ライフサイエンスコーパス: cognitive aging

1 to represent a ubiquitous characteristic of cognitive aging.

2 egion important for memory and implicated in cognitive aging.

3 ocyte n-3 content are associated with better cognitive aging.

4 amined the effects of food supplement use on cognitive aging.

5 tween the deficiency of ovarian hormones and cognitive aging.

6 Estrogen withdrawal accelerated the rate of cognitive aging.

7 tients, neuroimaging studies, and studies of cognitive aging.

8 offering new opportunities for understanding cognitive aging.

9 ume (GMV) recovered in key brain regions for cognitive aging.

10 er of the hippocampal-dependent component of cognitive aging.

11 uits and vegetables that have been linked to cognitive aging.

12 nderstand how these networks support healthy cognitive aging.

13 ystemic inflammation and its relationship to cognitive aging.

14 ls for examining sex dimorphism in brain and cognitive aging.

15 age to better understand the neural bases of cognitive aging.

16 ein conformational changes in a rat model of cognitive aging.

17 r how the bereavement experience accelerates cognitive aging.

18 population-based approach to promote healthy cognitive aging.

19 Inflammation plays a major role in cognitive aging.

20 t to develop strategies that promote healthy cognitive aging.

21 esent one end of a nonpathologic spectrum of cognitive aging.

22 peutic interventions that support successful cognitive aging.

23 confirmed the role of the basal forebrain in cognitive aging.

24 dults is closely linked with trajectories of cognitive aging.

25 ividuals in the US are associated with worse cognitive aging.

26 and risk estimation of future functional and cognitive aging.

27 of an association between air pollution and cognitive aging.

28 empirical research on determinants of social cognitive aging.

29 x-dependent protein complexes for predicting cognitive aging.

30 very old individuals representing successful cognitive aging.

31 timulation, enhanced cognition and countered cognitive aging.

32 s to promote equity in dementia research and cognitive aging.

33 h about what is preserved and prioritized in cognitive aging.

34 is important to understand the mechanisms of cognitive aging.

35 Women live longer than men and exhibit less cognitive aging.

36 ons-which has been proposed to contribute to cognitive aging.

37 unction was equivalent to 1.7 fewer years of cognitive aging.

38 critical for understanding genetic risk for cognitive aging.

39 varied among international cohort studies of cognitive aging.

40 mer's disease (AD) but also occurs in normal cognitive aging.

41 all longitudinal research on determinants of cognitive aging.

42 inating diseases, psychiatric disorders, and cognitive aging.

43 ticocortical "disconnection" partly explains cognitive aging.

44 nd Alzheimer's disease, as well as in normal cognitive aging.

45 emory are often considered a core feature of cognitive aging.

46 e domains or global cognitive function or on cognitive aging.

47 tion patterns, we can improve upon models of cognitive aging.

48 for Alzheimer's disease, schizophrenia, and cognitive aging.

49 ive function, global cognitive function, and cognitive aging.

50 tical tissue is the foundation of successful cognitive aging.

51 ve aspects, were associated with accelerated cognitive aging.

52 s to evaluate their unique associations with cognitive aging.

53 ippocampal morphology across the spectrum of cognitive aging.

54 tal fat intake itself, appeared to influence cognitive aging.

55 could be a promising strategy for reversing cognitive aging.

56 ry is one of the most salient alterations in cognitive aging.

57 at similar mechanisms underlie physiological cognitive aging.

58 ence of a gene x environment interaction for cognitive aging.

59 vidence linking purpose in life to healthier cognitive aging across adulthood and diverse demographic

60 patial Working Memory (vWM) is a hallmark of cognitive aging across various tasks, and facing this de

61 n primates, and humans that demonstrates how cognitive aging affects the navigational computations su

62 ering insight into risk factors for abnormal cognitive aging after profound interpersonal loss.

63 ting (IF) is a diet with salutary effects on cognitive aging, Alzheimer's disease (AD), and stroke.

64 old enrolled in a population-based study of cognitive aging and 37 self-selected volunteers aged 30

65 both beta-amyloid and tau are biomarkers of cognitive aging and AD, cortical beta-amyloid deposition

66 he neural systems that may be compromised in cognitive aging and age-related conditions such as mild

67 enome in women and men, and its influence on cognitive aging and Alzheimer disease (AD) is largely un

68 gnificance of this biomarker with respect to cognitive aging and brain health over time.

69 nalysis of trials of n-3 PUFA supplements in cognitive aging and dementia prevention, and they suppor

70 or therapies to combat memory loss in normal cognitive aging and dementia.

71 dow of opportunity hypothesis in relation to cognitive aging and dementia.

72 e provides an empirical yet general model of cognitive aging and development.

73 s, a finding with important implications for cognitive aging and early detection of AD.

74 ers for improving understanding of normative cognitive aging and encourages future research to test t

75 entify contexts and mechanisms of successful cognitive aging and give science and society a hint abou

76 The role EAAT2 plays in cognitive aging and its associated mechanisms remains la

77 dings highlight sources for heterogeneity in cognitive aging and may hold useful information for cogn

78 TATEMENT Physical activity relates to better cognitive aging and reduced risk of neurodegenerative di

79 Common genetic variants may underlie both cognitive aging and risk of schizophrenia.

80 he hippocampal-dependent memory component of cognitive aging and that memory benefits of a flavanol i

81 both the Women's Health Initiative Study of Cognitive Aging and the Women's Health Initiative Memory

82 vides key insights into the heterogeneity of cognitive aging and underscores the need for a research

83 revention, and they support heterogeneity in cognitive aging and, possibly, in Alzheimer disease.

84 ors that contribute to risk or resilience in cognitive aging, and 2) whether, at old age (25 months),

85 ated work I have been involved in studies of cognitive aging, and I describe some theoretical and emp

86 e neural processes concerned with cognition, cognitive aging, and mood, but findings are inconsistent

87 confounding by neuroselection in research on cognitive aging, and they suggest the possibility that e

88 Immune mechanisms in vascular cognitive aging are incompletely characterized.

89 ents indicate that individual differences in cognitive aging are more strongly tied to functional alt

90 ons, but the neural correlates of successful cognitive aging are not well known.

91 tic and molecular mechanisms responsible for cognitive aging are not well understood.

92 hile the complexity of mechanisms underlying cognitive aging are still being elucidated, microbial ex

93 the associations between muscle strength and cognitive aging are unclear, particularly among middle-a

94 level) enrolled in a longitudinal cohort of cognitive aging at the Knight Alzheimer Disease Research

95 el for studying the neurobiological basis of cognitive aging, because they are vulnerable to age-rela

96 e, we also address positive aging and normal cognitive aging, both as an antidote to ageism and as a

97 sts that flavanol-rich diets protect against cognitive aging, but mechanisms remain elusive.

98 at the gut microbiota may be associated with cognitive aging, but must be replicated in larger sample

99 global cognition was equivalent to reducing cognitive aging by 2 y.

100 -0.02), which was equivalent to accelerating cognitive aging by about 4 years, as observed in this po

101 p explain the dynamic and complex process of cognitive aging by considering key causal pathways.

102 s challenge the current theoretical model of cognitive aging by identifying that factors such as conc

103 ndicating that berry intake appears to delay cognitive aging by up to 2.5 years.

104 unted for by peripheral sensory problems but cognitive aging can also be a contributing factor.

105 These variations in cognitive aging can be related to their neural bases via

106 al spatial representations in a rat model of cognitive aging characterized by individual differences

107 ed longitudinal cognitive data from 4 AD and cognitive aging cohorts.

108 Cognitive aging creates major individual and societal bu

109 ecline of the dopamine (DA) system in normal cognitive aging, DA neuromodulation is one plausible mec

110 Human cognitive aging differs between and is malleable within

111 That is, cognitive aging does not spell doom for financial decisi

112 rs may be critical targets for prevention of cognitive aging even before middle age.

113 ptor (ER) alpha are associated with enhanced cognitive aging, even in the absence of circulating estr

114 Most studies on peripheral inflammation and cognitive aging focused on selected major inflammatory b

115 ch highlights school segregation's impact on cognitive aging for older Black adults, yet the mediatin

116 ing results have recast our framework around cognitive aging from one of decline to one emphasizing p

117 between Lipoprotein (a) [Lp(a)] and healthy cognitive aging has not yet been sufficiently investigat

118 The field of cognitive aging has seen considerable advances in descri

119 idence of powerful individual differences in cognitive aging has sharpened focus on identifying biolo

120 Cross-sectional definitions of successful cognitive aging have been widely utilized, but longitudi

121 Rodent models of cognitive aging have focused on water maze learning and

122 Thus, these data reconcile two cognitive aging hypotheses by revealing that an interact

123 perienced at different life course stages on cognitive aging (i.e., level and change).

124 We propose that normal cognitive aging impairs associative memory formation by

125 sed as a potential indication for predicting cognitive aging in healthy Thai females.

126 help elucidate both healthy and pathological cognitive aging in humans.

127 atus may be a unique societal determinant of cognitive aging in LMIC settings.

128 lation-level intervention to support healthy cognitive aging in low-income settings is sparse.

129 hormone status can broadly influence normal cognitive aging in monkeys, affecting capacities mediate

130 sitive to hippocampal system dysfunction and cognitive aging in monkeys.

131 RTICIPANTS: Population-based cohort study of cognitive aging in Olmsted County, Minnesota, that inclu

132 ng, a longitudinal population-based study of cognitive aging in Olmsted County, Minnesota.

133 g, a longitudinal, population-based study of cognitive aging in Olmsted County, Minnesota.

134 ele and generalize the role of this locus to cognitive aging in the general population.

135 ing a detailed neuropsychological account of cognitive aging in the monkey.

136 tribution of erythrocyte n-3 PUFA content to cognitive aging in the presence or absence of the APOE e

137 that hormone replacement therapy may benefit cognitive aging, in part by promoting mitochondrial and

138 st that hormone replacement therapy benefits cognitive aging, in part by retaining complex synaptic o

139 Past studies of cognitive aging included sample sizes that tended to be

140 al transcriptomic alterations in response to cognitive aging, including upregulation of stress respon

141 nts may be important strategies for reducing cognitive aging inequities.

142 Cognitive aging is a complex process influenced by diver

143 Cognitive aging is associated with impairments in these

144 decline in older age.SIGNIFICANCE STATEMENT Cognitive aging is associated with reduced ability to re

145 Cognitive aging is characterized by large heterogeneity,

146 We propose that successful cognitive aging is determined by interactions both withi

147 ow socioeconomic factors are associated with cognitive aging is important for addressing health dispa

148 Research on food insecurity and cognitive aging is scarce, and is mostly cross-sectional

149 cted by APOE genotype and that the course of cognitive aging is subject to selective alteration by a

150 One mechanism hypothesized to contribute to cognitive aging is the failure to recruit specialized ne

151 of homocysteine lowering to slow the rate of cognitive aging is uncertain.

152 tent to which social relationships influence cognitive aging is unclear.

153 cipation on dementia incidence in studies of cognitive aging is unknown.

154 theories of behavioral dedifferentiation in cognitive aging literature.

155 Typical cognitive aging may be defined as age-associated changes

156 tions such as depression, schizophrenia, and cognitive aging may result from the functional impairmen

157 suggest that one mechanism behind successful cognitive aging might be preservation of HC function com

158 ies linking active lifestyle with successful cognitive aging might be subject to bias from "neurosele

159 A classification of normal cognitive aging, mild cognitive impairment, and dementia

160 Three competing models of cognitive aging (neural compensation, capacity limitatio

161 parents and adult children may influence the cognitive aging of middle-aged and older adults in LMICs

162 e strategies, we investigated the effects of cognitive aging on the selection and adoption of navigat

163 ormation processing speed in nonpathological cognitive aging or in lifelong-stable processes.

164 y identify survivors at risk for accelerated cognitive aging or serve as an efficacy biomarker for ne

165 he effect of a cash transfer intervention on cognitive aging outcomes in older South African adults.

166 equated to 0.02 y (95% CI: -0.10, 0.13 y) of cognitive aging per year and excluded reductions of >1 m

167 he hyaluronan- and proteoglycan-rich ECM and cognitive aging phenotypes.

168 g lifecourse socio-economic status (SES) and cognitive aging primarily focus on non-Hispanic White ad

169 tervention as a viable method to curtail the cognitive aging process.

170 s important for both better comprehension of cognitive aging processes and will aid in the developmen

171 Using data from the Michigan Cognitive Aging Project, a cohort of 644 participants wa

172 h increased levels of brain ERalpha enhances cognitive aging remain unclear.

173 n many studies and is especially relevant in cognitive aging research because cognitive impairment st

174 up of individuals historically excluded from cognitive aging research.

175 studies with high mortality, as is common in cognitive aging research.

176 Neurobiological studies of stress and cognitive aging seldom consider white matter despite ind

177 the decline of associative memory in normal cognitive aging.SIGNIFICANCE STATEMENT According to prom

178 l lobe networks and ultimately contribute to cognitive aging.SIGNIFICANCE STATEMENT We report that lo

179 We used a primate model of human cognitive aging, the common marmoset, to examine the eff

180 lationship between two leading hypotheses of cognitive aging, the inhibitory deficit and the processi

181 That is, cognitive aging theories can be specific to the neural n

182 sized that exposure to stress may accelerate cognitive aging, though few studies have directly tested

183 These findings broaden the concept of cognitive aging to include evidence of Alzheimer's disea

184 ive sparing of familiarity observed in human cognitive aging to rats, and suggest a common age-relate

185 oversimplified this process by assuming that cognitive aging trajectories follow a uniform process an

186 Characterizing individual cognitive aging trajectories reveals inherent heterogene

187 classification of MCI, dementia, and normal cognitive aging was adjudicated by an expert consensus p

188 Assessing the impact of diet on cognitive aging, we conducted a controlled, randomized,

189 test the relevance of angiogenesis to human cognitive aging, we evaluated associations of circulatin

190 ss in old age is a foundation for successful cognitive aging when, instead, it is a lifelong associat

191 ed in the Women's Health Initiative Study of Cognitive Aging (WHISCA) was administered.

192 yles are promising targets for prevention of cognitive aging, yet the optimal time windows for interv

193 tyle are promising targets for prevention of cognitive aging, yet the optimal time-windows for interv