ライフサイエンスコーパス: combinatorially

1 evels, which allows the pathways to function combinatorially.

2 se residues are not specified and are varied combinatorially.

3 heart tissue, involves two components acting combinatorially.

4 chains were not constrained and were varied combinatorially.

5 molecular interactions that are readily used combinatorially.

6 alpha- and beta-tubulin tails, and these act combinatorially.

7 and receptors recognizing these determinants combinatorially.

8 th multiple activators and repressors acting combinatorially.

9 suggesting that these miRNAs might function combinatorially.

10 ors that bind DNA and modulate transcription combinatorially.

11 y, individual members of which are expressed combinatorially.

12 nergic neurons, en masse or a subset defined combinatorially.

13 tion factors that regulate these changes act combinatorially.

14 were found among the HSC clones even though combinatorially 54 groups were possible.

15 otic cells is complex and is orchestrated by combinatorially acting transcription factors.

16 TP53, BCL2, cyclin D1, MMSET/NSD2 and c-MAF) combinatorially activated in B lymphocytes following T c

17 Here, we engineer a combinatorially activated T cell circuit in which a synt

18 ally control some differentiation events and combinatorially affect others.

19 A key insight is that activators often work combinatorially, allowing signal integration.

20 The effect of individually and combinatorially altering these nine cysteines was examin

21 ssue, Wnt family members are often expressed combinatorially, although the significance of this is no

22 ell- or myeloid-targeting activators, and we combinatorially analyzed outcomes using partial least sq

23 n but present challenges because they signal combinatorially and exhibit overlapping activities in vi

24 d mechanism with dozens of effectors working combinatorially and following principles analogous to tr

25 factory bulb network that can reproduce both combinatorially and temporally sparse mitral cell codes.

26 can be used to pre-encode skeletal diversity combinatorially and thereby generate such small molecule

27 ion factors distinguish neuronal populations combinatorially, and exhibit extremely low transcription

28 Using a library of ~2,000 strands that are combinatorially arranged to create unique DNA-origami sl

29 vidually but are also capable of functioning combinatorially as a pattern.

30 hese results suggest that these proteins can combinatorially assemble into distinct 9-1-1 clamps that

31 For about half of the combinatorially assembled consortia, the amylolytic func

32 BAF53b is combinatorially assembled into polymorphic complexes wit

33 hat dendritic outgrowth requires a family of combinatorially assembled, neuron-specific chromatin rem

34 143 with dual-purpose degron/imaging tags to combinatorially assess their looping function and effect

35 ese results suggest that KIF3 family members combinatorially associate to power anterograde axonal tr

36 tic process by which a diverse repertoire of combinatorially assorted cytokine gene expression patter

37 a densely interconnected circuit by binding combinatorially at their own, and each other's, regulato

38 (a) slow due to the need to exhaustively and combinatorially break molecules and (b) inaccurate as th

39 al-specific gene expression may be regulated combinatorially, but the transcriptional mechanisms gove

40 lation pattern of this reporter is regulated combinatorially by a set of nine maternally supplied RBP

41 ic and that its activities can be controlled combinatorially by different inhibitory ligands.

42 red together, odors appear to be represented combinatorially by dynamical neural assemblies, defined

43 ere that arterial specification is regulated combinatorially by Notch signaling and SoxF transcriptio

44 Odor perceptions are encoded combinatorially by ORs and can be altered by slight chan

45 7), Cys(379), and Cys(408), were substituted combinatorially by Ser.

46 The pattern of Pn.p cell fusion is regulated combinatorially by two genes of the C. elegans Hox gene

47 lar and rapid interrogation of gene function combinatorially (C-CHIME), inducibly (I-CHIME), lineage-

48 synthesized on a programmable microarray and combinatorially cloned into a single scFv framework for

49 A combinatorially complete data set consists of studies of

50 se of a mathematical model parametrised with combinatorially complete fitness landscapes for Escheric

51 ions in the experimentally characterized and combinatorially complete fitness landscapes of a protein

52 -antitoxin systems as a model, we screened a combinatorially complete library of antitoxin variants a

53 easure equilibrium dissociation constants of combinatorially complete mutational libraries for two na

54 lving mostly single and double mutants, or a combinatorially complete subgraph involving only two ami

55 We present here a combinatorially complete, 160,000-variant fitness landsc

56 We conclude that combinatorially complex histone-based chromatin is not r

57 y approach wherein synthetic communities are combinatorially constructed and assayed in high throughp

58 gments (IRES modules) that independently and combinatorially contribute to overall IRES activity.

59 hanisms by which distinct signaling pathways combinatorially control proliferation during organogenes

60 This pathway is combinatorially controlled by at least two genes that ha

61 ast, the pathways of sulfur assimilation are combinatorially controlled by five transcriptional regul

62 nd that a much greater fraction of genes are combinatorially controlled than previously reported by c

63 , epoxide-functionalized block polymers were combinatorially cross-linked with a diverse library of a

64 rotonergic silencing, only one mapped to the combinatorially defined subset.

65 g the yeast galactose network as a model, we combinatorially deleted one of the two copies of its fou

66 implemented for high-throughput screening of combinatorially developed organic protective coatings fo

67 copic system for high-throughput analysis of combinatorially developed protective organic coatings ar

68 Recruitment of combinatorially distinct AP-1 complexes to these element

69 protective gammadelta IEL compartments, with combinatorially diverse heteromers having differential i

70 family in particular, in the generation of a combinatorially diverse Tcra repertoire.

71 Remodeling events appeared to be combinatorially driven by multiple TFs, with distinct TF

72 ut suggest that inhibitory circuits assemble combinatorially during odor presentations.

73 , we show that the four ETS factors function combinatorially during vascular and hematopoietic develo

74 This was accomplished by combinatorially editing the genome via gene deletions an

75 ate in molecular detail how protein kinase A combinatorially effects a key developmental switch.

76 structural variants in a complex mixture of combinatorially engineered Escherichia coli lipid A.

77 ough the simultaneous mapping of millions of combinatorially engineered genomes at single-cell resolu

78 rate a library of isogenic HEK293 cells with combinatorially engineered glycosylation capacities desi

79 illium funiculosum Cel7A were identified and combinatorially engineered into P. funiculosum cel7a, ex

80 Mechanistically, TFs combinatorially ensure expression of RBPs, which interac

81 Do the ligands act combinatorially, ensuring appropriate three-dimensional

82 te search space of atomic coordinates into a combinatorially enumerable search space.

83 eton Skel(left floor rhod right floor)(P) is combinatorially equivalent to Skel( left floor rhod righ

84 We selected 29 candidate genes to combinatorially express in Nicotiana benthamiana (tobacc

85 progress has been made in understanding how combinatorially expressed transcription factors control

86 interleukin 12 (IL-12) family are assembled combinatorially from shared alpha and beta subunits.

87 rove generalization, we augment PMechDB with combinatorially generated reactions and train models spa

88 topography, we experimentally surveyed 2176 combinatorially generated shapes embossed into polymers

89 n unbiased oligonucleotide library it should combinatorially identify energetically preferred hybridi

90 y natural ways to define group homophily are combinatorially impossible.

91 that these tuning modules can be implemented combinatorially in a predictable manner to further impro

92 te that TRiC contacts full-length substrates combinatorially in a subunit-specific manner.

93 sion patterns is evident; thus, XTHs may act combinatorially in determining wall properties of specif

94 this region are each necessary and function combinatorially in ERK-activated transcription.

95 t, while Prd can use its DNA-binding domains combinatorially in order to achieve different DNA-bindin

96 rotein structural information is pre-encoded combinatorially in polypeptide sequences, thus making it

97 s cells and are expressed stochastically and combinatorially in single neurons.

98 rtant facial social judgements are processed combinatorially in the amygdala.

99 n of the two factors allows them to function combinatorially in the regulation of cardiac gene expres

100 The pyknons arrange combinatorially in the untranslated and coding regions o

101 factors and Semaphorin/Plexin repellents to combinatorially increase Mical-mediated F-actin disassem

102 s splint oligonucleotides (oligos) to enable combinatorially indexed dsc-seq of DNA-barcoded antibodi

103 esults demonstrate that promoter activity is combinatorially influenced by recruitment of TFIID and s

104 thesis of aromatic amino acid derivatives by combinatorially inserting multiple T7 promoters simultan

105 SKY is based on cohybridization of combinatorially labeled chromosome-painting probes with

106 brary of 96 synthetic barcode sequences that combinatorially labels each cell.

107 bles simultaneously, as this would require a combinatorially large number of mixed selectivity neuron

108 ants of nanoparticles can be manufactured in combinatorially large sets, varying by only one transpor

109 gies often fail to meet the demands of these combinatorially large systems.

110 er of potential interactions to be tested is combinatorially large.

111 w that a mixture of peptide fragments can be combinatorially ligated and used directly in affinity se

112 in-situ mutagenesis in multiple genomic loci combinatorially limits the study of complex biological f

113 ylome suggested that RIP and DNA methylation combinatorially maintain G. sinense genome stability by

114 port analysis of complex mixtures of lipid A combinatorially modified during development of vaccine a

115 using peptide arrays containing a library of combinatorially modified histone peptides.

116 over, surfactin and riboflavin titers of the combinatorially mutant strains improved by 42% and 15-fo

117 l changes targeted throughout the genome and combinatorially optimize complex (multigenic) traits usi

118 Thus, CRX combinatorially orchestrates the transcriptional network

119 g its unique strength to efficiently profile combinatorially perturbed cells.

120 haromyces cerevisiae laboratory backgrounds, combinatorially perturbed in histidine, leucine, methion

121 ns is a broad host range plant pathogen that combinatorially recognizes diverse host molecules includ

122 local sampling also produced GrCs that were combinatorially redundant, even when input diversity was

123 at the transcription factors Twist and Snail combinatorially regulate a multicellular pattern of late

124 me2, AR and FoxA1 within the same CTCF block combinatorially regulate a subset of distally located an

125 r and a heptad of transcription factors that combinatorially regulate genes in HSCs.

126 ulsatile transcription factors Msn2 and Mig1 combinatorially regulate their target genes through modu

127 coherent sets of functionally related mRNAs combinatorially regulated by common RBPs.

128 lar analysis of ThrbCRM1 revealed that it is combinatorially regulated by the Otx2 and Onecut1 transc

129 ow that podocyte expression of some genes is combinatorially regulated by two transcription factors i

130 signaling constitutes a second pathway that combinatorially regulates Sbf/Rab35 recruitment.

131 These interfaces combinatorially reinforce each other, suggesting coat ol

132 In Saccharomyces cerevisiae, we combinatorially replace all regulatory network promoters

133 of three cell-specific TFs and two RBPs are combinatorially required for sad-1 exon inclusion.

134 These three different cytotoxic cells combinatorially responded to viremia, showing a relative

135 is of plasticity: the sets of genes that are combinatorially selected by exogenous and endogenous env

136 Combinatorially selected defense peptides, previously sh

137 Newly developed algorithms deconvolved combinatorially selected ions to identify and quantify P

138 We demonstrate that a combinatorially-selected dodecapeptide and its variants

139 LA3 (AP3), PISTILLATA (PI), and AGAMOUS (AG) combinatorially specify the identity of Arabidopsis flor

140 many mechanistic step types that were later combinatorially spread in catalytic history.

141 le with respect to individual traits but are combinatorially strong.

142 ss this need, we view bio-ontologies more as combinatorially structured databases than facilities for

143 The transplastomic plants were then combinatorially supertransformed with cassettes for all

144 activity and pioneer factor function can be combinatorially suppressed.

145 We combinatorially synthesize 180 cationic, degradable lipi

146 , a large number of dipeptide aldehydes were combinatorially synthesized and manually evaluated for t

147 ing both commercially available polymers and combinatorially synthesized cross-linked polymers.

148 A combinatorially synthesized RNA ligand and a cocaine ana

149 Pools of related dipeptide aldehydes were combinatorially synthesized, and the most active pool wa

150 ng protein 2 (MECP2) restoration for RTT and combinatorially target factors in the interactome of Xis

151 tumor suppressor and provide a rationale for combinatorially targeting proto-oncogenic tyrosine kinas

152 We find that PNs use lineage and birth order combinatorially to build the initial dendritic map.

153 Transcription factors (TFs) bind combinatorially to cis-regulatory elements, orchestratin

154 ent findings suggest that these TFs are used combinatorially to code for cellular determination in th

155 of olfactory receptors (ORs), which are used combinatorially to detect different odorants and encode

156 hways to control gene expression and can act combinatorially to enforce or reverse epigenetic marks i

157 Instead, stickers and spacers act combinatorially to ensure localization, mechanosensing,

158 changes in all three genes together function combinatorially to further promote cell viability.

159 ronmental signals, which are often processed combinatorially to generate particular phenotypic respon

160 ronmental signals, which are often processed combinatorially to generate specific genetic responses.

161 infection, whereas TLR7 and TLR9 contribute combinatorially to immune responses as infection progres

162 that compound genetic variants can interact combinatorially to induce DCM, particularly when influen

163 a mechanism by which secreted morphogens act combinatorially to induce the stable expression of targe

164 der set of potent therapeutic tools that act combinatorially to inhibit metastatic prostate cancer.

165 The leg gap genes act combinatorially to initiate the expression of the Notch

166 w input features contribute individually and combinatorially to network decisions.

167 Although it is known that miRNAs act combinatorially to regulate genes, precise identificatio

168 structure was tuned both systematically and combinatorially to select optimal vectors.

169 born neuronal identity; that Pdm and Cas act combinatorially to specify a temporal identity distinct

170 sis, responds precisely, differentially, and combinatorially to three chemically distinct tubulin mod

171 where multiple motifs within PNUTS are used combinatorially to tune binding affinity to PP1, and the

172 ite mechanism where multiple motifs are used combinatorially to tune binding affinity to PP1.

173 ological programs may reflect its ability to combinatorially use multiple site selection criteria.

174 ofilament dynamics, how these regulators are combinatorially utilized in organismal tissues to genera

175 the parts, containing identity elements, and combinatorially varies all other parts to generate chime

176 Individually and combinatorially, we applied these therapies to disease-s

177 ises the possibility of gene targeting PSIP1 combinatorially with CCR5 for HIV-1 cure.

178 The cis-acting elements function combinatorially with documented examples of synergism, a

179 (ii) demonstrate that Mcm1-Fkh2 can function combinatorially with other activators to yield late M/G(

180 turnover or repressing translation, and act combinatorially with other regulatory proteins.

181 of hematopoiesis GATA-1 and GATA-2 function combinatorially with Scl/TAL1, another key regulator of

182 The cardinality of this set grows combinatorially with the number of network nodes, which

183 h the number of possible intermediates grows combinatorially with the number of subunits in the capsi

184 an upstream activator of Dpp and Wg, Ci acts combinatorially with them to activate D/V-h expression.

185 The second-order neuron L3 acts combinatorially with two previously known inputs, L1 and

186 ct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in spec

187 lating activities act with cohesin, alone or combinatorially, with or without CTCF, to implement prec

188 ests that Mcm ATPase active sites are formed combinatorially, with Walker A and B motifs contributed