ライフサイエンスコーパス: colonic

1 leukin-12/interleukin-23 treatment on SB and colonic ACE2 expression in 3 clinical trials.

2 SB and colonic ACE2 expression in active CD and UC were restore

3 Reduced SB but elevated colonic ACE2 levels in IBD are associated with inflammat

4 Within UC, colonic ACE2 was elevated in active disease and in patie

5 This process is referred to as colonic adaptation.

6 The risk of recurrent colonic adenoma associated with high-grade dysplasia (HG

7 Recurrence of colonic adenoma at time of follow-up colonoscopy is comm

8 uring screen colonoscopy to assess recurrent colonic adenoma risk factors.

9 redict interval development of preneoplastic colonic adenoma.

10 rs, discovered in two animal models of early colonic adenomagenesis, were studied in patients using q

11 abetes medications may reduce development of colonic adenomas and may contribute to CRC prevention.

12 l novel risk factors, including a history of colonic adenomas or caffeine usage.

13 ffeine intake, and low-grade dysplasia while colonic adenomas trended towards significance.

14 The influence of GABA signalling on colonic afferent excitability was assessed in an ex vivo

15 BA signalling in the periphery may influence colonic afferent excitability.

16 or GABA(B) receptor agonists attenuated the colonic afferent response to colon stretch.

17 genous agonists decrease the excitability of colonic afferents and suppress visceral nociception.

18 ent to establish the resting excitability of colonic afferents as well as the behavioural response to

19 nstrate the concurrent development of distal colonic aganglionosis and intestinal ganglioneuromas.

20 ribution of GH9 domains among dominant human colonic anaerobes.

21 Bacteria in colonic and fecal samples were analyzed by both 16S ribo

22 ecific bacterial profiles were linked to the colonic antibacterial gene expression.

23 Colonic antigen-experienced lymphocytes such as tissue-r

24 ent presenting with colitis characterized by colonic apoptosis and no identified known VEOIBD variant

25 This increase in the concentration of colonic arginine promotes virulence gene expression in C

26 tidase N (ApN) were analyzed in duodenal and colonic biopsies from nine SBS patients in a late stage

27 cal processes and activated cell types, to a colonic biopsy dataset that included healthy volunteers,

28 logic disease activity was evaluated in 2630 colonic biopsy samples from patients with UC treated in

29 used to validate the system along with human colonic biopsy samples.

30 Mesocolic involvement can compromise colonic blood supply leading to ischemic complications;

31 oth mucin 2 (MUC2) and MUC5AC from HT29-18N2 colonic cancer cells.

32 e of a 75-year-old with a medical history of colonic carcinoma.

33 nificantly for ileocolonic, small bowel, and colonic CD.

34 lc7a2-deficient mice, as marked by increased colonic CD11b(+)F4/80(+)ARG1(+) cells with no alteration

35 Here we compiled an unbiased atlas of human colonic CD8(+) T cells in health and ulcerative colitis

36 Thus, we identify colonic CD8(+) T-cell phenotypes in health and UC, defin

37 that AdipoRon decreased the rigidity of the colonic cell PM.

38 We found that multiple colonic cell types, especially enterocytes, express ACE2

39 anoids (hPSC-COs) to explore the response of colonic cells to SARS-CoV-2 infection.

40 nscriptomics from tissue samples (4 SB and 2 colonic cohorts; n = 495; n = 387 UC; n = 94 non-IBD), w

41 s (BF) is an integral component of the human colonic commensal microbiota.

42 rticles was degraded to hydroxytyrosol under colonic conditions.

43 was significantly prolonged due to impaired colonic contractility.

44 ignaling in patients with anti-TNF-resistant colonic Crohn's disease (cCD) and ulcerative colitis (UC

45 gree of active inflammation in patients with colonic Crohn's Disease.

46 er, we find that prior to the development of colonic crypt hyperplasia, T3SS-mediated intimate attach

47 Previous work showed that during colonic crypt hyperplasia, type III secretion system (T3

48 0 paralleled expression of WNT2b and WNT4 in colonic crypts at days 6 and 12 post-infection with Citr

49 We whole-genome sequenced 446 colonic crypts from 46 IBD patients and compared these t

50 A three-dimensional organoid assay in colonic crypts isolated from CR-infected mice revealed e

51 ry from dextran sodium sulfate (DSS)-induced colonic damage.

52 -I response through induction of IFN-beta by colonic DCs.

53 arrhea in the industrialized world, triggers colonic disease through the release two toxins, toxin A

54 Isolated colonic disease was associated with fewer surgeries.

55 tine procedure in diagnosis and treatment of colonic disease.

56 n on the "secondary" effects associated with colonic disturbance.

57 l develop symptomatic diverticulosis, termed colonic diverticular disease (also known as diverticular

58 Colonic diverticulitis is a painful gastrointestinal dis

59 Colonic diverticulosis (the presence of diverticula in t

60 initial loss of cardiac MIBG signal and 11C-colonic donepezil signal followed by loss of putaminal F

61 loped to target the carcinogenetic impact of colonic dysbiosis and inflammation.

62 th manometry and/or a barostat, can identify colonic dysmotility.

63 closure of mucosal defects with clips after colonic endoscopic mucosal resection (EMR) prevents dela

64 luable to have a better understanding of the colonic ENS.

65 trical sacral nerve stimulation can activate colonic enteric neurons.

66 ed SYNPO in epithelial cell lines and murine colonic enteroids through mechanisms possibly involving

67 th the defect in mucosal barrier function of colonic epithelia and secretory cell lineages, EP4 cKO c

68 ds (BA) in western diet (WD)-induced loss of colonic epithelial barrier (CEB) function in mice with a

69 , Radioprotein-1, on gamma-radiation-induced colonic epithelial barrier dysfunction using Caco-2 and

70 unction integral protein deregulation alters colonic epithelial cell (CEC) differentiation, and promo

71 Notably, we found that colonic epithelial cell-secreted extracellular vesicles

72 n peroxide (H(2)O(2)) was analyzed in murine colonic epithelial cells and colonoid cultures.

73 The average mutation rate of affected colonic epithelial cells is 2.4-fold that of healthy col

74 etectable AC6 levels in small intestinal and colonic epithelial cells.

75 ntial alternative, we present the successful colonic epithelial laser ablation by means of picosecond

76 nction in bacteria associated with a primary colonic epithelial monolayer in an in vitro human gut mo

77 In mice, TBI and PBI-BM5 disrupted colonic epithelial tight junction and adherens junction,

78 The colonic epithelial turnover is driven by crypt-base stem

79 th restoration of normal architecture of the colonic epithelium and muscle, reduction in inflammation

80 ucus layer and increased colonization of the colonic epithelium by Wild-type EAEC than its isogenic P

81 Binding of TcdA to the colonic epithelium can be reduced by surfen, a small mol

82 The colonic epithelium can undergo multiple rounds of damage

83 r exotoxin contributing to disruption of the colonic epithelium during C. difficile infection.

84 tight junction (TJ) and barrier function of colonic epithelium is highly sensitive to ionizing radia

85 We hypothesized that reduction in c-Cbl in colonic epithelium is likely to increase the levels of n

86 Ectopic lysozyme production in colonic epithelium suppressed lysozyme-sensitive bacteri

87 Restoring mitochondrial bioenergetics in the colonic epithelium with 5-amino salicylic acid, a PPAR-g

88 regulated in adenoma) is expressed mainly in colonic epithelium, where it dehydrates the stool by fac

89 impaired mitochondrial bioenergetics in the colonic epithelium, which triggered dysbiosis.

90 haracteristic markers of small intestinal or colonic epithelium.

91 l hindgut cells populate the majority of the colonic epithelium.

92 cus layer penetration or colonization of the colonic epithelium.

93 beta-containing sEVs is detected in cultured colonic explants from colitic mice, GSDMD deficiency sub

94 ndent inhibition of pSTAT phosphorylation in colonic explants post-oral dose but low systemic exposur

95 ty translated into compounds displaying high colonic exposure and low systemic exposure after oral do

96 Colonic expression was associated with a better clinical

97 s of in-vitro gastrointestinal digestion and colonic fermentation of a rosemary aqueous extract were

98 d to in vitro gastrointestinal digestion and colonic fermentation to examine the accessibility of pol

99 ta deficiency activates the reprogramming of colonic fibroblasts to generate a predominant SOX2-depen

100 pool and modulate an important population of colonic FOXP3(+) regulatory T (T(reg)) cells expressing

101 ife-GMB relationships is based on studies of colonic GMB communities derived from the feces of captiv

102 ia coli was associated with the formation of colonic goblet cell-associated antigen passages (GAPs),

103 We report that isolated colonic goblet cells express components of several infla

104 eration and countered butyrate inhibition of colonic growth.

105 c approach in UC patients with severe, acute colonic haemorrhage.

106 lation in injured epithelium led to impaired colonic healing and genomic instability.

107 ents that regulate immune responses, promote colonic health, and suppress mast cell-mediated diseases

108 However, the molecular factors mediating colonic homeostasis are not well characterized.

109 te the role of epithelial EP4 in maintaining colonic homeostasis by characterizing the intestinal epi

110 These findings suggest that Ninj1 mediates colonic homeostasis by modulating M1/M2 macrophage balan

111 Disruption of colonic homeostasis caused by aberrant M1/M2 macrophage

112 Ctnnb1 or Apc, respectively, leads to severe colonic hyperplasia.

113 association between Blastocystis infection, colonic hypersensitivity (CHS), behavioral disturbances

114 We employed Ca(2+) imaging of colonic ICC-IM in situ, using mice expressing GCaMP6f in

115 Colonic ICC-IM receive excitatory inputs from cholinergi

116 and ODQ increased Ca(2+) transient firing in colonic ICC.

117 ng primary cultures of CD47-deficient murine colonic IEC or human colonoid-derived IEC treated with C

118 These observations suggest that colonic IFN-gamma, responsible for inhibiting the intrac

119 HFD mice displayed an increase in colonic IL-1beta and MDA, and a reduction of occludin at

120 Colonic IL-6 levels as well as substance P and S100beta

121 ng G-protein-coupled receptors that regulate colonic ILC3s remain poorly understood.

122 hat metabolites shape the composition of the colonic immune cell population.

123 in the mesenteric lymph nodes, to delineate colonic immune niches at steady state.

124 ons, which may contribute to increased basal colonic inflammation and microbial imbalance.

125 n elevated levels of active IL-18 and severe colonic inflammation following Citrobacter rodentium inf

126 d-spectrum antibiotics substantially reduced colonic inflammation in Itch(-/-) mice.

127 Chronic colonic inflammation leads to dysplasia and cancer in pa

128 ut have NK cells, also displayed more severe colonic inflammation than Rag2(-/-) mice.

129 s directed to innate immune markers detected colonic inflammation, with (89)Zr-alpha-IL-1beta providi

130 generate a predictive model for identifying colonic inflammation.

131 he impact of aberrant lysozyme production in colonic inflammation.

132 talization of ACE2-related biology in SB and colonic inflammation.

133 coincided with alterations in the cecal and colonic inflammatory transcriptome, bile acid-activated

134 h was characterized by delayed recovery from colonic injury and associated with enhanced expression o

135 population and gut acetate levels, improved colonic integrity, normalized endotoxemia, plasma trimet

136 Colonic interleukin (IL)-1beta, IL-6, and malondialdehyd

137 Stimulation of this colonic intestinalization process by drugs, nutrients, a

138 Colonic intramuscular interstitial cells of Cajal (ICC-I

139 Colonic intramuscular interstitial cells of Cajal (ICC-I

140 esting bacteria in the colon, which enhances colonic lactose processing and possibly results in the r

141 and S100A9 in mice altered the phenotypes of colonic lamina propria macrophages, compared with wild-t

142 ral killer (NK) cells was accumulated in the colonic lamina propria of Gitr(-/-) mice as compared to

143 ten inadequate in patients with CF, and that colonic lavage using modified CF bowel preparation is re

144 antly reduced colonic pathology and restored colonic length to naive levels.

145 erentiating between colorectal cancer (CRC), colonic lesions caused by inflammatory bowel disease (IB

146 between obesity, beta-Catenin expression and colonic lesions in African Americans.

147 107 patients with CRC, 113 IBD patients with colonic lesions, and 96 participants with NTC were retro

148 ment with NX-13 alleviates disease severity, colonic leukocytic infiltration, and cytokine markers of

149 mpared with mice given only water, and their colonic LMMP had reduced numbers of nitrergic neurons, r

150 had prolonged whole gut transit times; their colonic LMMP had reduced total neurons and a smaller pro

151 Colonic LMMP of germ-free mice given TLR2 agonist had in

152 Colonic LMMP of mice given the TLR4 inhibitor did not ha

153 Cells were isolated from colonic LMMP of Nestin-creER(T2):tdTomato mice and incub

154 In cells isolated from the colonic LMMP, incubation with the TLR2 agonist increased

155 aves are generated in smooth muscle cells of colonic longitudinal muscles (LSMC).

156 In closed colonic loops in vivo, luminal CDCA produced a robust se

157 difference in O(2) concentration between the colonic lumen and air-exposed serosal surface was around

158 rominent human commensal as it colonizes the colonic lumen, mucus or epithelial tissue of mice.

159 Furthermore, colonic luminal filtrates from the mice transplanted wit

160 l pain and inflammatory syndrome revealing a colonic mass.

161 Abnormal synthesis of PGE2 by colonic mast cells appears to induce visceral hypersensi

162 rrent study were to: (1) assess densities of colonic mast cells, eosinophils, and TH17 cells in youth

163 ed new microenvironmental characteristics of colonic mesenchymal cells, including the intrinsic invol

164 flammatory efficacies of two highly abundant colonic metabolites, M2 (a cysteine-conjugated metabolit

165 The colonic microbiome stimulates cytosolic receptors activa

166 al variation for metabolites produced by the colonic microbiome.

167 Here, we profile the murine colonic microbiota along longitudinal and lateral axes u

168 ous fibers and delivery of substrates to the colonic microbiota by more fermentable particulate fiber

169 The colonic microbiota exhibits cross-sectional heterogeneit

170 Our findings indicate that colonic microbiota help maintain the adult ENS via a spe

171 affected CRC risk through its effects on the colonic microbiota that produce tumor-suppressive or -pr

172 e of the infection due to their altering the colonic microbiota, which is necessary to suppress the i

173 major carbon sources available to the human colonic microbiota.

174 ts, but generally represent <1% of the adult colonic microbiota.

175 d propulsive contractions represented by the colonic migrating motor complexes (CMMCs) via the alpha1

176 onment are associated with a tumor-promoting colonic milieu as reflected by the high rates of adenoma

177 of in vitro gut microbial culture in a human colonic model (HCM).

178 gut, where they activate the inflammasome in colonic mononuclear phagocytes, triggering inflammation.

179 rocesses might be developed for treatment of colonic motility disorders related to use of antibiotics

180 s in sympathetic neural regulation of murine colonic motility was investigated.

181 it, followed if necessary with assessment of colonic motility with manometry and/or a barostat, can i

182 tionally in delayed gastric emptying, slowed colonic motility, and prolonged total gastrointestinal t

183 r of sympathetic neural regulation of murine colonic motility.

184 receptor sensitivity and effectiveness), and colonic motor function (transit time) examinations.

185 Furthermore, disorders of colonic motor function, such as irritable bowel syndrome

186 s commonly found in the terminal location of colonic mucin glycans where it is a much-coveted nutrien

187 r numbers of hypermethylated genes in murine colonic mucosa (vs.

188 etics from matched inflamed and non-inflamed colonic mucosa [50 Crohn's disease (CD); 80 ulcerative c

189 g differentiated active UC from active CD in colonic mucosa and blood samples; top discriminating fea

190 was detectable in pharyngeal, bronchial, and colonic mucosa but not bile.

191 ive interleukin 18 (IL-18) production in the colonic mucosa by deubiquitinating NLRP6.

192 Biopsy samples of inflamed colonic mucosa from patients and mice with colitis relea

193 eous release of molecules from mast cells in colonic mucosa from patients with IBS with diarrhea (IBS

194 The colonic mucosa must therefore tightly regulate fluid inf

195 reaks and proliferation were observed in the colonic mucosa of 11G5-infected Apc(Min/+)/Atg16l1(Delta

196 ducing Escherichia coli (CoPEC) colonize the colonic mucosa of a higher proportion of patients with v

197 We performed CyTOF analysis of colonic mucosa samples (n = 87) and peripheral blood mon

198 In an analysis of fecal and colonic mucosa samples from patients receiving FMT for a

199 Compared with controls, colonic mucosa samples from patients with IBD had increa

200 Colonic mucosa samples from patients with UC were charac

201 Patient colonic mucosa with CoPEC colonization had higher levels

202 encoding proteins involved in autophagy than colonic mucosa without these bacteria.

203 al smooth muscle, colonic smooth muscle, and colonic mucosa).

204 vere inflammation, massive ulceration of the colonic mucosa, and bloody diarrhea.

205 m3D is associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation

206 sistant bacterial species and strains on the colonic mucosa.

207 ases in PGE2, histamine, and tryptase in the colonic mucosa.

208 ed greater recruitment of neutrophils to the colonic mucosa.

209 ents and mitigates gamma-irradiation-induced colonic mucosal barrier dysfunction and endotoxemia.

210 y regulate obesity-associated defects in the colonic mucosal barrier, even in the presence of dietary

211 so induced the expression of VEGF-A in human colonic mucosal biopsies.

212 sevelamer to WD-fed knockout mice attenuated colonic mucosal inflammation and improved CEB.

213 elastase (NE) have been reported in inflamed colonic mucosal tissue.

214 ) encoding proteins involved in autophagy in colonic mucosal tissues from patients with sporadic CRC

215 igh blood glucose levels displayed a healthy colonic mucus barrier, indicating that the mucus defect

216 ly obese (ob/ob) mice have a defective inner colonic mucus layer that is characterized by increased p

217 ed spontaneous phasic contractions (SPCs) of colonic muscle through activation of a SK conductance.

218 as a specific Ano1 antagonist hyperpolarized colonic muscles by ~10 mV.

219 ation contributes to excitatory responses of colonic muscles.

220 eNAD exposed to colonic muscularis of wild-type mice produced eADPR, eAM

221 pha(+) cells (PDGFRalpha(+) cells) in murine colonic musculature.

222 Numbers of colonic myenteric neurons increased after mice were swit

223 these consistent, early microbial changes in colonic neoplasia.

224 In the adult mouse colon, TLR2 promotes colonic neurogenesis, regulated by intestinal bacteria.

225 itric oxide synthase production, and reduced colonic neurogenesis.

226 ne the role of enteric glial cells (EGCs) in colonic neuromuscular dysfunctions in a mouse model of h

227 he intestinal segment they occupy; ileal and colonic neurons are more responsive to microbial coloniz

228 Pr agonists inhibited mechanically sensitive colonic nociceptors.

229 maximizing long-term survival by preventing colonic obstruction.

230 ompared intestinal microbiota (from fecal or colonic or ileal tissue samples) among patients (adult o

231 me-free HIOs that can be primed towards more colonic or proximal intestinal lineages in serum-free de

232 eding was gastric or duodenal, one-third was colonic or rectal, and one-third was from an unknown GI

233 ermined by LEF luciferase reporter assay and colonic organoid proliferation, respectively.

234 re also generated complementary hPSC-derived colonic organoids (hPSC-COs) to explore the response of

235 l signaling and a reduction in the growth of colonic organoids from stem cells isolated from infected

236 We also show, using both mouse and human colonic organoids, that TcdB from epidemic ribotype 027

237 ng the number of Lgr5(+) stem cells in mouse colonic organoids.

238 tablished colon cancer cells and transformed colonic organoids.

239 re modified according to the severity of the colonic pain, and whether the changes were associated wi

240 DRA-KO mice exhibited an increased colonic paracellular permeability with significantly dec

241 drocortisone treatment significantly reduced colonic pathology and restored colonic length to naive l

242 ich are both potent inducers of GVHD-induced colonic pathology, indicating that GM-CSF constitutes a

243 oscopy patients and has been misdiagnosed as colonic perforation in previously reported cases of retr

244 Four patients experienced colonic perforation, 2 of whom required surgery.

245 tributed to treatment, including one grade 4 colonic perforation.

246 hibited increased serum histamine levels and colonic permeability after acute restraint stress.

247 Despite having no effect on colonic permeability, exposure to PB caused major shifts

248 ecrease in occludin mRNA and the increase in colonic permeability.

249 K) were assessed in whole mount specimens of colonic plexus by immunohistochemistry.

250 vent delayed bleeding after removal of large colonic polyps has not been established.

251 out to identify which cell(s) contribute to colonic regeneration by performing genetic fate-mapping

252 , is also expressed in peripherally induced, colonic regulatory CD4(+) T cells.

253 his variation and may be the main drivers of colonic resection for diverticular disease.

254 toration of the intestinal BA pool increases colonic RORgamma(+ )T(reg) cell counts and ameliorates h

255 -producing consortia increased the number of colonic RORgammat-expressing T(reg) cells in a CNS1-depe

256 In conclusion, inflamed and non-inflamed colonic segments in both CD and UC differ in microbiota

257 Colonic sensitivity was assessed by colorectal distensio

258 Colonic sensorimotor disturbances and pelvic floor dysfu

259 like cells) isolated from murine jejunal and colonic smooth muscle and/or mucosal tissues as well as

260 Spontaneous excitability and contractions of colonic smooth muscle cells (SMCs) are normally suppress

261 e associated tissues (jejunal smooth muscle, colonic smooth muscle, and colonic mucosa).

262 We wished to analyze the role of Nkx2.3 in colonic solitary intestinal lymphoid tissue composition

263 to cynomolgus monkeys (nonhuman primates) by colonic spray increased circulating levels of IL-1R anta

264 However, its effects on the function of colonic stem and progenitor cells remain largely unexplo

265 investigate infection-mediated damage to the colonic stem cell compartment and how this affects epith

266 bone morphogenetic proteins (BMP) to promote colonic stem cell differentiation, we aimed to investiga

267 thesized that adiponectin signaling supports colonic stem cell maintenance through modulation of the

268 r5(+) stem cells increases the percentage of colonic stem cells and enhances organoid initiating capa

269 Exposure and susceptibility of colonic stem cells to intoxication compromises their fun

270 mice, such as reduction in the percentage of colonic stem cells, promotion of stem cell differentiati

271 e AhR-FoxM1 axis, at least in part, mediates colonic stem/progenitor cell behavior.

272 ter rodentium, a pathogen that colonizes the colonic surface, to identify microbial traits that licen

273 e fibers are equally effective at increasing colonic T1 over a period of 24 h.

274 Colonic tachykininergic contractions, elicited by electr

275 nal computed tomography revealed substantial colonic thickening and several focal intramural gas bubb

276 the pathogen capacity to penetrate into the colonic tissue in vivo.

277 hus identifying a novel relationship between colonic tissue integrity and behavioral responses that i

278 xel concurrently affects the gut microbiome, colonic tissue integrity, microglia activation, and fati

279 regulated the resting membrane potential of colonic tissues as a specific Ano1 antagonist hyperpolar

280 potential therapeutic approach of protecting colonic tissues by blocking these interactions.

281 Expression of occludin in colonic tissues was examined by western blot.

282 Colonic tissues were collected from mice and analyzed fo

283 f patients, hyperalgesia in 22%, accelerated colonic transit in 18%, delayed transit in 7%, anxiety i

284 All patients underwent assessments of colonic transit time (radiopaque markers); compliance, a

285 colon volumes (P < 0.001, ANOVA) and delayed colonic transit times (P = 0.01, Kruskal-Wallis).

286 Three different patterns of delayed colonic transit were seen.

287 Colonic transit, followed if necessary with assessment o

288 d gastric emptying, small-bowel transit, and colonic transit.

289 lls, providing a physiological adaptation of colonic Treg cells as a function of the age of the cell

290 CL9/9l is particularly effective at blocking colonic tumourigenesis and mutations that most resemble

291 g metabolism of 1,N(6) -etheno-NAD (eNAD) in colonic tunica muscularis and in SMCs, ICC and PDGFRalph

292 degradation of 1,N(6) -etheno-NAD (eNAD) in colonic tunica muscularis of wild-type, Cd38(-/-) , Nt5e

293 onsistently reduced in SB CD and elevated in colonic UC compared with non-IBD controls.

294 thological examination of tissue sample from colonic ulcer biopsy revealed invasive intestinal mucorm

295 bowel preparation is required to obtain good colonic visualisation.

296 to assess small bowel water content (SBWC), colonic volumes, and T1 of the ascending colon (T1AC) as

297 of the ascending colon (T1AC) as measures of colonic water.

298 Here we describe an intravital murine colonic window with a stabilizing ferromagnetic scaffold

299 impaired mucosal repair after biopsy-induced colonic wounding and recovery from dextran sulfate sodiu

300 efective mucosal repair after biopsy-induced colonic wounding or Dextran Sulfate Sodium (DSS)-induced