ライフサイエンスコーパス: coeliac disease

1 central role of IL-15 in the pathogenesis of coeliac disease.

2 ily history of inflammatory bowel disease or coeliac disease.

3 a burdensome life-long gluten-free diet for coeliac disease.

4 e recent scientific and clinical advances in coeliac disease.

5 e critically the recent research advances in coeliac disease.

6 onhuman leucocyte antigen genetic factors in coeliac disease.

7 he molecular pathways involving cytokines in coeliac disease.

8 tive gluten peptides presented by HLA-DQ8 in coeliac disease.

9 mune system is central to the development of coeliac disease.

10 sponsiveness, and tissue transglutaminase in coeliac disease.

11 3) known to induce small intestine damage in coeliac disease.

12 P kinase might have the potential to control coeliac disease.

13 help improve quality of life of people with coeliac disease.

14 an adaptive immune response in patients with coeliac disease.

15 ents with this disorder are investigated for coeliac disease.

16 ry care should be investigated routinely for coeliac disease.

17 ontrols, both of whom were EMA positive, had coeliac disease.

18 uodenal biopsy to confirm the possibility of coeliac disease.

19 the commonest neurological manifestation of coeliac disease.

20 urrent aphthous ulcerations in patients with coeliac disease.

21 -15) is implicated in the pathophysiology of coeliac disease.

22 bowel disease, irritable bowel syndrome, and coeliac disease.

23 elial stress, which has been associated with Coeliac disease.

24 that is analogous to the gluten-free diet in coeliac disease.

25 ion and markedly ameliorate the pathology of coeliac disease.

26 ent of pathologies such as food allergies or coeliac disease.

27 be warranted in patients with non-responsive coeliac disease.

28 to gluten-challenge studies of patients with coeliac disease.

29 body to be investigated for the treatment of coeliac disease.

30 rapeutic vaccine, Nexvax2, designed to treat coeliac disease.

31 nt of this potential therapeutic vaccine for coeliac disease.

32 l biopsy for those tested positive to detect coeliac disease.

33 ology found no causes for anaemia other than coeliac disease.

34 first months after diagnosis of complicated coeliac disease.

35 in resolving long-lasting health problems in coeliac disease.

36 sed symptoms and impaired quality of life in coeliac disease.

37 dditional primary care costs associated with coeliac disease.

38 proximately 1% of the population suffer from coeliac disease.

39 gnostic approach to reduce underdiagnosis of coeliac disease.

40 RD0.1), Urticaria (1.58[1.57-1.60], RD1.9), Coeliac disease (1.42[1.37-1.47], RD0.1), Ulcerative col

41 re), 58% a TSH dosage (7%) and 8% a test for coeliac diseases (1%) and the year after: 44% (8%), 43%

42 ad positive antibody results, of whom 14 had coeliac disease (11 EMA positive, three EMA negative).

43 e meta-analysis measured gut permeability in coeliac disease, 17 studies in Crohn's disease.

44 The largest increases were seen in coeliac disease (2.19 [2.05-2.35]), Sjogren's syndrome (

45 eliac disease than Controls (median [Q1, Q3] coeliac disease: 2104 pg/mL 1493, 2457] vs Controls: 938

46 son's disease (IRR 26.5 [95% CI 17.3-40.7]), coeliac disease (28.4 [25.2-32.0]), and thyroid disease

47 opsy samples from 42 patients with untreated coeliac disease, 37 treated patients, and 18 controls, w

48 in our understanding of the pathogenesis of coeliac disease(4), the respective roles of disease-pred

49 gluten-free diet is the only means to manage coeliac disease, a permanent immune intolerance to glute

50 based study involved 873 adult patients with coeliac disease and 563 non-coeliac controls.

51 nity including thyroiditis, type 1 diabetes, coeliac disease and alopecia areata(1,2).

52 lude the association of Down's syndrome with coeliac disease and Alzheimer's disease, and improved me

53 enes at HLA-unlinked loci also predispose to coeliac disease and are probably stronger determinants o

54 develop biomarkers of small bowel damage in coeliac disease and Crohn's disease.

55 rker of small bowel damage, in children with coeliac disease and Crohn's disease.

56 nded to occur rapidly after the diagnosis of coeliac disease and cumulative survival dropped in the f

57 dietary gluten intake in conditions such as coeliac disease and dermatitis herpetiformis.

58 ersensitivity (FHS), including food allergy, coeliac disease and food intolerance, is a major public

59 falls of vitamin A supplementation in active coeliac disease and have enabled identification of oat a

60 untries experienced: poor dietary intake for coeliac disease and inflammatory bowel disease, cultural

61 ng, the well established association between coeliac disease and insulin dependent diabetes mellitus,

62 ptibility to type 1 diabetes (T1D) with both Coeliac disease and multiple sclerosis.

63 isk to people affected by conditions such as coeliac disease and non-coeliac gluten sensitivity.

64 understanding of the complex pathogenesis of coeliac disease and novel therapeutic targets.

65 tic susceptibilities that are both unique to coeliac disease and overlap with other autoimmune diseas

66 mall bowel Crohn's disease, complications of coeliac disease and surveillance of polyposis syndromes.

67 e the possible concealed burden of untreated coeliac disease and the effects of a gluten-free diet.

68 especially regarding the natural history of coeliac disease and the effects on long-term health for

69 sidue at position beta57 are associated with coeliac disease and type I diabetes.

70 5-positive patients aged 18-70 years who had coeliac disease and were on a gluten-free diet.

71 NCWS individuals, in whom coeliac disease and wheat allergy were ruled out, receiv

72 ren participated and 240 were diagnosed with coeliac disease, and a study involving members of the Sw

73 ed age 18-80 years, a confirmed diagnosis of coeliac disease, and adherence to a gluten-free diet for

74 d urine of children with ulcerative colitis, coeliac disease, and Crohn's disease at diagnosis and fr

75 tunity to both increase our understanding of coeliac disease, and develop new therapeutic strategies.

76 icanus larvae for allergic rhinitis, asthma, coeliac disease, and multiple sclerosis.

77 or all immune recognition of wheat gluten in coeliac disease, and to explore if the tissue transgluta

78 ases such as systemic lupus erythematosus or coeliac disease, antibodies to specific membrane targets

79 learned about the mechanisms of MS by using coeliac disease as a model.

80 designed for the selective amplification of coeliac disease associated alleles (DQA1*05, DQB1*02, DQ

81 time and place of diagnosis and presence of coeliac disease-associated or other co-morbidities.

82 ies against tissue transglutaminase (marking coeliac disease autoimmunity) also appeared early (2-4 y

83 l criterion to compare duodenal histology in coeliac disease before and after gluten withdrawal.

84 Crohn's disease and coeliac disease both demonstrate considerable overlap in

85 gliadin antibodies are a marker of untreated coeliac disease but can also be found in individuals wit

86 eurological syndromes may be associated with coeliac disease but it is unclear whether these are dire

87 esis and improving diagnostic strategies for coeliac disease, but further work into the treatment of

88 (age and sex matched) were investigated for coeliac disease by analysis of serum IgA antigliadin, Ig

89 Although coeliac disease can be misdiagnosed as irritable bowel s

90 gnosis, and a low QALY score for undiagnosed coeliac disease cases.

91 ildren with IgE-mediated wheat allergy (WA), coeliac disease (CD) and Helicobacter pylori infection (

92 The consequences of subclinical coeliac disease (CD) in Type 1 diabetes mellitus (T1DM)

93 Coeliac disease (CD) is an inflammatory autoimmune disea

94 coeliac disease (CD) is an inflammatory condition of the

95 Coeliac disease (CD) is characterised by diverse clinica

96 studies have shown that the knowledge about coeliac disease (CD) is not satisfactory among healthcar

97 -endopeptidase treatment may not be safe for coeliac disease (CD) patients.

98 Coeliac disease (CD), an enteropathy caused by cereal gl

99 for proteins with epitopes that can trigger coeliac disease (CD), and several contain a 33-mer pepti

100 Coeliac disease (CD), due to its protean clinical manife

101 Despite the considerable health impact of coeliac disease (CD), reliable estimates of the impact o

102 ed by several clinical conditions, including Coeliac Disease (CD).

103 ant microbiota may play a pathogenic role in coeliac disease (CD).

104 o a gluten-free diet (GFD) for patients with coeliac disease (CD).

105 s been proposed to play a pathogenic role in coeliac disease (CD).

106 loci shared between two autoimmune diseases: coeliac disease (CeD) and rheumatoid arthritis (RA).

107 Coeliac disease (CeD) is an autoimmune disease in which

108 Coeliac disease (CeD) is characterized by gliadin-induce

109 such as inflammatory bowel disease (IBD) and coeliac disease (CeD).

110 The number of people diagnosed with coeliac disease continues to rise, and this article crit

111 y of the mechanism of the immune response in coeliac disease could provide insight into the mechanism

112 s have mainly been studied: Turner syndrome, coeliac disease, cystic fibrosis, growth hormone deficie

113 Coeliac disease develops in genetically susceptible indi

114 -related extra-intestinal diseases including coeliac disease, diabetes mellitus type 1, bronchial ast

115 Prior to the coeliac disease diagnosis, 56% of the patients had exper

116 resence of abdominal symptoms at the time of coeliac disease diagnosis, long diagnostic delay and fem

117 n our genetic and immunological knowledge of coeliac disease, early introduction of a gluten-free die

118 The long-term implications of active coeliac disease emphasize the need for early detection a

119 breed bread wheat varieties with fewer or no coeliac disease epitopes.

120 ore, similar to the involvement of gluten in coeliac disease, Epstein-Barr virus (EBV) infection is n

121 ina propria that is characteristic of active coeliac disease, expresses the predisposing HLA-DQ8 mole

122 We have examined these regions in 28 coeliac disease families by linkage analysis.

123 iopsy did not identify any causes other than coeliac disease for iron deficiency anaemia, suggesting

124 astrointestinal symptom rating scale (GSRS), coeliac disease GSRS, and Bristol stool form scale (BSFS

125 as lost, at which point 25% of patients with coeliac disease had detectable gluten in faeces, whilst

126 in developing new strategies for preventing coeliac disease has motivated efforts to identify cereal

127 manifestations in patients with established coeliac disease have been reported since 1966, it was no

128 Notably, IEL from patients with Coeliac disease have high PIM expression.

129 ociated with systemic lupus erythematosus or coeliac disease, have not in general disclosed consisten

130 erstanding of inflammatory bowel disease and coeliac disease, hindered by language and literacy barri

131 in two patients, and changes compatible with coeliac disease in 11.

132 Worldwide awareness of coeliac disease in all ages continues to grow.

133 ious oral manifestations are associated with coeliac disease in children, whereas data on adults are

134 barley and rye, or gluten protein, can cause coeliac disease in individuals not tolerating gluten.

135 g offers additional sensitivity in detecting coeliac disease in individuals who have self-prescribed

136 a measure of cryptic gluten sensitivity, and coeliac disease in neurological patients.

137 om group 1 revealed histological evidence of coeliac disease in nine (35%), non-specific duodenitis i

138 candidate locus conferring susceptibility to coeliac disease in some families.

139 nded our knowledge of the long-term risks of coeliac disease, in addition to excluding infertility as

140 Within our cohort of patients with coeliac disease, inflammatory bowel disease was signific

141 testinal and endocrine diseases, focusing on coeliac disease, inflammatory bowel disease, diabetes, a

142 Coeliac disease is a common enteropathy characterized by

143 Coeliac disease is a complex, polygenic inflammatory ent

144 Coeliac disease is a genetically-determined chronic infl

145 Currently, the only effective treatment for coeliac disease is a lifelong strict gluten-free diet; h

146 The diagnosis of coeliac disease is achieved by combining coeliac disease

147 Coeliac disease is also considered to be a systemic diso

148 Coeliac disease is an autoimmune disorder that primarily

149 Complicated coeliac disease is an extremely serious condition with a

150 Coeliac disease is an immune-mediated enteropathy agains

151 Epidemiological studies have shown that coeliac disease is as common in parts of Asia, Africa an

152 Undiagnosed coeliac disease is associated with a substantial decreme

153 Coeliac disease is caused by a genetically determined, s

154 The natural history of complicated coeliac disease is characterised by two different types

155 Coeliac disease is characterised by villous atrophy, whi

156 Living with undiagnosed symptomatic coeliac disease is connected with deteriorated health, a

157 sentation, diagnosis remains a challenge and coeliac disease is heavily underdiagnosed.

158 Clinical presentation of coeliac disease is highly variable and includes classica

159 ease, but further work into the treatment of coeliac disease is needed.

160 Coeliac disease is the prototypical gluten-sensitive dis

161 Epidemiological studies have shown that coeliac disease is very common and affects about one in

162 e molecular basis for the HLA association in coeliac disease is well defined, and B cells have a clea

163 was to determine the cost-effectiveness of a coeliac disease mass screening at 12 years of age, takin

164 A coeliac disease mass screening is cost-effective based o

165 ion is difficult because occult sub-clinical coeliac disease occurs commonly and background prevalenc

166 Coeliac disease occurs in about 1% of people in most pop

167 d with deteriorated health, and persons with coeliac disease often wait a long time for their diagnos

168 macodynamics of the vaccine in patients with coeliac disease on a gluten-free diet.

169 with cerebellar ataxia and SG diagnosed with coeliac disease or gluten sensitivity, 15% had RFC1 expa

170 ased or wheat-based foods, in the absence of coeliac disease or wheat allergy.

171 systemic sclerosis (OR 1.60, 1.29-2.22), and coeliac disease (OR 1.38, 1.12-1.69).

172 systemic sclerosis (OR 3.20, 2.21-4.53) and coeliac disease (OR 1.71, 1.36-2.14).

173 Coeliac disease, or gluten-sensitive enteropathy, is onl

174 l syndrome was significantly associated with coeliac disease (p=0.004, odds ratio=7.0 [95% CI 1.7-28.

175 gate these issues in a large cohort of adult coeliac disease patients both at diagnosis and while on

176 d messenger RNA (mRNA) expression changes in coeliac disease patients challenged with gluten using PA

177 While on GFD, coeliac disease patients had higher prevalence of recurr

178 ficant duodenal mucosal deterioration in all coeliac disease patients on gluten challenge.

179 In our material, 8/245 (3,2 %) coeliac disease patients presented inflammatory bowel di

180 Evidence suggests that many coeliac disease patients suffer from persistent clinical

181 Fifteen coeliac disease patients were challenged with 4 g of glu

182 a cytokine greatly upregulated in the gut of coeliac disease patients, retinoic acid rapidly activate

183 osed with active CD, CD on a GFD, Refractory coeliac disease (RCD) type I and II, and enteropathy ass

184 Patients with established coeliac disease referred for neurological opinion show s

185 - 13 years (range 19-64)) with biopsy proven coeliac disease referred for neurological opinion.

186 Coeliac disease-related data were collected from medical

187 Our findings on coeliac disease replicate the previous SNP results and s

188 and sent to 4000 individuals with diagnosed coeliac disease, requesting information on respondents'

189 Diagnosis of coeliac disease requires a positive serology (IgA anti-t

190 Optimizing diagnosis and care in coeliac disease requires continuous research and educati

191 The cost for coeliac disease screening was 40,105 Euro per gained QAL

192 of coeliac disease is achieved by combining coeliac disease serology and small intestinal mucosal hi

193 Coeliac disease serology was positive in all cases.

194 present in cereal proteins that do not cause coeliac disease, Shan and colleagues suggest that genera

195 A strong HLA association is seen in coeliac disease [specifically to the DQ(alpha1*0501,beta

196 cts on long-term health for individuals with coeliac disease still eating gluten.

197 Before diagnosis, people with coeliac disease suffer reduced quality of life, which im

198 to assess changes over time in prevalence of coeliac disease symptoms/associated medical conditions,

199 was higher in patients with newly diagnosed coeliac disease than Controls (median [Q1, Q3] coeliac d

200 t, at diagnosis and on GFD, in patients with coeliac disease than in the controls, and they were asso

201 of course: patients with a new diagnosis of coeliac disease that do not improve despite a strict glu

202 orwegian Human Milk Study, and Prevention of Coeliac Disease) that collaborate in the European Union-

203 data, clinical presentation and treatment of coeliac disease, time and place of diagnosis and presenc

204 Although the evidence for linkage of coeliac disease to chromosome 15q26 is not strong, the w

205 ee diet, rapid progression from symptom-free coeliac disease to coeliac disease with symptoms, long d

206 Refractory coeliac disease type 2 is a rare subtype of coeliac dise

207 In patients with refractory coeliac disease type 2 who were treated with AMG 714 or

208 lts with a confirmed diagnosis of refractory coeliac disease type 2.

209 may be warranted in patients with refractory coeliac disease type 2.

210 , on the activity and symptoms of refractory coeliac disease type 2.

211 Conditions such as coeliac disease, type 1 diabetes, Crohn's disease and ul

212 datasets spanning gastrointestinal cancers, coeliac disease, ulcerative colitis and Crohn's disease

213 after 12 weeks of treatment in patients with coeliac disease undergoing gluten challenge, was not sig

214 diseases including asthma, Crohn's disease, coeliac disease, vitiligo, multiple sclerosis and type 1

215 Coeliac disease was associated with excessive health car

216 In 7/8 patients the diagnosis of coeliac disease was made first and inflammatory bowel di

217 significant evidence in favour of linkage to coeliac disease was obtained for chromosomes 3q27, 5q33.

218 gical dysfunction is a known complication of coeliac disease we have investigated the frequency of an

219 A notable exception is coeliac disease, where genetically susceptible individua

220 gate the effects of AMG 714 in patients with coeliac disease who underwent gluten challenge.

221 coeliac disease type 2 is a rare subtype of coeliac disease with high mortality rates; interleukin 1

222 We aimed to assess the association of coeliac disease with irritable bowel syndrome in patient

223 ression from symptom-free coeliac disease to coeliac disease with symptoms, long delay from celiac di

224 ultiple sclerosis (MS) is similar to that of coeliac disease, with human leukocyte antigen (HLA) bein