ライフサイエンスコーパス: collagen III

1 , p63-alpha, CD45, CD73, CD105, Vimentin and Collagen III).

2 gene, which encodes the pro-alpha 1 chain of collagen III.

3 five sites on collagen II and three sites on collagen III.

4 lation of collagen I, and down-regulation of collagen III.

5 en III levels and the ratio of Collagen I to Collagen III.

6 f collagen III was similar to that of native collagen III.

7 s, including a-SMA, desmin, fibronectin, and collagen III.

8 .001), collagen I (0.8-fold; p < 0.001), and collagen III (1.4-fold; p < 0.001), as well as protein l

9 r T3-SCI, the MCA had more collagen I (42%), collagen III (24%), transforming growth factor beta (47%

10 (33%, P < 0.02), collagen I (28%, P < 0.01), collagen III (34%, P < 0.01), fibronectin (48%, P < 0.01

11 On the other hand, both TG2/laminin and collagen III activate the receptor by dissociating the N

12 renal expression of fibronectin, collagen I, collagen III, alpha-SMA, PAI-1, fibroblast-specific prot

13 xpression of fibrosis markers collagen I and collagen III also increased in 15-mo LP offspring.

14 protein, laminin, to activate GPR56, whereas collagen III and 3-alpha-DOG signaled without any cofact

15 However, corneal fibrosis markers, Collagen III and alpha-smooth muscle actin, were signifi

16 sions of fibronectin, a-smooth muscle actin, collagen III and collagen I.

17 s of fibronectin, alpha-smooth muscle actin, collagen III and collagen I.

18 ccumulation of collagen III in the liver and collagen III and collagen IV in the heart; this is induc

19 immunolocalization of cellular fibronectin, collagen III and collagen IV.

20 Similarly, increased collagen III and collagen VI deposition with exaggerated

21 splayed a reduced deposition of interstitial collagen III and fibronectin as well as total tissue col

22 Furthermore, ASM collagen III and laminin in asthma were correlated with

23 To date, two natural GPR56 ligands, collagen III and tissue transglutaminase (TG2), and one

24 zed fibrillar structure, with an increase in collagen III and V fibers and mesenchymal cells.

25 nificant greater cellularity and presence of collagen III and V than in Group II tendon, which showed

26 f Matrix Metalloproteinase (TIMP-3, TIMP-4), collagen-III and elastin levels were measured in whole b

27 ulation and immunohistochemical staining for collagens III and IV and attenuated glomerular and tubul

28 with multiple ECM components (e.g., laminin, collagens III and IV) to drive the formation of the cell

29 (total lung collagen content, peribronchial collagens III and V) and significantly less peribronchia

30 tin, beta-myosin heavy chain), and fibrosis (collagen III), and increased LV prosurvival signaling (a

31 GF-beta-stimulated expression of collagen I, collagen III, and alpha-smooth muscle actin.

32 tial infiltrates and fibrosis, deposition of collagen III, and apoptosis of tubular epithelial cells.

33 disease progression, including fibronectin, collagen III, and chemoattractants that were identified

34 Extracellular matrix proteins, collagen I, collagen III, and elastin, blocked NK cell cytotoxicity

35 by decreasing the expression of collagen I, collagen III, and fibronectin mRNA and protein.

36 rix-associated genes, including collagen VI, collagen III, and tissue inhibitor of metalloproteases-1

37 Immunohistochemical staining with collagen III antibody demonstrates an abundance of colla

38 ellular matrix, we identified collagen I and collagen III as well as mixtures of collagen I/collagen

39 d postradiation accumulation of interstitial collagen III but less myocardial degeneration in hearts

40 7%; p = 0.002), and N-terminal propeptide of collagen III by 3% (95% CI: 0% to 6%; p = 0.04) and incr

41 as alpha-smooth muscle actin (alpha-SMA) and Collagen III (Col III), in both HCFs and HKCs.

42 Collagen I (COL1A1), collagen III (COL3A1), hyaluronan synthase (HAS) 2, and

43 , cysteine-rich 61, collagen I (COL1A2), and collagen III (COL3A1).

44 g of 32 distinct combinations of collagen I, collagen III, collagen IV, fibronectin, and laminin.

45 extracellular matrix molecules (collagen I, collagen III, collagen IV, laminin and fibronectin) on c

46 than in control tendons (p=0.0079), whereas collagen III content was not different (p=1.0).

47 ntracutaneous fibrillin-rich microfibril and collagen III deposition and decreased mammalian target o

48 While collagen III deposition was not affected by the transgen

49 immunoreactive inflammation area, endomysial collagen III deposition, and hind limb grip strength.

50 c macrophages and was associated with excess collagen III deposition.

51 l of gene transcription, with collagen I and collagen III exhibiting similar dynamics in the Fb model

52 c alterations, with significant reduction in collagen III expression and deposition.

53 We tested whether TGF-beta mediates collagen III expression by treating animals with TGF-bet

54 en III antibody demonstrates an abundance of collagen III expression in this ECM.

55 Collagen III expression is seen in apposition to gels at

56 th diminished bone formation, lower CD31 and collagen III expression, and increased osteoclast number

57 ptor on the activation of human platelets by collagen; (iii) generated low-GPVI mice in which the alp

58 gh affinity integrin-binding motifs in human collagen III (GROGER and GLOGEN) and a third motif (GLKG

59 methods included whole-slide digital images: collagen III immunohistochemistry and a new technique us

60 alysis, an approximately twofold increase in collagen III immunolabeling within the interstitial comp

61 Loss of LAP paralleled induction of collagen III immunoreactivity in this tissue compartment

62 smooth muscle cells (ASMCs)-a rich source of collagen III in lung.

63 t notion, iCAFs, rather than myCAFs, produce collagen III in response to chemotherapy, supporting the

64 in intervention reverses the accumulation of collagen III in the liver and collagen III and collagen

65 protein connective tissue growth factor and collagen III in vitro and decreased pulmonary vascular f

66 sed but of normal composition (predominantly collagen III) in 2 cases, and collapsed and condensed co

67 ow these amino acid substitutions affect the collagen III-integrin alpha(2)beta(1) interaction.

68 ow that AMPK activation by metformin reduced collagen III levels and the ratio of Collagen I to Colla

69 ion, decreased myofibroblast presence, lower collagen III levels, and elevated collagen I production.

70 as potentially the best for clinical trials: collagen III morphometry and visual assessment of trichr

71 sion of collagen I mRNA lagged expression of collagen III mRNA and peaked at day 42 after PRK with a

72 .003), whereas collagen I did not change and collagen III mRNA increased 1.5-fold (P=0.02).

73 Collagen III mRNA levels peaked on day 21 with a 700-fol

74 t radiation-induced elevation of total gland collagen III mRNA was also blocked by neutralizing antib

75 n in previously published referent controls; collagen III N-terminal propeptide (5.6 [4.3-6.9] ng/mL)

76 galectin-3, matrix metalloproteinase-2, and collagen III N-terminal propeptide were measured in the

77 n content (P<0.0001), collagen I (P<0.0001), collagen III (P<0.0001), and myocyte size (P<0.0001).

78 of key fibrotic markers such as collagen I, collagen III, periostin, plasminogen activator inhibitor

79 ICP) and the amino terminal peptide from pro-collagen III (PIIINP), correlate with left atrial (LA) f

80 Serum YKL-40, N-terminal propeptide of collagen III (PIIINP), TGF-beta, and TNF-alpha were meas

81 lagen I (PINP), and N-terminal propeptide of collagen III (PIIINP).

82 (WT) mice, associated with lower collagen I, collagen III, plasminogen activator inhibitor (PAI-1), a

83 were validated for CCL2 and CXCL10 mRNA and collagen III protein.

84 -alpha2 integrin-subunit antibody and type I collagen, (iii) recombinant alpha2-I domain bound the wi

85 Thus, collagen III regulates the proper lamination of the cere

86 The proportion of collagen III relative to collagen I increased significan

87 the expression pattern of the GPR56 ligand, collagen III, revealed no visible gradient pattern.

88 Collagen III secretion was reduced 80% in both HCFs and

89 Collagen III, Sirius Red unpolarized, and visual scores

90 Radiation-induced collagen III staining in the adipose stroma was blocked

91 r or weaker than the corneal stroma, whereas collagen III staining was focal and slightly more intens

92 by trypsin, a property also seen for native collagen III, supporting a local structural relaxation o

93 The ratio of collagen III to collagen I was significantly lower in PR

94 to 6 months, at which time the proportion of collagen III was 70% above baseline values.

95 chimera containing six triplets (P7-P11') of collagen III was similar to that of native collagen III.

96 ing the entire triplehelical domain of human collagen III was used to locate binding sites for the co

97 titial area stained with picrosirius red and collagen III) was significantly increased 14 d after UUO

98 ), alpha-smooth muscle actin, collagen I and collagen III were increased at 2 and/or 6 weeks, but pro

99 Single glycine substitutions in collagen III, which predominates in vascular walls, resu

100 onal studies suggest that the interaction of collagen III with its receptor GPR56 inhibits neural mig