ライフサイエンスコーパス: cognitively

1 squid, are widely considered to be the most cognitively advanced group of invertebrates.

2 dings as evidence that the stories were more cognitively and emotionally engaging at a physiological

3 ot wired into the amygdala, but is instead a cognitively assembled understanding that you are in harm

4 We show that, while higher-order states are cognitively assembled, the requirements are in fact cons

5 search neuroimaging center on a cohort of 71 cognitively asymptomatic adults enriched for AD risk.

6 In a very small per cent of cognitively asymptomatic members of families with autoso

7 In cognitively asymptomatic mutation carriers, dysdiadochok

8 dictive value for mutation carrier status in cognitively asymptomatic participants (50% a priori risk

9 constructs intuitions that are not otherwise cognitively available.

10 l stage where signalers neither needed to be cognitively aware of the combinatorial strategy in place

11 ive bounds, what we previously introduced as Cognitively Bounded Rational Analysis, is a promising an

12 lan to investigate the ItchyQuant further in cognitively challenged populations.

13 found impact on achievement in school and in cognitively challenging careers.

14 tiated social relationships is thought to be cognitively challenging.

15 entral amygdalofugal bundle) through which a cognitively complex form of emotional action regulation

16 we saw no evidence for use of priors in our cognitively-complex (allocentric) task, unlike in previo

17 ns is a vital social skill but thought to be cognitively complicated.

18 ion of automatic motor responses in favor of cognitively controlled movements.

19 ion of automatic motor responses in favor of cognitively controlled movements.SIGNIFICANCE STATEMENT

20 elevant information would presumably also be cognitively costly.

21 I criteria, 70% were cognitively stable, 19% cognitively declined and 11% improved over 36 months.

22 5 and 2SD), 25% were cognitively stable, 41% cognitively declined, 15% improved and 19% fluctuated ov

23 ese data support the biological coherence of cognitively defined subgroups and nominate novel genetic

24 We assigned people to cognitively defined subgroups on the basis of relative p

25 pected cue during correct performance on the cognitively demanding 5-choice response assay relative t

26 ary for optimal behavioral performance under cognitively demanding conditions.

27 t extinction learning can be improved with a cognitively demanding eye-movement intervention.

28 r production per se was assumed to require a cognitively demanding setup, in which birch bark is heat

29 nd this may change how the brain responds to cognitively demanding situations more generally.

30 ur findings suggest that the automation of a cognitively demanding task may result in more segregated

31 ed participants choices between performing a cognitively demanding task or experiencing thermal pain.

32 the age pattern in individual performance in cognitively demanding tasks changed over the past centur

33 itive processing (compared with rest and non-cognitively demanding tasks) and is associated with impr

34 l of visceromotor activity, including during cognitively demanding tasks.

35 tal gray (PAG) should also be engaged during cognitively demanding tasks.

36 It is, however, unclear whether [1] any cognitively-demanding task can enhance extinction, or wh

37 Hypercholesterolemia is associated with cognitively deteriorated states.

38 Cognitively driven pupil modulations reflect certain und

39 More generally, cognitively driven pupil responses are likely a form of

40 ated ICU filled with patients who are awake, cognitively engaged, and mobile with family members enga

41 from nonpharmacologic approaches, including cognitively engaging activities such as reading, physica

42 Cognitively engaging lifestyles have been associated wit

43 everyday objects such as brands can trigger cognitively engaging, emotional, and socially meaningful

44 nderlying neural substrates for developing a cognitively flexible brain during early infancy.

45 was analyzed in postmortem frontal cortex of cognitively healthy and histopathologically confirmed in

46 MRI-based brain oxygen extraction shows that cognitively healthy carriers of the apolipoprotein E4 ge

47 au-specific PET radioligand (18)F-AV-1451 in cognitively healthy control (HC) and Alzheimer disease (

48 m two independent cohorts of probable AD and cognitively healthy control participants, and a cohort o

49 tic mild cognitive impairment (aMCI), and 10 cognitively healthy controls (HCs).

50 Among 193 cognitively healthy controls, 197 patients with mild cog

51 d to measure plasma NFL concentration in 193 cognitively healthy controls, 197 patients with mild cog

52 s: 70 patients with bvFTD and 78 age-matched cognitively healthy controls.

53 imer's disease factors in a cohort including cognitively healthy elderly individuals and individuals

54 t with or without dementia (cases group) and cognitively healthy elderly people (control group); data

55 tive effects of a 2-y walnut intervention in cognitively healthy elders.

56 Cognitively healthy euploid controls aged up to 75 years

57 Results A total of 143 cognitively healthy individuals (mean age 6 standard dev

58 Data from 368 cognitively healthy individuals born during 1 week in 19

59 tion of prefrontal cortex gray matter in 396 cognitively healthy individuals with ages spanning 100 y

60 verse adult brain regions across a cohort of cognitively healthy individuals.

61 between cortical thickness and YoE among 122 cognitively healthy older human individuals (87 female).

62 METHODS AND We analysed data from 2,315 cognitively healthy participants aged 65 y and over in t

63 ntial growth, and (ii) the brain networks of cognitively healthy people and patients exhibiting late

64 demonstrated analyzing plasma samples from a cognitively healthy subject.

65 luid, yielding neurotypical and preclinical, cognitively healthy, subgroups.

66 igh accuracy, moderate speed), Subtype 2 was cognitively impaired (low accuracy, slow speed), and Sub

67 RIAD, n = 116; 74 cognitively unimpaired, 42 cognitively impaired (MCI n = 16, Alzheimer's disease de

68 DNI [n = 198; 110 cognitively unimpaired, 88 cognitively impaired (MCI n = 67, Alzheimer's disease de

69 on-cognitively impaired controls (NCI), mild-cognitively impaired (MCI) and AD cases.

70 groups: cognitively unimpaired (n = 203); or cognitively impaired (n = 134, a combined group of parti

71 cognitively unimpaired elderly (n = 89), and cognitively impaired (n = 65)] who underwent amyloid-bet

72 PET in cognitively unimpaired and tau PET in cognitively impaired (P < 0.05).

73 Among the 332 participants with MS, 87 were cognitively impaired and 180 had preserved cognitive fun

74 ie, eigenvector centrality dynamics) between cognitively impaired and cognitively preserved participa

75 Cognitively impaired and preserved groups were compared

76 0 years old (357 cognitively unimpaired, 118 cognitively impaired at baseline, mean age of 83.5 +/- 3

77 f post-mortem human brains (n = 74) from non-cognitively impaired controls (NCI), mild-cognitively im

78 ean age+/-SD 62+/-11 years; 16% (n=237) were cognitively impaired during hospitalization, and 11% (n=

79 The cognitively impaired group included a higher proportion

80 In the cognitively impaired group, younger age (P = 0.02), high

81 vely normal HIV-positive individuals, and 17 cognitively impaired HIV-positive individuals.

82 sp2 and Deltatau314 proteins are elevated in cognitively impaired individuals compared to cognitively

83 14 proteins are elevated in the brain of the cognitively impaired individuals compared to the cogniti

84 ds to test affective state without excluding cognitively impaired individuals is a future challenge f

85 In cognitively impaired individuals, imaging and clinical v

86 gene that fails to be induced by learning in cognitively impaired male aged rats.

87 ression of Gadd45gamma in the hippocampus of cognitively impaired male mice.

88 nitively unimpaired control subjects and 767 cognitively impaired participants (mild cognitive impair

89 omplete loss of this negative correlation in cognitively impaired participants compared with cognitiv

90 visual network regions on functional MRI in cognitively impaired participants versus cognitively pre

91 Compared with CN individuals, cognitively impaired patients had a greater frequency of

92 Cognitively impaired patients showed increased variabili

93 ficance of diagonal earlobe crease (DELC) in cognitively impaired patients using imaging biomarkers,

94 30 cognitively impaired patients who were calling out repet

95 Compared with Abeta-negative cognitively impaired patients with minimal WMH, Abeta-po

96 tigate network dynamics on functional MRI in cognitively impaired patients with MS.

97 Conclusion As shown on functional MRI, cognitively impaired patients with multiple sclerosis no

98 ctively, that could be used to differentiate cognitively impaired persons from those without cognitiv

99 f amyloid imaging results is desired by many cognitively impaired subjects and seems to be safe once

100 eta(1-42) levels at baseline were more often cognitively impaired than patients with intermediate and

101 11, 60 subjective cognitive decline, 36 mild cognitively impaired, and 19 AD dementia).

102 s who called out were moderately or severely cognitively impaired, often had delirium, were very phys

103 because many of these patients are severely cognitively impaired, often immobile and dependent on th

104 ost severe symptoms after diagnosis and were cognitively impaired.

105 ls who were either cognitively unimpaired or cognitively impaired.

106 Older adults admitted to hospital are often cognitively impaired.

107 By the technical-reasoning hypothesis, cognitively-impaired individuals will lack the cognitive

108 shell beads, the idea that Neanderthals were cognitively inferior to modern humans is becoming increa

109 younger than 60 years (range, 33-57 years), cognitively intact "aged" individuals aged older than 60

110 from 79 individuals was evaluated, including cognitively intact "young" individuals aged younger than

111 iod and five who were successfully extubated cognitively intact and without focal neurologic deficits

112 patients with late-onset AD (LOAD), and 7001 cognitively intact controls (age at examination, >65 yea

113 e (AD), mild cognitive impairment (MCI), and cognitively intact controls using OCT angiography.

114 e 6-mm circle (P = 0.033) when compared with cognitively intact controls.

115 ogy (p < 0.001) were more severe in MCI than cognitively intact controls.

116 heimer's neuropathology" (NDAN) individuals, cognitively intact despite displaying pathologic feature

117 s analysis of cerebrospinal fluid (CSF) from cognitively intact elderly patients (N = 28) with MDD an

118 dized uptake value ratio (SUVR) in 267 older cognitively intact individuals with subjective memory co

119 the basal forebrain connectivity at rest in cognitively intact older adults at risk for Alzheimer di

120 A total of 1657 cognitively intact older adults receiving treatment for

121 global fibrillary amyloid-beta pathology in cognitively intact older adults with subjective memory c

122 We followed 2,556 cognitively intact participants aged >=60 years from the

123 In 133 aMCI and 68 cognitively intact participants the PSS score was higher

124 (MCI), a prodromal stage to dementia, and 17 cognitively intact, elderly controls completed (18)F-ASE

125 A community-based sample of 181 cognitively intact, healthy adults were recruited from t

126 uals older than 85 years of age who remained cognitively intact.

127 A sensitivity analysis was performed in cognitively-intact participants only.

128 Fourteen TD and 12 PIGD cognitively-intact patients and 21 age- and sex-matched

129 ctively proliferate within islets and expand cognitively interactive pathogenic T cells from a pool o

130 us, calcium, iron, zinc, copper, selenium in cognitively normal (CN) and AD subjects.

131 Cognitively normal (CN) participants had olfactory funct

132 Among cognitively normal (CN) participants oversampled for ele

133 participants, but could also be found in the cognitively normal (CN) participants.

134 ly individuals without dementia, including a cognitively normal (CN) subsample of 144 adults, enrolle

135 linical evidence of cerebrovascular disease: cognitively normal (CN) without WMH (CN without SCeVD, n

136 (CNN)-based classification model of AD from cognitively normal (CN) yielded an average accuracy of 9

137 This study included 83 cognitively normal (CN), 160 mild cognitive impairment (

138 raphy (PET) images in independent discovery [cognitively normal (CN), 19; mild cognitive impairment (

139 antly greater odds of having aMCI than being cognitively normal (odds ratios (ORs) = 1.36-1.43 for th

140 n the analyses of AD risk, 1400 individuals (cognitively normal = 747, AD = 653) in the CSF biomarker

141 and AD risk in 309 individuals (191 AD, 118 cognitively normal [CN] controls) from the San Francisco

142 pir uptake was quantified in a sample of 131 cognitively normal adults (age: 20-93 years; 47 amyloid-

143 acquired in a cohort of 20- to 82-year-old, cognitively normal adults (n = 205) to define their meta

144 isodic-memory performance and MTL atrophy in cognitively normal adults, independent of Abeta.

145 ears old at the beginning of the study, were cognitively normal at baseline (a Mini-Mental State Exam

146 Exploratory analyses of a cognitively normal cohort followed up for a median of 3.

147 (AD) ( n = 24) than in age- and sex-matched cognitively normal control subjects ( n = 24).

148 YKL-40 and sAPPbeta between groups and with cognitively normal controls (n=77), and assessed their d

149 onset Alzheimer disease (AD) cases and 5,096 cognitively normal controls primarily of European ancest

150 ed to SUVRs derived from young, non-autopsy, cognitively normal controls used as a standard for tau n

151 as of increased tracer retention compared to cognitively normal controls, adjusting for age as a cova

152 linical dataset representing the spectrum of cognitively normal controls, individuals with mild cogni

153 r's disease, though higher than age-matched, cognitively normal controls.

154 sues from late-onset Chinese AD patients and cognitively normal controls.

155 frequencies for each subgroup to those from cognitively normal elderly controls.

156 0-min scan and a 90- to 110-min scan) on 190 cognitively normal elderly individuals (mean age, 70.4 y

157 Cognitively normal elderly individuals who engage in spe

158 approach for assessing amyloid disease in a cognitively normal elderly population.

159 e examined 165 participants consisting of 17 cognitively normal elderly subjects, 45 patients with Pa

160 T scans of up to 150 min were performed on 4 cognitively normal HE subjects, 4 AD subjects, and 2 amn

161 ients with symptomatic Alzheimer disease, 15 cognitively normal HIV-positive individuals, and 17 cogn

162 sion tomography (PET) were compared among 19 cognitively normal human immunodeficiency virus (HIV)-ne

163 T) imaging, we measured tau and Abeta in 124 cognitively normal human older adults (74 females, 50 ma

164 The study comprised 265 cognitively normal individuals (135 women and 130 men; m

165 vious studies report conflicting findings in cognitively normal individuals at high risk of AD.

166 sing CSF samples from the PREVENT-AD cohort (cognitively normal individuals at risk for Alzheimer's d

167 hippocampal volume changes from baseline in cognitively normal individuals from Alzheimer's Disease

168 or Alzheimer-related cognitive decline among cognitively normal individuals with elevated brain amylo

169 cognitively impaired individuals compared to cognitively normal individuals, and (4) levels of Deltat

170 th the presence of moderate to severe WMH in cognitively normal individuals, and NAFLD severity predi

171 Among cognitively normal individuals, elevated brain amyloid (

172 itively impaired individuals compared to the cognitively normal individuals, indicating a possible ro

173 In cognitively normal individuals, neurodegeneration biomar

174 tabolism, and grey matter degeneration in 15 cognitively normal mutation non-carriers, 20 asymptomati

175 A subsample of 50 cognitively normal older (26 amyloid-beta-positive) and

176 Results Evaluated were 150 cognitively normal older adults (mean age, 69 years +/-

177 MTL atrophy contribute to episodic memory in cognitively normal older adults (n = 83; age, 77 +/- 6 y

178 analyses of fMRI data from a large cohort of cognitively normal older adults (N=100) to measure hippo

179 rment (MCI) is an intermediate stage between cognitively normal older adults and AD.

180 s secondary analysis of a prospective study, cognitively normal older adults underwent QSM MRI to mea

181 These interactions were not detected in cognitively normal older adults with "neurotypical" leve

182 with multiple biomarkers of inflammation in cognitively normal older adults with abnormal amyloid an

183 Conclusion Among cognitively normal older adults, quantitative susceptibi

184 ttern was related to clinical progression in cognitively normal older adults.

185 sure FC, and PET to measure tau and Abeta in cognitively normal older adults.

186 nal change in Abeta using PIB-PET imaging in cognitively normal older adults.

187 ation of Alzheimer's pathology are common in cognitively normal older adults.

188 ctivity in the MTL during memory encoding in cognitively normal older adults.

189 anges in human sleep quantity and quality in cognitively normal older adults.

190 But this needs further investigation among cognitively normal older adults.

191 er with beta-amyloid affects cognition among cognitively normal older adults.

192 neuropsychiatric symptoms such as anxiety in cognitively normal older individuals.

193 Cognitively normal older male and female human adults we

194 ease (AD) but both pathologies also occur in cognitively normal older people.

195 ction of diagnostic group among Abeta- older cognitively normal or clinically diagnosed Alzheimer's d

196 We report data from 238 cognitively normal participants (humans), sampled across

197 Here, 546 cognitively normal participants 18-88 years old viewed a

198 rican American (n = 131) and white (n = 685) cognitively normal participants age 45 years and older.

199 n the PREVENT-Dementia cohort were analysed (cognitively normal participants aged 40-59, stratified b

200 A total of 209 cognitively normal participants had data on neurodegener

201 ons of tau and Abeta deposits in a sample of cognitively normal participants in the Harvard Aging Bra

202 ected from a pool of Alzheimer's disease and cognitively normal patients from the Alzheimer's Databas

203 esilience to Abeta and therefore may benefit cognitively normal patients that are at high risk for de

204 zheimer's disease (AD) but are also found in cognitively normal people.

205 sease patient versus a group of age-matched, cognitively normal subjects across two independent datas

206 clinically diagnosed Alzheimer's disease and cognitively normal subjects from the Alzheimer's Disease

207 In contrast, florbetapir Abeta- older cognitively normal subjects showed an increase in florta

208 icipants 50 years old or older, including 57 cognitively normal subjects, 97 clinically defined mild

209 exus region of interest) compared to younger cognitively normal subjects, but no increased standard u

210 with greater self-reported anxiety among 118 cognitively normal volunteers, aged 65-90 years, and whe

211 assessment, we addressed these questions in cognitively normal young and older adults.

212 Methods: Fifty-one individuals ranging from cognitively normal young controls to persons with dement

213 and for whom (18)F-FDG PET (30 AD, 6 MCI, 2 cognitively normal) and amyloid-beta (Abeta) PET (17 AD,

214 disease > mild cognitive impairment > older cognitively normal) and was significantly elevated for A

215 nd amyloid-beta (Abeta) PET (17 AD, 3 MCI, 2 cognitively normal) were available.

216 Among patients previously classified as cognitively normal, 14 (4.3%, population-based cohort) a

217 s for AD on brain functional connectivity in cognitively normal, preclinical, prodromal, and AD demen

218 defined as amyloid-beta (Abeta) positive but cognitively normal.

219 with congenital pain insensitivity, but are cognitively normal.

220 me genes in 654 psychiatric patients and 889 cognitively-phenotyped control subjects, on whom we prev

221 ts of temporal discounting may result from a cognitively plausible adaptive response to the costs of

222 sciplinary discussion necessary to produce a cognitively plausible model of linguistic representation

223 s patients and healthy volunteers (HV) or as cognitively preserved (CP) and impaired (CI) patients.

224 a higher proportion of men compared with the cognitively preserved group (35 of 87 [40%] vs 48 of 180

225 nitively impaired participants compared with cognitively preserved participants (r = -0.04 vs r = -0.

226 y dynamics) between cognitively impaired and cognitively preserved participants with MS were investig

227 in cognitively impaired participants versus cognitively preserved participants.

228 Alzheimer's disease (AD) varies a great deal cognitively regarding symptoms, test findings, the rate

229 iency to test the mediating effects of FC in cognitively salient brain networks (fronto-parietal; dor

230 umption that the origin of criminal law is a cognitively sophisticated human nature.

231 Participants were characterized as cognitively stable (CS), mild cognitive impairment-DS (M

232 associated with baseline global cognition in cognitively stable 80+ (the resilience signature); (ii)

233 lic areas underlying cognitive resilience in cognitively stable 80+ participants, which we call the '

234 tified a subset of 'resilient' participants (cognitively stable 80+, n = 192) who maintained normal c

235 sruption of cognitive development (44%), and cognitively stable adolescent development (37%).

236 Cognitively stable individuals had the best adult clinic

237 nitive PGSs relative to control subjects and cognitively stable individuals.

238 silon3/epsilon3 group, all patients remained cognitively stable or improved; in the ApoE epsilon3/eps

239 As opposed to a group of cognitively stable participants, participants developing

240 Applying level I criteria, 70% were cognitively stable, 19% cognitively declined and 11% imp

241 level II criteria (1, 1.5 and 2SD), 25% were cognitively stable, 41% cognitively declined, 15% improv

242 llowed patients with SCD or MCI who remained cognitively stable, converted to AD dementia, or convert

243 We argue that animals are not cognitively stuck in time.

244 109 lesions were analyzed, including 39 with cognitively targeted sampling.

245 iffuse plaques are predominantly observed in cognitively unaffected, amyloid-positive (CU-AP) individ

246 l contexts associated with Neanderthals, the cognitively undemanding connection between burning birch

247 hen compared to either amyloid-beta-negative cognitively unimpaired (0.4 +/- 2.7%), amyloid-beta-nega

248 ent (-0.4 +/- 2.3%) or amyloid-beta-positive cognitively unimpaired (1.2 +/- 2.8%).

249 e a slope reduction in amyloid-beta-positive cognitively unimpaired (71 participants per arm in amylo

250 d p-tau217 compared to amyloid-beta-negative cognitively unimpaired (beta = 0.56, P < 0.001, using li

251 se Neuroimaging Initiative (ADNI), including cognitively unimpaired (CU), mild cognitive impairment (

252 The study participants were cognitively unimpaired (n = 153), or patients with mild

253 ip in one of two clinical diagnostic groups: cognitively unimpaired (n = 203); or cognitively impaire

254 Seventy per cent of cognitively unimpaired and 74% of FTD participants fell

255 ith subsequent development of AD dementia in cognitively unimpaired and MCI subjects.

256 associations were specific to amyloid PET in cognitively unimpaired and tau PET in cognitively impair

257 This finding is apparent in cognitively unimpaired APOE4 carriers and more severe in

258 Of the participants, 92% (441/480) were cognitively unimpaired but the A+T+(N)+ group had the la

259 Neuroimaging Initiative [ADNI: n = 1149; 382 cognitively unimpaired control subjects and 767 cognitiv

260 ssed 176 individuals [young adults (n = 22), cognitively unimpaired elderly (n = 89), and cognitively

261 ) curves based on clinical classification of cognitively unimpaired elderly versus Alzheimer disease

262 erials and Methods Between 2011 and 2013, 61 cognitively unimpaired former collegiate and professiona

263 In the cognitively unimpaired group, only higher baseline amylo

264 potentially resilient individuals to remain cognitively unimpaired in the face of substantial neurop

265 istics and prevalence of each ATN profile in cognitively unimpaired individuals aged 50 years and old

266 METHODS AND We included cognitively unimpaired individuals aged 60-75 y, consist

267 A total of 395 cognitively unimpaired individuals and 204 individuals w

268 ion and atrophy were assessed relative to 49 cognitively unimpaired individuals and among phenotypes.

269 In 2 cohorts of cognitively unimpaired individuals at risk of AD, we exa

270 lation is leading to an increasing number of cognitively unimpaired individuals, who are concerned th

271 dary analyses restricting comparisons to the cognitively unimpaired LLD participants as well as when

272 r's disease from young adults (AUC=100%) and cognitively unimpaired older adults (AUC=84.44%), but no

273 beta-negative young adults (AUC=99.40%) and cognitively unimpaired older adults (AUC=90.21-98.24% ac

274 ion cohorts (TRIAD and BioFINDER-2) included cognitively unimpaired older adults (mean age 63-69 year

275 concentrations in the amyloid beta-positive cognitively unimpaired older adults and MCI groups, to t

276 ns in amyloid beta-negative young adults and cognitively unimpaired older adults, through higher conc

277 ar objects but not scenes in male and female cognitively unimpaired older adults.

278 separately among individuals who were either cognitively unimpaired or cognitively impaired.

279 We identified 48 cognitively unimpaired participants (22 with elevated CS

280 ish BioFINDER-2 cohort (cohort 2), including cognitively unimpaired participants (n = 301) and clinic

281 We studied 150 cognitively unimpaired participants and 100 patients wit

282 , with a total of 589 individuals, including cognitively unimpaired participants and patients with mi

283 sion Project study and 119 nondepressed (ND) cognitively unimpaired participants matched on age, sex,

284 PET biomarker stratified groups in initially cognitively unimpaired participants sampled from the Wis

285 ia, or converted to non-AD dementias, and in cognitively unimpaired participants.

286 (AD), other neurodegenerative dementias, and cognitively unimpaired patients with cerebrovascular dis

287 thological profiles can be identified in the cognitively unimpaired population.

288 In the cognitively unimpaired subcohort (53.8 +/- 4.6 years at

289 In a cognitively unimpaired subcohort (n = 330), beta-amyloid

290 ith faster rates of cognitive decline in the cognitively unimpaired subgroup with abnormal amyloid PE

291 e matter volume loss; grey matter atrophy in cognitively unimpaired was specific to APOE epsilon4 car

292 tified 457 participants >= 80 years old (357 cognitively unimpaired, 118 cognitively impaired at base

293 rs in Aging and Dementia [TRIAD, n = 116; 74 cognitively unimpaired, 42 cognitively impaired (MCI n =

294 assessed in two cohorts: ADNI [n = 198; 110 cognitively unimpaired, 88 cognitively impaired (MCI n =

295 gative cognitively unimpaired, Ptau positive cognitively unimpaired, and Ptau positive individuals wi

296 and replication cohort (n = 39) of initially cognitively unimpaired, longitudinally assessed older-ad

297 p in one of five clinical diagnostic groups: cognitively unimpaired, mild cognitive impairment, front

298 Preclinical (amyloid-beta-positive cognitively unimpaired, n = 62) and prodromal (amyloid-b

299 and education-matched groups: Ptau negative cognitively unimpaired, Ptau positive cognitively unimpa

300 abnormalities among individuals who remained cognitively unimpaired.