ライフサイエンスコーパス: collagen IV

1 using the H score (MMPs) or pixel intensity (collagen IV).

2 for, but not limited to, the crosslinking of collagen IV.

3 of elevated glucose on deposition of FN and collagen IV.

4 o kinds of alloantibodies against allogeneic collagen IV.

5 necrosis factor-alpha or cell attachment to collagen IV.

6 on of cellular fibronectin, collagen III and collagen IV.

7 ondrial ROS production (DCF and MitoSOX) and collagen IV.

8 mmunobeads recognizing either laminin 332 or collagen IV.

9 factor (CDAF) that is processed from alpha1 collagen IV.

10 the only BMP ligand in Drosophila that binds collagen IV.

11 ith magnetic beads coated with antibodies to collagen IV.

12 hanism of BMP shuttling that is catalyzed by collagen IV.

13 culature was dual stained with isolectin and collagen IV.

14 of Perlecan, which counters constriction by Collagen IV.

15 es, polymerizing, and binding to nidogen and collagen IV.

16 mbrane, as mirrored by an increase in plasma collagen IV.

17 to the membrane of Caco-2 cells spreading on collagen IV.

18 fferentiate, but showed impaired adhesion to collagen IV.

19 l epithelial cell spreading and migration on collagen IV.

20 ulation of Caco-2 spreading and migration on collagen IV.

21 oodpasture auto-antigen, the alpha3 chain of collagen IV.

22 anoma cells did not affect their adhesion to collagen IV.

23 o both native and recombinant NC1 domains of collagen IV.

24 s by integrin signaling when cells attach to collagen IV.

25 nderlying chain selection in the assembly of collagen IV.

26 n, cell aggregation, or protease cleavage of collagen IV.

27 apico-basal polarity markers Podocalyxin and Collagen IV.

28 2-mediated crosslinking of basement membrane collagen IV.

29 tes the formation of covalent cross-links in collagen IV.

30 the formation of sulfilimine cross-links in collagen IV.

31 FIX binds tightly to collagen IV.

32 in, heparin, bovine serum albumin, mucin, or collagen IV.

33 The aggregated platelets released collagen IV, a critical BL component, onto the PAR4-AP-m

34 oteinases (MMPs) have the ability to degrade collagen IV, a main component of the breast lobular base

35 o chromatin to increase the transcription of collagen IV, a major collagen upregulated in fibrosis.

36 d of an IOL placed on a membrane coated with collagen IV, a major constituent of the lens capsule.

37 regates and in addition showed focal loss of collagen IV, a principal component of basal lamina.

38 Collagen IV accumulation in HG was markedly reduced in H

39 etic mice, Sema3a(+) exacerbates laminin and collagen IV accumulation in Kimmelstiel-Wilson-like glom

40 r signal-regulated kinase (ERK1/2, p38), and collagen IV accumulation in mesangial cells.

41 lointerstitial total collagen and glomerular collagen IV accumulation) benefits were seen upon dual t

42 on in ROCK activity, albuminuria, glomerular collagen IV accumulation, and urinary collagen IV excret

43 se induces FN assembly, which contributes to collagen IV accumulation.

44 induced phosphorylation of these targets and collagen IV accumulation.

45 h islets seeded onto scaffolds adsorbed with collagen IV achieved euglycemia fastest and their respon

46 ), a receptor tyrosine kinase that acts as a collagen IV adhesion receptor.

47 D mutation in the collagen domain of COL4A2 (collagen IV alpha chain 2) in a family displaying porenc

48 neys showed significantly less expression of collagen IV, alpha-smooth muscle actin, and other marker

49 product of the alpha1alpha2alpha1 network of collagen IV (alpha1alpha2alpha1(IV) truncated protomer)

50 membrane disorder caused by mutations in the collagen IV alpha3, alpha4, or alpha5 genes that results

51 The dragnet gene, drg, encodes collagen IV(alpha5) (Col4a5), a basement membrane compon

52 In addition to dysregulation of collagen IV, Alport GBM contains aberrant laminins, whic

53 We observed that collagen IV also stimulated Src-dependent phosphorylatio

54 is required for sulfilimine formation within collagen IV, an event critical for BM assembly and tissu

55 viking/collagen IV and betaPS-integrin are known to promote tis

56 llel to perlecan and in opposition to viking/collagen IV and betaPS-integrin to keep CNS lineages roo

57 tegrin interacts with two different ligands, collagen IV and CDH17, using two different binding sites

58 Other molecular (collagen IV and connective tissue growth factor) and his

59 ntrast, the processed form of LOXL2 binds to collagen IV and crosslinks the 7S domain.

60 cess that involves deposition of laminin and collagen IV and de-nitrosylation of laminin.

61 ockdown cells revealed increased adhesion to collagen IV and decreased invasion through the Matrigel.

62 IV modifying enzymes rescued ER retention of collagen IV and EC apoptosis and resulted in normal deve

63 rosis, mesangial expansion, and ECM protein (collagen IV and fibronectin) accumulation as well as inc

64 uction in EC resulted in impaired folding of collagen IV and its retention in the endoplasmic reticul

65 extracellular matrix (ECM), with a focus on collagen IV and its variant, spongin short-chain collage

66 Collectively, we conclude that collagen IV and its variant, spongin, are primordial com

67 lomerular basement membrane (GBM) components collagen IV and laminin 10 and 11.

68 Immunofluorescent staining of collagen IV and laminin and electron microscopy analysis

69 capillary-like branches in ECs and increased collagen IV and laminin expression.

70 urthermore, glomerular nodules overexpressed collagen IV and laminin extensively.

71 that contains tissue-restricted isoforms of collagen IV and laminin.

72 oted euglycemia, yet required more time than collagen IV and less time than serum.

73 trated a 2-fold increase in the levels of BM collagen IV and LOX, key determinants of capillary BM st

74 and differentiated into SMCs when seeded on collagen IV and maintained in differentiation media.

75 enesis decreases proliferation and increases collagen IV and MT-MMP expression.

76 ver, in Col4a3(-/-) Alport mice, both intact collagen IV and NC1 hexamers from murine GBM elicited Ig

77 ion, respectively) Caco-2 sheet migration on collagen IV and noticeably inhibited lamellipodial exten

78 Collagen IV and pan-laminin were present in the disorgan

79 Our results uncover incorporation of Collagen IV and Perlecan into BMs as a major determinant

80 ation, altered peritracheal distributions of collagen IV and Perlecan, misregulated ASP growth, and a

81 transcriptome and available genomic data for collagen IV and peroxidasin.

82 The resulting upregulation of alpha1 collagen IV and production of Arresten by the tumor cell

83 hos-Foxo3a, phos-NF-kappaB, fibronectin, and collagen IV and reduced expressions of Sirt1 and total-F

84 ow that p53 induces the expression of alpha1 collagen IV and release of Arresten-containing fragments

85 issues, is primarily composed of laminin and collagen IV and serves as a structural barrier to cancer

86 1 knockdown decreased melanocyte adhesion to collagen IV and shifted melanocyte localization in a man

87 We first established a protocol using collagen IV and VEGF to drive the functional differentia

88 hesion of both fetal and adult beta-cells to collagen IV and vitronectin also results in the marked s

89 pendent adhesion of fetal beta-cells to both collagen IV and vitronectin induces significant glucose-

90 remodeling in old mice, including increased collagen IV and XVI and decreased Fraser syndrome comple

91 Fibronectin and collagens IV and I protein levels were elevated in both

92 connective tissue growth factor (CTGF), and collagens IV and VI found in diabetic wild-type mice was

93 own to bind decay-accelerating factor (DAF), collagen IV, and carcinoembryonic antigen-related cell a

94 ses Col4a2 and intracellular accumulation of collagen IV, and decreases the proteolytic release of co

95 -derived growth factor beta, fibronectin and collagen IV, and enhanced cell migration.

96 (4) significant accumulation of perivascular collagen IV, and fibrin deposits (5) significantly incre

97 affinities to extracellular matrix proteins, collagen IV, and fibronectin.

98 eases in the levels of glomerular TGF-beta1, collagen IV, and fibrosis only in WT diabetic mice.

99 rticipates in regulation of cell adhesion on collagen IV, and is required for maximal PAK1 kinase act

100 llular matrix proteins-including collagen I, collagen IV, and laminin V-to modulate intercellular Eca

101 ment membrane (BM) constituents, laminin 10, collagen IV, and nidogen-2 (but not perlecan) are consid

102 factor-beta1 (TGF-beta1), fibronectin (FN), collagen IV, and p21/WAF1Cip1 (p21) were analyzed.

103 icate a functional connection between Br(-), collagen IV, and peroxidasin.

104 th invasive outgrowths, their degradation of collagen IV, and their secretion of urokinase-type plasm

105 capillary knot, dysregulation of nephrin and collagen IV, and ultrastructural changes in the trilamin

106 that the structural and genomic features of collagen IV are homologous to those of non-bilaterian an

107 e using lysozyme and RGD-alpha3NC1 domain of collagen IV as model proteins in vitro.

108 opy after immunohistochemically staining for collagen IV basement membrane markers, in addition to ex

109 The collagen IV binding receptor integrin alpha1beta1 has be

110 A collagen IV binding-deficient Dpp mutant signals at long

111 n this article, we show that adhesion by the collagen IV-binding integrin alpha1beta1 unexpectedly in

112 Collagen IV, but not vitronectin, induces comparable res

113 integrin consistent with the modification of collagen IV by hypochlorous (HOCl) and hypobromous acids

114 bilized the expression of full-length alpha1 collagen IV by upregulation of alpha(II) prolyl-hydroxyl

115 n as PLOD3) into newly identified post-Golgi collagen IV carriers and that VIPAR-dependent sorting is

116 he 7/10/22 subfamily and broadly distributed collagen IV chains (alpha1/2) promote clustering of syna

117 Synapse-specific collagen IV chains (alpha3-6) accumulate only after syna

118 at intermolecular epitope spreading to other collagen IV chains also was induced.

119 our previous studies, establish that the six collagen IV chains are organized into three canonical pr

120 tress arising from defective localization of collagen IV chains in human podocytes contributes to the

121 Assembly of collagen IV chains into heterotrimeric molecules and net

122 ted by pathogenic anti-GBM alloantibodies to collagen IV chains present in the renal allograft but ab

123 d bone-morphogenetic protein-4 and growth on collagen IV-coated plates.

124 Factor IX (FIX) binds to collagen IV (Col4) in the subendothelial basement membra

125 nt-related gene changes, including decreased collagen IV (COL4A1, COL4A2) and ephrinA1 (EFNA1).

126 or the effects of FA on fibronectin (FN) and collagen IV (Coll IV) expression.

127 protein quantification showed a dominance of collagen IV, collagen I, and laminin isoforms in the glo

128 tivity of structural ECM genes (fibronectin, collagen IV, collagen VI, myocilin), matricellular genes

129 aran sulfate chains were integrated into the collagen IV-containing network.

130 nd extracellular matrix components (laminin, collagen IV) correlate with tissue softening.

131 (trans), microvessel volume, and circulating collagen IV correlated with duration of overall survival

132 ucture and proposed biosynthetic function in collagen IV cross-linking.

133 tes showed moderate to minimal inhibition of collagen IV crosslinking.

134 structural requirements of LOXL2 that enable collagen IV crosslinking.

135 ent in vivo was associated with increases in collagen IV, decreases in laminin, and varied changes in

136 In addition, collagen IV deposition in the vascular basement membrane

137 An inhibitor of FN matrix assembly prevented collagen IV deposition, demonstrating dependence of coll

138 gen VI anchorage, in turn leading to reduced collagen IV deposition.

139 ne, excessive ROS production, and consequent collagen IV deposition.

140 foot processes, lowered proteinuria, lowered collagen IV deposits in the mesangial matrix, diminished

141 Here we report that a novel collagen IV derived biomimetic peptide inhibits breast c

142 We also show that incorporation of Collagen IV determines organ shape, first by mechanicall

143 orms of the major ECM components laminin and collagen IV did not reproduce the effect; or (3) inhibit

144 The protective effect of culture on collagen IV diminished with decreasing cell density.

145 stress are potential therapeutic options for collagen IV diseases including haemorrhagic stroke.

146 be suppressed by loss of the ECM components collagen IV (EMB-9) and fibulin (FBL-1).

147 ch involves degradation or reorganization of collagen IV (EMB-9), whereas FBL-1 opposes GON-1 by stab

148 microenvironment, and as a component of BM, collagen IV enabled the assembly of a fundamental archit

149 nity of the extracellular alpha1 I domain to collagen IV enhances outside-in signaling by potentiatin

150 dermal-epidermal junction, we propose that a collagen-IV-enriched DEJ may, in part, explain its well-

151 immunization with native forms of allogeneic collagen IV exclusively elicited antibodies to quaternar

152 erular collagen IV accumulation, and urinary collagen IV excretion compared with untreated db/db mice

153 for diabetic vs. treated) and a reduction in collagen IV expression following sTbetaRII.Fc treatment

154 decreased BMPR2 and downstream signaling and collagen IV expression.

155 Follicle epithelia mutant for integrin or collagen IV fail to rotate and elongate, which results i

156 helial colony-forming cells (ECFCs), deposit collagen IV, fibronectin, and laminin that assemble to a

157 ct combinations of collagen I, collagen III, collagen IV, fibronectin, and laminin.

158 d that in vivo ITF2357 decreased collagen I, collagen IV, fibronectin, integrin alphaVbeta3 expressio

159 of lactide and glycolide were adsorbed with collagen IV, fibronectin, laminin-332 or serum proteins

160 llagen III as well as mixtures of collagen I/collagen IV/fibronectin as having a positive effect on L

161 ed by MAPK inhibitors and drugs that promote collagen IV folding.

162 nesis because it was necessary for export of collagen IV from EC and deposition in vascular basement

163 In these mice, intact collagen IV from murine GBM was not immunogenic.

164 We also provide in vivo evidence that collagen IV functions as a scaffold to promote shuttling

165 als at longer range in vivo, indicating that collagen IV functions to immobilize free Dpp in the embr

166 To evaluate the origins of collagen IV further, we transplanted embryonic kidneys f

167 agen IV + heparan sulfate + laminin (CHL) or collagen IV + gelatin + heparan sulfate (CGH) demonstrat

168 ereditary nephropathy caused by mutations in collagen IV genes and characterized by ultrastructural l

169 ereditary nephropathy caused by mutations in collagen IV genes and characterized by ultrastructural l

170 ar matrix proteins fibronectin, laminin, and collagen IV have been shown to function as receptors for

171 Combinatorial ECMs composed of collagen IV + heparan sulfate + laminin (CHL) or collage

172 able to compete for the alpha1 I domain from collagen IV (IC(50) approximately 3 mum), GFOGER is much

173 sue from P1 and P2 was found to have reduced collagen IV immunoreactivity at the muscle basement memb

174 The sclerotic index values, density of collagen IV immunoreactivity in the microvasculature and

175 lesion at 4 weeks postinjury indicated less collagen IV immunostaining in Acomys (p < .05).

176 he formation of the sulfilimine crosslink in collagen IV in basement membranes.

177 ific covalent sulfilimine bonds to reinforce collagen IV in basement membranes.

178 We identified basement membrane (BM) and collagen IV in Ctenophora, and show that the structural

179 valuated expression of MMPs 2, 9, and 14 and collagen IV in LCIS and adjacent normal breast tissue am

180 the N- and C-termini of agrin, laminin, and collagen IV in mouse and human GBM revealed a highly ori

181 was identified as the isoform cross-linking collagen IV in mouse embryonal PFHR-9 cells.

182 Enhanced breakdown of collagen IV in the basal lamina and of fibrillar collage

183 llagen III in the liver and collagen III and collagen IV in the heart; this is induced by HF feeding.

184 resulted in markedly decreased deposition of collagen IV in the mesangium and less beta-galactosidase

185 itions under which Arresten is released from collagen IV in vivo or whether the protein functions in

186 ood vessels, localized to the same region as collagen IV, in 2 representative human tissues: liver an

187 cumulation of the basement membrane protein, collagen IV, in LVV-forming endothelial cells (EC), and

188 BA treatment reduced ER stress and increased collagen IV incorporation into BMs, the persistence of d

189 Intriguingly, defective collagen IV incorporation into the dermal BM was observe

190 Collagen IV incorporation into the matrix was also incre

191 mKL promoted cell adhesion to collagen IV, increased FAK and Akt phosphorylation, and

192 tion proteins, did not affect degradation of collagen IV induced by the tMCAO, but altered cell types

193 human alpha3 noncollagenous (NC1) domain of collagen IV inhibits angiogenesis and tumor growth.

194 Collagen IV is a family of 6 chains (alpha1-alpha6), tha

195 Moreover, collagen IV is absent in unicellular sister-groups.

196 endent release of bioactive NC1 domains from collagen IV is critical for integrating collagen IV synt

197 Our analysis also revealed that mutant collagen IV is degraded via the proteasome.

198 overed that the extracellular matrix protein collagen IV is important for BMP gradient formation.

199 es and the vascular basement membrane marker collagen IV is mislocalized, suggesting that ECs fail to

200 We found with this method that Collagen IV is synthesized by the fat body, secreted to

201 here is a novel strain-specific alternative collagen IV isoform switch that is associated with the d

202 y GBM components (fibronectin, laminins, and collagen IV isoforms), or podocyte integrins could be ob

203 MTM cells expressed TM markers, including collagen IV, laminin, and alpha-smooth muscle actin.

204 matrix structure and composition in terms of collagen IV, laminin, and fibronectin.

205 extract (Adipogel) comprising ECM proteins (collagen IV, laminin, hyaluronan, and fibronectin) and i

206 The protein expression of collagen-IV, laminin, claudin-5, occludin, and zonula oc

207 P-2-dependent pericellular proteolysis of BM collagen IV, leading to myofibroblast invasion.

208 vessel volume, and the change of circulating collagen IV levels, all after a single dose of cediranib

209 g glucose-mediated oxidative modification of collagen IV lysine residues rescued the alterations in c

210 ce the function of transplanted islets, with collagen IV maximizing graft function relative to the ot

211 ibitors of MAPK and 2-oxoglutarate dependent collagen IV modifying enzymes rescued ER retention of co

212 Importantly, we demonstrate the presence of collagen IV NC1 domains in developing tissue.

213 re detected within the assembly interface of collagen IV NC1 domains isolated from renal ECM of diabe

214 Furthermore, recombinant collagen IV NC1 domains rescue branching morphogenesis a

215 IV, and decreases the proteolytic release of collagen IV NC1 domains.

216 MN) and Alport syndrome (AS) are progressive collagen IV nephropathies caused by mutations in COL4A3/

217 The predominant collagen IV network is composed of triple helical protom

218 pha5(IV) heterotrimer, which forms the major collagen IV network of the glomerular basement membrane

219 inforcing sulfilimine cross-links within the collagen IV network, an event essential to basement memb

220 rt GBM is effective at restoring the missing collagen IV network, slowing kidney disease progression,

221 -helical molecules of the alpha3alpha4alpha5 collagen IV network.

222 Collagen IV networks are ancient proteins of basement me

223 important structural cross-linking domain of collagen IV networks that provide mechanical stability t

224 r, the mechanism whereby podocytes adhere to collagen IV networks, a major component of the glomerula

225 us (NC1) hexamers, key connection modules of collagen IV networks, are modified via oxidation and chl

226 modifications of renal ECM, and specifically collagen IV networks, contribute to functional protein d

227 molecular machinery that forms cross-linked collagen IV networks, which are essential for glomerular

228 ical protomers, reinforcing the stability of collagen IV networks.

229 n IV deposition, demonstrating dependence of collagen IV on FN matrix.

230 iloxane) chamber and coating a thin layer of collagen IV on top of the electrode surface.

231 specific activity toward triple helices from collagen IV or V.

232 Failure of hemocyte migration, loss of collagen IV, or abrogation of BMP signaling results in t

233 ysis and muscle damage could be rescued with collagen IV overexpression, matrix metalloproteinase (MM

234 Collagen IV, pan-laminin, perlecan and laminin-alpha5 in

235 ting and treating established adult ICH, but collagen IV patients will require stratification based o

236 fected mice and correlated with staining for collagen IV; PMN was a source of MMP-9.

237 ell death, and basement membrane constituent collagen IV production were examined in an organotypic d

238 eterozygous mice in association with reduced collagen IV production, decreased N1ICD, and attenuated

239 ericytes with TNF-alpha and IL-17A augmented collagen IV production, similar to in vivo remodeling.

240 se inhibits cell proliferation and increases collagen IV production.

241 ed proliferation and migration and increased collagen IV production.

242 Nuclear FUS binds to the collagen IV promoter, commencing gene transcription that

243 After binding of Dpp/Scw and Sog to collagen IV, protein interactions are remodeled, generat

244 5R, which binds better than wild-type FIX to collagen IV, provides better hemostasis than wild-type F

245 rabbit anti-VWF, rat ani-CD105, rabbit anti-collagen IV, rat anti-ICAM-2, rabbit anti-desmin, and ra

246 ecause the molecular mechanisms whereby this collagen IV receptor mediates endothelial cell functions

247 ient recombinant laminins, with retention of collagen IV, reiterating the basement membrane (BM) chan

248 othelial denudation, exposing the underlying collagen IV-rich basal lamina, which promotes both intra

249 tended to localize in close proximity to the collagen IV-rich basement membranes of either the airway

250 mbrane from the lens capsule of the eye is a collagen IV-rich matrix that can easily be extracted and

251 Collagen IV scaffold is a principal component of the bas

252 evelopment and architecture found within the collagen IV scaffold of basement membranes (BMs).

253 ely, our findings establish that the triad-a collagen IV scaffold with sulfilimine cross-links, perox

254 ysine residues to structurally reinforce the collagen IV scaffold, a function critical for basement m

255 A collagen IV scaffold, a major component, is essential fo

256 stigate the alpha121, alpha345, and alpha565 collagen IV scaffolds and to develop therapies for manag

257 domain, a structural domain that stabilizes collagen IV scaffolds in the basement membrane.

258 ole for the chloride ring in the assembly of collagen IV scaffolds of BMs, a critical event enabling

259 confers critical structural reinforcement to collagen IV scaffolds.

260 Collagen IV sensitizes tubule cells to localized BMP gui

261 Our results show that the collagen IV sheet anchors secreted factors at the surfac

262 Mouse mesangial cells plated on MGO-modified collagen IV showed decreased adhesion and migration.

263 Chemotaxis assays through collagen IV showed more efficient migration of Itga1(-/-

264 Cells plated on glucose-modified collagen IV showed reduced proliferation and migration a

265 tein receptor type 2 (BMPR2) and its target, collagen IV, signaling of the phosphorylated form of the

266 ease by Tsg through specific disruption of a collagen IV-Sog interaction.

267 Collagen IV stainings were negative in both controls and

268 demonstrated normal patterns of laminin and collagen IV subunit expression.

269 The collagen IV sulfilimine cross-link and its catalyzing en

270 r an order of magnitude of stiffness values, collagen IV surfaces lead to enhanced motility compared

271 from collagen IV is critical for integrating collagen IV synthesis and proteolysis with epithelial pr

272 bstitutions have enhanced down-regulation of collagen IV synthesis, which is mediated by the ERK/MAPK

273 Moreover, systemic administration of collagen IV targeted Ac2-26 NPs (in as low as 1 microg p

274 actic-co-glycolic acid)-b-polyethyleneglycol collagen IV-targeted polymers.

275 Previously, we reported the engineering of collagen IV-targeting nanoparticles (NPs) and demonstrat

276 lymeric NPs were surface functionalized with collagen IV-targeting peptides and loaded with paclitaxe

277 In collagen I and collagen IV (targets for MMP1 and MMP3, respectively) su

278 study in vivo the biogenesis and assembly of Collagen IV, the main constituent of BMs, we used a GFP-

279 hough the cells adhered to the BrM component collagen IV, these cells preferentially adhered to lamin

280 ing in EC that is necessary for EC export of collagen IV, thus permitting the development of LVV and

281 2) is required by both cell types to produce collagen IV to activate ILK (integrin-linked kinase).

282 tein functionality, including the ability of collagen IV to interact with glomerular mesangial cells.

283 e microelectrodes in the MEA was coated with collagen IV to promote cell adhesion and further single-

284 h blood vessels (labeled with an antibody to collagen IV) to measure the coverage of vessel walls by

285 LNNd was found to mediate laminin binding to collagen IV, to bind to galactosyl sulfatide, and to sel

286 ranslocation reduces FUS nuclear content and collagen IV transcription.

287 In older pancreases, collagen IV, V and VI were present throughout the islet-

288 intracerebral haemorrhage (ICH), and common collagen IV variants are a risk factor for sporadic ICH.

289 nset disease were studied with antibodies to collagens IV, VIIIA1, VIIIA2, fibronectin, and laminin.

290 ing VNC, the extracellular matrix components Collagen IV, Viking and Peroxidasin are not deposited ar

291 To identify collagen IV, we first evaluated defect-free erupted teet

292 on and localization of Ki-67, caspase-3, and collagen IV were examined by immunohistochemistry.

293 e basement membrane components laminin V and collagen IV were severely diminished.

294 , alpha-Actinin), and the basement membrane (Collagen IV), were down-regulated upon SRF depletion.

295 a its N-terminal CUB domains, interacts with Collagen IV, which enhances Tolloid activity towards its

296 oteins that contain this amino acid, such as collagen IV, which is an important structural component

297 Integrin alpha1beta1 binding to collagen IV, which is mediated by the alpha1-inserted (I

298 Incubation of collagen IV with pathophysiological levels of either the

299 ucts, and in a zymography assay, reaction of collagen IV with products of A2E photodegradation result

300 substrate, but fails to crosslink insoluble collagen IV within the extracellular matrix.