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1 sitivity for low numbers of arrays, but this came at a cost of high false positive results (24% false

2 required for rescue and that colocalization came at a cost to L. pneumophila fitness.

3 r, housing with a sterile male early in life came at a cost to lifespan, which was observed in the ab

4 when exposed to a lethal predator, but this came at a cost to their growth.

5 hen the invader was common, but these traits came at a cost when the invader was rare.

6 imulation following sunlight exposure of DOM came at a cost.

7 t this protection of the newly formed memory came at a cost.

8 Resistance to AmB came at a great cost.

9 This remarkable improvement came at a price: adapting directions that before learnin

10 However, these benefits came at a substantial cost: The reconciliation treatment

11 e usefulness of rockets for this application came at a time when measurements had not been made above

12 zobia intensify with decreasing N supply and come at a carbon cost to the host.

13 accuracy and quality in variant calling can come at a computational cost.

14 tionality characteristic of active sites has come at a considerable cost to enzyme stability.

15 tion to the public (e.g., URL inclusion) may come at a cost in terms of message amplification; on the

16 tive to the baseline emission pathway) would come at a cost of 0.3-0.5 degrees C additional warming d

17 However, evolving resistance to one drug may come at a cost of decreased fecundity or increased sensi

18 TAC minimization may come at a cost of higher rates of dnDSAs, and TAC time i

19 The dramatic improvement in cancer has come at a cost of increased risks of life-threatening in

20 f neurotransmitter biosynthesis, it may also come at a cost of insufficient development of immune sel

21 These modern materials come at a cost of toxicity as well as being derived from

22 However, curiosity may come at a cost that sometimes puts people in harmful sit

23 e survival in the presence of predators, but come at a cost to growth.

24 a superior ability to resist herbicides may come at a cost to overall plant fitness.

25 ons, which lead to new protein functions but come at a cost to protein stability.

26 ion of this restriction mechanism by HPV may come at a cost to the host by promoting cancer mutagenes

27 At the same time, this reprogramming may come at a cost with resultant metabolic vulnerabilities.

28 Given that sex is assumed to come at a cost, these mixed reproductive strategies typi

29 l to improve response precision might itself come at a cost--a cost to attenuate a proportion of intr

30 inical benefit observed in many patients may come at a cost.

31 ver, this speedy epithelial regeneration can come at a cost.

32 rove estimation of object properties but may come at a cost: loss of single-cue information.

33 wever, MCUB incorporation into the mtCU does come at a cost; acute decreases in (m)Ca(2+) uptake impa

34 These benefits come at a high and increasing cost, with development of

35 apeutic advances in bladder cancer care have come at a high cost to payers, providers, and patients.

36 However, these responses come at a high metabolic price, and avoiding pathogens b

37 in children is that dual-energy CT does not come at a higher radiation exposure.

38 These small advantages, however, come at a potentially significant price: the ferrocene-b

39 However, large dataset sizes come at a price of data consistency, often aggregating r

40 yme-bound cofactors is unparalleled, it does come at a price.

41 Plasticity of mast cell genes has come at a price.

42 ces in cardiovascular molecular imaging have come at a rapid pace over the last several years.

43 nosis and treatment of multiple myeloma have come at a rapid pace, especially with several new drugs

44 es in the treatment of childhood cancer have come at a remarkable pace, but the search for new treatm

45 ovement in graft survival; however, this may come at a risk of rejection.

46 btained with probabilistic inference methods comes at a computational cost in terms of runtime and ma

47 smission/disequilibrium test (TDT), but this comes at a considerable cost in the need to collect DNA

48 ergy as cell size decreases, miniaturization comes at a considerable energetic cost for a phytoplankt

49 However, protection by BCL6 protein comes at a cost during conditions of dietary excess, whi

50 adaptation, where fitness in one environment comes at a cost in another, should lead to spatial varia

51 However, this beneficial activity comes at a cost of collateral damage when the immune sys

52 Although side-chain distortion comes at a cost of foldability, it suppresses the rate o

53 hanging resource conditions, but exploration comes at a cost of higher potential exposure to threats.

54 , adults' integration of sensory information comes at a cost of losing access to the individual estim

55 promoting translesion synthesis (TLS), this comes at a cost of potentially error-prone lesion bypass

56 manipulating water levels, we show that this comes at a cost of reduced attractiveness to females.

57 here help support a model in which fidelity comes at a cost of replication kinetics and may help exp

58 e to current sperm competition, but one that comes at a cost to future mating performance.

59 id starvation by decreasing GTP level, which comes at a cost to growth, while (p)ppGpp enables rapid

60 from their mothers;(3) however, whether this comes at a cost to mothers' reproductive success is not

61 y guide therapies, but this information also comes at a cost to patients that might or might not be j

62 h serves other information processing roles, comes at a cost to the speed with which neurons can tran

63 ve sites for substrate recognition typically comes at a cost to the stability of the folded form of t

64 Therefore, escape from ENF comes at a cost to viral fitness and may confer enhanced

65 petitive advantage once glucose runs out, it comes at a cost while glucose is still present.

66 Dual inhibition comes at a cost, however, as simultaneous expression of

67 However, such focal processing comes at a cost, namely, functional blindness for unatte

68 However, operational simplicity comes at a cost, with one-pot assays typically being les

69 dvantage and close noting that the advantage comes at a cost-one trades off prediction for generation

70 This strategy comes at a cost-sequencing the same molecule multiple ti

71 l fate potential upon NSC activation, but it comes at a cost.

72 that successful immune response to infection comes at a cost.

73 er time, but acquiring information typically comes at a cost.

74 multiplexing methods involve labeling, which comes at a cost.

75 g loss, even successful speech communication comes at a cost.

76 Yet, social dependency also comes at a cost.

77 However, in our model, this flexibility comes at a cost: the random connections overlap, leading

78 However, this comes at a cost: those true positive sequences below thi

79 The indole production comes at a fitness cost to the highly resistant isolates

80 Fortunately, chloroquine resistance comes at a fitness cost to the parasite; this can be lev

81 expression of virulence-associated proteins comes at a fitness cost.

82 is only possible when antibiotic resistance comes at a fitness cost.

83 of the "normal" straight axon morphology, it comes at a great cost by interrupting axonal transport,

84 The resulting repaired chromosome comes at a great cost to the cell, as BIR promotes mutag

85 ssation of foraging due to human disturbance comes at a high cost, as porpoises must maintain their h

86 This comes at a high metabolic cost that is sustainable if ad

87 However, error tolerance comes at a high price in that these networks are extreme

88 come by increasing the sample size, but this comes at a higher cost.

89 stering cells based on phenotypic similarity comes at a loss of single-cell resolution and often the

90 This aligning of benefits comes at a potential cost, however, with the possibility

91 Such sensitivity comes at a price because it may be difficult to distingu

92 s suggest that the chemoradiotherapy success comes at a price in terms of late toxicity.

93 This capability comes at a price of a factor of three in additional qubi

94 The transparency of the proposed approach comes at a price of being less broadly applicable than M

95 minating sets optimized for small size alone comes at a price of being vulnerable to damage; dominati

96 aggressive combined therapies, but treatment comes at a price.

97 r, this mode coupling (or splitting) usually comes at a price.

98 Effective immune surveillance, however, comes at a price.

99 The improvement comes at a price: we hypothesized that random alignment

100 ganisms well adapted to multiple constraints comes at a significant complexity cost.

101 Here we show that this comes at a significant cost for cancer cells with high l

102 However, this response comes at a significant cost reflected in decreased photo

103 titution at more than one or two sites often comes at a significant energetic cost to fold stability.

104 This development of whole-body MR imaging comes at a time marked by the rapid development of moder

105 The increasing pressure to lower HAI rates comes at a time when advances in the clinical microbiolo

106 ecologically important traits in corals and comes at a time when sequencing efforts in other cnidari

107 This comes at a time when yield improvements are slowing or s

108 These benefits will come at an additional construction cost of up to $410 mi

109 is type of temperature compensation need not come at an additional metabolic cost of spike generation

110 al camouflage, and suggest that benefits may come at an energetic cost that animals are unwilling or

111 drugs from the cytoplasm, but this response comes at an energetic cost.

112 eractions in the solid-state -a process that comes at an intramolecular energy cost.

113 Yet, this exquisite control over selectivity comes at an operational price that is generally not just

114 ibitors, the development of entry inhibitors comes at an opportune time.

115 s natural long term virologic control may be coming at an immunologic and clinical cost.

116 Rapid, local gain control comes at another cost: noise in the signal controlling g

117 ts' ability to generate strong suction flows comes at considerable energetic expense.

118 utations that confer echinocandin resistance come at fitness and virulence costs, which may limit the

119 However, shrinking photonics has come at great cost to performance, and assembling such d

120 ing coherent systems in integrated photonics comes at great expense in hardware integration and energ

121 The forced implementation came at high cost to hospitals and with the strong endor

122 However, tandem mass spectrometers come at high capital expenditure and maintenance costs.

123 rts, but they are difficult to implement and come at high computational costs.

124 atients with MELD scores of 40 or higher but come at high pretransplantation and posttransplantation

125 their range of off-stoichiometry, eventually coming at high pressure to a diamondoid NaTl-type LiB.

126 However, the necessary calculations come at large computational costs, which has introduced

127 id changes may be a bellwether of changes to come at lower latitudes and have the potential to affect

128 Notably, this improvement to PSI-BLAST comes at minimal computational cost as SIB-BLAST utilize

129 Pakistan confirms that the performance gains come at no expense to the pages' look and functionality.

130 Even though this observation comes at odds with the current view that the APC/C acts

131 only apply to a limited pool of chemicals or come at prohibitively high cost.

132 for treatment of autoimmune diseases but may come at risk for reduced immune tolerance in the intesti

133 order brings to biological systems, this can come at severe kinetic and thermodynamic cost.

134 and humans promote group survival but often come at some cost to the individual.

135 ubstitutes, however, are often imperfect and come at some cost.

136 This adaptation could have come at some expense to the protein's housekeeping role

137 tchover to low-molecular weight heparins may come at some loss of this effect.

138 These modest improvements came at substantial cost to the Medicare program in fees

139 ields, and it has been argued that this lack comes at substantial economic costs.

140 This efficacy came at the cost of an increased frequency of gastrointe

141 was due to increased response initiation but came at the cost of goal-directed efficiency.

142 urces for their children, even when doing so came at the cost of low-SES families.

143 These benefits came at the cost of more frequent anemia and thrombocyto

144 tion conferred by these individual mutations came at the cost of reduced mating efficiency with cells

145 ation showed that increased model generality came at the cost of reduced model reliability (goodness-

146 However, this increase in sensitivity came at the expense of a decrease in specificity.

147 tion of the sarcoplasmic reticulum (SR), but came at the expense of decreased muscle strength.

148 We find no evidence that these improvements came at the expense of employment, sales, credit ratings

149 tive in reducing hERG binding affinity, this came at the expense of higher than desired Pgp-mediated

150 2000 more than 55% of new agricultural land came at the expense of intact forests, and another 28% c

151 Translesion synthesis came at the expense of lesion-skipping replication resta

152 Bypass by DNA polymerase IV came at the expense of the inherent leading strand lesio

153 This skewing came at the expense of the number of lymphoid-primed MPP

154 nd the locality of the synaptic update rules come at the cost of a poor storage capacity, compared wi

155 This increase in integration does not come at the cost of accuracy as GENIE3 produces networks

156 nhanced thermostability does not necessarily come at the cost of activity, the process by which the m

157 llment into randomized controlled trials has come at the cost of an unreasonable number of negative t

158 But strong amplification has come at the cost of considerably delaying the fixation e

159 However, this may come at the cost of damaging local environments if cash

160 n be achieved by background removal that may come at the cost of distortions in fine structure.

161 have boosted global food production but have come at the cost of environmental degradation and biodiv

162 eous characteristics of schematic memory may come at the cost of episode-specific information.

163 tional component of motivation, however, can come at the cost of goal-directed efficiency when a sust

164 However, these design advantages come at the cost of having to evolve and maintain a cell

165 nting GVHD are broadly immunosuppressive and come at the cost of increased risk of relapse and/or inf

166 nucleic acids are available, but they often come at the cost of long tethers, are dependent on the p

167 atment with chemotherapy and radiation often come at the cost of long-term toxicity and morbidity.

168 Lower mortality rates come at the cost of more bleeding and transfusion requir

169 precisely defining known effects of interest come at the cost of much other information in the "clean

170 mprove patients' understanding, but this may come at the cost of patients' satisfaction with them.

171 bial nucleic acids; however, these responses come at the cost of potential autoimmunity owing to inap

172 the sensitivity to periodic fields, but they come at the cost of reduced bandwidth and cannot be appl

173 on of low-frequency bacteria, these advances come at the cost of sequencing read length, limiting the

174 gated simultaneously, but this precision may come at the cost of systematic inaccuracy resulting from

175 This can come at the cost of their partner's condition as mass lo

176 he development of stress-resistant cultivars come at the cost of yield under ideal conditions?

177 's robust interest in identifying causes has come at the expense of a more rigorous engagement with t

178 improved control of B-cell lymphoma, but may come at the expense of an increased risk of bacterial an

179 Dramatic changes in cardiology have come at the expense of bedside cardiology which needs to

180 icial effects on adiposity, this benefit may come at the expense of beta-cells, resulting in an incre

181 These spending reductions did not come at the expense of clinical quality.

182 Unfortunately, these methods come at the expense of decreased acquisition speed and s

183 These advantages might come at the expense of efficiency and feasibility.

184 ad of ME due to pentamer suppression did not come at the expense of efficient cell-to-cell spread, an

185 on to threat following violence exposure may come at the expense of encoding contextual information,

186 the benefits of photoacoustic imaging do not come at the expense of existing ultrasound functions; ph

187 ciety on intervention and cure has sometimes come at the expense of good end-of-life care.

188 Increased precision has come at the expense of interpretability.

189 Increased crypt cell numbers come at the expense of Lgr5(+) stem cells.

190 cover loss are critical for policy but have come at the expense of long-term, multidirectional analy

191 EI regulation strategies for Si-based anodes come at the expense of manufacturability and cost.

192 t these expectations during a new experience come at the expense of memory for that experience.

193 han livestock; however, those benefits could come at the expense of more intensive energy use as biol

194 nses are presumed to be costly and therefore come at the expense of other traits related to fitness.

195 s conferring new function to a protein often come at the expense of protein folding or stability, red

196 This number improvement did not come at the expense of reduced accuracy as the added dat

197 These improvements have come at the expense of system complexity with microscope

198 Such adaptation can come at the expense of the original protein's function,

199 cases illustrate how adaptive advantages can come at the expense of the truth.

200 er, that even if latency is achieved, it may come at the expense of tissue damage if the response is

201 The improved ranking of such decoys can come at the expense of true ligands.

202 pproaches for strengthening steels typically come at the expense of useful ductility, a dilemma known

203 in waitlist death/deterioration and did not come at the expense of worse post-transplant survival.

204 ore materials than ever before, but this has come at the high cost of unprecedented global declines i

205 d with vitamin A deprivation in Xenopus rods come at the high metabolic cost of a 15-fold increase in

206 Unfortunately, these large enhancements come at the price of high optical losses due to absorpti

207 ucture could be ignored, this robustness can come at the price of power.

208 ll factor in the DTG-containing cells, which comes at the cost of a slightly lower open circuit volta

209 I for the detection of extracapsular disease comes at the cost of a slightly reduced specificity.

210 Inflammation comes at the cost of a transient decline in tissue funct

211 ective by phagocytosing Abeta; however, this comes at the cost of activated innate immunity that caus

212 biology of aging where germline immortality comes at the cost of an aging soma [T.

213 The balancing role of TTP comes at the cost of an increased risk of bacterial infe

214 re-ground segregation; however, this benefit comes at the cost of decreased neuronal sensitivity.

215 This adaptation comes at the cost of enhancing mortality to a subsequent

216 However, the improvement comes at the cost of experimental accessibility.

217 However, this comes at the cost of generating large scale, complex hyp

218 encing-based reference panels; however, this comes at the cost of high computational burden due to th

219 palliative surgery can benefit patients, it comes at the cost of high mortality and substantial hosp

220 However, this comes at the cost of high technical noise, including cel

221 However, this comes at the cost of impaired freezing tolerance.

222 th massive burns, but whether their survival comes at the cost of impaired quality of life is unknown

223 gainst viruses; however, heightened immunity comes at the cost of increased autoimmune toxicity.

224 However, achieving high-tunability often comes at the cost of increased dielectric loss or the ne

225 However, this improvement comes at the cost of increased distances to care and wor

226 and vessel recanalization, which frequently comes at the cost of increased risk of hemorrhagic event

227 o pathological ATAD3 variants; however, this comes at the cost of inducing cholesterol aggregation in

228 ng combination antiretroviral therapy (cART) comes at the cost of life-shortening side effects and de

229 ntrast, our data show that low symbiont load comes at the cost of lower growth rate, a tradeoff that

230 However, increasing strength typically comes at the cost of lowering the ductility and vice-ver

231 enes in error-containing fragments, however, comes at the cost of much lower (50%) specificity and ov

232 However, this mechanism comes at the cost of not being able to discriminate betw

233 mon trade-off persists: increasing coherence comes at the cost of operational speed, reflecting the n

234 This advantage, however, comes at the cost of other limitations.

235 However, this comes at the cost of positive-mean noise making it diffi

236 tion, changing diets, and biofuel production comes at the cost of reduced carbon stocks in natural ve

237 our findings demonstrate that this strategy comes at the cost of reduced fatigue life, with conseque

238 arasite genotype and abiotic environment and comes at the cost of reduced photosystem gene expression

239 ed nucleotide, but this enhanced specificity comes at the cost of reduced speed of nucleotide flippin

240 This low K(M), however, comes at the cost of reduced substrate turnover.

241 The improved performance comes at the cost of requiring a more complex paper spra

242 ichness of these counting-based measurements comes at the cost of routinely handling tens to hundreds

243 bipolar disorder, long-term lithium therapy comes at the cost of severe renal side effects, includin

244 o patients, whereas this improved compliance comes at the cost of significant time, money, and staff

245 This comes at the cost of some independence and the satisfact

246 The gain of stability region around site B comes at the cost of stability in regions more distal to

247 ibozymes suggests that the acquired activity comes at the cost of substrate versatility, and indicate

248 of single amino acid substitutions typically comes at the cost of the other, regardless of whether th

249 This N reduction comes at the expense 0.7-4.6 kg CO2 eq per m(3) rainwate

250 similar regions in sequences; this, however, comes at the expense of a higher false positive rate due

251 urrent networks improve model accuracy, this comes at the expense of a loss in the interpretability o

252 wever, DSB-induced chromosome reorganization comes at the expense of an increased rate of translocati

253 he formation of functional globular proteins comes at the expense of an inherent aggregation propensi

254 ntage afforded by this integration, however, comes at the expense of attentional selection.

255 The declarative nature of ASP-G comes at the expense of being slower than the more dedic

256 yed by people in the richest countries often comes at the expense of CO2 emissions produced with tech

257 xists, whereupon the increase in data volume comes at the expense of completeness, uniformity, and co

258 and thermal resistance and tensile strength) comes at the expense of degradability and recyclability.

259 High hardness, however, comes at the expense of extensibility.

260 omponents due to material limitations, which comes at the expense of extra system complexity and incr

261 This strategy comes at the expense of genome protection because DNA br

262 However, this comes at the expense of global computations.

263 injury in the early stages of treatment, it comes at the expense of hepatocyte injury and is subopti

264 with invasive pathogens, but this adaptation comes at the expense of immunopathology.

265 tant for clearing SARS-CoV-2 infection, this comes at the expense of increased inflammation and patho

266 The advantage of being bilingual comes at the expense of increased processing demands and

267 ly, increasing the signal-acquisition period comes at the expense of increasing ion decay, which lowe

268 However, the small augmented performance comes at the expense of increasing running time to O(N(2

269 and expansion of apical-basal domains, which comes at the expense of lateral membrane height in MDCK

270 n minimize the undesirable effects, but this comes at the expense of on-target editing efficiency.

271 it extremely high strength, but this benefit comes at the expense of other important properties like

272 impact of taxi services on cities, but this comes at the expense of passenger discomfort quantifiabl

273 Cs seen with activation of LvNotch signaling comes at the expense of presumptive endoderm cells, whil

274 g notion that the ability to respond to heat comes at the expense of protein homeostasis (proteostasi

275 cause of its excellent sensitivity but often comes at the expense of robustness.

276 In contrast, high flux comes at the expense of selectivity in many synthetic fi

277 However, PRIMPOL activation comes at the expense of single-strand gap formation, and

278 ry is that energy invested into reproduction comes at the expense of somatic maintenance and repair,

279 ural modifications can improve stability, it comes at the expense of synthetic cost and molecular wei

280 tion of chaperonins as increased GFP folding comes at the expense of the ability of GroEL/S to fold i

281 nce of dark fields reduces calculability and comes at the expense of the original MOND premise, that

282 vation of the divergent (suppressed) pathway comes at the expense of the principal oncogenic driver a

283 However, the dynamicity comes at the expense of the stability of the QD suspensi

284 We find that spore production comes at the expense of time to complete aggregation, an

285 o use monaural cues for the horizontal plane comes at the expense of using those cues to localize in

286 and gate metal can reduce leakage; but this comes at the price of a reduced drain current.

287 cts than do these other techniques, but this comes at the price of additional assumptions.

288 f the coagulation cascade, which unavoidably comes at the price of an increased propensity to bleed.

289 y increasing I(Ca) and SR Ca(2+) content, it comes at the price of an increased risk for spontaneous

290 ble to record from the whole brain, but this comes at the price of either limited spatiotemporal reso

291 ever, the greater resolving power of LC x LC comes at the price of higher dilutions (thus, reduced se

292 ds to better one-trial memory, but that this comes at the price of increased interference in semantic

293 to meet increased metabolic demand, but this comes at the price of insulin secretory dysfunction.

294 er, consequently, higher sulfonate retention comes at the price of lower sequence coverage in negativ

295 However, its simplicity comes at the price of relying on correct specification o

296 ypes of BCR-ABL+ leukemias in vivo, but this comes at the price of significant complexity.

297 may provide substantial carbon benefits, it comes at the rapidly accruing cost of woody plant specie

298 cation can result in yield increases without coming at the expense of biodiversity loss.

299 inversely correlated with an increase in oil coming at the expense of protein and vice versa.

300 ocessing of fear was not entirely automatic, coming at the expense of specificity of response.