ライフサイエンスコーパス: colon

1 trolled release to the proposed drug target (colon).

2 ulation was unique to the proximal or distal colon.

3 eption is the invagination of ileum into the colon.

4 ed by microbial fermentation of fiber in the colon.

5 ogy to identify biopsy-worthy lesions in the colon.

6 lity of primary afferents that innervate the colon.

7 anatomical alterations detected in the human colon.

8 gulatory T cells between lymphoid tissue and colon.

9 ith specialized cellular distribution in the colon.

10 d homeobox 1 (PROX1) in the developing chick colon.

11 ike structures, called diverticula, over the colon.

12 ounts in both the mesenteric lymph nodes and colon.

13 neration and suppressed tumorigenesis in the colon.

14 rences between the ileum and proximal/distal colon.

15 injury and pathological inflammation in the colon.

16 rger than 5 mm, both proximal to the sigmoid colon.

17 velopment of adenomas in small intestine and colon.

18 ses and peptidases can be upregulated in the colon.

19 ommunity residing in the small intestine and colon.

20 5- to 10-fold higher than that in uninfected colons.

21 mGy/MBq) in normal tissues were to the right colon (0.167 +/- 0.04) and small intestine (0.153 +/- 0.

22 co-2 cells at the concentrations seen in the colon (1.0 mug/mL).

23 art:mediastinum ratios (P < 10-5, ANOVA) and colon 11C-donepezil standard uptake values (P = 0.008, A

24 We report that opioids from the inflamed colon activate delta-opioid receptors (DOPr) in endosome

25 and 47 cancers from The Cancer Genome Atlas Colon Adenocarcinoma database.

26 man colon but significantly downregulated in colon adenocarcinoma.

27 d be used to identify functional clusters of colon afferents from thoracolumbar (TL), lumbosacral (LS

28 In addition, transcriptionally, NG colon afferents were almost completely segregated from c

29 n epithelial cells communicate directly with colon afferents.

30 Reduced pathology in colon after DMOG treatment associates with intestinal ep

31 ceived a deceased-donor small intestinal and colon allograft with standard immunosuppressive treatmen

32 ukin-22 (IL-22) production in the tonsil and colon; an increase in the levels of CD107a, gamma interf

33 ion led to a 3-fold depletion of ILC3 in the colon and an increase in the levels of NK cells in tonsi

34 Furthermore, colon and bladder afferents expressed genes at similar l

35 There were clusters of colon and bladder afferents, defined by mRNA profiling,

36 by which platelets promote the metastasis of colon and breast cancer cells and suggests that GPVI rep

37 well as human GPVI, had platelet adhesion to colon and breast cancer cells.

38 d experimental and spontaneous metastasis of colon and breast cancer cells.

39 cell line, but also cell lines derived from colon and breast tissues.

40 The major sensory nerve pathway between the colon and central nervous system (spinal cord and brain)

41 activation and migration profiles along the colon and characterize the transcriptional adaptation tr

42 patients afflicted with pancreatic, breast, colon and colorectal cancer show that our proposed metho

43 These findings were all restricted to the colon and correlated to circulating markers of enterocyt

44 ated with increased numbers of mast cells in colon and expression of the receptor for AGER in proxima

45 parison of monocyte differentiation into the colon and ileum-resident macrophages revealed the gradua

46 onal frequency from the cecum to the sigmoid colon and link this to the increasing number of reactive

47 how that human APOBEC3A expression in murine colon and liver tissues increases tumorigenesis.

48 Here we demonstrate that, within colon and pancreatic ductal adenocarcinoma tumors, effic

49 lation inhibited both contractions of distal colon and propulsive contractions represented by the col

50 r risk stratification for cancers of breast, colon and prostate, but less so for others because of mo

51 t scores were associated with risk of distal colon and rectal cancers, after adjusting for other risk

52 atures in gut mucosal specimens from sigmoid colon and terminal ileum of 19 INR and 20 IR in addition

53 selection mechanisms in the colitis-affected colon and that somatic mutations potentially play a caus

54 ising from DRG were identified in the distal colon and their morphological features and CGRP immunore

55 Colon and tumor tissues were analyzed by histology, quan

56 We next examined patient skin, colon, and blood during acute GVHD.

57 e removed, and colon contents (feces, distal colon, and tumor) were collected.

58 according to the histologic layers of mouse colon, and we compared cellular properties between micro

59 In conclusion, CGRP+ baskets in mouse colon are formed by intrinsic enteric neurons with a neu

60 RORgamma+ and Helios+ Treg cells in the colon are phenotypically and functionally distinct, but

61 The small bowel and colon are the sites most commonly involved.

62 that these mice exhibit Mn deficiency in the colon associated with impaired intestinal barrier functi

63 ied tumor-characteristics (primary T4, right colon), biological features (K/N-RAS status), and respon

64 Colon biopsies from patients with IBS-D had increased le

65 e patients using 16S rRNA gene sequencing of colon biopsies, coupled with metagenomic and metatranscr

66 colon length, and histopathology analysis of colon biopsies.

67 ir phosphorylation profile and truncation in colon biopsy specimens from 16 Crohn's disease (CD) and

68 Colon biopsy specimens from patients with IBD (30 with C

69 dataset to examine 12 tumor types (including colon, breast, prostate, pancreas, lung adenocarcinoma,

70 , 95% CI: 1.06, 1.36) of cancer of the right colon but not of the left colon (HR = 0.96, 95% CI: 0.80

71 of cancer of the left (distal or descending) colon but not of the right (proximal or ascending) colon

72 A1 is robustly expressed in the normal human colon but significantly downregulated in colon adenocarc

73 intains its long-lasting colonization in the colon by evading IFN-gamma from group 3-like ILCs.

74 tested in high-AQP1-expressing cancer lines, colon cancer (HT29) and AQP1-expressing breast cancer (M

75 they have a higher incidence of right-sided colon cancer (RCC).

76 t male smokers are at increased risk of left colon cancer and female smokers are at increased risk of

77 Furthermore, using PDX models of colon cancer and resected tumors from colon cancer patie

78 was reported in the secukinumab group due to colon cancer and was assessed as not related to the stud

79 of RSK1 and MSK2, can suppress the growth of colon cancer by attenuating RSK1 and MSK2 signaling.

80 Around 20% colon cancer cases are closely linked with colitis.

81 that 4-hydroxyacetophenone (4-HAP) inhibits colon cancer cell adhesion, invasion, and migration in v

82 ctangular geometries of bio-printed 3D human colon cancer cell constructs.

83 We performed Protect-seq on the human colon cancer cell line HCT-116 and observed overlap with

84 In vivo, SHH interference in colon cancer cell lines decreased primary tumor growth a

85 as well as several Ras mutations in lung and colon cancer cell lines on fast 10 min gradient separati

86 iated mutations, we report that human HCT116 colon cancer cells also survive when ORC5 protein expres

87 ax as well as cleaved caspase-3 and -PARP in colon cancer cells by downregulating RSK1 and MSK2 downs

88 Furthermore, GNL1 protects colon cancer cells from chemo-drug-induced apoptosis.

89 nst various human cancer cells, killing SW48 colon cancer cells in particular with a submicromolar ha

90 % of active MYC alleles at any given time in colon cancer cells.

91 on of talin1 inhibited 3D spheroid growth in colon cancer cells.

92 signal and redox state in human cervical and colon cancer cells.

93 and p120-catenin isoform switching in SW480 colon cancer cells: fl-APC increased the expression of g

94 re we find that cohesin depletion in a human colon cancer derived cell line results in endomitosis an

95 aluate the role of G6PD in lung, breast, and colon cancer driven by oncogenic K-Ras.

96 for pancreas, esophageal, lung, rectal, and colon cancer from 2014 to 2016 were identified.

97 omparatively evaluate CNNs on 170 breast and colon cancer images with pathologist-annotated nuclei, f

98 mption was associated with a reduced risk of colon cancer in age-adjusted analyses (P for trend < 0.0

99 mechanisms contributing to the promotion of colon cancer in obese individuals.

100 0.70-0.99; P trend = 0.04) for the proximal colon cancer incidence.

101 tor which allows stratification of stage III colon cancer into high- and low-risk recurrence groups,

102 nic inflammation leads to the development of colon cancer is lacking.

103 e need for adjuvant chemotherapy in stage II colon cancer is still debated.

104 Colon cancer is the most aggressive tumor in both men an

105 liver-metastasis resection for treatment of colon cancer may increase the risk of further metastasis

106 the metastatic burden in an in vivo model of colon cancer metastasis to the liver.

107 atively correlated with the survival rate of colon cancer patients and that depletion of talin1 inhib

108 els of colon cancer and resected tumors from colon cancer patients, our data demonstrated that HT-DBP

109 w toxicity, it could be potentially used for colon cancer prevention or therapy.

110 one in identifying subclones using stage III colon cancer primary tumor samples as well as simulated

111 they may in part explain how obesity drives colon cancer progression.

112 esenting a non-cell autonomous mechanism for colon cancer progression.

113 ecule adiponectin receptor agonist, suppress colon cancer risk in part by reducing the number of Lgr5

114 the adiponectin signaling pathway attenuates colon cancer risk remains to be addressed.

115 extent to which CRM involvement exists after colon cancer surgery is unknown.

116 enous n-3 PUFAs on inflammatory cytokines in colon cancer surgery.

117 RSK1 and MSK2 were overexpressed in colon cancer tissues confirmed by western blot and IHC.

118 se of tumor burden in an orthotopic model of colon cancer via luciferase-positive CT26 cells.

119 ant chemotherapy for patients with stage III colon cancer was not confirmed in terms of overall survi

120 oma and a patient-derived xenograft model of colon cancer with a favorable safety profile.

121 efficacy and bioavailability in ovarian and colon cancer xenograft models when evaluated for dose-ra

122 ancer cell lines (MCF-7 breast cancer, SW480 colon cancer, and PC3 prostate cancer), and one kind of

123 Tumor entities comprised esophageal cancer, colon cancer, rectal cancer and pancreatic cancer.

124 of long non-coding RNAs (lncRNAs) in primary colon cancer, their role in mCRC and treatment resistanc

125 s an alternative to animal studies or use of colon cancer-derived cell lines.

126 hlights the therapeutic potential of Gal2 in colon cancer.

127 l of a highly aggressive liver metastasis of colon cancer.

128 emale smokers are at increased risk of right colon cancer.

129 e the potential targets for the treatment of colon cancer.

130 ver injury following IRI in a mouse model of colon cancer.

131 al outcomes based on the presence of TILs in colon cancer.

132 ity in tumour-bearing mice and patients with colon cancer.

133 n to aid treatment planning during stage III colon cancer.

134 gen positive (ER(+ve)) breast cancer and for colon cancer.

135 to 76% for breast cancer, and 11% to 80% for colon cancer.

136 end = 0.03), and were restricted to proximal colon cancer.

137 tumor efficacy on mouse models of breast and colon cancers, with cure rates of 40% and 60%, respectiv

138 origenesis via the Wnt-Ras-p53 axis in human colon cancers.

139 has a potential to be used as an effector in colon carcinogenic transformation.

140 e series, HSGN-218, is nontoxic to mammalian colon cells and is gut-restrictive.

141 Organoids from colon cells of CRT-knockout mice and control mice were a

142 than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic

143 ffects by inducing different gene markers in colon cells.

144 icantly increased histological damage in the colon compared to control.

145 apoptotic factors (Aifm1 and Bcl2l10) in the colon compared to control.

146 pectively reviewed to identify patients with colon complications, including ischemia, perforation, fi

147 days later, distal colons were removed, and colon contents (feces, distal colon, and tumor) were col

148 ion, increased arginine concentration in the colon correlated with down-regulation of the host SLC7A2

149 In turn, O-glycans on proximal colon-derived Muc2 modulate the structure and function o

150 expression of alpha-1 adrenoceptors in human colon emphasize the translational relevance of our mouse

151 Here we review recent studies on how colon epithelial cells communicate directly with colon a

152 o colorectal cancer cells, but not to normal colon epithelial cells.

153 ression of the receptor for AGER in proximal colon epithelium.

154 , CHI3L1, OR1D4, and LIPG in breast; IGF2 in colon; ETV1 in prostate; and IGF2BP3 and SIX2 in thyroid

155 te that the intrinsic neural networks of the colon exhibit unique transcriptional profiles that are c

156 nally, applying YIGSR to E13.5 EdnrB(NCC-/-) colon explants resulted in 80%-100% colonization of the

157 Colon expression of alpha-SMA was significantly lower in

158 Colon-extracted lipids revealed that DiNP exposure signi

159 cient Chlamydia sp. was able to colonize the colon following an intracolon inoculation, suggesting th

160 relatively little is known about its role in colon formation during embryogenesis.

161 oderm, is required for hindgut extension and colon formation.

162 e the extension of the hindgut that leads to colon formation.

163 Colon from 2 pediatric patients with Hirschsprung diseas

164 se obstruction was located in the descending colon had a better TTP compared with ES group (HR 0.44 (

165 gallbladder, displacement of the transverse colon, hepatic flexure and duodenum.

166 ferent types of organoids, including kidney, colon, hepatocyte, ovarian, and breast.

167 s demonstrate the essential role of Fam3D in colon homeostasis, protection against inflammation assoc

168 ancer of the right colon but not of the left colon (HR = 0.96, 95% CI: 0.80, 1.15).

169 but not of the right (proximal or ascending) colon (HR = 1.03, 95% CI: 0.89, 1.18), while female ever

170 0.96; P-trend < 0.001), particularly distal colon (HRQ5 vs. Q1: 0.84; 95% CI: 0.73, 0.96; P-trend =

171 the viscoelastic moduli and mass of adherent colon (HT-29) and breast cancer (MCF-7) cells from the i

172 proliferative effects on cervical (HeLa) and colon (HT-29) cancer cells.

173 n and Rac-1 activation in B16F10, metastatic colon [HT29(US)] and breast cancer (MDA-MB-231) cell lin

174 ficant decrease in alpha4beta7 expression in colon ILC3.

175 Full-thickness colon images, viewed with a 10x objective lens, were as

176 gest that more undigested starch reaches the colon in individuals with low AMY1 CN, and that the fate

177 Colon inclusive grafts had higher complication rates (P

178 Here, we found that Ninjurin1 (Ninj1) limits colon inflammation by regulating macrophage polarization

179 showed increased morbidity, weight loss, and colon injury, with a concomitant increase in inflammator

180 and provides protection against DSS-induced colon injury.

181 We hypothesized that the development of colon involvement in necrotizing pancreatitis (NP) negat

182 Colon involvement in necrotizing pancreatitis is associa

183 Colon involvement in necrotizing pancreatitis is common;

184 Gradient Boosting-Colon is an independent machine prognostic predictor whi

185 The colon is innervated by intrinsic and extrinsic neurons t

186 how it organizes to function throughout the colon is unclear.

187 estive enzyme expression in the duodenum and colon is upregulated in SBS patients.

188 Clostridioides difficile infection of the colon leads to severe inflammation and damage to the gas

189 IIa significantly attenuated the DSS-induced colon length shortening, rectal bleeding, bodyweight los

190 everity was determined based on body weight, colon length, and histopathology analysis of colon biops

191 se the body weight loss, macroscopic damage, colon length, histological alteration, and inflammation

192 duced experimental colitis, as judged by the colon length.

193 IgA2+ and IgA1-IgA2+ bacteria coexist in the colon lumen, where Bacteroidetes is preferentially targe

194 ficant increases in the expression of IL6 in colon macrophages from Ptpn2-LysMCre mice.

195 s mechanism relies on a population of distal colon macrophages that are equipped with "balloon-like"

196 Rarely, a colon malignancy is misdiagnosed as diverticulitis.

197 Later, sNCCs enter the colon mesenchyme to colonize and contribute to the intri

198 The altered colon microbiome approximated clinical findings in PD pa

199 l CART(+) neurons, enriched in the ileum and colon, modulated feeding and glucose metabolism.

200 dicate that subacute exposure to DiNP alters colon morphology and physiology in adult female mice.

201 Mice given ampicillin had reduced colon motility compared with mice given only water, and

202 PCR expression was markedly decreased in the colon mucosa during colitis.

203 e microbiota as well as transcription in the colon mucosa.

204 In mice, we found that colon mucus consists of two distinct O-glycosylated enti

205 Colon mucus segregates the intestinal microbiota from ho

206 is is generally considered a risk factor for colon neoplasia.

207 ction, with increased expression of CD103 in colon NK cells and curtailment of CXCR3, and a significa

208 While SBTS in neoplastic colon obstruction may reduce morbidity and need for a st

209 We determined that the jejunum and colon of black bears do not harbor significantly differe

210 were performed in full thickness segments of colon of five CD and five control subjects, in primary c

211 in the bacterial composition of the sigmoid colon of IBS patients were linked to symptoms and immune

212 The proximal colon of T. suis-infected pigs exhibited general inflamm

213 ime of peak disease severity in the ceca and colons of all mice infected with a high-virulence strain

214 anoids (colonoids) generated from the distal colons of mice.

215 3-year average annual IRs increased in both colon-only (+13% [12.21 to 13.85 per 100 000]; P < 0.050

216 injected into proximal and distal regions of colon or bladder, followed by single-cell qRT-PCR and an

217 patients age 18 years or older with breast, colon, or lung cancer who were prescribed cancer drug re

218 intestinal sphingolipid, both in mice and in colon organoids (colonoids) generated from the distal co

219 L1 insertions, we studied adenocarcinomas of colon, pancreas, and stomach, and found a variable numbe

220 Eighty percent, 64%, and 8% of human colon, pancreatic, and lung cancer cells, respectively,

221 ned unchanged, autocrine SHH interference in colon, pancreatic, and lung cell lines triggered cell de

222 ally significant risk factors for developing colon pathology include tobacco use (odds ratio (OR), 2.

223 he increased sensitivity of NIR readouts for colon permeability is shown using dextran sulfate sodium

224 Colon polyp surveillance now accounts for 25% of all col

225 ogic diagnoses (including different types of colon polypoid lesions), ablation, piecemeal resection.

226 a associated with high-grade dysplasia (HGD) colon polyps at baseline colonoscopy remains unclear.

227 In this pilot study we found that low-volume colon preparation may be preferred in the inpatient sett

228 Data collection included colon preparation quality, based on the Boston Bowel Pre

229 The selected model (Gradient Boosting-Colon) provided a hazard ratio (HR) for high- vs. low-ri

230 itories for 11 cancers (oesophagus, stomach, colon, rectum, anus, liver, pancreas, lung, breast, cerv

231 iculosis (the presence of diverticula in the colon; referred to as diverticulosis) remains asymptomat

232 ither pancreas, esophageal, lung, rectal, or colon resection for cancer at a hospital within the high

233 ,557 Medicare patients underwent an elective colon resection for diverticulitis at 2462 hospitals ove

234 Forty-four patients undergoing elective colon resection for nonmetastasized cancer were randomly

235 variation (excess of 3-fold) in standardized colon resection ratios for recurrent diverticulitis.

236 Standardized colon resection ratios ranged from 0 in the Tuscaloosa H

237 Individuals who underwent colon resection, coronary artery bypass graft (CABG), lu

238 re associated with higher predicted rates of colon resection.

239 me sequence reported in the present study in colon resections with primary anastomosis.

240 samples; in contrast, the majority of normal colon samples displayed no detectable expression.

241 emical profiles of human small intestine and colon scaffolds, indicating that they can be used interc

242 innate lymphoid cells (ILCs) located in the colon secondary to simian immunodeficiency virus (SIV) i

243 Evidence for any dysplasia, colon segment resection, aneuploidy, male sex, and age w

244 sults in reduced peristaltic activity of the colon, similar to that observed in microbiota-depleted m

245 After entering the colon, single axons ramified rostrally or caudally along

246 The development of the colon starts with the formation and extension of the hin

247 ccludin and E-cadherin genes in DRA-KO mouse colon, suggesting that posttranscriptional mechanisms pl

248 The use of robotic-assisted colon surgery is increasing.

249 se in the use of Pickering emulsions for the colon-targeted delivery of SCFAs.

250 developed a 3-dimensional imaging method for colon that provides more information about ENS structure

251 atty acids limits oxygen availability in the colon, thereby maintaining a balanced microbial communit

252 For the colon, this overlapping innervation is proposed to facil

253 s in stress distribution engendered over the colon tissue by the presence of a pouch-like structure.

254 rophil infiltration into the Il10(-/-) mouse colon tissue compared to Cj-P0, which was attenuated wit

255 iltration, and inflammatory cytokines in the colon tissue.

256 tients without IBD (control individuals) and colon tissues from mice (with and without disruption of

257 Colon tissues from patients with IBD had reduced levels

258 al biomarkers that differentiate the healthy colon tissues from the diseased tissues were identified

259 ative spectra of the hydrated and dehydrated colon tissues further revealed significant peak shifts a

260 Colon tissues were analyzed by histology for the presenc

261 Colon tissues were collected from some mice and analyzed

262 (46 CRCs, 74 advanced adenomas and 32 normal colon tissues).

263 rents were almost completely segregated from colon TL and LS neurons.

264 cognised prebiotic carbohydrate, reaches the colon to be fermented by the intestinal microbiota.

265 low cytometry and cell stimulation assays in colon, tonsil, and oral lymph node samples.

266 bes a case of intramural gas gangrene of the colon, treated conservatively with antibiotic therapy in

267 ression decreased the proliferation of human colon tumor epithelial cells and blunted H(2)O(2)-induce

268 e to its ability to induce colitis and cause colon tumor formation in mice through the production of

269 strate that Gal2 plays a suppressive role in colon tumor growth and highlights the therapeutic potent

270 jury-induced cell proliferation and promotes colon tumorigenesis in a preclinical colitis-associated

271 Loss of FFAR2 promotes colon tumorigenesis in mice by reducing gut barrier inte

272 , the genetic factors regulating colitis and colon tumorigenesis remain elusive.

273 al data indicate that adiponectin suppresses colon tumorigenesis.

274 Metabolomics analysis of patient colon tumors (n = 197) and normal tissues (n = 39) revea

275 Here we integrated topological maps for colon tumors and normal colons with epigenetic, transcri

276 Colon tumors from Apc(Min/+)Ffar2(-/-) mice had a higher

277 Colon tumors from IL-17RD-deficient mice are characteriz

278 ice developed significantly more spontaneous colon tumors than Apc(Min/+) mice and had increased gut

279 ointestinal tract and downregulated in human colon tumors.

280 on CT from 22 right-sided and 64 left-sided colon tumours.

281 Although inflammation of the mid-descending colon typically resolved, a subset showed characteristic

282 r groups, the PDRBD+ group also had enlarged colon volumes (P < 0.001, ANOVA) and delayed colonic tra

283 ry bowel disease (IBD), and normal thickened colon wall (NTC) on computed tomography (CT) and assess

284 MRC showed increased colon wall thickness in TNBS group compared to controls

285 eces, and mucosa of the duodenum and sigmoid colon was determined by 16S rRNA-amplicon-sequencing.

286 The whole colon was then removed and stained to visualize single a

287 percentage of IFN-gamma(+) ILCs in infected colons was 5- to 10-fold higher than that in uninfected

288 as associated with growth failure, increased colon weight/length ratio (p < 0.01), but did not affect

289 Conversely, the stomach and colon were associated with structurally and functionally

290 Twenty-one days later, distal colons were removed, and colon contents (feces, distal c

291 In contrast to the normal colon, where clonal expansions outside the confines of t

292 Some BAs (approximately 5%) escape into the colon, where gut commensal bacteria convert them into va

293 enesis is believed to occur in the ileum and colon, where the bacteria adhere and form a robust aggre

294 d differences in environmental milieu of the colon which vary between the sexes.

295 ta, and a minor form derived from the distal colon, which adheres to the major form.

296 Muc2: a major form produced by the proximal colon, which encapsulates the fecal material including t

297 a abrogated expression of SYNPO in the mouse colon, which was rescued with butyrate repletion.

298 topological maps for colon tumors and normal colons with epigenetic, transcriptional, and imaging dat

299 immune cells across the healthy, adult human colon, with paired characterization of immune cells in t

300 l ganglion innervated the proximal or distal colon, with processes closely opposed to multiple cell t

301 Hirschsprung disease was used to show distal colon without enteric ganglia, as well as a transition z