ライフサイエンスコーパス: combination

1 d drought, increased N deposition, and their combinations).

2 pending on tube voltage and energy threshold combination.

3 ements, but these have not been evaluated in combination.

4 nd tfc covering the basic polygons and their combinations.

5 for new beta-lactam/beta-lactamase inhibitor combinations.

6 eraction with five different PNAs across six combinations.

7 different tests, scores, cut points, or test combinations.

8 ll as investigations of multimodal biomarker combinations across fluids, brain imaging and other doma

9 d the extraction socket was grafted with the combination allograft and covered with a nonresorbable m

10 ic acid (GA), methyl gallate (MG), and their combination alone and together with lecithin (L) were ev

11 those of the synthetic lethal p53 mutant/MK2 combination alone.

12 Combination analysis of both parameters enhanced their d

13 efficacies to measured efficacies for >5000 combinations) and in a systematically selected set of cl

14 mensions needed to summarise their tolerance combinations, and the best trade-off model among those c

15 e case in the setting of early initiation of combination antiretroviral therapy (cART), at high CD4 c

16 animals with viremia initially controlled by combination antiretroviral therapy (cART), CPT31 monothe

17 infected and HIV-monoinfected individuals on combination antiretroviral therapy (cART).

18 HIV, especially for individuals on long-term combination antiretroviral therapy with well controlled

19 ected cells to persist in individuals during combination antiviral therapy (ART).

20 New drugs or combinations are needed to improve patient therapy and t

21 ses, respectively, with the following result combinations: BC positive and PCR/ESI-MS negative, 4.3%;

22 eous melanoma, while those three regimens or combination BRAF/MEK inhibitor therapy with dabrafenib/t

23 in mathematically predictable ways; specific combinations can even actively misdirect them.

24 Gemcitabine-platinum combination chemotherapy initiated within 90 days after

25 and rare variants that, acting alone and in combination, confer risk of disease.

26 Rather than single applications, ligand combinations could synergistically potentiate immune res

27 -clinical data supporting the drug-biomarker combinations, current evidence shows that a limited numb

28 rent evidence shows that a limited number of combinations demonstrate clinically relevant benefits, w

29 predictions closely agree with measured drug combination efficacies both in vitro (Pearson's correlat

30 h was annulled by empagliflozin during their combination (empagliflozin + LY2409021).

31 ty between both vaccines, with JENVAC/JENVAC combination exhibiting the highest immune response.

32 t-cost' theory posits that the optimal trait combination for a given environment is that where the su

33 efits of any intervention individually or in combination for the 6 end points at 3 years.

34 e were smaller in the olanzapine/samidorphan combination group compared with the olanzapine group.

35 The combination group had a significant decrease of neovascu

36 r LAMP amplification either singularly or in combination have potential in a full dynamic range quant

37 aseline eGFR, proton pump inhibitor use, and combination immune checkpoint inhibitor therapy were eac

38 th mortality in UK Biobank and 12 of the top combinations in the Taiwan NDCMP.

39 The current approach to designing drug combinations includes in vitro optimization to maximize

40 eflect convergence towards predictable trait combinations, indicating that morphological variation is

41 inity, cold and particularly their different combinations, inflict a heavy toll on crop productivity

42 scular diseases featured in 18 of the top 20 combinations most highly associated with mortality in UK

43 erwent randomization (olanzapine/samidorphan combination, N=280; olanzapine, N=281), 538 had at least

44 s the safety and efficacy of an intracameral combination of 2 mydriatics and 1 anesthetic (ICMA, Mydr

45 live neurons in the three conditions using a combination of a biophysical network model of the inferi

46 e an enhanced capability of F-TD through the combination of a customized F-TD inlet with chemical ion

47 The combination of a pipette tip, wire electrodes, enzyme, a

48 his exploratory study was to investigate the combination of a radiopharmaceutical, nanoparticles and

49 ions during adaptation, characterized by the combination of a slow-progressive feedforward process an

50 The novel combination of A-TEEM and XGBDA was found to have great

51 The combination of ADCRPs performed better than (18)F-FDG-AD

52 A combination of age >5 years (AUC = 0.77), prodromal feve

53 We show that combination of agonistic anti-CD40 with antiangiogenic a

54 -phenylundecane alone attracted workers, the combination of all six compounds showed greater arrestan

55 It is demonstrated that the combination of an inversion layer, induced by holes (or

56 In mice, the combination of anti-PD-1 inhibitory and anti-OX40 agonis

57 ning algorithms were developed to identify a combination of antigen- and epitope-specific antibodies

58 s on a randomized clinical trial testing the combination of apremilast, a phosphodiesterase 4 inhibit

59 Here, we use a combination of atom-resolved scanning probe microscopy a

60 ctors bind to specific DNA sequences using a combination of base readout and shape recognition, some

61 transplant candidates were treated with the combination of belatacept and PI therapy, which signific

62 Using a combination of biochemical and functional studies, we fi

63 gression was performed to select the optimal combination of biomarkers, diagnostic accuracy was deter

64 Our study demonstrates the need for a combination of biosystematics with biological and ecolog

65 al bleeding (127 of 334 patients, 38%), or a combination of bleeding and ascites (38 of 334 patients,

66 s asymmetric feedback, visual saliency, or a combination of both (Skerswetat et al.

67 The combination of both factors had no additional effect on

68 arious stimuli evoke sparse responses from a combination of broadly and narrowly tuned neurons.

69 Using a combination of calorimetric, scattering, electron micros

70 The sequential combination of canaloplasty followed by trabeculotomy pe

71 for multiple cell modifications, redosing or combination of CAR T cells directed against different ta

72 In this work, we use a combination of chemogenetics, fast scan cyclic voltammet

73 Despite the combination of chemometrics and sensors, to capture new

74 A combination of clinical features and biomarkers may aid

75 logy-symptom correlations occurred between a combination of CNS and visceral sensitivity parameters,

76 Herein we describe a combination of computational and experimental design of

77 Using a combination of confocal, super-resolution and EM, we def

78 Ultimately, the combination of controlled release microspheres with a th

79 c deletion in mouse embryo fibroblasts and a combination of CRISPR-mediated gene editing and RNAi-med

80 ts of a set of molecules using any available combination of DFT theory, solvent model, and NMR-active

81 tectal feature map originates from a linear combination of diverse, functionally specialized, lamina

82 The combination of earlier spring blooms and lower summer fo

83 s limited in these wild populations due to a combination of factors including low concentrations of b

84 A combination of feasible manufacturing and renewable modu

85 Homo naledi displays a combination of features across the skeleton not found in

86 orest (RFE-RF) was used to identify the best combination of features to distinguish AAH from controls

87 Using a combination of field theoretical techniques and density

88 The PCL Film is prepared using a combination of film casting and sacrificial material lea

89 By exploiting a combination of frustrated total internal reflection and

90 The combination of FTND and NCC in discerning disease severi

91 res regression model was able to explain the combination of genes that contributed to increased fruit

92 ctors for early transient rhinitis involve a combination of genetic and early environmental exposures

93 Here, we use a combination of genetic rescue experiments with CSLD-CESA

94 The combination of hard (titanium) and soft (calcium) metals

95 tries but for many people would require some combination of higher income, nutritional assistance, an

96 A combination of highly processive RNA polymerases, allost

97 95% confidence interval, 86.3%-99.7%) by the combination of histology and imaging/clinical follow-up.

98 Our unique study uses a novel combination of human association analysis, CRISPR genome

99 Here, a combination of hydrogen-deuterium exchange, electron par

100 Through a combination of imaging approaches including super-resolu

101 Using a combination of immunohistochemistry, in situ hybridizati

102 Realization of a single imaging unit with a combination of in-built memory and signal processing cap

103 that this limited translation is driven by a combination of intersubject heterogeneity and the relati

104 cular weights greater than 65 kDa, through a combination of intra- and intermolecular metal-mediated

105 We used a combination of intragastric, intrajejunal, and intracolo

106 The combination of Intralipid with half the standard clinica

107 eneracy of the Dirac bands is protected by a combination of inversion, time-reversal, and an addition

108 Here, using a combination of isotope-edited infrared spectroscopy and

109 The combination of IT CMP-001 with systemic anti-PD-1 enhanc

110 Our data also show that the combination of KP372-1 with PARP inhibition creates enha

111 Consequently, the combination of KY1070 and Darbepoetin alfa resulted in a

112 ionine residue at this position has a unique combination of length, flexibility, and chemistry to act

113 m of the present study was to ascertain if a combination of leukocyte and platelet-rich fibrin (L-PRF

114 s alternative co-receptors for RSPO3 using a combination of ligand mutagenesis and ligand engineering

115 llumina HT12 array and analysed in R using a combination of Limma and Illuminaio.

116 We concluded that the combination of linkage analyses and WGS to search for di

117 habitats for insects and mites, analysing a combination of local-scale experimental plot data and ge

118 The combination of long-range exciton transport and slow ann

119 The innovative protocol that uses the combination of luminol and an ionic liquid in water exhi

120 dings support the clinical evaluation of the combination of LuTate and PARP inhibition in SSTR2-expre

121 Complex cellular geometries based on the combination of many different fundamental building block

122 medical management alone was superior to the combination of medical management and interventional the

123 Dab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence

124 A combination of molecular and functional profiling of bon

125 day cross-latitudinal vessel transit using a combination of molecular methods.

126 Furthermore, the combination of MTP-PE and IFN-gamma on AML blasts genera

127 We used a combination of multiplex SNaPshot assays, Sanger sequenc

128 The combination of n electrodes, demonstrating individually

129 Compared with nivolumab alone, the combination of nivolumab and ipilimumab in EOC resulted

130 hock, and the most frequent comparator was a combination of norepinephrine plus dobutamine.

131 A combination of nutrition education and food supplements

132 For this study, we use an unprecedented combination of observed data from the United States comp

133 A combination of olanzapine and the opioid receptor antago

134 Using a combination of optogenetics and chemogenetics we show th

135 By using a combination of optogenetics, in vivo electrophysiology,

136 The combination of our bioassays and the transcriptomic anal

137 Hence, based on a combination of our data and additional literature inform

138 allylic substitution reaction catalyzed by a combination of palladium and a chiral phosphoric acid wa

139 , a relationship that can be attributed to a combination of passive body dynamics and active sensorim

140 The results suggested that the combination of Pickering stabilization and thymol additi

141 rliest scorpion yet reported, and it shows a combination of primitive marine chelicerate and derived

142 The combination of probiotics and prebiotics might be useful

143 Here, we use a combination of protein semisynthesis, NMR, and enzymolog

144 Through a combination of proteomics and gene expression analysis,

145 ly COVID-19 can be reasonably explained by a combination of pulmonary embolism, ventilation-perfusion

146 nd immunostimulatory activities and rational combination of PVs with other therapies.

147 chieved by airway administration of a single combination of relatively small amounts of three anti-in

148 Further work defining what number and which combination of risk variables works best for predicting

149 Analysis of a combination of RNA-seq, Capture Hi-C, and patient surviv

150 6 introgression line (IL) population using a combination of scanning electron microscopy (SEM) techni

151 This connection is revealed through a combination of scanning PTE and electron microscopy meas

152 In this study, we observed that the combination of subjective assessment with a parsimonious

153 nto the difficulties in choosing the correct combination of targets for engineering increased fruit y

154 This powerful combination of techniques allows us to obtain valuable i

155 ical characterisation is achieved by using a combination of techniques, including magneto-transport i

156 Using a diverse combination of techniques, we purified these serpins fro

157 egravir 50 mg; or once-daily oral fixed-dose combination of tenofovir disoproxil fumarate 300 mg, emt

158 Therefore, the combination of the correct administration procedure, sui

159 of these polar textures is driven by the (re)combination of the elementary topological defects, meron

160 The combination of the lysimeter study with CSIA enabled ins

161 The combination of the scaffold of the polar antioxidant lea

162 Vaccination with a combination of the single-antigen vectors expressing PfL

163 ) to g-C(3) N(4) , taking advantage from the combination of their optimal photophysical properties.

164 ucture remains unreliable, even when using a combination of thermodynamic stability and evolutionary

165 Because the combination of these actions results in Grp1 being recru

166 hygroma, increased nuchal translucency, or a combination of these conditions.

167 The combination of these emissions led to near-perfect white

168 Combination of these properties in one filter will lead

169 The combination of these results with a model of mass transf

170 Thus, the combination of these therapeutic classes is of intense r

171 availability, altered water chemistry or any combination of these.

172 resent a new data-driven approach based on a combination of tree ring width (TRW) records, growing se

173 ce metastructure that takes advantage of the combination of two oppositely oriented coaxial domes, pr

174 Using a combination of vibrational and photoemission spectroscop

175 To address this question, we used a combination of viral shRNA and conditional mutation to p

176 ments with single-, dual- and triple-isotope combinations of (99m)Tc, (111)In, (123)I, (177)Lu, and (

177 ing site for PF-05089771 and suggesting that combinations of agents targeted to the pore-region bindi

178 drought (-30.4%), N deposition (-31.0%), and combinations of available multiple environmental change

179 ces (mainly pharmaceuticals) under different combinations of bacterial diversity and bedform-induced

180 w >10 crops, but only 2% did so in 2017, and combinations of crop types that once characterized entir

181 Using different combinations of deuterated and proteated acid and hydrid

182 Combinations of DNMT inhibitors with anti-TIGIT or anti-

183 tic regression analyses) aimed to detect any combinations of events predicting poor outcome as define

184 ASAP-SML identifies features and combinations of feature values found in the MMP-targetin

185 Specifically, the frequencies (or combinations of frequencies) that most robustly encode s

186 reference of females was quantified in seven combinations of gradients of both temperature (11-37 deg

187 To identify combinations of greater than two hits, we used a compres

188 pre-clinical findings to identifying optimal combinations of immune-based therapies for any given pat

189 To illuminate the combinations of ingredients most important to align and

190 m drinking water Pb reduction actions (i.e., combinations of lead service lines [LSL] and corrosion c

191 The data indicates that unfavorable combinations of lifestyle risk factors lead to a high li

192 conditions can allow synthesis of unlimited combinations of ligand nano-sequences and frequencies, m

193 n soil samples, but slight modifications and combinations of methods may prove promising and need to

194 ealthy donors were stimulated with different combinations of molecules, and PD-1 expression was studi

195 ogeneous ensembles with (essentially) random combinations of monomer glycoforms; (4) native top-down

196 We highlight combinations of NNs with other ideas such as permutation

197 ese distinct responses emerge from different combinations of rates and sequences of arriving stimuli.

198 systematically analyze effects of different combinations of steroid mixtures in zebrafish embryos to

199 oduced SAFs for all source region and target combinations of the 2 International Commission on Radiol

200 different MNW types, and fit them to linear combinations of the individual type signatures to determ

201 mmunity assembly was predictable from linear combinations of the taxa maintained on each individual m

202 largely ignored for the frequently occurring combinations of toxicants with natural stressors.

203 However, only combinations of traits associated more directly with pla

204 static cancer using the same indications and combinations offered to women.

205 te effects of L-theanine, caffeine and their combination on sustained attention, inhibitory control a

206 HA substitutions, either individually or in combination, on receptor binding, pH of fusion, thermal

207 d that CYD-TDV and TIRS interfere: while the combination outperforms either alone, performance is low

208 iscriminative potential for NTM-PD and their combination provided an improved diagnostic value for NT

209 r, albeit limited, PFS, with toxicity of the combination regimen comparable to prior reports.

210 the clinical data for various BRAF plus MEK combination regimens in three cancer types with underlyi

211 Interestingly, many combinations resulted in distinct lipid nanostructures.

212 , we have measured the signatures of several combination samples containing two or four different MNW

213 Finally, a bortezomib (BTZ)/MEK inhibitor combination showed enhanced activity in vivo specificall

214 ions, less ambitious implementations of this combination still produce amplified, longer-lasting effe

215 Yet reliable analysis of combination studies remains an open challenge.

216 of under $100 per patient, which makes this combination suitable for elimination protocols in resour

217 r diseases show that network-principled drug combinations tend to have low toxicity.

218 domly assigned to once-daily oral fixed-dose combination tenofovir alafenamide 25 mg and emtricitabin

219 lutegravir 50 mg; once-daily oral fixed-dose combination tenofovir disoproxil fumarate 300 mg and emt

220 We identified specific gene combinations that were associated with distinct MDS/MPN

221 Owing to the high expression levels of HER2, combination therapies are currently required for the tre

222 tner drug, all recommended artemisinin-based combination therapies have shown reduced efficacy in som

223 ming and further emphasizes the advantage of combination therapies in prolonging transplant survival.

224 gs might pave a way for new synthetic lethal combination therapies.Significance: These findings highl

225 In phase 2, patients treated with combination therapy achieved an overall response rate of

226 decision to choose multiple antibiotics for combination therapy against drug resistant bacteria can

227 was to assess the long-term effectiveness of combination therapy for intermittent claudication, compa

228 itiation that is vulnerable to inhibition as combination therapy in cancer.

229 Yet, combination therapy with CD40 agonist and Flt3 ligand re

230 ssive agents, and especially those receiving combination therapy, have an impaired immune response co

231 ography, indocyanine green angiography, or a combination thereof.

232 In combination, these findings establish a key role for mic

233 erent polar-aprotic and polar-protic solvent combinations to disrupt the H-bonds and hydrophobic inte

234 ial of the quantitative parameters and their combinations to predict GGG 1 vs >1, using logistic regr

235 Carnosic acid-idebenone combination treatment promoted NQO1-dependent Complex I

236 IMspire150 aimed to evaluate first-line combination treatment with BRAF plus MEK inhibitors and

237 cell lines (HCT116 and CAL27) to single and combination treatments of radiation (0-20 Gy), and hyper

238 These results suggest that combination treatments targeting vascular health, amyloi

239 tional addiction in cancer cells and suggest combination treatments that target RNA processing and DN

240 rapies via the development of rational novel combination treatments.

241 used to knockout AR-FL or AR-V7 alone or in combination were evaluated.

242 lenced in their expression (and their binary combinations) were planted in a diseased field plot in t

243 96.5% for different anatomic site infection combinations, whereas negative percent agreement was 98.

244 nt out that the bulky diol at 1 mol L(-1) in combination with 18-crown-6 is able to produce an 18-fol

245 or-bearing mice with gemcitabine alone or in combination with a CXCR4 antagonist (AMD3100) or hedgeho

246 CP by using an optimized scoring function in combination with a deterministic searching algorithm.

247 The platform was used in combination with a sample pretreatment step, when detect

248 Taken in combination with additional genetic and other risk facto

249 ed force-ramp and force-jump experiments, in combination with advanced statistical analysis, to show

250 nocatalyst was employed as a model system in combination with an arsenal of mechanistic techniques, i

251 up at the 3'-end of each oligonucleotide, in combination with an N-alkyl imidazole organocatalyst.

252 a monotherapy, and to a greater extent as a combination with anti-PD1, SG7 slows tumor growth in mul

253 fluorescence staining of CXCR5 and CXCL13 in combination with CD20 reveals the formation of tertiary

254 sed together with marijuana, particularly in combination with cigarette smoking.

255 rent synergistic and antagonistic effects in combination with clindamycin.

256 with posttransplantation cyclophosphamide in combination with CTLA4Ig-based T-costimulation blockade.

257 In combination with density functional theory calculations,

258 the isolated molecules in a frozen glass, in combination with DFT/MRCI calculations, show that (sigma

259 a negative allosteric modulator/activator in combination with dofetilide corrected both congenital an

260 Two-plex molecular imaging in combination with down-conversion Er nanoparticles (ErNPs

261 r-to-normal tissue ratio offered by TMRET in combination with dual-contrast enhanced subtraction imag

262 e of epinephrine and vasopressin alone or in combination with epinephrine.

263 Further combination with fluorescence microscopy allows users to

264 In combination with functional characterization, this work

265 urface by the metalloproteinase, ADAM-10, in combination with heparan sulfate.

266 Elevated anxiety symptoms in combination with high-risk biological factors such as AP

267 The S5 classifier alone or in combination with HPV16/18/31/33 genotyping also showed s

268 r AMG 510 can potentiate immune rejection in combination with immune checkpoint blockade.

269 Dapagliflozin treatment in combination with insulin resulted in a dose-dependent in

270 lectrospray ionization (vt-ESI) technique in combination with ion mobility spectrometry (IMS) and mas

271 e development of anti-cancer therapeutics in combination with ionizing radiation (IR).

272 s regarding the contribution of genetics, in combination with known treatment-related risks, for the

273 l studies, in vivo, and in vitro studies, in combination with mathematical modeling can help optimize

274 on-tissue enzyme-assisted derivatization in combination with microliquid extraction for surface anal

275 In combination with minimal material consumption (reactions

276 ing functional magnetic resonance imaging in combination with multivoxel pattern analysis and computa

277 , neoadjuvant treatment with atezolizumab in combination with nab-paclitaxel and anthracycline-based

278 model of post-traumatic stress disorder, in combination with optogenetic activation of hypothalamic

279 using tools to improve statistical power in combination with orthogonal analyses in mice, we detecte

280 Avadomide is being evaluated in combination with other antilymphoma agents.

281 anced to clinical trials, both singly and in combination with other existing US Food and Drug Adminis

282 edge of its effects and to its being used in combination with other experimental techniques.

283 This, in combination with other physiological data, and in contra

284 architectures obtained through NCA ROP or in combination with other polymerization methods are review

285 rable therapeutic effect, especially when in combination with oxaliplatin.

286 In combination with pharmacological JAK inhibition, YBX1 in

287 the surgery, who underwent TDSRF alone or in combination with PPV.

288 Reactivity studies, in combination with quantum chemical analysis, suggest that

289 icant reactivation of the inactive allele in combination with removal of methyl groups from CpG dinuc

290 ssigned to (177)Lu-PSMA alone (n = 31) or in combination with SIRT (n = 5) were retrospectively analy

291 entify that the neonatal microenvironment in combination with STAT5 is critical for post-thymic gamma

292 -nucleocapsid IgG assay was used alone or in combination with the anti-spike IgG assay to determine b

293 Here, we evaluate TDF and FTC in combination with the broadly neutralizing antibody VRC01

294 These moths can use visual cues in combination with the geomagnetic field to guide their fl

295 Hemodynamic study of the target kidney in combination with the histological analysis reveals a saf

296 quisition speed or high separation powers in combination with the increased sensitivity of MALDI-2 av

297 , to receive either tucatinib or placebo, in combination with trastuzumab and capecitabine.

298 multi-starters were successfully applied in combination with wood in a controlled and accelerated fe

299 or ustekinumab, either as monotherapy or in combination (with immunomodulators), to mitigate these r

300 inib and trastuzumab emtansine), alone or in combination, yield a number of intracranial responses in