ライフサイエンスコーパス: comet

1 nits or the spindle checkpoint inhibitor p31(comet).

2 re we report that 288P is a binary main-belt comet.

3 ly progressing comet is followed by a faster comet.

4 ges induced by the rotation and orbit of the comet.

5 ore and/or after being incorporated into the comet.

6 o split at a rate of about 0.01 per year per comet.

7 ng was localized to the "neck" region of the comet.

8 he Rmaps by more than four times compared to cOMet.

9 ill wait in space for a yet-to-be-discovered comet.

10 ss of the role of energetic negative ions in comets.

11 morphology and dynamics of Nck-induced actin comets.

12 present a fraction of the building blocks of comets.

13 ere thought, but not proved, to originate in comets.

14 id not reconstitute dynamic, elongated actin comets.

15 prevents the inhibitory effect of tau on EB comets.

16 f comets were used for the interpretation of comets.

17 han those seen in carbonaceous chondrites or comets.

18 ts on the microtubule lattice at the rear of comets.

19 ide-that had not previously been reported in comets.

20 -COU-AA-301, AFFIRM, ELM-PC-5, ELM-PC-4, and COMET-1- ClinicalTrials.Gov identifiers: NCT00638690, NC

21 rogen, oxygen and nitrogen in particles from comet 1P/Halley.

22 egates in the near-surface of the nucleus of comet 67P also provides a mechanism for lowering the ten

23 ow bilobate shapes, including the nucleus of comet 67P/Churyumov-Gerasimenko (67P), visited by the Ro

24 ouchdown of the Rosetta lander Philae on the comet 67P/Churyumov-Gerasimenko (67P), we show that no g

25 Images of comet 67P/Churyumov-Gerasimenko acquired by the OSIRIS (

26 By combining surface inspection of comet 67P/Churyumov-Gerasimenko and three-dimensional (3

27 is the main species observed in the coma of comet 67P/Churyumov-Gerasimenko and water is the major c

28 Here we report that pits on comet 67P/Churyumov-Gerasimenko are active, and probably

29 ement of the D/H ratio in the Jupiter family comet 67P/Churyumov-Gerasimenko by the ROSINA mass spect

30 The Rosetta mission shall accompany comet 67P/Churyumov-Gerasimenko from a heliocentric dist

31 The Rosetta spacecraft has investigated comet 67P/Churyumov-Gerasimenko from large heliocentric

32 ctural similarities between the two lobes of comet 67P/Churyumov-Gerasimenko indicate that the early-

33 Therefore comet 67P/Churyumov-Gerasimenko is an accreted body of t

34 The peculiar bilobed shape of comet 67P/Churyumov-Gerasimenko may be the result of the

35 ity and internal structure of the nucleus of comet 67P/Churyumov-Gerasimenko on the basis of its grav

36 of dune-like patterns at the surface of the comet 67P/Churyumov-Gerasimenko requires conceptual and

37 cecraft has measured the coma composition of comet 67P/Churyumov-Gerasimenko with well-sampled time r

38 observations of water ice on the surface of comet 67P/Churyumov-Gerasimenko, appearing and disappear

39 quired maps of the subsurface temperature of comet 67P/Churyumov-Gerasimenko, at 1.6 mm and 0.5 mm wa

40 er 2014, the Philae lander descended towards comet 67P/Churyumov-Gerasimenko, bounced twice off the s

41 situ measurement of N2 in the Jupiter family comet 67P/Churyumov-Gerasimenko, made by the Rosetta Orb

42 he Rosetta spacecraft spent 2 years orbiting comet 67P/Churyumov-Gerasimenko, most of it at distances

43 athered at the Philae landing site Abydos on comet 67P/Churyumov-Gerasimenko, we found the diurnal te

44 ort in situ measurement of O2 in the coma of comet 67P/Churyumov-Gerasimenko, with local abundances r

45 lecular oxygen was discovered in the coma of comet 67P/Churyumov-Gerasimenko.

46 rt in situ measurements of dust particles at comet 67P/Churyumov-Gerasimenko.

47 surface area located in the Anhur region of comet 67P/Churyumov-Gerasimenko.

48 of the Agilkia site during its descent onto comet 67P/Churyumov-Gerasimenko.

49 on (CONSERT) measurements of the interior of Comet 67P/Churyumov-Gerasimenko.

50 hdown of the Philae lander on the surface of comet 67P/Churyumov-Gerasimenko.

51 for in situ analysis of organic molecules on comet 67P/Churyumov-Gerasimenko.

52 n Space Agency's Rosetta spacecraft orbiting comet 67P/Churyumov-Gerasimenko.

53 rbon-bearing compounds on the nucleus of the comet 67P/Churyumov-Gerasimenko.

54 nalyzed the isotopes of xenon in the coma of comet 67P/Churyumov-Gerasimenko.

55 anic matter in the dust particles emitted by comet 67P/Churyumov-Gerasimenko; the carbon in this orga

56 ovided detailed mineralogy of particles from comet 81P/Wild, the fine-grained aggregate component was

57 This was clearly demonstrated on comet 9P/Tempel 1, where the dust jets (driven by volati

58 -74 per cent) dusty body, similar to that of comet 9P/Tempel 1.

59 n short-lived outbursts seen near sunrise on comet 9P/Tempel 1.

60 Here, we identify p31(comet), a negative regulator of MAD2 and the spindle ass

61 R suppresses the metabolic phenotypes of p31(comet) ablation.

62 Here, we investigated the regulation of p31(comet) action.

63 COMET allows successful and sustained restoration of ocu

64 p31(comet) also participates in the extraction of REV7 from

65 posable Mammalian Elements of Transcription (COMET)-an ensemble of TFs and promoters that enable the

66 We introduce CoMEt, an algorithm to identify combinations of alterati

67 We developed coMET, an R package and online tool for visualisation of

68 n caused intracellular oxidative stress, and comet analysis revealed introduction of formamidopyrimid

69 In this work we present the Comet and Comet-swarm families of undirected graphs.

70 range of fitness values of the mutants, the Comet and Comet-swarm graphs have fixation probability s

71 lmonary fibrosis in two independent cohorts (COMET and Yale).

72 Observations of comets and asteroids show that the solar nebula that spa

73 -hydrogen (D/H) ratios in the reservoirs for comets and Earth's oceans.

74 dition, we explored the relationship between COMETs and haplotypes in lymphoblastoid cell lines of Af

75 molecular clouds, and, more importantly, in comets and in primitive meteorites that have most probab

76 to habitable planets such as early Earth by comets and meteorites.

77 easurably influence the spin rates of active comets and might lead to the splitting of bilobate comet

78 Asteroids, comets and moons are leftovers of planet formation.

79 f approximately 1-12, comparable to those of comets and the low end estimated for planetesimals.

80 P13 is composed of subsites specific for p31(comet) and C-Mad2-containing complex.

81 Furthermore, p31(comet) and checkpoint complexes mutually promote the bin

82 ide the first evidence for regulation of p31(Comet) and demonstrate a previously unknown event contro

83 the oligomeric form of TRIP13 binds both p31(comet) and MCC.

84 Purified Plk1 bound to p31(comet) and phosphorylated it, resulting in the suppressi

85 The C-Mad2-binding protein p31(comet) and the ATPase TRIP13 promote MCC disassembly and

86 ng VAP accumulate high levels of PI4P, actin comets, and trans-Golgi proteins on endosomes.

87 tion and even solar system formation because comets are considered remnant volatile-rich planetesimal

88 Heat transport and ice sublimation in comets are interrelated processes reflecting properties

89 Comets are not consistent with spreading motility or oth

90 This finding is significant because comets are thought to have preserved the icy grains orig

91 Comets are thought to preserve almost pristine dust part

92 We show here that vapor flow emitted by the comet around its perihelion spreads laterally in a surfa

93 Collectively, our results suggest COMET as a new target to improve drug-based cancer thera

94 .g. Mercury, Jupiter's moon Europa, near-Sun comets), as well as terrestrial applications.

95 nt for the Minimum Information for Reporting Comet Assay (MIRCA) providing recommendations for descri

96 firming this phenomenon, we have revealed by comet assay and currently the most sensitive method of D

97 yed ICL processing as revealed by a modified Comet assay and gamma-H2AX foci persistence.

98 nhanced DNA damage, as measured by using the comet assay and gammaH2AX staining.

99 DNA damage following BPA exposure using the comet assay and immunofluorescence staining, and used ce

100 Moreover, as measured by the Comet assay and the induction of gamma-H2A.X, quercetin,

101 CA) providing recommendations for describing comet assay conditions and results.

102 lated using published potencies based on the comet assay for Chinese hamster ovary cells (assesses th

103 Our high-throughput variant of the comet assay greatly increases the number of samples anal

104 Sources of variability in the comet assay include variations in the protocol used to p

105 The comet assay is a widely used test for the detection of D

106 The alkaline comet assay is an established method for detecting DNA s

107 Thus, DNA Comet Assay may be a practical quarantine control method

108 ify the relevant conditions because detailed comet assay procedures are not always published.

109 to MIRCA recommendations should ensure that comet assay results can be easily interpreted and indepe

110 correlated very well with rodent 1/TD50 and Comet assay results.

111 n combination with DNA methylation sensitive comet assay to determine the effects of vitamin B12 or M

112 platform (a higher throughput more sensitive comet assay) to create the 'HepaCometChip', enabling the

113 orescent microscopy, imaging flow cytometry, comet assay, and RT-qPCR.

114 but induced DNA damage, as determined by the comet assay, at all concentrations tested.

115 tivation, spontaneous DNA damage by alkaline comet assay, basal micronuclei levels, the number of lar

116 Induction of minority MOMP was tested via comet assay, CyQuant, annexin V, JC-1, cytochrome C subc

117 doses of 0.1 to 1.5 kGy and analyzed by DNA Comet Assay.

118 -/-)p53(-/-) MEFs as demonstrated by neutral Comet assay.

119 assessed DNA damage by means of the neutral comet assay.

120 T3-L1 normal cells was detected by using the comet assay.

121 ential induced DNA damage in vitro using the Comet Assay.

122 amage measured by H2AX phosphorylation and a comet assay.

123 of damage could be evaluated in real time by comet assay.

124 ononuclear cells from 13 pSS patients, using comet assay.

125 foci; DSB levels were determined by neutral comet assay; western blotting was used to evaluate prote

126 emcitabine-induced DNA damage as measured by comet assays and quantification of gammaH2AX foci.

127 DNA repair as revealed by gammaH2AX foci and comet assays and to the up-regulation of Ku70 and DNA-de

128 Comet assays demonstrated that DNA repair was delayed in

129 In addition, COMET assays show that excess NEIL3 Zf-GRF repeat reduce

130 ion and genetic instability, as indicated by comet assays that showed increased numbers of DNA-strand

131 including active RAS pulldown, reporter and Comet assays, small interfering RNA-mediated depletion o

132 Random bombardment by comets, asteroids and associated fragments form and alte

133 s do not alter CLIP-170's capability to form comets at growing microtubule ends, both phosphomimetic

134 Initially, the solar wind permeates the thin comet atmosphere formed from sublimation, until the size

135 Comet behaviour does share many similarities with a form

136 adapter protein p31(comet) We show that p31(comet) binding to the TRIP13 N-terminal domain positions

137 p31(comet) binds to the REV7-Shieldin complex in cells, prom

138 p31(comet) blocks the MAD2-BUBR1 interaction and prevents sp

139 We propose that p31(comet) bound to C-Mad2-containing checkpoint complex is

140 cess is mediated by TRIP13 together with p31(comet), but the mode of their interaction remained unkno

141 wed the separated tails from the head of the comet by increasing applied doses from 0.1 to 1.5 kGy.

142 We propose that the phosphorylation of p31(comet) by Plk1 prevents a futile cycle of MCC assembly a

143 Furthermore, p31(comet) can counteract REV7 function in translesion synth

144 R) spectroscopy, we show that TRIP13 and p31(comet) catalyze the conversion of C-Mad2 to O-Mad2, with

145 Liver-specific ablation of p31(comet) causes insulin resistance, hyperinsulinemia, gluc

146 Many decades of asteroid and comet characterization have yielded formation models tha

147 o, are examined for the interstellar medium, comets, chondritic meteorites, and terrestrial planets;

148 elegans orthologue of the Mad2 inhibitor p31(comet)(CMT-1) interacts with TRIP13(PCH-2) and is requir

149 rs also genetically interact, as loss of p31(comet)(CMT-1) partially suppressed the requirement for T

150 We propose that TRIP13 and p31(comet) collaborate to inactivate the spindle assembly ch

151 icrobes in a community, e.g. as predicted by COMETS (Computation of Microbial Ecosystems in Time and

152 Comets contain the best-preserved material from the begi

153 Crucially, we conclude that comets containing water enriched in deuterium contribute

154 hat TRIP13, aided by the adapter protein p31(comet), converts the HORMA-family spindle checkpoint pro

155 the comet tail have stopped moving; (3) the comet core is held together by a matrix of slime; and (4

156 Among them, we identified COMET (Correlated-to-MET), a natural antisense transcrip

157 COMET currently comprises 44 activating and 12 inhibitor

158 ndetectable bulky lesions are converted into comet-detectable single strand breaks.

159 d turnover similar to those of N-WASP in Nck comets, did not reconstitute dynamic, elongated actin co

160 red in the form of differentially methylated COMETs (DMCs).

161 Altogether, COMET enables the design and construction of customizabl

162 d together by a matrix of slime; and (4) the comets etch trails in the agar as they move forwards.

163 and mechanical material properties determine comet evolution and even solar system formation because

164 osed ice was observed a short time after the comet exited local winter; following the increased illum

165 f standard proteomics search engines such as Comet for peptide sequence assignment, greatly simplifyi

166 onditions during the early solar system when comets formed.

167 GBS methylomes into blocks of comethylation (COMETs) from which lost information can be recovered in

168 coMET generates a regional plot of epigenetic-phenotype

169 s applied to track the 3D position of a live comet goldfish.

170 nd were encountered once per 44 s of EB3-RFP comet growth time with about 5 s half-lifetime.

171 They may even date from earlier if the comet had a larger volatile inventory, particularly of C

172 An S102A mutant of p31(comet) had a greatly decreased sensitivity to inhibition

173 milarities with the detected coma species of comet Halley suggest the presence of a radiation-induced

174 Using systematic methods according to the COMET handbook we searched key electronic bibliographic

175 Comets harbor the most pristine material in our solar sy

176 The Mad2-binding protein p31(comet) has important roles in the inactivation of the mi

177 anetesimal coagulation, and the formation of comets, ice giants and the cores of gas giants.

178 that points to a nonbiogenic origin, such as comet impact plume condensates in what may be very rapid

179 sults highlight the oncogenic role of lncRNA COMET in thyroid and indicate it as a potential new targ

180 We observed comets in a diverse selection of S. aureus isolates and

181 he approximately 750,000 known asteroids and comets in the Solar System is thought to have originated

182 CoMEt includes an exact statistical test for mutual excl

183 The presence of cyanides in comets, including 0.01 per cent of methyl cyanide (CH3CN

184 counting several O2 production mechanisms in comets, including photolysis and radiolysis of water, so

185 units increased the percentage of retrograde comets initiated at boutons, indicating that gamma-tubul

186 uropean Space Agency (ESA) recently selected Comet Interceptor as its first 'fast' (F-class) mission.

187 Therefore, TRIP13-p31(comet) intercepts and disassembles free MCC not bound to

188 onchoalveolar lavage obtained as part of the COMET-IPF (Correlating Outcomes with Biochemical Markers

189 The structure of the upper layer of a comet is a product of its surface activity.

190 coMET is available to a wide audience as an online tool

191 nts where a slow and erratically progressing comet is followed by a faster comet.

192 composition of the neutral gas comas of most comets is dominated by H2O, CO and CO2, typically compri

193 her method to error correct Rmap data, named cOMet, it is unable to scale to even moderately large si

194 The solid, central part of a comet--its nucleus--is subject to destructive processes,

195 Philae spent almost two minutes of its cross-comet journey, producing four distinct surface contacts

196 Here, we show that whole-body p31(comet) knockout mice die soon after birth and have reduc

197 RNAiFold 1.0, rewritten from the now defunct COMET language to C++.

198 an important process in the evolution of the comet, leading to cyclical modification of the relative

199 Comet lesions appeared as hyper-reflective round lesions

200 Finally, p31(comet), like TRIP13, is overexpressed in many cancers an

201 tion of excavated volatiles causes transient comet-like activity.

202 -equal component size, high eccentricity and comet-like activity.

203 Comet-like compositions of simple and complex volatiles

204 functional TRIP13 residues that mediate p31(comet)-Mad2 binding and couple ATP hydrolysis to local u

205 bility of TRIP13(PCH-2) to disassemble a p31(comet)/Mad2 complex, which has been well characterized i

206 Moreover, silencing COMET markedly increased sensitivity to vemurafenib, a c

207 Comets may have brought this component to the Earth's at

208 enous damage markers and by electrophoretic "comet" measurements.

209 he timing of mitotic slippage is through p31(comet)-mediated suppression of MAD2 activation.

210 r algorithm outperforms the state-of-the-art CoMEt method in terms of discovering mutually exclusive

211 tips was stationary and originated from EB3 comets moving with the growing MT tips.

212 AAA-ATPase and the Mad2-binding protein p31(comet) Now we have isolated from extracts of HeLa cells

213 suggested here would preferentially decimate comet nuclei during migration to the inner solar system,

214 Observations of comet nuclei indicate that the main constituent is a mix

215 Separately, over two-thirds of comet nuclei that have been imaged at high resolution sh

216 and might lead to the splitting of bilobate comet nuclei.

217 tal process in the evolution of short-period comet nuclei.

218 We present Comet Nucleus Sounding Experiment by Radiowave Transmiss

219 y to investigate the internal structure of a comet nucleus, providing information about its formation

220 ommon finding on the surfaces of many of the comets observed so far.

221 efer to as EB3-islands, were detected on 56% comets of growing MTs and were encountered once per 44 s

222 Yet in comets, often considered the most primitive bodies in th

223 Plk1 phosphorylated p31(comet) on S102, as suggested by the prevention of the ph

224 he object is spectrally red, consistent with comets or organic-rich asteroids that reside within the

225 We demonstrate that CoMEt outperforms existing approaches on simulated and r

226 odel that provides mechanistic insights into COMET performance characteristics.

227 In growing root hair cells, ARK1 comets predominantly localize on the growing-end of micr

228 Unlike asteroids, comets preserve a nearly pristine record of the solar ne

229 The surface and subsurface of comets preserve material from the formation of the solar

230 TRIP13 and p31(comet) prevent APC/C inhibition by MCC components, but c

231 COMET profiled monocyte counts in 45 patients with idiop

232 The MAD2 inhibitory protein p31(comet) promotes checkpoint inactivation and timely chrom

233 p31(comet) promotes the disassembly of mitotic checkpoint co

234 ), jointly with the Mad2-binding protein p31(comet), promotes the inactivation of the mitotic (spindl

235 COMET repression inhibited viability and proliferation o

236 More specifically, cOMet required 9.9 CPU days to error correct Rmap data g

237 Depletion of COMET resulted in reduced expression of genes within thi

238 ange and their propagation at the scale of a comet revolution.

239 Measurements were made over many comet rotation periods and a wide range of latitudes.

240 sence of large density variations within the comet's body testify that large-scale deformation occurr

241 he major landforms were created early in the comet's current orbital configuration.

242 ice-that is, water ice from the time of the comet's formation 4.5 billion years ago-in their interio

243 was incorporated into the nucleus during the comet's formation, which is unexpected given the low upp

244 O2 incorporated into the nucleus during the comet's formation.

245 layering to have occurred at the time of the comet's formation.

246 t resulted in substantial alterations to the comet's landscape.

247 Here we report that the comet's major lobe is enveloped by a nearly continuous s

248 gularities in cell alignments in the form of comet-shaped topological defects.

249 Because EB3 comet splitting was also observed in control microtubule

250 that Eribulin increases the frequency of EB3 comet "splitting," transient events where a slow and err

251 2.06, 95% CI 1.22-3.47; p=0.0068) across the COMET, Stanford, and Northwestern datasets).

252 ragments of a large, disintegrating asteroid/comet struck North America, South America, Europe, and w

253 en by temperature differences just below the comet surface.

254 In this work we present the Comet and Comet-swarm families of undirected graphs.

255 fitness values of the mutants, the Comet and Comet-swarm graphs have fixation probability strictly la

256 s limitations such as angular dependency and comet tail artifacts.

257 Initiation of comet tail assembly is more efficient in cytosol than it

258 important role for CRMP-1 in Listeria actin comet tail formation and open the possibility that CRMP-

259 p2/3 complex through mutagenesis all inhibit comet tail formation and reduce the size and number of a

260 ed as an important factor for Listeria actin comet tail formation in brain cytosol.

261 tracellular motility and spreading via actin comet tail formation.

262 tail'; (2) they move when other cells in the comet tail have stopped moving; (3) the comet core is he

263 CP1, and p62 through a WHAMM-dependent actin-comet tail mechanism.

264 or autophagosome biogenesis through an actin-comet tail motility mechanism.

265 rexpression caused loss of the typical actin comet tail shape induced by Nck aggregation.

266 oteins to assemble an Arp2/3-dependent actin comet tail to power its movement through the host cell.

267 other S. aureus cells behind them forming a comet 'tail'; (2) they move when other cells in the come

268 cterium to drive its movement using an actin comet-tail mechanism.

269 Actin comet tails were often detected at the rear end of nucle

270 displaying prominent accumulation on actin "comet tails" that emanate from focal adhesions in stretc

271 he formation of Listeria monocytogenes actin comet tails, thereby implicating it in actin assembly.

272 ck SH3 domains at the membrane induces actin comet tails--dynamic, elongated filamentous actin struct

273 ation and maintenance of Nck-dependent actin comet tails.

274 LC3-containing membranes that move on actin comet tails.

275 present state, but it may be a Halley-family comet that entered the resonance through an interaction

276 We show that the SNX9-driven actin comets that arise on human disease-associated oculocereb

277 n a subset of the asteroids called main-belt comets, the sublimation of excavated volatiles causes tr

278 We apply CoMEt to five different cancer types, identifying both k

279 Using best fit analysis, we show COMETs to be correlated in a population-specific manner,

280 ary matter and the potential contribution of comets to inner-planet atmospheres are long-standing pro

281 ved building blocks of life by meteorites or comets to planet Earth are discussed in this Perspective

282 ation Modeling for Efficiency Technologies" (COMET) to understand how vehicle manufacturers implement

283 Twenty-five minutes after Philae's initial comet touchdown, the COSAC mass spectrometer took a spec

284 In two validation cohorts (COMET trial and the Yale cohort), patients with higher m

285 System objects related to icy asteroids and comets underwent a phase of magmatic activity early in t

286 In this way, comet-undetectable bulky lesions are converted into come

287 As evidenced by an alkaline comet unwinding assay, 3 induces extensive DNA damage, s

288 In papillary thyroid carcinomas, COMET was part of a coexpression network including diffe

289 The near-comet water population comprises accelerated ions (<800

290 AD2 with the help of the adapter protein p31(comet) We show that p31(comet) binding to the TRIP13 N-t

291 Observed comets were evaluated by image analysis.

292 It has been shown that comets were not strong contributors to the so-called lat

293 he tail length, tail moment and tail DNA% of comets were used for the interpretation of comets.

294 (chromosomal breaks, gamma-H2AX and neutral comets) when treated with CTNAs and exhibit significant

295 surface of media in structures that we term 'comets', which advance outwards and precede the formatio

296 s is regulated by CMT-1, the ortholog of p31(comet), which is required for both PCH-2's localization

297 ics in the gas phase are similar to those in comets, which suggests an even higher relative abundance

298 ounts were at higher risk for poor outcomes (COMET Wilcoxon p=0.025; Yale Wilcoxon p=0.049).

299 All patients underwent COMET, with an aim of fornix reconstruction and visual r

300 ted by fragmentation of a large short-period comet within the inner Solar System.