ライフサイエンスコーパス: coding region

1 ngle nucleotide polymorphisms in the protein coding region).

2 STK19 D89N substitution is thus outside the coding region.

3 hnology, we inserted stop codons into the gH coding region.

4 adenylation at near-cognate sites within the coding region.

5 s which had >=95% nucleotide homology in VP1 coding region.

6 and p53-binding sites in the proximal MALAT1 coding region.

7 rom premature termination codons in the mRNA coding region.

8 receptor beta gene (PDGFRB), a juxtamembrane-coding region.

9 dORF) located downstream of the nucleocapsid coding region.

10 and a shorter construct containing only the coding region.

11 le small open reading frames upstream of the coding region.

12 number of ribosomes on the principal protein-coding region.

13 ich had >=95% nucleotide homology in the VP1 coding region.

14 et elements located at the beginning of thiM coding region.

15 Positive selection is detected in the bindin coding region.

16 l rebound between blood and semen in one HIV coding region.

17 nsense variants in TET3 occur throughout the coding region.

18 is also located within a larger constrained coding region.

19 cludes three (nonidentical) copies of the 3B coding region.

20 ite difference in the HIV type 1 (HIV-1) pol coding region.

21 rcoil at gene boundaries, while Top1 acts at coding regions.

22 ay pathway hybridized near the 3' end of the coding regions.

23 less complete than our understanding of the coding regions.

24 ifferential DNA methylation occurring in non-coding regions.

25 3 non-canonical loci, with two involving non-coding regions.

26 data to identify deleterious variants in non-coding regions.

27 ive under-characterization of 90% of protein coding regions.

28 eneity and can readily be applied outside of coding regions.

29 outside of functionally well-defined protein coding regions.

30 tely predict all or even most of the protein-coding regions.

31 mutations occur at similar frequencies as in coding regions.

32 introduced premature termination codons into coding regions.

33 unknown function and located outside protein-coding regions.

34 CEs) that predominantly (>99%) reside in non-coding regions.

35 in coding regions and approaching 90% in non-coding regions.

36 asis of the presence of mutations in protein-coding regions.

37 g indicating disease-causing variants in non-coding regions.

38 ilized target sites lie predominantly within coding regions.

39 known about cancer-causing mutations in non-coding regions.

40 (s) for reducing misincorporation in protein-coding regions.

41 nslated regions (UTRs), introns, and protein-coding regions.

42 tations and genomic polymorphisms in protein-coding regions.

43 ed because most GWAS SNPs are located in non-coding regions.

44 affected transcripts but rather the protein-coding regions.

45 il diffusion and nucleosome repositioning at coding regions.

46 ssed genes with large effect variants in the coding regions.

47 most of the sites were located within genes' coding regions.

48 ber variations (CNVs) and point mutations in coding regions.

49 variance is accounted for by SNPs outside of coding regions.

50 unclear, especially when they appear in non-coding regions.

51 variants and/or may be uninformative for non-coding regions.

52 ecular inversion probes that targeted mainly coding regions.

53 s in non-European populations and outside of coding regions.

54 at gene boundaries and over-wound DNA within coding regions.

55 only 34 of which contain the 51 full-length coding regions.

56 nstream of the first (+1) nucleosome in gene coding regions.

57 ncreased acetylation of histones within gene coding regions.

58 microsatellites, of which 71 were in the non-coding regions.

59 subjects of European ancestry and focused on coding regions.

60 of peripheral-blood gene expression included coding regions (11.41x), conserved regions (4.67x), and

61 ulation of peripheral-blood gene expression: coding regions (4.47x), conserved regions (4.51x), and t

62 better overall accuracy (particularly in non-coding regions), a consistent threshold that can be appl

63 int mutations and structural variants in non-coding regions across 2,658 genomes from the Pan-Cancer

64 e expression analysis revealed that this non-coding region alteration is associated with the signific

65 Non-coding regions amplified beyond oncogene borders have la

66 the amount of poly(A) site usage within the coding region and 5' untranslated regions (5'-UTRs), and

67 s process requires that the ASOs bind in the coding region and reduce the target mRNA by RNase H1 whi

68 , RTC4 transcription begins near the protein-coding region and the resulting short transcript leader

69 t extends 13 nucleotides into the N-terminal coding region and, when a mRNA structure overlaps or par

70 e methods, reaching 74% balanced accuracy in coding regions and 69% in non-coding regions, whereas ev

71 e methods, reaching 91% balanced accuracy in coding regions and 70% in non-coding regions, while even

72 es and eukaryotes in general - nearly 80% in coding regions and approaching 90% in non-coding regions

73 ders (AUD), usually identify variants in non-coding regions and cannot by themselves distinguish whet

74 nucleotide variants (SNVs) that occur in non-coding regions and determined the regulatory function an

75 learning to predict novel conserved protein-coding regions and efficiently guide their manual curati

76 ents with HIES without candidate variants in coding regions and essential splice sites.

77 oded particles can be designed with specific coding regions and generate numerous distinct patterns e

78 tive nucleotide triplet substitutions in non-coding regions and in 4-fold degenerate sites.

79 RNAs with 3' ends within protein-coding regions and introns were less stable than mRNAs t

80 rous abundant termini were also found within coding regions and introns, including several major TSS

81 5' positioning of the ER-targeting sequence coding regions and is facilitated by the RNA-binding dom

82 ngle nucleotide variations (SNVs) in protein coding regions and one SNV in the 5' untranslated region

83 und evidence that this mechanism of using 5' coding regions and particular RBPs to achieve gene-speci

84 oportion of risk variants are located in non-coding regions and remain unexplained by current express

85 ations between mutations in MTB genes or non-coding regions and resistance, followed by validation in

86 T, their distribution between coding and non-coding regions and synonymous-to-non-synonymous mutation

87 ed a greater contribution of SNPs in protein-coding regions and within 3'-UTR regions of genes.

88 The majority of these are in non-coding regions, and are commonly assigned to the nearest

89 and directly proportional to each other, in coding regions, and decrease abruptly around the cleavag

90 jority of Psi moieties in mRNAs are found in coding regions, and our study suggests that one conseque

91 he identified associated variants are in non-coding regions, and presumably influence gene expression

92 (SO)-R-loops were generally spread over the coding regions, and their peak levels corresponded inver

93 de changes that alter amino acids in protein-coding regions are one of the major causes of human phen

94 Similar to coding region transcription, non-coding regions are split at transcriptional sites.

95 l established for coding genes; however, non-coding regions are thought less likely to be determinant

96 However, because protein-coding regions are under high selective constraints, the

97 The model prioritizes non-coding regions associated with regulation of important g

98 our MGW-prioritization approach to three non-coding regions associated with systemic lupus erythemato

99 dictions can be seen as complementary to the coding region based predictions, which suggests that bot

100 the existing ComiR web-tool by including the coding region based trained model, available together wi

101 ex.In this work, we tested whether including coding region binding sites in ComiR algorithm improves

102 ination may facilitate regulation of a given coding region by multiple cytoplasmic signals.

103 t The Functional Alteration Bias Recovery In Coding-regions Cancer Portal, a comprehensive catalogue

104 e have created a detailed map of constrained coding regions (CCRs) by leveraging variation observed a

105 ely 35% of m(6)A residues located within the coding region (CDS).

106 nt burden of rare exonic (that is, affecting coding regions) CNVs and were enriched for known genomic

107 ific HLA peptides derived from annotated non-coding regions could elicit anti-tumor immune responses.

108 occurs, but RNAP II is absent from the gene-coding region, demonstrating Sas3 and Ada2-dependent his

109 LARP4 mRNA contains a translation-dependent, coding region determinant (CRD) of instability that limi

110 glioma-associated oncogene 1 (GLI1) mRNA by coding region determinant binding protein (CRD-BP) throu

111 tory apparatuses, and the composition of the coding region determines the abundance of mRNAs near the

112 Remarkably, we find that coding regions display the highest structural propensity

113 ntroduced a frameshift mutation in the early coding region, ensuring faithful gene knockout.

114 In addition to genetic variants in coding regions (exons) that can change a protein sequenc

115 s higher in semen than in blood in all three coding regions for most participants.

116 -associated genetic variants that lie in non-coding regions found by genome-wide association studies

117 system produced trans-spliced mRNAs in which coding regions from independent transcripts were fused i

118 r and terminator regions, and regulatory and coding regions (gene "crumpling").

119 ophilia B, the large size of the factor VIII coding region has precluded improved outcomes with gene

120 Our new coding regions help elucidate disease-associated regions

121 lecular consequences of mutations in protein coding regions, however nearly all approaches have been

122 al relevance of recurrent alterations in non-coding regions identified with WGS and highlight the cen

123 fied structural variants (SVs) affecting non-coding regions, implicating recurrent deletions in the p

124 verning translation initiation at N-terminal coding regions, improving the predictive design of post-

125 t years have revealed essential roles of non-coding regions in gene regulation.

126 ll type-specific epigenetic variation of non-coding regions in neuropsychiatric disorders is increasi

127 The sizes of non-coding regions in the Longidoridae nematodes were very s

128 es(2-4), we present a high-resolution map of coding regions in the SARS-CoV-2 genome, which enables u

129 anscription generates RNA-DNA hybrids within coding regions, independently of fork orientation.

130 ion of any intergenic or deeply intronic non-coding region, indicating that proximal regulatory seque

131 is recognized by miR-449a, whereas the CCNA2 coding region is targeted by miR-424.

132 this gene has accumulated mutations, so its coding region is unlikely to produce a functional protei

133 trained with the information related to the coding regions is more efficient in predicting the micro

134 t fraction of Pol III transcription from non-coding regions is not subjected to Xist-mediated transcr

135 fying these transcriptional regions from non-coding regions is the first step towards lincRNA recogni

136 Based on the position of introns relative to coding regions, it categorizes introns into three groups

137 ica, and the variations at both promoter and coding regions lead to an increased level of thiolated t

138 rast, the number of coding genes, as well as coding region length, has remained similar.

139 ct introgression of a small part of the BCO2 coding region (<3 kb) in S. discolor and S. vitellina, i

140 omplex dermatologic diseases fall within non-coding regions, making assignment of function difficult.

141 These results suggest that SVs within non-coding regions may play an important role in ADHD develo

142 sequencing analysis revealed no increase in coding region mutations in HSPCs from EGF-treated mice,

143 function is often observed in the absence of coding region mutations in TET genes.

144 mutations in pbp1, pbp2, and/or pbp3 within coding regions near known amoxicillin binding motifs.

145 The entire coding region of 15 OpSCC driver genes was sequenced by

146 ly designed RNA hairpins into the N-terminal coding region of a reporter protein with steadily increa

147 aused by an Ac transposon insertion into the coding region of a unique NAC transcription factor withi

148 This variant is located in the coding region of all nine YAP1 spliceforms, and results

149 For engineering nuclear male sterility, the coding region of Brassica napus cysteine protease1 (BnCy

150 igator cathelicidin gene into a targeted non-coding region of channel catfish (Ictalurus punctatus) c

151 strongly suggest a single-base change at the coding region of ClVST1(97) as a major molecular event d

152 nd a dinucleotide (CA) microsatellite in the coding region of FGFRL1.

153 Inserting the ER-targeting sequence coding region of NA into different 5' UTRs confirmed tha

154 n the viral genome, ORF3, ORF5, and the nsp2-coding region of ORF1a accumulated the majority of nucle

155 larin lead to Nm modification in the protein-coding region of peroxidasin (Pxdn).

156 d recombinants throughout the non-structural coding region of poliovirus from dually transfected cell

157 approach to effectively delete an important coding region of Sav1, which increased the editing effic

158 We found that certain ASOs targeting the coding region of some mRNAs that initially reduce target

159 ns, that two mutations had arisen within the coding region of the 2A protease.

160 ed amphiphilic repression (EAR) motif in the coding region of the apple ETHYLENE RESPONSE FACTOR4 (ER

161 METTL3 induces m(6)A modification within the coding region of the associated mRNA transcript, and enh

162 which is an expansion of CAG repeats in the coding region of the causative genes that are otherwise

163 on of expanded CCUG repeat RNAs from the non-coding region of the CCHC-type zinc finger nucleic acid-

164 Nucleotide sequence analysis of the entire coding region of the CLCN1 gene revealed the absence of

165 A representative iRAP within the coding region of the essential gene, nadD, greatly reduc

166 ition gene, while the analysis of the entire coding region of the FANCM gene in familial index cases

167 to gain functional insights and replaced the coding region of the fly gene CG12333/wdr37 with GAL4.

168 -associated risk loci are located in the non-coding region of the genome and therefore, their target

169 ere we show, by sequencing beyond the capsid-coding region of the heat-selected virions, that two mut

170 mechanism, namely, by directly targeting the coding region of the L1 RNA and by repressing a required

171 f oncogenic H-Ras and K-Ras, we replaced the coding region of the murine K-Ras locus with H-Ras(G12V)

172 showing that the mRNAs terminate within the coding region of the opposite open reading frame.

173 s have identified non-sense mutations in the coding region of the PCLO gene, suggesting a functional

174 f mitochondria and have been mapped over the coding region of the POLG ORF.

175 lso increase RNA Polymerase I loading to the coding region of the rDNA and this is Ncl dependent.

176 Heterozygous mutations in the coding region of the RET gene cause a severe form of Hir

177 Most sequencing reads of the VP1 coding region of the SAT1 virus inoculum clustered aroun

178 ed low-frequency mutations (~25%) within the coding region of transmembrane domain 1 (TMD1) of E prot

179 This particular 22 bp duplication within the coding region of UGT1A1 can be a founder mutation in the

180 Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5);

181 iple evolutionary events in the promoter and coding region of VAC-INVcis-QTL were also detected for A

182 Here we sequence the protein-coding regions of 10,503 adult participants in the Pakis

183 ore than 10 million mutations in the protein-coding regions of 2,735 mutant lines of tetraploid and h

184 ion in 2538 patients with DCM across protein-coding regions of 56 commonly tested genes and compare t

185 In addition, CpG methylation is found in coding regions of active genes.

186 Sequencing of the coding regions of all linked genes failed to identify bi

187 rt through every guide targeting the protein-coding regions of any mouse or human gene.

188 tructure, expression, or function of protein-coding regions of cancer-biology related genes (gHFI) de

189 otide sequence repeats within coding and non-coding regions of different genes.

190 odel specifically studies the effects of non-coding regions of DNA (in this case, CpG sites) on mappi

191 ty of DNMT3A colocalize with H3K36me2 at non-coding regions of euchromatin.

192 ential missense and other alterations in the coding regions of every IGF family gene, but the vast ma

193 Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosi

194 depletions of gene fusion breakpoints within coding regions of fused genes as well as an N-terminal e

195 Thus most EoE risk loci are outside of the coding regions of genes, suggesting a key role for gene

196 titutive transcription initiation within the coding regions of genes.

197 eplacement of DNA fragments that contain the coding regions of genes.

198 As most corrections were within the coding regions of GPI-CWP genes, our genome assembly est

199 hairpin RNAs (dual-shRNA) against different coding regions of HBV delivered by a self-complementary

200 e nearly always in highly conserved, protein-coding regions of host mRNAs.

201 Heterozygous in-frame mutations in coding regions of human STAT3 underlie the only known au

202 K exome sequencing data, we interrogated the coding regions of KAR and NETO genes in individuals with

203 Fs encode conserved functional peptides, the coding regions of most uORFs are not conserved.

204 binding to the 5' untranslated and/or early coding regions of mRNA targets, causing changes in trans

205 ethyl decreased mRNA levels when targeted to coding regions of mRNAs in a translation-dependent, RNas

206 tion of VACV transcripts start or end within coding regions of neighbouring genes.

207 Recent genomic analyses revealed that the coding regions of PbANKA and the closely related Plasmod

208 The significance of editing within non-coding regions of RNA is poorly understood.

209 ults uncover a function for ribosomes on non-coding regions of RNAs and reveal the mechanisms underly

210 loped an exome-capture assay to sequence the coding regions of the Atelopus genome.

211 atistical approach to isolate coding and non-coding regions of the cancer genome that appear enriched

212 by stage of disease and driver counts in non-coding regions of the cancer genome, in addition to driv

213 meaningful prediction in both coding and non-coding regions of the cancer genome.

214 We sequenced coding regions of the cluster of differentiation 36 (CD3

215 et goal is to minimize the essential protein coding regions of the exported DNA while maintaining its

216 hly constrained phosphorylation sites in the coding regions of the gene and is also located within a

217 8.4% involved associations with flanking non-coding regions of the gene.

218 ority of GWAS-implicated variants are in non-coding regions of the genome and require in depth follow

219 sociation studies (GWASs) are located in non-coding regions of the genome and thought to act through

220 An analysis of the coding regions of the genome in 886 index cases of PID f

221 s, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumorige

222 derstanding of the rules that govern the non-coding regions of the genome is less complete than our u

223 ions that occur in the extensive non-protein-coding regions of the genome remain poorly understood.

224 factors, other protein coding genes, and non-coding regions of the genome with regulatory potential.

225 e contribution of regulatory and non-protein coding regions of the genome, we conducted aggregate tes

226 or somatic point mutations in coding and non-coding regions of the genome, we propose CScape, an inte

227 or somatic point mutations in coding and non-coding regions of the genome, we propose CScape-somatic,

228 iants are often not causal and reside in non-coding regions of the genome.

229 ge is magnified for variants residing in non-coding regions of the genome.

230 susceptibility regions reside in non-protein-coding regions of the genome.

231 aetiological variants in the coding and non-coding regions of the genome.

232 have focused on somatic mutations within the coding regions of the genome.

233 especially chromosomal rearrangements in non-coding regions of the human genome, remains one of the b

234 ect, pathogenic or neutral, of indels in non-coding regions of the human genome.

235 potential pathogenic impact of indels in non-coding regions of the human genome.

236 cing, our method successfully identified all coding regions of the mouse picobirnavirus for the first

237 ~8100 mutations in 152 genes, and within the coding regions of these genes are over 60,000 missense v

238 The non-coding regions of tumour cell genomes harbour a consider

239 ility mRNAs, the 5'-untranslated regions and coding regions of which are enriched in the motif (U/A)U

240 We investigated the impact of an uORF coding region on gene regulation by assaying the functio

241 edicting the effects of mutations in protein coding regions on nucleic acid binding affinities.

242 cial role in the study of the effects of non-coding regions on the molecular classification of cancer

243 protein-centric standpoint; however, protein-coding regions only make up approximately 1% to 2% of th

244 efficiently link the effects of mutations in coding regions or promoter elements in a highly parallel

245 A population-restricted single-nucleotide coding region polymorphism (SNP) at codon 47 exists in t

246 nsisting of an sgRNA adjoining a GFP protein coding region produced indels and viral-based GFP overex

247 We propose histone H3 acetylation in the coding region provides rate-limiting control during the

248 he most common modifications present in mRNA coding regions, pseudouridine (Psi), impacts protein syn

249 r two protein-coding genes and conserved non-coding regions putatively involved in replication and/or

250 fied SMs that enable different functions, SM-coding regions rapidly evolve in fungal genomes.

251 Anchoring the coding region rbcL in multigene tiered approach, the com

252 ought to test this assumption by focusing on coding regions required for splicing.

253 single nucleotide polymorphism (SNP) in the coding region resulted in a nonsynonymous amino acid sub

254 iants, with the vast majority falling in non-coding regions resulting in no eventual protein products

255 Their impact on retrotransposons in non-coding regions shed light on important aspects of mammal

256 ggests that both predictions, from 3'utr and coding regions, should be considered in comprehensive an

257 mic regions and also showed that defined non-coding regions, such as first introns of genes and regul

258 -effect variants(1) located primarily in non-coding regions, suggesting that the underlying causal ef

259 cluding the polyA tail), including 909 bp of coding region that encoded a polypeptide of 302 amino ac

260 ied a single nucleotide variant in the CASZ1 coding region that potentially contributes to ERMS tumor

261 ngle nucleotide polymorphisms (SNPs) in CPG2 coding regions that affect CPG2 expression, localization

262 ation study to discover germline variants in coding regions that affect risk for pancreatic cancer, c

263 hical reports are offered for coding and non-coding regions that annotate the potential impact of put

264 d clinical covariates and detect loci in non-coding regions that are difficult to interpret.

265 those targeting intergenic and intronic non-coding regions that eluded previous exome focused strate

266 any disease-associated loci are found in non-coding regions that house regulatory elements.

267 stream gene interactions and integrating non-coding regions that may be regulating gene expression le

268 R and LR rats, we identified alleles in gene-coding regions that segregate between the two lines.

269 ts population-specific genomic signatures in coding regions that show adaptations unique to Nunavik I

270 For coding regions, the corresponding percentages were 83.5%

271 arry 2.9 rare structural variants that alter coding regions; these variants affect the dosage or stru

272 dramatically increased diversity in the gene coding regions, though obvious blocks were formed on mos

273 me to stabilize attenuation determinants, 2C coding region to prevent recombination, and 3D polymeras

274 plication element (CRE) from the polyprotein coding region to the 3' non-coding region we have furthe

275 rd Nanopore Technologies reduce dark protein-coding regions to approximately 50.5%, 35.6%, and 9.6%,

276 w a GRB-based approach to assign loci in non-coding regions to potential target genes, and apply it t

277 Similar to coding region transcription, non-coding regions are spli

278 identify evolutionary signatures of protein-coding regions using multispecies genome alignments.

279 n of randomly selected low-frequency protein-coding regions using twelve different balanced samples w

280 activity) were transfected with each of the coding region variants of SLC43A3.

281 e-pair changes in intergenic enhancer sites, coding-region variants, and SNP-gene proximity, we were

282 e show that editing levels in non-repetitive coding regions vary more between tissues than editing le

283 n, Setting, and Participants: The entire GBA coding region was screened for mutations and E326K in 74

284 The improved accuracy in non-coding regions was mainly achieved using novel repetitiv

285 the polyprotein coding region to the 3' non-coding region we have further developed a cell-based ass

286 in RNA (shRNA) targeted against the reporter coding region, we have characterized the dynamics of the

287 t mutations and a common risk variant in the coding region, we have identified an important contribut

288 To further characterize the burdening of non-coding regions, we used NIMBus to screen transcription f

289 e TERT promoter and tumor protein P53 (TP53) coding region were analyzed in 101 HBV-related HCC cases

290 Sequence polymorphisms in the B1 coding region were not observed in diverse wheat germpla

291 nhanced coverage within the DENV polyprotein coding region were observed.

292 h high CpG/UpA sequences inserted into a non-coding region were similarly replication defective.

293 hose somatic mutations that occur at the non-coding regions where AR binds DNA.

294 ed accuracy in coding regions and 69% in non-coding regions, whereas even higher accuracy may be achi

295 ed accuracy in coding regions and 70% in non-coding regions, while even higher accuracy may be achiev

296 0 variants, we replaced the Drosophila Tom70 coding region with a Kozak-mini-GAL4 transgene using CRI

297 Haplotype analysis revealed a conserved B1 coding region with proximal polymorphisms and supported

298 on of intraspecies constraint by identifying coding regions with a scarcity of variation.

299 segment roughly follows that seen within the coding regions, with HLA-B showing the highest ( approxi

300 the GENCODE gene set, as well as additional coding regions within 236 previously annotated protein-c