ライフサイエンスコーパス: cofactor

1 eports made for isolated protein lacking the cofactor.

2 hat require double-stranded RNA (dsRNA) as a cofactor.

3 Almost half of all enzymes utilize a metal cofactor.

4 teins, yet they instead possess a Ca(2+)-PQQ cofactor.

5 with the oxidation of a pyridine nucleotide cofactor.

6 nsity as the knot tightens to secure the SAM cofactor.

7 ystallographically characterized without its cofactor.

8 ition to support the rapid binding of a heme cofactor.

9 on of high stoichiometric amounts of reduced cofactor.

10 s widely required by eukaryotes as an enzyme cofactor.

11 protein, with each subunit containing a heme cofactor.

12 lfide into the trisulfide versus a disulfide cofactor.

13 idase (GAO) contains a Cu(II)-ligand radical cofactor.

14 interactions of a UGT protein with UDP-sugar cofactors.

15 Exact Tests to assess enrichment of TFs and cofactors.

16 utative binding sites of primary factors and cofactors.

17 iggered increases in other PRC2 subunits and cofactors.

18 id side chains, internal water molecules, or cofactors.

19 nery including the DNMTs and their essential cofactors.

20 fected PACN formation to a lower degree than cofactors.

21 agents, molecular oxygen, and no additional cofactors.

22 that engage the ATP phosphates and the metal cofactors.

23 yme machineries with unique metal-containing cofactors.

24 ge-specific DNA shape features and predicted cofactors.

25 ucose and thereby yields the necessary redox cofactors.

26 ting the oxidation of these critical protein cofactors.

27 ctors that act as influenza virus polymerase cofactors.

28 ptibility and show that loss of the negative cofactor 2 complex leads to resistance, not only to the

29 n supplying a suitably isotopically-labelled cofactor ([4-(2)H]-NADH).

30 tage of this process resides the active site cofactor, a complex metallocluster organized around a tr

31 tions would be infeasibly slow without metal cofactors, a detailed understanding of how protein struc

32 c cells and prevented CFH from mediating its cofactor activity on MDA-modified surfaces, resulting in

33 d dependency on nuclear transport associated cofactors, altered integration targeting preferences and

34 e cytochrome P450 proteins contain heme as a cofactor and are involved in oxidoreduction.

35 oteins that a) utilize a molybdenum ion as a cofactor and b) are involved in the biogenesis of fimbri

36 in a facile manner, such as the type of the cofactor and its quantity within the protein.

37 o determine subunit stoichiometry as well as cofactor and lipid binding.

38 ns while LGP2 has been described as both RLR cofactor and negative regulator.

39 Our results demonstrate that the nuclease cofactor and structural functions of CtIP may depend on

40 Among the changes driven by both cofactor and substrate, HDX-MS highlighted several surfa

41 FAO superfamily reveals a modular fold with cofactor and substrate-binding domains allowing for dive

42 tional crosstalk between BRCA1-BARD1 and its cofactors and antagonists will illuminate the molecular

43 transcription factors and 37 transcriptional cofactors and chromatin regulator proteins, and represen

44 s single-stranded DNA-binding protein (SSBP) cofactors and DNA-binding basic helix-loop-helix (bHLH)

45 s, with metals typically serving in place of cofactors and enzymes.

46 olutionary lineages that bind small molecule cofactors and metabolites with phosphate moieties.

47 the critical role of Clf1 and Cwc2 splicing cofactors and specific domains of the Prp8 protein as si

48 lays cooperative kinetics and uses NADH as a cofactor, and its crystal structure at 1.72 angstrom res

49 he binding pattern of AAR with its substrate/cofactor, and suggest a potential aldehyde-transferring

50 m metabolite levels in amino acid, lipid and cofactor, and vitamin pathways.

51 binatorial binding of transcription factors, cofactors, and chromatin modifiers spatially segregates

52 nol and the regeneration of the NAD+ and FAD cofactors, and complex III oxidizes ubiquinol back to ub

53 TMs impact PrP interactions with polyanionic cofactors, and highlight PTMs as a major force driving t

54 could accommodate large signaling molecules, cofactors, and substrates remains an outstanding challen

55 mmed instability of the oxidized form of the cofactor appears to be a unifying characteristic of the

56 Enzymes dependent on nicotinamide cofactors are important components of the expanding rang

57 low reduction potentials of the active site cofactors are optimized for fast elimination of the toxi

58 ic functions, but these structurally diverse cofactors are synthesized by only a subset of bacteria a

59 Here, we show that primase can use metabolic cofactors as initiating substrates, instead of its canon

60 r these results indicate that utilization of cofactors as substrates by primase may influence regulat

61 tro and in vivo and utilizes similar in vivo cofactors as the metazoan maintenance methylase Dnmt1.

62 archives 2314 ChIP-seq tracks of 684 TFs and cofactors assayed across a 117 human cell lines under a

63 AM) enzyme that is essential for nitrogenase cofactor assembly.

64 to aid substrate recognition, and the metal cofactor at the active site.

65 AR dependence on cofactors at sAREs may be the basis for differential mod

66 with exonuclease activity aided by two metal cofactors at the active site.

67 What began with studies showing that cofactor availability drives global abundances of chroma

68 ms draw on ChIP-seq tracks to define TFs and cofactors behind gene changes.

69 ture reveals asymmetric displacements of the cofactor belt sulfurs (S2B or S3A and S5A) with distinct

70 ylbenzimidazole tail in moving the cobalamin cofactor between active sites.

71 determinants in the MVV Vif are required for cofactor binding and stabilization of the E3 ligase comp

72 s the key determinant of MxB sensitivity and cofactor binding defective HIV-1 capsid mutants P90A (de

73 , it is unclear which residues in the UGT2B7 cofactor binding domain are responsible for the preferen

74 ces of HDX against corresponding kinetic and cofactor binding parameters.

75 ong this path is required for mtClpX to gate cofactor binding to ALAS.

76 7 binding site responsible for the selective cofactor binding.

77 ound to play critical roles in catalysis and cofactor binding.

78 )-helix within the Rossmann fold, abolishing cofactor binding.

79 In the present study, the fluorescence-based cofactor-binding assay was adapted to detect binding of

80 we quantify the similarity between proximal cofactor-binding folds and show that they are derived fr

81 trate analogue to occupy both substrate- and cofactor-binding sites of NTMT1, but the bisubstrate ana

82 occurred during the autocatalytic process of cofactor biogenesis.

83 ological functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and s

84 o MtNifB is fully assembled and competent in cofactor biosynthesis.

85 inorganic chemistry of the essential metallo-cofactor biosynthesis/maintenance, the transport of a ra

86 involved in phosphate and metal uptake, and cofactor biosynthetic enzymes.

87 Importantly, in its holo form with the cofactor bound, UvrC forms high affinity complexes with

88 requires a reductive activation of the FeMo-cofactor, but the precise structure and atomic compositi

89 commonly associated with the molybdenum-iron cofactor called FeMoco or the M-cluster, and it has been

90 Although the cofactor can directly interact with the ATPase, Cdc48 an

91 deciphering how protein-bound intramolecular cofactors can facilitate such long-range ET.

92 Cofactors can target PP1 to substrates or subcellular lo

93 The mechanism by which ATR signals that its cofactor cargo is ready (AdoCbl) or not [cob(II)alamin]

94 me apoenzyme, which, in complex with a hemin cofactor, catalyzes the color change of the sample's sol

95 l, mutational, and biochemical analyses, the cofactor channel and the substrate channel of VvAHGD are

96 nsecutive connection and interruption of the cofactor channel and the substrate channel via the confo

97 for the synthesis and use of cobalt-bearing cofactors (cobalamins) in their genomes.

98 aptan with NADPH was the preferred substrate-cofactor combination.

99 ct of disease-associated mutations on enzyme-cofactor complexes in the hemostatic system.

100 The light-triggered rearrangements of the cofactor configuration and eventually the protein confor

101 These cofactors consist of an ADP core covalently bound to ext

102 the formation of this complex depends on the cofactor content on HydF.

103 ike scaffold, which supports a central metal cofactor coordinated by three histidines.

104 with carbide insertion into an [Fe(8)S(9)C] cofactor core (designated L) on NifB.

105 formation of an intermediate that lacks the cofactor core arrangement in this MaNifB variant.

106 g of D/N Vif variants to the transcriptional cofactor core binding factor beta (CBFbeta), which is ex

107 dependent carbide insertion concomitant with cofactor core formation.

108 usters, representing the precursor to an 8Fe cofactor core, are each coordinated by one His and two C

109 dard bases, some with features that resemble cofactors, could have facilitated that first moment in w

110 ed with the stable confinement of the enzyme/cofactor couple (HBD/NAD(+)) and with a stable and selec

111 aptic vesicle proteins, endo- and exocytosis cofactors, cytoskeleton components, and trafficking prot

112 The cofactors decorated QDs (ZnO@PLP and ZnO@Py) were applie

113 t metalation of proteins requiring iron as a cofactor demands that such a readily accessible source o

114 ed by a biologically unique hexanuclear iron cofactor denoted the H-cluster.

115 se genetics to separate HIV-1 nuclear import cofactor dependence from MxB sensitivity.

116 s may be explained in part by changes in the cofactor-dependent conformational dynamics of tubulin pr

117 results highlight the dynamic nature of the cofactor during catalysis and provide evidence for parti

118 ng adaptors" that link dynein to its general cofactor, dynactin, and cargoes.

119 reducing equivalents at the active-site FeMo-cofactor (FeMo-co), generating a state (denoted E(4)(4H)

120 Fe-S clusters in catalysis include the Fe-Mo cofactor (FeMoco) of nitrogenase and its V and all-Fe va

121 OG-L002, which covalently attach to the LSD1 cofactor flavin adenine dinucleotide (FAD) to inhibit de

122 ivalent cation in metazoans and an essential cofactor for ATP, nucleic acids, and countless metabolic

123 We found that Ifit1c acts as a stimulatory cofactor for both Ifit1 and Ifit1b, promoting their tran

124 periments establish scoutRNA as an essential cofactor for Cas12c-catalyzed pre-crRNA maturation.

125 encircles DNA, where it acts as an essential cofactor for DNA polymerases and other proteins.

126 Lissencephaly-1 (Lis1) is a key cofactor for dynein-mediated intracellular transport tow

127 C4b, C3/C5 convertase decay accelerator, and cofactor for factor I-mediated cleavage of C3b and C4b.

128 Vitamin C serves as a cofactor for Fe(II) and 2-oxoglutarate-dependent dioxyge

129 Heme is an essential cofactor for many biological processes in aerobic organi

130 ng an explanation for why Lis1 is a required cofactor for most cytoplasmic dynein-driven processes in

131 NAD(+) is also an essential cofactor for non-redox NAD(+)-dependent enzymes, includi

132 nthetic resulting from its role an essential cofactor for photosystem II (PSII).

133 Vitamin K is a cofactor for proteins involved in prevention of vascular

134 micronutrient for bacteria and an essential cofactor for redox-active cuproenzymes.

135 s study identifies Shp1 as the crucial Cdc48 cofactor for signal-induced selective disassembly of a m

136 Magnesium is a cofactor for SpxB catalytic activity, and supplementatio

137 dysfunction, might be due to its function as cofactor for sulfide:quinone oxidoreductase (SQOR), the

138 Iron is an essential cofactor for symbiotic nitrogen fixation, required by ma

139 alpha-ketoglutarate, in turn, serves as the cofactor for the epigenetic regulator TET2 to catalyze D

140 acellular alpha-ketoglutarate, an obligatory cofactor for various histone and DNA demethylases involv

141 DEAD-box RNA helicase DDX3X is an essential cofactor for viral replication but dispensable for cell

142 ks for 11 TFs and identified 4 more putative cofactors for 6 TFs.

143 Thus, MARCH E3 ligases can act as cofactors for antitumor Abs that target cell surface pro

144 int, B12 and FA have largely been studied as cofactors for enzymes in the one-carbon (1C) cycle in fa

145 tra Amido Macrocyclic Ligand) can be used as cofactors for incorporation into streptavidin to assembl

146 mbrane lipids act as solvents and functional cofactors for integral membrane proteins.

147 merase and the requirement of specific metal cofactors for maximal RNA polymerase activity.

148 not NSAID and exercise, were other relevant cofactors for systemic reactions.

149 ures distinguish enzymes that use Ln(3+)-PQQ cofactors from those that do not.

150 ent gene expression, suggesting general GATA cofactor functions.

151 e enzymes that utilise a carboxy-SAM (cxSAM) cofactor generated from SAM by a cxSAM synthase (CmoA).

152 at GROWTH-REGULATING FACTOR 4 (GRF4) and its cofactor GRF-INTERACTING FACTOR 1 (GIF1) substantially i

153 -component hydroxylases that use flavin as a cofactor (group A).

154 The importance of the tail in cofactor handover from ATR to MCM is revealed by the fai

155 ossible contributions of Fe2+ as a ribosomal cofactor have been largely overlooked, despite the ribos

156 d structural rearrangements around the metal cofactors have to be considered when biochemical data of

157 MP and GMP), a vitamin (pyridoxal-5P), and a cofactor (heme) in both the acute and latent stages of i

158 f factor XII (FXII), prekallikrein (PK), and cofactor high-molecular-weight kininogen (HK).

159 CofActor holds promise for the tracking of early stage e

160 Finally, we find that transcriptional cofactor HOPX is upregulated in mouse models and in huma

161 lator, strongly inhibits the initiation with cofactors, hypothetically due to competition for overlap

162 r systems are due to nonessential activating cofactors.IMPORTANCE A factor other than the virus recep

163 reactions occurred without any identifiable cofactor in 39 (44%) cases.

164 Siroheme is the central cofactor in a conserved class of sulfite and nitrite red

165 nderstanding the electronic structure of the cofactor in all (detectable) states of the enzymatic pro

166 We also investigated the role of the Mg(2+) cofactor in catalysis, analyzing the first crystal struc

167 demic in Africa, has not been evaluated as a cofactor in eBL pathogenesis.

168 Heme b is an iron-containing cofactor in hemoproteins that participates in the fundam

169 Besides other roles, BH4 functions as cofactor in neurotransmitter biosynthesis.

170 Although its roles as a cofactor in several enzymes and in maintaining optimal p

171 cule dicarboxylate that acts as an essential cofactor in this process and works in synergy with SDHAF

172 an regulate levels of both mRNAs and NADP(H) cofactors in a manner specified by its location in cells

173 COX inhibitors are also frequent cofactors in anaphylaxis.

174 een biosynthesis and salvage of vitamins and cofactors in apicomplexans.

175 tanding of the essential role of elements as cofactors in biological and pathological processes.

176 eductase (CPR) domain containing FAD and FMN cofactors in distinct domains of the CPR.

177 tanding of how Six1 cooperates with distinct cofactors in feedforward loops to control lineage-specif

178 Porphyrinoids, well-known cofactors in fundamental processes of life, have stimula

179 t produces meaningful predictions of TFs and cofactors in transcriptomic experiments.

180 due to the redox of either a dissociated FAD cofactor, in the case of AAOx and AOx, or denatured enzy

181 cy from different cyanidin-3-derivatives and cofactors, in order to facilitate PACN production.

182 om organic and inorganic compounds and their cofactors, including amino acids, vitamins, oxygen, nitr

183 istent with [4Fe4S] coordination with 60-70% cofactor incorporation, and additionally, we show that,

184 levulinic acid synthase (ALAS), by promoting cofactor incorporation.

185 neat solvents to model the amino acids of a cofactor-independent oxygenase.

186 data showed only one halogen remained in the cofactor, indicating that an oxidative carbon-chlorine/f

187 manner distinct from currently known capsid cofactors, influenced by pentamer composition or curvatu

188 amino acids, carboxylic acids, fatty acids, cofactors, inorganic ions, and nucleotides across the mi

189 l the iron coordination geometry when a heme cofactor is allowed to bind to either histidine or cyste

190 When its cofactor is Ca(2+) rather than Mg(2+), the reaction is f

191 Synthesis of the cofactor is essential for Mycobacterium tuberculosis to

192 ent of the flavin adenine dinucleotide (FAD) cofactor is supported.

193 ly, we show that, bound to UvrC, the [4Fe4S] cofactor is susceptible to oxidative degradation with ag

194 This study demonstrates that the NPN cofactor is used by a diverse superfamily of alpha-hydro

195 Organization of the active cofactors is mainly driven by noncovalent interactions b

196 s correlated with its sensitivity to the ZAP cofactor KHNYN.

197 intracellular adapter proteins talin and its cofactor, kindlin, to the integrin receptors induces int

198 vated complexes dependent on availability of cofactor ligands, BH4 and phenylalanine, respectively.

199 that can grow in alkaline soils, where metal-cofactors like Fe(III) are sparingly available.

200 s autoxidation to methemoglobin, followed by cofactor loss and globin unfolding.

201 which KIF5B binds poorly, likely because its cofactors, MAP7-family proteins, are slow in populating

202 inability of MaNifB to serve as a source for cofactor maturation upon substitution of histidine-43 wi

203 play an essential role in plants as protein cofactors mediating diverse electron transfer reactions.

204 ed by the nuclear abundance of transcription cofactor, megakaryoblastic leukemia, and protein levels

205 rentiation through direct effects on the HOX cofactor MEIS1, paving the way for clinical trials.

206 The additional cofactors moieties apparently contact the 'basic ridge'

207 olecules acetate and beta-hydroxybutyrate or cofactors NAD(+) and NADH.

208 r dynamic simulations, here we show that the cofactor NADH is a key player in the GDH regulation proc

209 n deficiency of vitamins in AVNFH, an enzyme-cofactor network was generated.

210 , and state (solid or liquid), and potential cofactors (nonsteroidal anti-inflammatory drugs, protoni

211 es with capsid binding to the cellular HIV-1 cofactors Nup153 and CPSF6 that mediate viral nuclear im

212 BH(4) (cofactor of eNOS) biosynthesis enzyme dihydrofolate redu

213 e inefficient supply of NADPH, the preferred cofactor of GalA reductases.

214 d that the Med1 Mediator subunit serves as a cofactor of GATA TFs in Drosophila, as shown in mammals.

215 Here we report that Hoxb13 acts as a cofactor of Meis1 in postnatal cardiomyocytes.

216 e cytoplasmic 5'-to-3' exoribonuclease, as a cofactor of RNAi in budding yeast.

217 (RpsA) and competing with tmRNA, the natural cofactor of RpsA.

218 ractive domain 5A (ARID5A/Arid5a) is a known cofactor of transcription factors (TFs) that contributes

219 ework to predict non-classical functions and cofactors of a given HMR, based on ChIP-seq data mining.

220 d robust when taking into account additional cofactors of interest (e.g., age, sex, sleep apnea).

221 e I in vitro is specifically affected by the cofactors on its 5'-end.

222 he availability of virus receptors and entry cofactors on the surface of host cells.

223 nor AR-V7/AR-FL heterodimerization requires cofactors or DNA binding.

224 nhancers that are enriched for transcription cofactors or mediators in lymphoblasts may benefit EBV g

225 ture of RABV L bound with its phosphoprotein cofactor (P), determined by electron cryo-microscopy at

226 erobimetallic Mn/Fe proteins represent a new cofactor paradigm in bioinorganic chemistry and pose cou

227 e the MRE11-RAD50-NBS1 (MRN) complex and its cofactor, phosphorylated CtIP.

228 tein environment relative to the native CODH cofactor point to a biochemical CO oxidation mechanism t

229 tagenesis of GalA reductases to change their cofactor preference from NADPH towards NADH and demonstr

230 ed here as Drc (ssDNA-binding RNA Polymerase Cofactor), preferentially binds single-stranded DNA, yet

231 1 ENZ-Delta52PRO tetrameric complex with the cofactor product S-adenosyl-l-homocysteine (AdoHcy) at 2

232 carrier protein (ACP) is a highly conserved cofactor protein that is required by Type II fatty acid

233 ds on HIV-1 capsid conformation, rather than cofactor recruitment.

234 tificial membrane proteins can influence the cofactor repertoire of a living cell.

235 tein 5 (WDR5) binds to MYC and is a critical cofactor required for the recruitment of MYC to its targ

236 amin B(12) and other cobamides are essential cofactors required by many organisms and are synthesized

237 h, and Ebola, possess an essential L-protein cofactor, required to access the N-RNA template and coor

238 The assembly of this cofactor requires a dedicated maturation machinery inclu

239 Biosynthesis of the NiFe(CN)(2)(CO) cofactor requires the activity of at least six maturatio

240 extracts spiked with an S-adenosylmethionine cofactor, revealing possible catalysis by an S-adenosylm

241 peptide substrate and noncompetitive to the cofactor S-adenosylmethionine.

242 postulate that ABA4, with additional unknown cofactor(s), is required for, or contributes to, trans-t

243 ucture of RgNanOx in complex with the NAD(+) cofactor showed a protein dimer with a Rossman fold.

244 ion of a stimulus by interactions with other cofactors, showing that TNF has strikingly different eff

245 xcept for identifying the residues that tune cofactor specificity, these engineered variants may also

246 ive the evolution of metalloenzymes with new cofactor specificity.

247 tical overview of discoveries on nitrogenase cofactor structure, function, and activity over the last

248 , the requirement for two different cellular cofactors suggests that these two A3-targeting Vif prote

249 P), requires the bicistronic gene molybdenum cofactor synthesis 1 (MOCS1).

250 Ablation of tubulin-binding cofactors (TBCs) further sensitizes cells and their micr

251 paration to compartmentalize its DNA-binding cofactor TEAD4, coactivators BRD4 and MED1, and the tran

252 indings identify a new +TIP acting as a host cofactor that facilitates early stages of viral infectio

253 Ca(2+) is identified as a cofactor that is complexed with residues from both the r

254 gulator Phactr1 is a neuronally enriched PP1 cofactor that is controlled by G-actin.

255 y accumulated zinc protoporphyrin IX, a rare cofactor that is not used by natural metalloenzymes.

256 Cobalamin is a complex organometallic cofactor that is processed and targeted via a network of

257 phenotype of 200,000 mutants revealed a new cofactor that may help a group of rod-shaped bacteria el

258 Our findings identify CLASP2 as a new host cofactor that utilizes distinct regulatory domains to bi

259 uestion catalyze redox reactions using metal cofactors that are explicitly intertwined with their fun

260 Iron-sulfur (Fe-S) clusters are inorganic cofactors that are present in all kingdoms of life as pa

261 edicting the transcription factors (TFs) and cofactors that drive transcriptomic differences between

262 BCL9 and PYGO are beta-catenin cofactors that enhance the transcription of Wnt target g

263 f nutrients, cobamides (the family of enzyme cofactors that includes vitamin B(12)), is widely used f

264 trol the binding of generic or gene-specific cofactors that regulate CBC activities depending on the

265 ligands may also be nonessential activating cofactors that serve to accelerate receptor-catalyzed vi

266 Many riboswitches bind protein enzyme cofactors that, in principle, can catalyse a chemical re

267 of a catalytic subunit, the L protein, and a cofactor, the P protein.

268 A-dependent RNA polymerase, and a polymerase cofactor, the phosphoprotein (P), for transcription and

269 transketolase, TK(low), which also binds the cofactor thiamine pyrophosphate (TPP) with an affinity u

270 peptides, four proteins, one amino acid, two cofactors, three polyethylene glycol (PEG) derivatives,

271 n C in a reaction greatly accelerated by the cofactor thrombomodulin.

272 ein-derived cysteine tryptophylquinone (CTQ) cofactor to catalyze conversion of glycine to glyoxylate

273 (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a v

274 analogous fashion to human IFIT3, which is a cofactor to human IFIT1.

275 ddition of the sugar moiety from a UDP-sugar cofactor to relatively low-molecular weight lipophilic c

276 inding factor subunit beta as a noncanonical cofactor to stabilize the complex, the maedi-visna virus

277 These approaches assign TFs and cofactors to genes via a binary designation of 'target',

278 iously unappreciated contribution of protein cofactors to PBP activity.

279 ctor function of GATAs is modulated by their cofactors to refine the differentiation of neuronal subt

280 hromatin-modifying enzymes require metabolic cofactors to support their catalytic activities, providi

281 camer in its apo-form or loaded with its ATP cofactor, to a 1 MDa capsid-like homo-hexacontamer, we c

282 585) about interest in ApoL1 testing and its cofactors, under 2 scenarios: as a potential living dono

283 ates between N(2) and NH(3), and whether the cofactor undergoes significant rearrangement during turn

284 Here, we assessed the importance of this cofactor using kinetic, crystallographic, and computatio

285 a treatment limitation, considering relevant cofactors, was 18.1 (95% CI 16.8-19.4).

286 e-light switch, referred to hereafter as the CofActor, we accomplished both light- and energetic/oxid

287 and conditional model including smoking as a cofactor were investigated.

288 ment of motifs (for repressing vs activating cofactors) were decisive for the gene expression pattern

289 nvestigation of HOXB13 mutants and oncogenic cofactors when MEIS1/2 are silenced.

290 rganic class, metal ion and metal-containing cofactor, which will serve as a valuable, integrative da

291 9)C-(R)-homocitrate] species designated FeMo-cofactor, whose biosynthesis and insertion requires the

292 ool to probe processes of proteins harboring cofactors with electronic transitions in the visible ran

293 s reduced forms NAD(P)/NAD(P)H are all redox cofactors with key roles in energy metabolism and are su

294 ate through transfer of a hydride to the FAD cofactor, with differences observed in substrate specifi

295 ptor complexes formed between substrates and cofactors within protein active sites to facilitate elec

296 control machinery, RNA polymerase II and its cofactors, within biomolecular condensates.

297 The paralogous transcriptional cofactors Yes-associated protein (YAP) and transcription

298 Both TEAD4 and its cofactor, yes-associated protein 1 (YAP1), are specifica

299 fy a novel TAF4b-interacting transcriptional cofactor, ZFP628.

300 show that inactivation of a transcriptional cofactor ZFPM1 in mice results in a developmental failur