ライフサイエンスコーパス: combinatorial

1 e meristem and that FAC formation is largely combinatorial.

2 tors by odorants is comparably prevalent and combinatorial.

3 k inside a eukaryotic cell is defined by the combinatorial actions of transcription factors (TFs).

4 Cell identities in the maize SAM reflect the combinatorial activity of transcription factors (TFs) th

5 Finally, a novel quality assessment-based combinatorial algorithm was used to effectively map prot

6 amoxicillin, tetracycline, and rifampin, but combinatorial analyses for rdxA gene truncations and R16

7 Our system provides combinatorial and dynamic drug treatments to hundreds of

8 nally coordinated sets of mRNAs and involves combinatorial and dynamic interactions with other RBPs.

9 rom and pathogenesis of dementia depend upon combinatorial and opposite alterations in APP metabolism

10 delivery target specificity, researchers use combinatorial and rational library design strategies to

11 We also used combinatorial and single-nucleotide mutagenesis to evalu

12 alidate our system by performing individual, combinatorial, and sequential drug screens on human-deri

13 es the host myxobacterium to biosynthesize a combinatorial antibiotic library of 25 cystobactamid ana

14 This enhances combinatorial antigenic diversity in Gram-negative bacte

15 Using this combinatorial approach and proxies for oxaliplatin-DNA d

16 sue of Cancer Research, represents the first combinatorial approach based on epigenetic therapy primi

17 in this issue of Cancer Research proposes a combinatorial approach based on targeting the very mecha

18 The described combinatorial approach can be used to analyze libraries

19 The combinatorial approach guiding the nanoparticle synthesi

20 landscape is so vast that a high-throughput combinatorial approach is required to understand structu

21 This combinatorial approach provides a generally applicable s

22 Herein, we describe a dynamic combinatorial approach to generate structural divergence

23 w self-replicating molecules using a dynamic combinatorial approach.

24 stology-this is likely to be achieved with a combinatorial approach.

25 Potential combinatorial approaches aimed at disrupting Notch- and

26 ion, our results clearly indicate that these combinatorial approaches are superior to single treatmen

27 ical responses in some patients with RCC and combinatorial approaches involving checkpoint blockade a

28 TEC development and demonstrate the power of combinatorial approaches leveraging both in vivo models

29 Combinatorial approaches that enhance (131)I-mIBG tumour

30 Combinatorial approaches to materials discovery offer pr

31 Here, we use combinatorial approaches together with fast characteriza

32 d to all drugs recommended by MTB, including combinatorial approaches, while 38% received physician's

33 allenge is to decipher the comprehensive and combinatorial array of PTMs that modulate Hsp90 chaperon

34 Here, we develop Combinatorial Arrayed Reactions for Multiplexed Evaluati

35 The PVH uses combinatorial assemblies of molecularly defined neuron p

36 Combinatorial Atoh1 and Gfi1 induction is thus a promisi

37 This method allows in situ readout of dense combinatorial barcode libraries and single-base mutation

38 and Mertk in the TME is predicted to have a combinatorial benefit to enhance current immunotherapies

39 Interestingly, preferential combinatorial binding by these transcription factors was

40 o multiple ChIP-Seq datasets to decipher the combinatorial binding events of multiple TFs.

41 temporally control transcription through the combinatorial binding of local transcription factors.

42 Combinatorial binding of transcription factors to regula

43 Combinatorial binding of transcription factors, cofactor

44 Several models of how combinatorial binding of transcription factors, i.e. the

45 tfLDA is able to learn high-order combinatorial binding patterns of TFs from multiple ChIP

46 s with a rich collection of TFs and identify combinatorial binding patterns that show well-known TRMs

47 he present study, we developed an innovative combinatorial biophysical cue sensor array combining a s

48 Therefore, our innovative combinatorial biophysical cue sensor array to control NS

49 This work enables plug-and-play combinatorial biosynthesis of aromatic polyketides using

50 Combinatorial biosynthesis of glycosyltransferases and d

51 genesis, pathway engineering, and deoxysugar combinatorial biosynthesis with a focus on the generatio

52 penoids with valuable bioactivities based on combinatorial biosynthetic strategies.

53 path for the implementation of personalized combinatorial cancer therapy.

54 Our results demonstrate that a combinatorial CAR approach can improve target selectivit

55 nsensitive to serum IgG, we designed various combinatorial CAR constructs in order to maintain the CD

56 tion in vivo and reveal the potential use of combinatorial carcinoma treatments when such double-face

57 essenger RNA labeling (sci-fate), which uses combinatorial cell indexing and 4-thiouridine labeling o

58 lineage information and cell identity via a combinatorial cell indexing approach.

59 eration' implementation includes delivery of combinatorial cell populations exerting synergistic effe

60 The synergetic effects of the combinatorial cell therapy may have significant impacts

61 The combinatorial challenge of high-dimensional data is hand

62 r other applications in single-cell biology, combinatorial chemical synthesis, and drug screening.

63 lternative to established surface display or combinatorial chemistry approaches for the discovery of

64 d library (DEL) technology, the now-dominant combinatorial chemistry paradigm.

65 itors demonstrate the power of target-driven combinatorial chemistry to deliver bivalent drugs in a s

66 TLR triagonist adjuvant platform, which used combinatorial chemistry to link three different TLR agon

67 Using this combinatorial chemistry we encode more than 1.8 million

68 nt inhibition of protein targets and dynamic combinatorial chemistry.

69 olutionary history, and capacity to generate combinatorial chromatin states through hetero-oligomeric

70 ble range, and we optimize the corresponding combinatorial classical problem by sampling the QAOA out

71 We used biolistic combinatorial co-transformation (up to 20 transgenes) fo

72 encoding of odors is believed to begin as a combinatorial code consisting of distinct patterns of re

73 initially represented in the periphery as a combinatorial code with relatively simple temporal dynam

74 a small subset of the responsive ORs in this combinatorial code.SIGNIFICANCE STATEMENT Complex odors

75 nerated using a configurational (rather than combinatorial) code of transcription factors that produc

76 quence diversity, consistent with most other combinatorial codes previously measured in vivo The enco

77 enable the detection of sensory stimuli in a combinatorial coding space.

78 riminating all tastes and representing their combinatorial coding.

79 ole of other bZIP transcription factors, the combinatorial complexity of FAC formation, and their DNA

80 we propose an automated approach, employing combinatorial concatenation of roots from Latin and Gree

81 The landscape is mined to reveal combinatorial control of interleukins, checkpoints, and

82 Combinatorial control via phosphorylation also governs r

83 We demonstrate combinatorial cosputtering of cation-disordered, wurtzit

84 mass spectrometry is powerful for describing combinatorial coupling effects of a cooperative ligand p

85 Our findings describe combinatorial cpk mutants that function in CO(2) control

86 nations, which we validate systematically by combinatorial CRISPR, drug-drug screening in vitro, and

87 nal beta-cell mass, whereas T2D results from combinatorial defects in functional beta-cell mass plus

88 By taking a combinatorial deletion approach of both coding sequences

89 y of this electrochemical method relative to combinatorial design of colloidal syntheses have the pot

90 ubstrates, suggesting that multiple, perhaps combinatorial, determinants are involved in substrate se

91 ngth mRNAs transcriptome-wide and reveal the combinatorial diversity of cap-associated transcription

92 his process is the expansion of sequence and combinatorial diversity to increase the structural reper

93 ific CD8 T cells do not respond to single or combinatorial dosing of anti-CTLA4, anti-PD-L1, anti-PD-

94 al and synergistic and offers a strategy for combinatorial drug development.

95 ons, using two approaches: a high-throughput combinatorial drug screen with the clinical BET inhibito

96 Recapitulating ssd1Delta defects with combinatorial drug treatment selectively blocked prolife

97 leads to signaling defects likely to require combinatorial drug treatment to suppress patient phenoty

98 ft models, but the mechanism underlying this combinatorial effect is not known.

99 is an exciting method that can consider the combinatorial effect of groups of variants working in co

100 g disease progression and that examining the combinatorial effect of these components would uncover d

101 icular trait or phenotype resulting from the combinatorial effect of two or more genes or genetic var

102 responsiveness to anti-CTLA4 treatment with combinatorial effects after intratumoral administration.

103 We evaluated the combinatorial effects of Atoh1 and Gfi1 over-expression

104 ciation analysis was successful in resolving combinatorial effects of multiple loci.

105 ion and mesodermal specification, uncovering combinatorial effects of signaling pathway activation on

106 In both stages, GenEpi adopts two-element combinatorial encoding when producing features and const

107 erstood as stoichiometric aggregates, but as combinatorial ensembles.

108 uccessful assembly of the capsid is based on combinatorial entropy.

109 el primordia using ATAC-seq and characterize combinatorial epigenome features around these OCRs using

110 n the expression of protein markers requires combinatorial evaluation.

111 describe the design and implementation of a combinatorial exchange for trading catch shares in New S

112 a single experiment, offering advantages in combinatorial experimental design, large numbers of inde

113 Combinatorial experiments revealed that dysregulation of

114 We report a systematic combinatorial exploration of affinity enhancement of ant

115 Cell type-specific combinatorial expression of different classes of cadheri

116 It has been proposed that the combinatorial expression of gamma-protocadherins (Pcdh-g

117 c view of GPCR signalling that considers how combinatorial expression of isoforms in a particular cel

118 Substrates were efficiently accessed in a combinatorial fashion by a cross-Claisen/ alpha-arylatio

119 stem have long been known to be activated in combinatorial fashion by odorants.

120 suggest that Copines might be involved in a combinatorial fashion in Brn3b-dependent specification o

121 , and suggest that RsmA and Hfq may act in a combinatorial fashion on certain transcripts.

122 hich alter the thermal stability of MCR in a combinatorial fashion that is not readily predictable fr

123 off states of gene expression typically in a combinatorial fashion.

124 We propose a combinatorial formulation for the problem, and prove tha

125 be rationally designed to enable unique and combinatorial functionalities.

126 plasmids as vectors for directed evolution, combinatorial gene circuit tests, and for CRISPR multipl

127 e platform for the development of efficient, combinatorial gene-editing therapeutics.

128 complex with Gbetagamma, and the details of combinatorial genetic and physiological interactions of

129 ns, thereby generating both multiallelic and combinatorial genetic diversity.

130 indromic repeats)-based screening system for combinatorial genetic manipulation that employs coexpres

131 Recent progress in rapid combinatorial genetic modelling, the development of a ge

132 lar recorders, genetic circuits, biosensors, combinatorial genetic perturbations, large-scale genome

133 and robust CRISPR-Cas12a-based approach for combinatorial genetic screening in cancer cells.

134 RNA (crRNA), we can achieve high efficiency combinatorial genetic screening.

135 rom Acidaminococcus (enAsCas12a) for pooled, combinatorial genetic screens in human cells.

136 Using a combinatorial genomics-assisted breeding and functional

137 t the missing phenotypes from an incomplete, combinatorial genotype-phenotype map.

138 CQ transport activity for the remaining 204 combinatorial genotypes between PfCRT3D7 and PfCRTDd2.

139 ed nucleosomes, resulting in the presence of combinatorial H3K4me3Q5ser in vivo.

140 Furthermore, a combinatorial high-throughput drug screen revealed signi

141 Multiple clinical trials with combinatorial immune checkpoint strategies are ongoing;

142 l studies can be used for rational design of combinatorial immune checkpoint strategies.

143 ng, but the long-term deleterious effects of combinatorial immunosuppression regimens and allograft f

144 notherapy, providing a promising approach to combinatorial immunotherapy for cancer.

145 Furthermore, by using a combinatorial in vitro and in vivo proteomics approach b

146 ysis, we generate nine different single-cell combinatorial indexed Hi-C (sci-Hi-C) libraries from fiv

147 we present a method for combined single-cell combinatorial indexing and messenger RNA labeling (sci-f

148 atin accessibility, we devised a three-level combinatorial indexing assay and applied it to 53 sample

149 The recent boom in microfluidics and combinatorial indexing strategies, combined with low seq

150 For gene expression, we applied three-level combinatorial indexing to >110 samples representing 15 o

151 PETRI-seq uses in situ combinatorial indexing(11,12,18) to barcode transcripts

152 play between PRMT5 and PRMT1, and found that combinatorial inhibitor treatment of small cell lung can

153 Density of combinatorial innervation is theorized to determine the

154 How the convergence of combinatorial inputs to principle neurons of associative

155 We analyze the combinatorial interaction of ligands loaded on polymeric

156 Together, the results suggest that combinatorial interactions between LEC1 and other transc

157 n this review, we discuss the concept of the combinatorial interactions of key transcription factors

158 and their specific functions are defined by combinatorial interactions with dynamic receptor complex

159 LEC1 controls diverse processes through its combinatorial interactions with other transcription fact

160 Combinatorial interference with their functions leads to

161 The combinatorial interplay of these enzymes raises question

162 ecifying each DNMT's activity, we engineered combinatorial knock-in of human DNMT genes in Komagatael

163 f this strategy is predicting how single and combinatorial knockdowns of monolignol specific gene tra

164 High-diversity genetically-encoded combinatorial libraries (10(8)-10(13) members) are a ric

165 approach enables scaling up the screening of combinatorial libraries and, together with parallel synt

166 has formed the basis for the development of combinatorial libraries from which potent pore-forming p

167 d de novo sequencing procedures and prepared combinatorial libraries with up to 100 million biohybrid

168 f transcriptional regulatory elements out of combinatorial libraries.

169 ex mixtures, such as interconverting dynamic combinatorial libraries.

170 d positional scanning synthetic glycopeptide combinatorial library (PS-SGCL) that vary in number and

171 The equilibrated dynamic combinatorial library contains, amongst various macrocyc

172 Herein, we report a newly developed combinatorial library of cholesteryl-based disulfide bon

173 Here, we developed a combinatorial library of ionizable lipid-like materials

174 e improvements by assessing the effects of a combinatorial library of oncogenes and tumor suppressors

175 ernate starter unit 3-hydroxybenzoic acid, a combinatorial library of six polyketide products is read

176 We deployed combinatorial library screening to isolate a binding-pro

177 ck and DEL reaction design and deployment in combinatorial library settings, providing a framework fo

178 access to novel chemical space by empowering combinatorial library synthesis with a "few good reactio

179 ted epistasis constraints among them using a combinatorial library that revealed their individual and

180 Our data provide a key to the combinatorial logic that gives rise to different modifie

181 rants may be processed in a more nuanced and combinatorial manner in the periphery, allowing for more

182 d OR antagonism occurred frequently and in a combinatorial manner.

183 A combinatorial map between PfCRT3D7 and PfCRTDd2 consists

184 rculean task to measure every phenotype in a combinatorial map.

185 ession and defining anatomical location in a combinatorial mechanism.

186 Combinatorial metabolomic and transcriptomic analysis re

187 Here we describe a combinatorial method to identify short ribozymes from li

188 exploring the cascaded impact of single and combinatorial modifications of monolignol specific genes

189 Combinatorial molecular codes that arise from neurotrans

190 Interestingly, we found that a simple combinatorial MSA sampling algorithm will in almost ever

191 Combinatorial multilayered thin-film chips covering the

192 Combinatorial mutant screens have the potential to routi

193 ined favorable individual changes to produce combinatorial mutants that showed further improvements i

194 This advanced cellular construct based on a combinatorial nano-engineering and biomaterial encapsula

195 Despite the combinatorial nature of mechanical, thermal, and biochem

196 The combinatorial nature of this code provides a rich set of

197 We further suggest that combinatorial neuropharmacology approaches should exploi

198 To address this point, combinatorial optimization approaches have been establis

199 In this article, we present a novel combinatorial optimization method, CONETT, for detection

200 This review focuses on current combinatorial optimization methods and emerging technolo

201 amiltonian, which can be used to solve other combinatorial optimization problems through polynomial-t

202 owers of genetics and chemical synthesis via combinatorial optimization.

203 tein with different fluorophores) for either combinatorial or sequential release, respectively.

204 er cell death, thus constituting a promising combinatorial partner for immune checkpoint blockers.

205 IP-Seq profiles, interpret and visualize the combinatorial patterns.

206 genetic alterations by identifying relevant combinatorial patterns.

207 e analysed by a shotgun MS approach based on combinatorial peptide ligand libraries and iTRAQ-LC-MS/M

208 To address this problem, we used combinatorial peptide-presenting phage libraries and nex

209 few have their origin from the screening of combinatorial peptidomimetic library.

210 thus could provide an efficient solution to combinatorial percept synthesis in a sensory system with

211 cell CRISPR screens to be easily paired with combinatorial perturbation libraries that contain dual-g

212 res with mAb 7A1 binding was isolated from a combinatorial phage-display library constructed from a m

213 hensive, comparative study of the effects of combinatorial phosphorylation states on protein kinase c

214 promoters on separate expression vectors and combinatorial plant transformation.

215 are demonstrated by preparing patterns from combinatorial polymer and block copolymer brushes.

216 pression information and prior knowledge and combinatorial predictions are supported by known interac

217 nic architectures to efficiently solve large combinatorial problems motivates the development of nove

218 Here, we highlight emerging work on combinatorial processes in the brain and consider this w

219 delta-band is modulated by lexically driven combinatorial processing beyond prosody, and that lingui

220 nucleosome binding, and determination of the combinatorial promoter epigenetic signature on individua

221 The protein accumulation achieved with the combinatorial promoter stacking expression system was st

222 scape of sarcomeric proteoforms arising from combinatorial PTMs, alternative splicing, and genetic va

223 s of active and passive microneedles allow a combinatorial rapid burst response along with slow, sust

224 moreceptors, PhOTseq identified the complete combinatorial receptor code for a specific set of ligand

225 The results suggest that the combinatorial regimen could be an effective supplement t

226 uction in cancer cells can be exploited in a combinatorial regimen.

227 erve as the basis for its potential study in combinatorial regimens for childhood cancer.

228 el of autoimmune diabetes using nonablative, combinatorial regimens involving the anti-CD3 (alphaCD3)

229 To understand combinatorial regulation, we present the immune Synergis

230 g. co-binding TFs), which helps decipher the combinatorial regulatory mechanisms.

231 ations: a) pattern separation, whereby dense combinatorial representations of odors are preprocessed

232 Our studies establish combinatorial roles of Fgfr1 and Fgfr2 in development an

233 se methods can be used together to implement combinatorial routes to further genome streamlining and

234 tational design method, loop-helix-loop unit combinatorial sampling (LUCS), that mimics nature's abil

235 Further, a combinatorial score of NEK10 and TP53-target gene expres

236 Here, we use a combinatorial screening approach to identify a bis-benzo

237 Large-scale combinatorial screening of the Human TFome will compleme

238 dies illustrate the power of two-dimensional combinatorial screening to define molecular recognition

239 election-based screen, named two-dimensional combinatorial screening, revealed preferences in small-m

240 rons of associative learning regions receive combinatorial sensory inputs.

241 n module (DRM) has the potential to unlock a combinatorial set of rationally designed biological resp

242 refinement of each TF's binding profile in a combinatorial setting.

243 t that, similar to other patterning systems, combinatorial signaling is likely to be a major driver o

244 elop a data-driven framework for identifying combinatorial signaling perturbations that drive cells t

245 -generation therapeutics will likely require combinatorial SMN-dependent therapeutics and SMN-indepen

246 A core component of human language is its combinatorial sound system: meaningful signals are built

247 ibe an active learning approach to explore a combinatorial space of ~4,000,000 cell-free buffer compo

248 pecific drug combinations in a vast chemical combinatorial space.

249 beta aggregates can be measured only through combinatorial spectroscopic experiments.

250 l expression of recombinant proteins using a combinatorial stacked promoter system.

251 Combinatorial strategies are needed to overcome the resi

252 relevant neuroadaptations, thereby providing combinatorial strategies for treating stimulant abuse.

253 However, we postulated that combinatorial strategies might be superior to single the

254 tand mechanisms of resistance and to develop combinatorial strategies to improve responses to checkpo

255 )-modified T cells, to solid tumors requires combinatorial strategies to overcome immune suppression

256 nt questions regarding treatment sequencing, combinatorial strategies, and the use of CDK4/6 inhibito

257 may be leveraged for the rational design of combinatorial strategies.

258 This combinatorial study of multiple transgenes targeting pri

259 Here, we present a combinatorial study of Pd-Cu thin-film electrodes with w

260 Screening of tumor extracts with a hybrid combinatorial substrate library (HyCoSuL) identified a c

261 asatinib in PDGFRalpha-driven glioma through combinatorial synergism and increased tumor accumulation

262 Combinatorial syntheses of such libraries require water-

263 urified compounds generated by mixture-based combinatorial synthesis techniques.

264 By bridging split-and-pool combinatorial synthesis with the ligation of unique enco

265 Our work, which allows combinatorial systems in animals to be more easily ident

266 Combinatorial targeting of JAK/STAT, PI3K, and "BCR-like

267 cs of the highest calibre currently focus on combinatorial targeting of specific oncoproteins and tum

268 ng focus on the development of precision and combinatorial therapeutic regimens, ERBB3 is increasingl

269 Here, we explore combinatorial therapeutic strategies for either preventi

270 trategy for LCA that emphasizes the need for combinatorial therapies to both improve vision and slow

271 ghlight the need for development of specific combinatorial therapies, targeting myocardial inflammati

272 o deliver immunotherapies, and assessment of combinatorial therapies.

273 CCs ex vivo, opening an avenue for improving combinatorial therapies.

274 A combinatorial therapy in mouse models of breast cancer i

275 YAP1 in rhabdomyosarcoma can be inhibited by combinatorial therapy of DNMTi and dasatinib, laying the

276 ral immune contexture, we demonstrate that a combinatorial therapy of intermittent C, CI, and vinorel

277 This novel combinatorial therapy promotes engraftment of autoantige

278 17 and checkpoint blockade represent a novel combinatorial therapy with potential efficacy for this l

279 nd interferon-insensitive CAR T cells enable combinatorial therapy with VSVmIFNbeta.

280 and sequential release of dual cargos toward combinatorial therapy.

281 l miRNA-based viral gene targeting strategy, combinatorial to traditional promoter-based strategies.

282 used to annotate regulatory factors, such as combinatorial transcription factor binding motifs and lo

283 datasets based on existing hypotheses about combinatorial transcription factor binding site (TFBS) p

284 This dual-component configuration allows for combinatorial transgene optimization and increases safet

285 One ongoing approach is to design combinatorial treatment of different ICIs with other rea

286 Combinatorial treatment of pharmacological inhibition of

287 ism of action could inform the design of new combinatorial treatment strategies that might be more ef

288 provides the basis on which to advance this combinatorial treatment toward early-phase human trials.

289 Strikingly, the combinatorial treatment with lapatinib [dual kinase inhi

290 The study illustrates how combinatorial treatments for aggressive, T cell-deficien

291 omodulatory therapeutic ineffective in these combinatorial treatments.

292 ation reshapes enhancer function through the combinatorial usage and repurposing of both lineage-dete

293 This suggests that the combinatorial use of BSP-GFPtpz and DSPP-Cerulean can be

294 iew these advances and propose ways in which combinatorial use of multifunctional recognition molecul

295 diversity is induced by naturally occurring combinatorial "V(D)J" rearrangement, mutation, and selec

296 The study provides a framework for combinatorial vaccine therapies that could mount robust

297 Vaccination with the combinatorial vaccine(s) was able to reduce HPV infectio

298 A combinatorial variation of ZipSeq efficiently scales in

299 Combinatorial viral tools were used to restrict the expr

300 Here we used a combinatorial viral vector approach to restrict activati