ライフサイエンスコーパス: combinatorial chemistry

1 nt inhibition of protein targets and dynamic combinatorial chemistry.

2 S-active molecules that would be amenable to combinatorial chemistry.

3 the future of high-throughput screening and combinatorial chemistry.

4 des synthesized in situ using light-directed combinatorial chemistry.

5 ug design lay in strategies involving solely combinatorial chemistry.

6 he array is synthesized using light-directed combinatorial chemistry.

7 tical route to receptor-biased computational combinatorial chemistry.

8 iversity element generated by split-and-pool combinatorial chemistry.

9 isation would normally be approached through combinatorial chemistry.

10 ide substrates through in silico docking and combinatorial chemistry.

11 ovalent reactions are widely used in dynamic combinatorial chemistry.

12 sing the all-in-solution approach of dynamic combinatorial chemistry.

13 ting macrocycles was developed using dynamic combinatorial chemistry.

14 lified by work with protein-directed dynamic combinatorial chemistry.

15 representing robust reactions, amenable for combinatorial chemistry.

16 ements of self-sorting phenomena and dynamic combinatorial chemistry.

17 due to the advent of parallel synthesis and combinatorial chemistry.

18 lays the foundation for improved encoderless combinatorial chemistry.

19 drug development, environmental testing, and combinatorial chemistry.

20 ty of substitution patterns for ready use in combinatorial chemistry.

21 perimental methodologies from the arsenal of combinatorial chemistry.

22 n was initiated using molecular modeling and combinatorial chemistry.

23 will provide an advantage in applications to combinatorial chemistry.

24 ly specific inhibitors, even with the aid of combinatorial chemistry.

25 hod for the solid-phase peptide synthesis in combinatorial chemistry.

26 Here, using DNA-programmed combinatorial chemistry, a collection of 100 million dis

27 the past two years, the burgeoning field of combinatorial chemistry and biology has witnessed major

28 esign, site-directed mutagenesis, screening, combinatorial chemistry and classical medicinal chemistr

29 New technologies in both combinatorial chemistry and combinatorial biology promis

30 We used combinatorial chemistry and high-throughput in vivo scre

31 ands by exponential enrichment) process uses combinatorial chemistry and in vitro selection to yield

32 ant step forward in the field of metal-based combinatorial chemistry and its application towards the

33 for monitoring enzyme specificity using both combinatorial chemistry and mass spectrometry where, as

34 Combinatorial chemistry and multicomponent reactions, co

35 Many similarities exist between research on combinatorial chemistry and natural products and researc

36 4-benzodiazepine, Bz-423, identified through combinatorial chemistry and phenotype screening are desc

37 cyclic amino ionizable lipids via sequential combinatorial chemistry and rational design.

38 otease inhibitors have been identified using combinatorial chemistry and structure-based design.

39 We have used combinatorial chemistry and structure-based drug design

40 With the advent of combinatorial chemistry and the extensive libraries of p

41 tems allow both for achieving complexity, by combinatorial chemistry, and addressing it, by switching

42 -release applications in parallel synthesis, combinatorial chemistry, and advanced drug design.

43 n of "omics" technologies, microRNA studies, combinatorial chemistry, and bioinformatics are providin

44 h-throughput screening for genetic analysis, combinatorial chemistry, and clinical diagnostics benefi

45 screening arising from protein engineering, combinatorial chemistry, and functional genomics.

46 Recent advances in fungal genomics, combinatorial chemistry, and high-throughput screening m

47 w that iterative chemical derivatization and combinatorial chemistry, and in particular the amine-ald

48 in fields such as industrial biotechnology, combinatorial chemistry, and life sciences is becoming i

49 the basis of classical medicinal chemistry, combinatorial chemistry, and structural approaches, yet

50 h the advent of synthetic peptide chemistry, combinatorial chemistry, and the large number of commerc

51 We designed these inhibitors with a combinatorial chemistry approach fusing selective LRRK2

52 trans-1,2-diaminocyclohexane using a dynamic combinatorial chemistry approach has been examined.

53 Here, we use a dynamic combinatorial chemistry approach to optimize heparin bin

54 peptide-nucleobase subunits, using a dynamic combinatorial chemistry approach.

55 lternative to established surface display or combinatorial chemistry approaches for the discovery of

56 ketide, and terpenoid and steroid classes in combinatorial chemistry approaches for the production of

57 e subsite preferences of these enzymes using combinatorial chemistry approaches.

58 logies such as high-throughput screening and combinatorial chemistry are revolutionizing drug discove

59 These results establish dynamic combinatorial chemistry as a powerful approach to develo

60 These results establish dynamic combinatorial chemistry as a practical method not only f

61 recombinant mature PfPM1 were explored using combinatorial chemistry based peptide libraries.

62 To realize the full potential of combinatorial chemistry-based drug discovery, generic an

63 reviously shown that the Bacterial Enzymatic Combinatorial Chemistry (BECC) adjuvants, BECC438 and BE

64 Finally, as the miniaturization needs of combinatorial chemistry become more clear, inkjet dispen

65 sis underpins many advances in synthetic and combinatorial chemistry, biology, and material science.

66 In addition, we have demonstrated that combinatorial chemistry can be utilized to identify mole

67 Both parallel synthesis and combinatorial chemistry can lead to the exploration of a

68 Combinatorial chemistry (combichem) has had a significan

69 The results challenge the combinatorial chemistry concept of target-family-privile

70 tegies: thermodynamically controlled dynamic combinatorial chemistry (DCC) and kinetically controlled

71 amine nanoporous networks (MNNs) via dynamic combinatorial chemistry (DCC) at the kilogram scale towa

72 Dynamic combinatorial chemistry (DCC) has emerged as a powerful

73 Dynamic combinatorial chemistry (DCC) has emerged as a promising

74 Dynamic combinatorial chemistry (DCC) is a subset of combinatori

75 This was achieved by using a biased dynamic combinatorial chemistry (DCC) library to generate a rece

76 The discovery through dynamic combinatorial chemistry (DCC) of a new generation of don

77 lored; the possibilities for uses in dynamic combinatorial chemistry (DCC) or click chemistry were ex

78 The approach, termed dendrimer-supported combinatorial chemistry (DCC), centers on the use of den

79 Through combinatorial chemistry, DELs can grow to the unpreceden

80 The SELEX method and oligonucleotide combinatorial chemistry discovery process yields high-af

81 Combinatorial chemistry drives the biological generation

82 ication, and structure-based drug design and combinatorial chemistry for lead optimization.

83 apidly changing developments in genomics and combinatorial chemistry, generating new drug targets and

84 Combinatorial chemistry has become a popular tool for th

85 Combinatorial chemistry has deeply impacted the drug dis

86 Target-directed dynamic combinatorial chemistry has emerged as a useful tool for

87 Combinatorial chemistry has given chemists access to vas

88 The recent emergence of combinatorial chemistry has greatly advanced the develop

89 Dynamic combinatorial chemistry has proven to be a useful tool i

90 Recently, combinatorial chemistry has risen to this challenge, and

91 Phage display, SELEX and other methods of combinatorial chemistry have become very popular means o

92 y - genomics, high-throughput screening, and combinatorial chemistry - high-throughput screening has

93 In the last several years, through combinatorial chemistry, high-throughput and virtual scr

94 In the last 5 years, through combinatorial chemistry, high-throughput screening, comp

95 Solution phase combinatorial chemistry holds an enormous promise for mo

96 diversity descriptor particularly useful for combinatorial chemistry involving variations around a fi

97 Combinatorial chemistry is gaining wide appeal as a tech

98 Combinatorial chemistry is now commonplace in the pharma

99 rapidly scanning the extensive experimental combinatorial chemistry libraries now available for high

100 e identification of consensus sequences from combinatorial chemistry libraries or phage display.

101 By screening unbiased combinatorial chemistry libraries, using a cAMP-responsi

102 jection molecular weight characterization of combinatorial chemistry libraries.

103 now allowing us to analyze complex mixtures, combinatorial-chemistry libraries, bound drugs, unstable

104 Dynamic combinatorial chemistry linked to mass spectrometric ana

105 here, the study of immune recognition using combinatorial chemistry may offer new insights into the

106 icularly important since the one-dimensional combinatorial chemistry method developed by us allows fo

107 o methods to select high-affinity ligands by combinatorial chemistry methodologies promises unique an

108 of libraries of porous polymers prepared by combinatorial chemistry methods.

109 Using dynamic combinatorial chemistry, mixtures of dipeptide monomers

110 ed, the use of nucleic acid-directed dynamic combinatorial chemistry (NA-D DCC) is relatively limited

111 available compound libraries generated using combinatorial chemistry or derived from natural products

112 emistry, biomaterials and hydrogels, dynamic combinatorial chemistry, organic synthesis, and chemical

113 Protein-directed dynamic combinatorial chemistry (P-D DCC) is a powerful strategy

114 d library (DEL) technology, the now-dominant combinatorial chemistry paradigm.

115 One such combinatorial chemistry process, systematic evolution of

116 lution of ligands by exponential enrichment) combinatorial chemistry process.

117 as a secondary lead for the second round of combinatorial chemistry, producing a number of low-micro

118 Using combinatorial chemistry, pyrroles substituted with elect

119 Using a combination of virtual combinatorial chemistry, QSAR modeling, and molecular do

120 We have employed resin-bound dynamic combinatorial chemistry (RBDCC) to identify the first ex

121 Technologies such as combinatorial chemistry, recombinant DNA as well as comp

122 Encoderless combinatorial chemistry requires high-throughput product

123 Using two cross-validating combinatorial chemistry screening approaches, one using

124 aptamers, developed by oligonucleotide-based combinatorial chemistry, SELEX (systematic evolution of

125 of powerful new drug discovery technologies: combinatorial chemistry; sequence and functional genomic

126 This work combines the advantages of combinatorial chemistry, site-specific solid-phase radio

127 e.g., natural products) and synthetic (e.g., combinatorial chemistry) sources of molecular diversity.

128 y of potential drug candidates (usually from combinatorial chemistry) supplied as dimethyl sulfoxide

129 c world are cells in diagnostics or beads in combinatorial chemistry (tags).

130 hese results underscore the power of dynamic combinatorial chemistry targeting complex and elusive bi

131 more physico-chemical studies and the use of combinatorial chemistry techniques combined with solid p

132 ed using the OntoBLOCK system, a solid-phase combinatorial chemistry technology, in combination with

133 -in combination with structural genomics and combinatorial chemistry-the flood of new data is current

134 s of genes, as well as any other solid-phase combinatorial chemistry to be performed in high-density

135 itors demonstrate the power of target-driven combinatorial chemistry to deliver bivalent drugs in a s

136 The prognosis for combinatorial chemistry to discover fundamentally differ

137 ticular interest in combination with ceramic combinatorial chemistry to generate a library of e.g. cu

138 One tripeptide arm was prepared using combinatorial chemistry to generate the differential nat

139 We previously used Dynamic Combinatorial Chemistry to identify the first compounds

140 TLR triagonist adjuvant platform, which used combinatorial chemistry to link three different TLR agon

141 f combining structure-based drug design with combinatorial chemistry to produce effective species-spe

142 One-bead one-compound combinatorial chemistry together with a high-throughput

143 The biocatalytic approach to combinatorial chemistry uses enzymatic, chemoenzymatic,

144 Combinatorial chemistry was used to define the optimal s

145 Dynamic combinatorial chemistry was utilized to identify a novel

146 Using this combinatorial chemistry we encode more than 1.8 million

147 Accordingly, using combinatorial chemistry we evolved a small molecule agon

148 ibraries generated with reactions of dynamic combinatorial chemistry when rendering libraries pseudos

149 combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interc