ライフサイエンスコーパス: collagen V

1 to immobilized fibronectin, collagen I, and collagen V.

2 prospect of blocking Klebsiella adhesion to collagen V.

3 novo Abs to self-Ags, K-alpha1 tubulin, and collagen V.

4 that caused 50% reduction in col5a1 mRNA and collagen V.

5 in regulating tissue-specific production of collagen V.

6 he extracellular matrix proteins laminin and collagen V.

7 The sequence of this THP was derived from collagen V, a component of collagen I fibrils.

8 We demonstrate that collagen V, a minor constituent of heart scars, regulate

9 irculating protein and renal mRNA amounts of collagen V A1 (COL5A1) exhibited associations with kidne

10 During development (E18-P10) both collagen V and XI were comparably expressed; however, co

11 Tendons with altered collagen V and/or XI expression (Col5a1(+/-); Col11a1(+/

12 identified two main ligands for NG2, namely, collagens V and VI.

13 Collagens V and XI comprise a single regulatory type of

14 The data demonstrate coordinate roles for collagens V and XI in the regulation of fibril nucleatio

15 of this study was to determine the roles of collagens V and XI in the regulation of tendon fibrillog

16 nts: keratocan, keratan sulfate, collagen I, collagen V, and collagen VI.

17 a2(V) and alpha1(V) chains, respectively, of collagen V, and is most often caused by COL5A1 null alle

18 including procollagen I, procollagen III, pN-collagen V, and prolysyl oxidase.

19 dies to self-antigens (K-alpha 1 tubulin and collagen V) before and after antibody-directed therapy a

20 Analysis of collagen V binding of different MrkD1P mutants revealed

21 Collagen V, broadly expressed as alpha1(V)2 alpha2(V) he

22 igens such as vimentin, cardiac myosin (CM), collagen V (Col V), agrin, and angiotensin II receptor t

23 We have shown previously that collagen V (col(V)) autoimmunity is a consistent feature

24 T cell-mediated autoimmunity to collagen V (col-V), a sequestered yet immunogenic self-p

25 (DSA) and antibodies (Abs) to self-antigens, collagen-V (Col-V), and K-alpha1-Tubulin (KAT) in pathog

26 ) and decorin, and upregulation of biglycan, collagen V, collagen XII, PAI-1, Scleraxis, and Mohawk b

27 The ACL also had a higher collagen V content than did the flexor digitorum longus

28 We show that collagen V deficiency alters the mechanical properties o

29 enotype of increased post-injury scarring in collagen-V-deficient mice.

30 ments, as well as the role of alterations in collagen V expression in the pathobiology in classic Ehl

31 ibril assembly and abnormal fibrils, lacking collagen V, generated by unregulated sequestration of ty

32 e critical differential regulatory roles for collagen V in tendon and ligament structure and function

33 We define the function of collagen V in tendons and ligaments, as well as the role

34 00 in-bred strains of mice demonstrated that collagen V is a critical driver of postinjury heart func

35 suggest that alpha1(V)3 homotrimers, a rare collagen V isoform that occurs in the absence of suffici

36 ially compensate for loss of the most common collagen V isoform.

37 associated self-antigens Kalpha1-tubulin and Collagen-V leading to the development of obliterative ai

38 Depletion of collagen V led to a paradoxical increase in post-infarct

39 Lung self-antigens (K alpha 1 tubulin, Collagen V), LKB1 , nuclear factor kappa B, and EMT mark

40 s suggest that collagen V overexpression and collagen V-mediated immune response play roles in the pa

41 magnetic NMR that positions a triple-helical collagen V mimic (synthesized with nitroxide spin labels

42 uted by the trailing strand of the synthetic collagen V mimic, which also appears to ligate the catal

43 rum longus tendons from a haplo-insufficient collagen V mouse model of classic Ehlers Danlos syndrome

44 Collagen V mutations underlie classic Ehlers-Danlos synd

45 The collagen V-null ACL and flexor digitorum longus tendon b

46 Targeting was specific, resulting in collagen V-null tendons and ligaments.

47 Rotary shadowing of mixtures of NG2 and collagen V or VI confirms a direct interaction between t

48 antigens and autoantigens such as vimentin, collagen V, or alpha-tubulin and it has been postulated

49 cked transforming growth factor-beta-induced collagen V overexpression and alleviated transforming gr

50 Previous studies suggest that collagen V overexpression and collagen V-mediated immune

51 f miR-185 and miR-186 may be responsible for collagen V overexpression during idiopathic pulmonary fi

52 aimed to identify dysregulated miRNA-related collagen V overexpression during idiopathic pulmonary fi

53 V and XI were comparably expressed; however, collagen V predominated in mature (P30) tendons.

54 These observations demonstrate that collagen V regulates scar size in an integrin-dependent

55 ment structure and function and suggest that collagen V regulatory dysfunction is associated with an

56 S hallmarks to arise separately from loss of collagen V roles in control of collagen fibril growth an

57 e absence of collagen XI with a reduction in collagen V was associated with the most severe fibril ph

58 l fibrils with periodic immunoreactivity for collagen V where type I/V interactions regulate nucleati

59 We propose an evolving role for collagen V/XI isoforms as an adaptable polymeric templat