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1 R) and rare codons at the beginning of their coding sequence.
2 ranslated leader and the other is within the coding sequence.
3 in unique positions that did not disrupt the coding sequence.
4 ridine additions both reconstituting crucial coding sequence.
5 determine the impact of the mutation on the coding sequence.
6 s are corrected by reintroduction of a TgDCX coding sequence.
7 te translational derepression of the var2csa coding sequence.
8 allele causes a frame-shifted and truncated coding sequence.
9 tream from the start codon, or 1 kb into the coding sequence.
10 amoxifen-inducible Cre recombinase (CreERT2)-coding sequence.
11 utations in the Gag or reverse transcriptase coding sequence.
12 e transcription from the 3' end of the GAL10 coding sequence.
13 ribosome reinitiation at the downstream CHOP coding sequence.
14 AAV-PHP.B vector carrying the mouse Slc25a46 coding sequence.
15 equired for termination upstream of the ribD coding sequence.
16 or allele frequency of a SNP 3' of the GATA6 coding sequence.
17 the gradient, despite sharing most of their coding sequence.
18 iency increases p63gamma mRNA through APA in coding sequence.
19 , the second in-frame methionine of the TDP2 coding sequence.
20 and in the most conserved portion of protein-coding sequences.
21 d in association studies are located outside coding sequences.
22 ing control features embedded within protein-coding sequences.
23 opy repeats, most of which overlap predicted coding sequences.
24 reby leading to heterogeneity in base-editor coding sequences.
25 genes have been described, all targeting the coding sequences.
26 l tool for the genome-wide detection of AARS coding sequences.
27 rent 3' untranslated regions (3'UTRs) and/or coding sequences.
28 r to that affected by recurrent mutations to coding sequences.
29 create in-frame and frameshift insertions in coding sequences.
30 presentation for complex genomic regions and coding sequences.
31 ons and have the potential to change protein coding sequences.
32 uctures within the N-terminal regions of its coding sequences.
33 ining pause sites were identified in protein-coding sequences.
34 ed by the lack of recognizable mitochondrial coding sequences.
35 adds hundreds of uridines to create protein-coding sequences.
36 ead heterozygous structural variation within coding sequences.
37 ction of cases remain outside of single gene coding sequences.
38 ble to that of missense variation in protein-coding sequences.
39 ing from nutrient limitation shape microbial coding sequences.
40 fails to distinguish between coding and non-coding sequences.
41 haploidized to mask deleterious mutations on coding sequences.
43 including density of ribosomal footprints on coding sequences, 5' leader ribosomal densities, distrib
44 and estimate alpha = 0.135 in human protein-coding sequences, 72% of which is contributed by weakly
45 t adeno-associated virus containing the CRRY coding sequence (AAV-CRRY) into the subretinal space of
46 19-nCoV) RdRp (RNA-dependent RNA polymerase) coding sequence, achieving a detection limit of 0.4 fM w
47 art sites that were sometimes within protein-coding sequences, acquisition of polyadenylation sites,
48 tions are indeed conserved within homologous coding sequences across diverse eukaryotic, bacterial, a
51 which encodes a lung mucin and exhibits more coding sequence alleles than any HLA class I or II gene
52 ker than the selection on the same codons in coding sequences, although the switches between the codo
53 for animal evolution, our recent large-scale coding-sequence analyses from vertebrates and invertebra
54 ased on Freebayes and ExomeDepth to identify coding sequence and copy number variants, respectively,
55 on was found within the HvCslF6 promoter and coding sequence and does not explain variation in (1,3;1
56 evolutionarily plastic both at the level of coding sequence and expression across A. thaliana access
57 for miR-200c seed pairing in their 3'UTR and coding sequence and for genes that were downregulated by
58 f the C-terminal p63 isoforms through APA in coding sequence and mRNA translation and that the p63-PA
59 y genome-wide association studies map to non-coding sequence and their tissue-specific effects influe
60 th a correlation between m6A modification in coding sequences and enhanced translation, particularly
61 ng a combinatorial deletion approach of both coding sequences and enhancers, our work provides new in
63 occur in both protein-coding and non-protein-coding sequences and generate missense, nonsense, splice
64 iptomes (for 27 species in total), predicted coding sequences and identified single copy orthologues
65 ase deletions is preferentially increased in coding sequences and in short rather than long mononucle
66 wn role in ribosomal (rRNA) processing, many coding sequences and intergenic regions appeared to be d
67 c-rearrangement mutational process affecting coding sequences and noncoding regulatory elements and c
69 including disease-linked variants in protein-coding sequences and variants with trans regulatory effe
70 376 other individuals, we identified 244,246 coding-sequence and splice-site ultra-rare variants (URV
71 c copy number can influence gene expression, coding sequence, and zygosity, making them powerful acto
72 in the transcripts of many genes, notably in coding sequences, and identify consensus sites for hydro
73 the translational start codon, depletion in coding sequences, and mixed patterns of enrichment in th
75 ty patterns and coverage similarities across coding sequences, and showed that they yield comparable
76 ranslated region between the M and F protein coding sequences, and shown that, for more than half the
77 related species, evidence for ancestral non-coding sequences, and transcription and translation of t
78 vast majority of these novel contigs possess coding sequences, and we have validated their existence
79 ximately 6%), and a high fraction of protein-coding sequence ( approximately 39%) with relatively lon
81 ve in current studies, genes whose wild-type coding sequences are needed for tumor growth are also of
82 ary transcripts of eukaryotic nuclear genes, coding sequences are often interrupted by U2-type intron
83 ensure all single point mutations in protein-coding sequences are selected against while maintaining
85 create random nucleotide sequences, protein coding sequences are subject to a unique set of constrai
87 MNase HS regions are therefore on par with coding sequences as annotations that demarcate the funct
88 ae and I. pulchra genomes have many long non-coding sequences between genes, likely driving genome si
90 delaying modifier signal does not alter FAN1 coding sequence but is associated with increased FAN1 mR
91 inhibitors that target ribosomes within the coding sequence but not those targeting newly initiated
92 udes not only the duplication or deletion of coding sequences, but also the perturbation of noncoding
93 ally, Rho promotes termination at the end of coding sequences, but it can also terminate transcriptio
95 ion of an mRNA, despite carrying a canonical coding sequence, can directly cause gene repression.
96 (ORF) of the target gene which truncates the coding sequence (CDS) and targets the corresponding tran
97 a unit from which the extant repetitive AFGP-coding sequence (cds) arose through tandem duplications.
100 nservation was lost mostly downstream of the coding sequence (CDS), indicating the presence of high s
102 icrobial community by cataloging the protein-coding sequences (CDS) present in the metagenome of the
104 931,698 reads were annotated into 11,676 coding sequences (CDS), which were manually curated into
107 sis of 5'-truncated mRNA ends that mapped to coding sequences (CDSs) of Arabidopsis thaliana, rice (O
108 latory sequences and using native microalgal coding sequences (CDSs) with higher GC content improved
112 therefore the requirements for and order of coding sequence changes, expression changes, or gene dup
115 Here we present a protocol for generating coding-sequence-complete genomes, comprising an online p
116 s between the serogroup Y sublineages of all coding sequences, complex genomic regions, intergenic re
117 led CRISPR screening to disrupt NuRD protein coding sequences comprehensively in human adult erythroi
119 vergence (particularly of highly constrained coding sequence) contributes to convergent phenotypic ev
120 whereas alternative polyadenylation (APA) in coding sequence creates two more C-terminal isoforms p63
123 ted with p16 silencing in the absence of p16 coding sequence deletion and MAX induction restores p16
124 t interact in three dimensional space, while coding sequence duplicates are rare, GC-rich, short, and
125 identify the disruption of exon-proximal non-coding sequences (e.g., the promoter) as functionally co
126 ient function for ATHs and demonstrates that coding sequence evolution can underlie quantitative vari
128 al start codon while the bulk of the protein-coding sequence evolved through a CAG repeat expansion.
129 an clock-dependent AS by binding to exons at coding sequences flanking exons that are more frequently
130 tified an unusual gene in Apicomplexa with a coding sequence for membrane-docking and structure-speci
131 portion of RNA1 5' UTR but extends into the coding sequence for nine nucleotides, thus was missed in
134 deno-associated viral vectors to deliver the coding sequence for Transmembrane Channel-Like (Tmc) 1 o
136 or 99% of IMD isolates, including those with coding sequences for MnB, MnC, MnW, and MnY, and the phe
137 -associated virus serotype 10 expressing the coding sequences for the CLN2 gene implicated in late in
138 at specific positions in a set of homologous coding sequences, for example to tune translation rate w
139 o GPA was overcome by expression of the ADF3 coding sequence from the phloem-specific SUC2 promoter,
140 manized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replace
141 ble and can be warmed-up (gene promoters and coding sequences), from those that remain refractory (ge
142 g domains (MBDs) were deleted from the ATP7B coding sequence, giving rise to the miniATP7B protein (D
144 arasite lines, where the P. berghei csp gene coding sequence has been replaced with either full-lengt
146 le for synonymous rare codons farther within coding sequences has not yet been established, several r
148 Translated regions distinct from annotated coding sequences have emerged as essential elements of t
149 ls built on Arabidopsis thaliana genes or 2) coding sequence homology searches using curated database
152 Our results support a model in which a uORF coding sequence impacts its regulatory functions by alte
153 analyzed the genetic variation in the FOXP2 coding sequence in 63 chimpanzees, 11 bonobos, 48 gorill
156 osine (m6dA) accumulates along promoters and coding sequences in activated prefrontal cortical neuron
157 y polynucleotide and were located within the coding sequences in both wild type and degradosome mutan
158 supports the role of common variants in non-coding sequences in influencing complex phenotypes throu
160 arge number of GGDEF proteins, nearing 1% of coding sequences in some cases, raises the question of w
162 leotide tails were mostly located within the coding sequences in the degradosome mutants compared to
163 results shed light on the importance of non-coding sequences in the evolution of the S-locus, and on
165 P mutations are, however, relatively rare in coding sequence, in part because RIP preferentially atta
167 lastoid cell lines, we identified 7273 novel coding sequences, including 2442 translated upstream ope
169 e demonstrate that both gene disruptions and coding sequence insertions are efficiently generated, pr
171 election, followed by integration of the tag-coding sequence into the endogenous locus in zebrafish.
172 o start and stop codons are used to assemble coding sequences into expression units, avoiding scars a
173 e hybrid fragment containing these human non-coding sequences into the mTert locus in mouse embryonic
174 Small non-coding RNAs (ncRNAs) are short non-coding sequences involved in gene regulation in many bio
175 Sequence analysis revealed that the VP2-coding sequence is considerably conserved among FMDV ser
176 f ALAS2 expression, indicating that this non-coding sequence is indispensable for ALAS2 expression in
177 ity and/or translation, while changes in the coding sequences lead to mRNAs encoding distinct protein
178 ve ribosome pausing within the DENV envelope coding sequence, leading to enhanced protein stability.
180 vast majority of them are located outside of coding sequences, making it challenging to directly inte
181 However, most of these variants do not alter coding sequences, making it difficult to assign their fu
182 es upstream of the green fluorescent protein-coding sequence markedly reduces the levels of gfp mRNA
186 trains have over an order of magnitude fewer coding sequence mutations outside of duplicated domains
188 n people, with risk variants enriched in non-coding sequences near chondrocyte genes, loci that likel
189 In familial MDS/AML, mutations change the coding sequence of a gene to generate a mutant protein w
190 We then use genome editing to disrupt the coding sequence of a S. rosetta C-type lectin gene, rose
191 l II into transcriptional elongation) to the coding sequence of an active gene, ADH1, independently o
192 vigilin binds to CU-rich regions in the mRNA coding sequence of Apob and other proatherogenic secrete
193 showed that miR-K6-5p directly targeted the coding sequence of CD82 molecule (CD82), a metastasis su
196 ort the notion that SNPs in the 3'UTR or the coding sequence of disease-relevant genes may be importa
198 We show that the transgenes disrupt the coding sequence of endogenous genes in half of the lines
200 eotides, so-called polyA tracks, to the gene coding sequence of interest will decrease translation el
201 ion because overexpression of a noncleavable coding sequence of MYB83 significantly increased plant s
202 fied a number of mutations within the capsid-coding sequence of poliovirus (PV) that were established
204 epletion, especially at the beginning of the coding sequence of SMN-specific mRNAs, leading to impair
205 s suggest the existence of an IRES in the 5' coding sequence of TDP2 that translationally regulates e
208 c.1750G > A; p.Gly584Ser variant within the coding sequence of the KCNH2 gene implicated in Long QT
210 other than previously reported deletions at coding sequence of the ORF8 (open reading frame), spike,
211 The binding site within the beginning of the coding sequence of the prfA gene, which encodes the mast
214 diting and used these discoveries to correct coding sequences of 174 pathogenic transversion SNVs wit
216 ntron or when introduced into the 5'-UTR and coding sequences of an intronless construct, demonstrati
219 ll-known mutagen, has been maintained within coding sequences of crucial plant and animal genes.
220 r role in fruit ripening in more detail, the coding sequences of FvXTH9 and FvXTH6 were cloned into t
221 nes as well as between selection pressure on coding sequences of genes and their cold responsiveness.
222 led abundant genetic variation affecting the coding sequences of human transcription factors (TFs), b
223 both in promoter regions and throughout the coding sequences of many genes and is particularly enric
225 egion from within LUR, containing the entire coding sequences of ORF50-encoding reactivation transact
226 fy an average of 14+/-5 somatic mutations in coding sequences of sorted monocyte DNA and the signatur
228 the potential impact of mutations on the DNA coding sequences of these targets, and compare these res
229 raction reporter to intracellularly fuse the coding sequences of two interacting proteins and next-ge
230 ences on the papaya X chromosome and protein-coding sequences on the S. latifolia X chromosome, our m
233 nor the implications of DTU on their protein coding sequences or functions, are currently well unders
235 ion-elongation kinetics along a transcript's coding sequence plays an important role in the maintenan
236 on targeting, and also incorporates domains, coding sequence position, U6 termination (TTT), restrict
237 encode multiple, often undescribed, protein-coding sequences, potentially increasing the diversity o
238 y activating transcription, altering protein-coding sequences, producing noncoding RNAs, and even sup
239 ligands and receptors exhibit similarity of coding sequences, protein structures, and chromosomal po
241 on of gene structure by using the lengths of coding sequence regions and dinucleotide percentages to
242 s located adjacent to UGA codons, additional coding sequence regions necessary for efficient producti
244 -fold repetitive B1 gene, and more recently, coding sequence Rep 529 has been preferred, as it was re
245 We hypothesise that these modules in non-coding sequence represent distinct cis-regulatory loci t
247 ce genes that do not disrupt the target gene coding sequence, resulting in easy and flexible gene tag
248 orA) or no T (porA) at the 3' end of the gfp coding sequence revealed that both the transcript level
250 re, variants creating uORFs that overlap the coding sequence show signals of selection equivalent to
251 opsis thaliana lines expressing the effector-coding sequence showed altered expression levels of defe
255 NA identified several mutations in the opsin coding sequence, suggesting the loss of cone cell functi
256 iolate these parametric assumptions for such coding sequences, suggesting that a non-parametric appro
257 er, we show that when placed downstream of a coding sequence, sxRNA can be used to switch "ON" transl
258 ating more relaxed constraint on the FtsZ2-2 coding sequence than on those of FtsZ2-1 or FtsZ1-1 Our
260 rmatic analyses to identify putative protein-coding sequences that are specific to mosquito genomes.
261 3'UTRs that results in species-specific non-coding sequences that may contribute to bacterial divers
262 est that in addition to allelic variation of coding sequence, the heterogenous nature of the tetraplo
267 mutant mice reconstituted the otoferlin cDNA coding sequence through recombination of the 5' and 3' c
268 e resolution of sexual conflict over protein coding sequences, thus contributing to the long-term mai
269 en the TMPRSS2 promoter sequence and the ERG coding sequence (TMPRSS2:ERG) in urine, noninvasive scre
270 o acid change in the hexose transporter HXT7 coding sequence to be responsible for the evolved phenot
271 earrangement of the TERT gene juxtaposes the coding sequence to strong enhancer elements, leading to
272 the Waxy1 chloroplast targeting the peptide coding sequence to the Pgd1 and Pgd2 open reading frames
274 of Cpf1 by approximately threefold in human coding sequences to one cleavage site per approximately
275 dentified by in silico changing the C57BL/6J coding sequences to the SPRET/Ei sequences, converting t
276 ith the AXR1 promoter and either AXR1 or AXL coding sequences) to further study the extent of functio
280 erized RP were completely screened for TRNT1 coding sequence variants, and a second family was identi
281 Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in
283 emerging findings regarding the role of non-coding sequence variation offer opportunities for unders
284 ic specificity, and interprets the action of coding sequence variations in proteins, people and popul
286 gene-targeting approach where the mouse PrP coding sequence was replaced with elk or deer PrP, we sh
288 fected by recurrent mutations disrupting non-coding sequences was similar to that affected by recurre
290 1 RNA element that partially overlaps the PR coding sequence, we identified a novel function of the P
291 om which fragment antigen-binding nucleotide coding sequences were cloned as a single chain into a le
292 al genome and nuclear intergenic and protein-coding sequences were obtained by direct sequencing of g
293 tional ability of a luciferase reporter gene coding sequence when it is preceded by multiple tyrosine
294 d rare SVs that disrupt or duplicate protein-coding sequence, which suggests that genes that are high
295 erroneously annotated as containing protein-coding sequences, which over time have propagated to cre
296 a specific fragment of the Sola l 7 allergen coding sequence with appropriate RNA probes designed and
297 rooxidans species comprising of 6926 protein coding sequences with 23.04% (1596) core genes, 46.13% (
298 (>=99.4% shared core genome, >=99.6% shared coding sequence) with priority AMR were found in birds o
299 8) per base pair per generation in autosomal coding sequence, with a corresponding non-crossover gene