged in which the three most common retinal ga

62 suggest that neurons with useful functional coding exhibit heightened stability to support memory gu

63 llelic deletions were predicted to result in coding exon disruption.

64 greater identity across species than nearby coding exons, but their physiological role and molecular

65 yperactivity disorder are located in protein-coding exons, indicating a more substantial role of regu

66 uired regulatory sequence downstream of Gdf5 coding exons.

67 Two ophthalmologists without coding experience used an interactive application in MAT

68 In predictive coding, experience generates predictions that attenuate

69 t is unknown whether correlated noise limits coding fidelity.

70 ), consists of a 35.6-kb circular DNA genome coding for 52 proteins.

71 to have missense mutations in VPS4A, a gene coding for an ATPase that regulates the ESCRT-III machin

72 We used inductive coding for barriers or facilitators that could not be cl

73 .61% of layer chicken isolates carried genes coding for extended-spectrum SHV beta-lactamases.

74 GRM3 (the gene coding for mGluR3) is also genome-wide associated with r

75 RNAs coding for nAChR monomeric subunits and/or concatamers w

76 Compared to FF, FFPE transcripts coding for nuclear/cytoplasmic proteins involved in DNA

77 inct from neurons recruited into an ensemble coding for sucrose seeking suggest a finely tuned specif

78 ms in the CHRNA5-CHRNA3-CHRNB4 gene cluster, coding for the alpha5, alpha3, and beta4 nicotinic acety

79 associated with variants in the gene GABRB2, coding for the gamma-aminobutyric acid type A (GABA(A) )

80 e show that an OCS pipeline focused on genes coding for transcription factors increases isoform detec

81 Here, we develop an efficient coding framework for higher-level cognitive processes in

82 Within a predictive coding framework sensory information could be down-weigh

83 s stem abolishes the non-coding, but not the coding, function of the endogenous xbp-1 transcript.

84 inversions associated with expressed protein-coding fusions, breakend hypermutation, and acral, but n

85 cient translational bypassing of a 50-nt non-coding gap in a phage T4 topoisomerase subunit gene (gp6

86 luenced by a single QTL encompassing the Adh-coding gene and its known regulatory locus, delta-1.

87 sly undescribed mechanism of de novo protein-coding gene evolution.

88 verlap was found in plastid-targeted protein-coding gene families compared with Arabidopsis, but an a

89 for targeted discovery and validation of non-coding gene variants affecting gene expression and disea

90 The postsynaptic adapter protein-coding gene, SHANK2, located on Chromosome 11q13, was di

91 50.37-50.58 Mb, mm10) containing two protein-coding genes (Hnrnph1, Rufy1) that was necessary for red

92 stream genes in mouse, including 117 protein-coding genes and 144 lincRNA genes, 93.7% of which are m

93 We identify 1434 protein-coding genes and 39,806 noncoding regions for which mole

94 ndings implicate more than 5% of all protein-coding genes and provide evidence for gene sets involved

95 Genetic variants that inactivate protein-coding genes are a powerful source of information about

96 SSP-coding genes are frequently overlooked, because genome a

97 remarkably intron-poor, as more than 80% of coding genes are intronless.

98 utionary sequence analyses of 10,322 protein-coding genes as well as 229,001 genomic regions spanning

99 show that homologs of the identified protein-coding genes as well as genes in close proximity to the

100 overexpression of a large number of protein-coding genes compared to the susceptible genotype.

101 response to P starvation, 40% of all protein-coding genes exhibit a transition from one chromatin sta

102 sis that gene expression profiles of protein-coding genes expressed in peripheral white blood cells (

103 metabolites may exceed the number of protein-coding genes for many organisms, including humans, by or

104 atalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade.

105 Forty of the protein-coding genes in GRCh38 are missing from Ash1; however, a

106 we used new pol II promoters from endogenous coding genes to express crRNA for Cas12a and obtained a

107 istinct proteins covering 95% of Mtb protein-coding genes using artificial antigen-presenting cells (

108 Of the 23,248 predicted protein-coding genes, 12,346 venom-gland-expressed genes constit

109 ci tend to be close to their nearest protein-coding genes, and they may be transcriptionally related

110 In contrast to coding genes, many lncRNAs were specifically transcribed

111 be transcriptionally related to the protein-coding genes, particularly for antisense and intronic ln

112 the editing patterns of three putative dual-coding genes, ribosomal protein S12 (RPS12), the 5' edit

113 Unlike protein-coding genes, the majority of human long non-coding RNAs

114 potential drug targets, i.e. causal protein-coding genes, therefore, requires crossing the genetics

115 CBC in the nucleus, with a focus on protein-coding genes.

116 cially at the 5'-flanking regions of protein-coding genes.

117 ponsible for a quarter of all 36,254 protein-coding genes.

118 o 24 chromosomes and annotate 32,690 protein-coding genes.

119 accessions as the outcome of SNPs in enzyme-coding genes.

120 INFERence of the molecular mechanisms of NOn-coding genetic variants (SparkINFERNO), a scalable bioin

121 fy novel therapeutic targets in the vast non-coding genome to enhance radiation therapy.

122 e bioinformatics pipeline characterizing non-coding genome-wide association study (GWAS) association

123 pe of infrequent driver mutations in the non-coding genome.

124 be used for genome editing of coding and non-coding genomic regions effectively.

125 -productive splicing events in 7,757 protein-coding human genes, of which 1,246 are disease-associate

126 ase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR), which serves as a tem

127 According to the efficient coding hypothesis, sensory systems are adapted to maximi

128 oding analyses suggested observational value coding in amygdala neurons occurred in a different subse

129 tions for using XDream to investigate neural coding in biological preparations.

130 mon neurophysiological substrate for spatial coding in navigation and episodic recall.

131 Robust sound coding in noise is often viewed as a specific property o

132 he order of 10(-3)), they affect information coding in populations on the order of 100 s of neurons.

133 smitter systems in modulating working memory coding in prefrontal circuits.SIGNIFICANCE STATEMENT Ong

134 ibition of MEC led to a disruption of border coding in RSC, but not vice versa, indicating allocentri

135 We examined preparatory coding in the human hippocampus and mPFC, two regions th

136 E STATEMENT A key area of study in olfactory coding involves understanding the transformation from hi

137 Non-coding IPS1 RNA is highly expressed during Pi starvation

138 motion-related VIP neuron activity to visual coding is not known.

139 VINR, a Drosophila VSR-interacting long non-coding (lnc) RNA that activates non-canonical innate imm

140 ses and the detection of novel expressed non-coding loci.

141 ebellar activity through inhibition via rate coding mechanisms.

142 in average firing rates, but finer temporal coding might allow multiplexing and enhanced readout acr

143 Switching between these two spatial coding modes was supported by the interaction between ex

144 microRNAs (miRs) are small non-coding molecules that regulate post-transcriptional targ

145 genes and mechanisms that are altered by non-coding mutations and offer insights into additional canc

146 Using genes harboring coding mutations associated with obesity, we replicated

147 on diseases are caused by autosomal dominant coding mutations in the human prion protein (PrP) gene (

148 r gene expression signatures as samples with coding mutations in these genes.

149 RNA splicing is primarily altered by non-coding mutations in this cohort, and samples containing

150 s in this cohort, and samples containing non-coding mutations in well-known RNA splicing factors exhi

151 The contribution of coding mutations to oncogenesis has been largely clarifi

152 Pathogenic missense coding mutations were identified by in silico tools and

153 atterns of somatic mutations, especially non-coding mutations, and their roles in defining molecular

154 ilitate the identification of functional non-coding mutations, we present dbInDel, a database where w

155 proliferation pathways altered primarily by coding mutations, while developmental pathways, includin

156 s had variable proportions of coding and non-coding mutations, with chromatin remodeling and prolifer

157 nt and Notch, altered by both coding and non-coding mutations.

158 n the DNA that modulates the position of the coding nucleotide and thereby impacts the identity of th

159 Here, we hypothesize that the coding of foreseeable outcomes is potentially unclear fr

160 ed light on the transformation of rate-place coding of resolved harmonics along the auditory pathway.

161 ed sensory receptors able to provide dynamic coding of sound signals.

162 Adaptive coding of stimuli is well documented in perception, wher

163 ined neuron populations for grouped-ensemble coding of survival behaviors.

164 urs, calculation of CT FFR values, and color coding of the coronary tree according to CT FFR.

165 high-resolution surface features, with phase coding organized to support this function.

166 hat most associated variants fall in the non-coding part of the human genome.

167 for both the identification of candidate non-coding pathogenic variants and their functional validati

168 he core autophagy gene Atg16L1 and its T300A coding polymorphism identified by genome-wide associatio

169 t, when a purine nucleotide was in the first coding position, DNA synthesis fidelity was similar to t

170 Novel open reading frames (nORFs) with coding potential may arise from noncoding DNA.

171 d messenger RNAs) and others lacking protein-coding potential, named noncoding RNAs.

172 uld generate chimeric human-viral mRNAs with coding potential.

173 e of non-CAHs after accounting for different coding practices for in-hospital comorbidities.

174 However, diagnosis and coding practices vary widely between hospitals and are c

175 n grid spacing, no difference in the spatial coding properties of the grid cells across all three gro

176 thin these three groups have similar spatial coding properties.

177 Temporal coding quality was evaluated as vector strength in respo

178 ct introgression of a small part of the BCO2 coding region (<3 kb) in S. discolor and S. vitellina, i

179 s process requires that the ASOs bind in the coding region and reduce the target mRNA by RNase H1 whi

180 the existing ComiR web-tool by including the coding region based trained model, available together wi

181 strongly suggest a single-base change at the coding region of ClVST1(97) as a major molecular event d

182 which is an expansion of CAG repeats in the coding region of the causative genes that are otherwise

183 -associated risk loci are located in the non-coding region of the genome and therefore, their target

184 lso increase RNA Polymerase I loading to the coding region of the rDNA and this is Ncl dependent.

185 This particular 22 bp duplication within the coding region of UGT1A1 can be a founder mutation in the

186 ich had >=95% nucleotide homology in the VP1 coding region.

187 our MGW-prioritization approach to three non-coding regions associated with systemic lupus erythemato

188 ific HLA peptides derived from annotated non-coding regions could elicit anti-tumor immune responses.

189 mutations in pbp1, pbp2, and/or pbp3 within coding regions near known amoxicillin binding motifs.

190 tructure, expression, or function of protein-coding regions of cancer-biology related genes (gHFI) de

191 tion of VACV transcripts start or end within coding regions of neighbouring genes.

192 Recent genomic analyses revealed that the coding regions of PbANKA and the closely related Plasmod

193 ults uncover a function for ribosomes on non-coding regions of RNAs and reveal the mechanisms underly

194 meaningful prediction in both coding and non-coding regions of the cancer genome.

195 An analysis of the coding regions of the genome in 886 index cases of PID f

196 derstanding of the rules that govern the non-coding regions of the genome is less complete than our u

197 or somatic point mutations in coding and non-coding regions of the genome, we propose CScape-somatic,

198 fied SMs that enable different functions, SM-coding regions rapidly evolve in fungal genomes.

199 The majority of these are in non-coding regions, and are commonly assigned to the nearest

200 less complete than our understanding of the coding regions.

201 ive under-characterization of 90% of protein coding regions.

202 affected transcripts but rather the protein-coding regions.

203 most of the sites were located within genes' coding regions.

204 ecular inversion probes that targeted mainly coding regions.

205 eed to understand the functional role of non-coding regulatory elements (REs).

206 d as an indicator of the significance of non-coding regulatory variants.

207 ticated simulations to be set up with little coding required, thus lowering entry barriers to new use

208 ng to focused coding, through to theoretical coding, resulting in the production of core concepts and

209 f these are located within BANCR, a long non-coding RNA (lncRNA) exclusively expressed in primate fet

210 Metabolism Regulator (lincNMR) is a long non-coding RNA (lncRNA) which is induced in hepatocellular c

211 re sites for RNA biology including small non-coding RNA (ncRNA) mediated gene silencing.

212 could be identified by context-specific non-coding RNA (ncRNA) profiling, based on the observation t

213 PPARalpha directly upregulates the long non-coding RNA gene Gm15441 through PPARalpha binding sites

214 The long non-coding RNA NEAT1 serves as a scaffold for the assembly o

215 The long non-coding RNA Xist establishes an intra-chromosomal compart

216 Long intergenic non-coding RNA-Nucleotide Metabolism Regulator (lincNMR) is

217 (2.94-fold), GWAS loci (1.52-fold), and non-coding RNAs (1.44-fold), compared with random distributi

218 coding genes, the majority of human long non-coding RNAs (lncRNAs) are considered non-conserved.

219 Long non-coding RNAs (lncRNAs) are defined as non-protein-coding

220 Long non-coding RNAs (lncRNAs) are important regulators of develo

221 Long non-coding RNAs (lncRNAs) are often aberrantly expressed in

222 Non-coding RNAs are fundamental to the competing endogenous

223 Circular RNAs (circRNAs), a class of non-coding RNAs generated from non-canonical back-splicing e

224 We find that alignments for several long non-coding RNAs previously shown to lack covariation support

225 of EVs identifies diverse RBPs and small non-coding RNAs requiring the LC3-conjugation machinery for

226 MicroRNAs (miRs) are small non-coding RNAs that can have large impacts on oncogenic pat

227 Riboswitches are a class of nonprotein-coding RNAs that directly sense cellular metabolites to

228 MicroRNAs (miRNAs) are small non-coding RNAs that have been successfully identified to be

229 Small RNAs are non-coding RNAs that play important roles in the lives of bo

230 MicroRNA-27a/b are small non-coding RNAs which are reported to regulate inflammatory

231 s of changes in genome methylation, long non-coding RNAs, circular RNAs, micro-RNAs and fruit metabol

232 t eukaryotic pre-messenger RNAs and long non-coding RNAs, introns are removed through the process of

233 three highly abundant HHV-6 encoded long non-coding RNAs, one of which generates a non-polyadenylated

234 Enhancer RNAs (eRNA) are unstable non-coding RNAs, transcribed bidirectionally from active reg

235 lly targeted by differentially expressed non-coding RNAs.

236 dition to the ever-expanding pantheon of non-coding RNAs.

237 ng and/or degradation of both coding and non-coding RNAs.

238 ons, and regulation of transcription via non-coding RNAs.

239 nonlinear mixed selectivity may be a general coding scheme exploited by the brain for reliable and ef

240 A stable coding scheme simplifies readout for WM-guided behaviour

241 Indeed, we find that even within the stable coding scheme, memories drift during maintenance.

242 results indicate that the brain regions and coding schemes supporting relations and movements betwee

243 ds as well as an enhancement of the neurons' coding selectivity.

244 t interact in three dimensional space, while coding sequence duplicates are rare, GC-rich, short, and

245 trains have over an order of magnitude fewer coding sequence mutations outside of duplicated domains

246 We then use genome editing to disrupt the coding sequence of a S. rosetta C-type lectin gene, rose

247 The binding site within the beginning of the coding sequence of the prfA gene, which encodes the mast

248 ion-elongation kinetics along a transcript's coding sequence plays an important role in the maintenan

249 earrangement of the TERT gene juxtaposes the coding sequence to strong enhancer elements, leading to

250 emerging findings regarding the role of non-coding sequence variation offer opportunities for unders

251 P mutations are, however, relatively rare in coding sequence, in part because RIP preferentially atta

252 AAV-PHP.B vector carrying the mouse Slc25a46 coding sequence.

253 R) and rare codons at the beginning of their coding sequence.

254 icrobial community by cataloging the protein-coding sequences (CDS) present in the metagenome of the

255 931,698 reads were annotated into 11,676 coding sequences (CDS), which were manually curated into

256 ary transcripts of eukaryotic nuclear genes, coding sequences are often interrupted by U2-type intron

257 ll-known mutagen, has been maintained within coding sequences of crucial plant and animal genes.

258 atial orientation of regular repeats of rDNA coding sequences within the nucleoli.

259 opy repeats, most of which overlap predicted coding sequences.

260 rnative reading frames, we found a conserved coding signature in an alternative frame in exons 2 and

261 ), a web-based interface where users with no coding skills can compute the generation and post-select

262 Also, SSP-coding small open reading frames are often expressed at

263 ronger inside functional categories, such as coding SNPs and promoter regions.

264 These data indicate that non-coding somatic mutations disrupt the PAX8 transcriptiona

265 other hand, allows for identification of non-coding somatic variation and expanded estimation of back

266 1 snRNP (U1), vertebrates' most abundant non-coding (spliceosomal) small nuclear RNA, silences proxim

267 ies during new learning leads to dissociable coding strategies in hippocampal subfields, in line with

268 These differential coding strategies may favor temporal precision of cerebe

269 al Classification of Diseases, 10th Edition, coding strategies.

270 me information along with an ensemble pMHC-I coding strategy, and developed a group feature selection

271 We identified clustering of non-coding SVs around neuroactive ligand-receptor interactio

272 al Classification of Diseases, 10th Edition, coding systems, evaluating estimates of two previously p

273 ive debriefs between coach/coachee pairs, co-coding themes based on established principles of effecti

274 nalysis moved from initial coding to focused coding, through to theoretical coding, resulting in the

275 input areas, possibly differing in terms of coding, timing, and direction of information flow (e.g.,

276 accuracy emphasizes the potential for ICD-10 coding to be used effectively in database research.

277 nd memo writing, analysis moved from initial coding to focused coding, through to theoretical coding,

278 that lncRNAs are distinct from both protein-coding transcripts and genomic background noise in terms

279 ng RNAs (lncRNAs) are defined as non-protein-coding transcripts that are at least 200 nucleotides lon

280 reviously unreported subset of small peptide-coding transcripts was identified from these lncRNA loci

281 Unique dipeptide-coding uORFs and nucleotide motifs, such as '5'-UGA(C/G)

282 coding was stimulus specific, as opposed to coding value independent of the identity of the option.

283 raises key questions regarding how a single coding variant can contribute to this diversity of clini

284 e population sequencing data in studying non-coding variant classes.

285 The strongest coding variant in schizophrenia GWAS is a missense mutat

286 Rare and low-frequency functional protein-coding variants (minor allele frequency, <=5%) measured

287 tients with nsCL/P and identified three rare coding variants (p.Ala86Thr, p.Met91Iso and p.Arg546Gln)

288 e regulatory role of enhancer-associated non-coding variants in cancer epigenome, and to facilitate t

289 Coding variants in TMEM175 are likely to be responsible

290 Previous genome-wide scans found many non-coding variants under selection, suggesting a pressing n

291 nts (RE) and genes perturbed by acquired non-coding variants, here we establish epigenomic and transc

292 noncoding variants and/or by rare but severe coding variants, many de novo.

293 ast genetic diversity as naturally occurring coding variants, yet the impact of these variants on pro

294 been achieved by studying rare de novo (DN) coding variants.

295 needed to identify individual risk genes, as coding variation across many genes confers risk for SCZ

296 tended to select de novo, loss-of-function, coding variation, while maize domestication more frequen

297 on processing, we tested whether CA1 spatial coding was altered in this desynchronized circuit, using

298 0 weeks after transplantation; adverse event coding was centralised.

299 We also found that OFC value coding was stimulus specific, as opposed to coding value

300 ntegrating the concepts of neural population coding with distributed processing.