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1 nd LeuP10, into a depression in the antibody combining site.
2  the encoded proteins to form a polyspecific combining site.
3 lace the antigenic peptide away from the TCR combining site.
4 ll geometry approximating CDRs in the parent combining site.
5 urface that diametrically opposes the normal combining site.
6 Fab')2 molecule containing only a single 7E3 combining site.
7 itopes or differential positioning in the Ag combining site.
8 ete alpha helical segment of the MHC antigen combining site.
9  inhibitory anti-LMO2 intracellular antibody combining site.
10 at binds deeply into a cleft in the antibody-combining site.
11 bility and complexity in the topology of the combining site.
12 op connecting two alpha-helices of the F-box-combining site.
13 n of the polar lactam moiety in the antibody-combining site.
14 e catalytic activity belongs to the antibody combining site.
15 RPAP sequence is immobilized in the antibody-combining site.
16 89), which reorients to form the base of the combining site.
17 , or both chains in forming the 23F-specific combining site.
18  to maintain the structural integrity of the combining site.
19 ructural plasticity in the germline antibody-combining site.
20 wo have indirect effects on the shape of the combining site.
21 ion of the cocaine molecule at their antigen-combining site.
22 er of different amino acid residues in their combining sites.
23 so present in eluates which blocked anti-DNA combining sites.
24  using at most one or two gene pairs to form combining sites.
25 s that bind to proteins have relatively flat combining sites.
26 attern of conserved configurations for their combining sites.
27 tive selection were associated with antibody combining site A or B or the sialic acid receptor bindin
28 gested that the overall shape of the antigen combining site (ACS) of antibodies is correlated with th
29 nce of both anti-DNA and antiidiotypic (anti-combining site) activity in human anti-DNA Id column elu
30 ical with that of WT Ab, suggesting that the combining site adopts a WT conformation.
31 ion between one high-affinity anti-HIV-gp140 combining site and a second low-affinity site on another
32  Ligand recognition was via the alphabetaTCR combining site and involved the identical germline-encod
33 e Trp420 side chain is largely buried in the combining site and that the Asn417 side chain, which is
34 2 formed typical IgG monomers containing two combining sites and a small fraction of a higher-molecul
35 try to monitor both occupancy of surface IgE combining sites and association of antigen with the cell
36 hain Fv clones mimicking physiological VL-VH-combining sites and minority IgV populations with nonphy
37  corresponds to a 2G12 dimer containing four combining sites and present a model for how intermolecul
38 gents with different architectures, antibody combining sites, and linkers.
39 orces that steer the antigen to the antibody-combining site are computed by solving the linearized Po
40 ordered water molecules in the free antibody-combining site are retained and that additional waters a
41 omposed of soluble CD59 fused to an antibody-combining site at the end of CH1, after the hinge (H), a
42 to the transplantation of an intact antibody-combining site between a rodent and a human framework, a
43  to be held 4 angstrom further down into the combining site between the 2 variable domains.
44 -terminal domain extending over the antibody-combining site, blocking entry to large antigens.
45 ic antibody capable of blocking SLE anti-DNA combining sites bound to Id+ affinity columns.
46  antibody possessed a large and deep antigen combining site bounded primarily by the third complement
47             This process changes the antigen combining site by replacing a portion of the original V(
48 egions (CDR) forming the structure of the Ab combining site, CDR3 of heavy chain is the most variable
49 , ABT-325 and 125-2H differ significantly in combining site character and architecture, thus explaini
50 mmune disease, and open the possibility that combining site chemical reactivity is a factor driving t
51  of inner strands, thus placing the receptor combining sites close to the sheets.
52 f germline antibodies to adopt more than one combining-site configuration, with both antigen binding
53                                          The combining site consists of a deep cleft, heavily lined w
54 at the center and at the periphery of the D5 combining site contribute to shape complementarity and e
55 ed distance and flexibility between antibody combining sites correlated with enhanced neutralization
56 am LUDI was used to epitope map the antibody-combining site, correlating peptide reactivity patterns.
57 verse of potential antigens and how antibody-combining sites could be tailored to engage antigens wit
58 oids are inserted more deeply into the 1E9dm combining site, creating more hydrophobic contacts that
59                                           By combining site-directed mutagenesis and sequencing, we d
60 function of L5 in the mitotic kinesin Eg5 by combining site-directed mutagenesis of L5 with transient
61                                           By combining site-directed mutagenesis with femtosecond spe
62                                           By combining site-directed mutagenesis, biochemical assays,
63                                           By combining site-directed mutagenesis, heterologous expres
64 sidues for oxygen diffusion were verified by combining site-directed mutagenesis, rapid kinetics expe
65                         S55-3 and S55-5 have combining sites distinct from anti-lipid A antibodies pr
66 ortion of the Ig sequence for determining Ab combining site diversity, our data provide the molecular
67  providing a significant contribution to TCR combining site diversity.
68 A minimal conserved motif in the pristine Ag-combining site essential for multispecificity and Ag bin
69 of amino acid sequence convergence in the Ag combining sites exhibited by members of independent clon
70                                 The antibody-combining site features a long (22 amino acid residues)
71 aDeltaG(Ala-WT) >or= 1 kcal/mol) that formed combining site features critical to the affinity of the
72 or "preconfigured flexibility" by modulating combining site flexibility.
73 lic acid is an essential element of the mZP3 combining site for sperm.
74 -linked oligosaccharides located at the mZP3 combining site for sperm.
75 find Abd compounds as surrogates of antibody-combining sites for novel drug development in a range of
76 ency is modulated by two cavities in the TCR combining site, formed mainly by CDRs 3alpha, 3beta, and
77  demonstrate that evolution localized the Ab-combining site from a heterogeneous ensemble of conforma
78                               The variety of combining sites generated by diversification within indi
79 pears to occur through reorganization of the combining site geometry in a manner that optimizes the b
80 peptide binding complements the shape of the combining site groove much better than pentasaccharide b
81       Conformational flexibility in antibody-combining sites has been hypothesized to facilitate poly
82 Despite the low affinity of the polyreactive combining site, heteroligation demonstrably increases th
83                 The structure of the antigen combining site in the complex is nearly identical to tha
84 r nonadditivity will be observed only if the combining sites in both associating proteins involve lar
85                      The number of bound IgE combining sites in excess of the number of bound antigen
86 require a structural fitness of the antibody combining site involving heavy and light chain variable
87 ural mimicry of the DENV E epitope by the E1 combining site is achieved via the formation of numerous
88                                      The TCR combining site is relatively flat except for a deep hydr
89 tation of the cyclic peptide in the antibody-combining site is rotated by 180 degrees compared to the
90                A key feature of the antibody-combining site is the protruding, finger-like long CDR H
91 anti-anti-idiotypic mAb GH1002 through their combining sites is extremely tight and intricate, closel
92 ctable change in the microenvironment of the combining site, it did alter the kinetic parameters of b
93                            The more flexible combining sites likely result from longer HCDR3 loops an
94 and equilibrium dialysis suggested two sugar-combining sites located in subdomains 1 alpha and 2 gamm
95 c antibodies are characterized by an antigen-combining site mediating specific interactions with two
96 nificant changes in the configuration of the combining site occur upon binding of hapten to the germl
97 tact residues, it is possible to reorder the combining site of a high affinity antibody, resulting in
98  have examined the plasticity of the antigen-combining site of a high-affinity antibody.
99 ymorphonuclear neutrophils; effect on the Ab-combining site of Abs; and in vivo inflammatory activity
100 s initially started in 1970 to determine the combining site of antibodies based on the available amin
101 s initially started in 1970 to determine the combining site of antibodies based on the available amin
102 (CDRs) located in the center of the antibody combining site of C6.5, a human single-chain Fv (scFv) i
103 alanine substitutions were introduced in the combining site of D1.3, and their effects on affinity fo
104 ubstitutions in 9 out of 21 positions in the combining site of E5.2 involved in contacts with D1.3 an
105                                  The antigen combining site of HuCC49DeltaCH2 is very similar, but no
106                                          The combining site of RA6.3 was epitope mapped using a novel
107 -imidazole cofactor is incorporated into the combining site of the aldolase antibody 38C2.
108      Comparative analysis of the groove-like combining site of the toxin-bound anti-AahII Fab and pla
109 benzoic acid molecule was sequestered in the combining site of the unliganded antibody.
110 linked oligosaccharides located at the sperm combining site of zona pellucida glycoprotein mZP3.
111 r understand how the relatively flat antigen-combining sites of antibodies interact with the concave
112 Possible interactions of fullerenes with the combining sites of IgG are discussed based on the physic
113                             In contrast, the combining sites of the unliganded mouse and humanized an
114 igenic features, usually associated with the combining sites, of other antibodies.
115 ctin has two different types of carbohydrate-combining sites: one type for oligomannoses, which prefe
116   Antibody 38C2 features a large hydrophobic-combining site pocket with a highly nucleophilic lysine
117                The hapten complex revealed a combining site pocket with high shape complementarity to
118 origins that generate two markedly different combining-site pockets that are complementary both in sh
119                              The 7A9 antigen combining site presents a groove resembling the structur
120      Insights into the evolution of antibody-combining sites provided by this and other structural st
121 Rs, which use an Ab-like structure to form a combining site, recognize molecular complexes consisting
122                                          The combining site residues of complexed Fab HyHEL-63 exhibi
123 proteins through essentially the same set of combining site residues.
124            Based on a molecular model of the combining site, residues at the base (Arg98 and Asp108)
125 pyramid array for intravesicular analysis by combining site-selective dielectrophoresis (DEP) and Ram
126 extended turn conformation within the BR55-2 combining site, serving to overlap the peptides with the
127 ave analysed antigen-contacting residues and combining site shape in the antibody Fv and Fab crystal
128  secondary structure and may contain similar combining site shapes.
129 idues which are located centrally within the combining site; some less central CDR residues are only
130 nes encode a substantial element of antibody combining site specificity, there is scant evidence for
131 alyzed for VH-D-J(H) gene usage and antibody combining site structure.
132 s been developed and applied to the antibody combining site surfaces.
133 alactosides, it has an extended carbohydrate-combining site that exhibits highest specificity and aff
134                    The reorganization of the combining site that was nucleated by hapten binding is f
135 series of architectures for the b12 and 4E10 combining sites that differed in size, valency, and flex
136 D) domain-swapped structure with two aligned combining sites that facilitates recognition of its carb
137                                       In the combining site, the grafted CDRs retained conformational
138 bonds in an elongated groove in the antibody-combining site through interactions with Complimentarity
139  PAK-13, which would allow the same antibody combining site to accommodate either trans or cis topolo
140 thod for selection and evolution of antibody combining sites using antibody-ribosome-mRNA (ARM) compl
141                   We have also sequenced the combining sites (variable regions) of the antibodies and
142 ted that release of CRM107 from the antibody combining site was fast, and its toxic action was unimpe
143                                          The combining site was found to be relatively flat, like oth
144 s (DeltaG degrees (nonel)) at the anti-ssDNA combining site was used for the estimation of the specif
145           Significant inhibition of SLE APAD combining sites was observed with eluates from anti-DNA
146 o distinctly different types of carbohydrate-combining sites was purified from tubers of Xanthosoma s
147 ues that potentially interact with the RA6.3 combining site were identified by data base screening us
148                                     Antibody combining sites were fully occupied at pH 5.5, partially
149 with an Fd region known to generate a Hib PS-combining site when paired with an A2-Arg(95a)-Jkappa1 V
150 nsive structural rearrangements occur in the combining site, where residue H47 acts as a specificity
151 or the core oligosaccharide is buried in the combining site, which explains the lack of LPS recogniti
152 or the core oligosaccharide is buried in the combining site, which explains their inability to recogn
153                          Within the antibody-combining sites, which are dominated by the protrusion o
154 nds revealed a considerably altered antibody-combining site with a closed binding pocket.
155     The riboflavin is located in the antigen-combining site with its isoalloxazine ring stacked betwe
156 tigen is bound in the middle of the antibody combining site with most of the six complementarity-dete
157 ular region of DAF was joined to an antibody combining site with specificity for the hapten dansyl, a
158 body 93F3 Fab' at 2.5A resolution revealed a combining site with two lysine residues, including LysL8
159                            This diversity of combining sites within B cell clones supports the propos

 
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