ライフサイエンスコーパス: common disease

1 Bladder cancer (BC) is a common disease.

2 the role of genetics and epigenetics in this common disease.

3 dly validating any biological marker of this common disease.

4 mparable resource has not been available for common disease.

5 ntial for therapeutic insights for this very common disease.

6 r, and also have emerging roles in aging and common disease.

7 2/3, changing the treatment outlook for this common disease.

8 ntial to dissect the molecular mechanisms of common disease.

9 itis of the sigmoid colon is an increasingly common disease.

10 dvance our understanding of this complex and common disease.

11 ty to unravel the functional architecture of common disease.

12 sarily appropriate for epigenetic studies of common disease.

13 on would allow for better management of this common disease.

14 gating the role of rare genetic variation in common disease.

15 ubstantial genetic diversity underlying this common disease.

16 cal significance of rare genetic variants in common disease.

17 faced in identifying pathogenic variants in common disease.

18 ine-mapping and candidate gene discovery for common disease.

19 known about the utility of these scores for common disease.

20 ifies potential therapeutic targets for this common disease.

21 iologic regulatory mutations associated with common diseases.

22 rovide mechanistic insights into age-related common diseases.

23 tified many individual genes associated with common diseases.

24 the impact of copy number variants (CNVs) on common diseases.

25 nto genomic regulatory mechanisms underlying common diseases.

26 nt insights into the genetic architecture of common diseases.

27 that control transcript isoforms relevant to common diseases.

28 gets to prevent developmental programming of common diseases.

29 age structure of the population and the most common diseases.

30 ctive for describing genetic complexities of common diseases.

31 ses and screening methods relevant for other common diseases.

32 ing pathways, which are important in several common diseases.

33 le in contemporary surgical therapy for many common diseases.

34 ght provide insights into understanding more common diseases.

35 usually acquired conditions associated with common diseases.

36 ants of m(6)A modification and their role in common diseases.

37 with autoinflammatory syndromes and several common diseases.

38 systems that have impacted the treatment of common diseases.

39 substantial fraction of the heritability of common diseases.

40 and environmental factors related to complex common diseases.

41 important role in disease susceptibility of common diseases.

42 not yet demonstrated robust association with common diseases.

43 nts influencing gene expression and risk for common diseases.

44 sparse concerning 131I-related risk of these common diseases.

45 ictive performance for ten complex traits or common diseases.

46 iation (CNV) can influence susceptibility to common diseases.

47 ential biomarkers and therapeutic agents for common diseases.

48 c variants contributing to susceptibility to common diseases.

49 covery of additional susceptibility loci for common diseases.

50 inheritance/susceptibility of multifactorial common diseases.

51 development of drug treatments for rare and common diseases.

52 the mechanisms underlying susceptibility to common diseases.

53 with the co-occurrence of obesity with other common diseases.

54 ess were calculated, in addition to the most common diseases.

55 is for selecting of drug targets for complex common diseases.

56 shown to have predictive value for multiple common diseases.

57 croarrays has identified epigenetic links to common diseases.

58 peutics and using rare disease to understand common diseases.

59 nisms and therapeutic targeting of RIPK1 for common diseases.

60 35.9 billion annually-greater than for other common diseases.

61 d closely associated with current and future common diseases.

62 ctions and therapeutic development for these common diseases.

63 hogenesis and therapy of seemingly unrelated common diseases.

64 hown promise in predicting susceptibility to common diseases(1-3).

65 of genetic variants that influence risk for common diseases(1-4).

66 e as a minimally invasive technique in these common diseases, a comprehensive molecular profiling cha

67 al species on human skin and can promote the common disease acne vulgaris.

68 The most common diseases across cancer types involved cardiovascu

69 es, however its application to understanding common disease aetiology is limited.

70 Nephrolithiasis is a common disease affecting almost all populations, with an

71 urrent aphthous stomatitis (RAS) is the most common disease affecting oral mucosae.

72 Vaginal candidiasis is common disease affecting women; however, how Candida alb

73 largement of the prostate, is among the most common diseases affecting aging men, but the underlying

74 ted SLE heritability is not accounted for by common disease alleles analyzed by SNP array-based GWASs

75 isease-associated SNPs and demonstrated that common disease alleles contain multiple causal variants

76 emonstrated that, under realistic scenarios, common disease alleles would become associated at P < 5

77 inflammation of the middle ear, is the most common disease and cause for surgery in infants worldwid

78 ian disease-derived pathogenicity scores for common disease and improve upon existing scores.

79 The genes influencing common disease and quantitative traits remained largely

80 Peanut allergy is a common disease and the cause of severe, life-threatening

81 Stroke is one of the most common diseases and a leading cause of death and disabil

82 notypic annotations for over 10,000 rare and common diseases and can be used for examining the phenot

83 ate published pathogenicity scores across 41 common diseases and complex traits (average N = 320K).

84 tified thousands of variants associated with common diseases and complex traits, only a handful of th

85 the mechanisms responsible for many rare and common diseases and driven development of novel preventa

86 rol of cellular homeostasis, dysregulated in common diseases and implicated in the ageing process.

87 ool is disease-agnostic across both rare and common diseases and is showcased by exploring multimorbi

88 In sequencing studies of common diseases and quantitative traits, power to test r

89 as prospectively documented the incidence of common diseases and related mortality in high-income cou

90 family-based studies and instead focused on common diseases and traits in populations of unrelated i

91 In the present analysis of five common diseases and traits, including body mass index, t

92 e discovered >1,200 variants associated with common diseases and traits, these variants typically app

93 iants that are significantly associated with common diseases and traits.

94 fied many noncoding variants associated with common diseases and traits.

95 Acute cholecystitis is a common disease, and laparoscopic surgery is the standard

96 usible causes of a substantial proportion of common disease, and rare CNVs have been found to be pote

97 Calcific aortic stenosis is a common disease, and some of its early causes are the act

98 Environmental adaptation, predisposition to common diseases, and, potentially, speciation may all be

99 ntext, complicating experimental analysis of common disease- and trait-associated variants that local

100 miologic data to support undiagnosed HS as a common disease are lacking.

101 Complex traits and common diseases are extremely polygenic, their heritabil

102 It is possible that common diseases are simply lagging behind due to the inh

103 Because most common diseases arise out of a combination of factors an

104 majority of common variants associated with common diseases, as well as an unknown proportion of cau

105 Venous thromboembolism (VTE) is a common disease associated with high risk for recurrences

106 pro- and anti-inflammatory cytokines and how common disease-associated genetic variants (e.g., rs1294

107 New work reveals that a common disease-associated mtDNA mutation is selectively

108 The most common disease-associated mutation in the CFTR gene-dele

109 copy of the I1061T variant of NPC1, the most common disease-associated mutation leading to NPC diseas

110 cause Parkinson's disease (PD), and the most common disease-associated mutation, G2019S, increases ki

111 The common disease-associated sample characteristics across

112 o create differential diagnoses for rare and common diseases at brain MRI has not been demonstrated.

113 summarize the potential use cases for seven common diseases (breast cancer, prostate cancer, coronar

114 Stress is a key precipitant for many common diseases, but established biological markers to t

115 tudies have identified thousands of loci for common diseases, but, for the majority of these, the mec

116 riants that colocalize with risk alleles for common diseases can expose disease-associated pathways,

117 Four of the eight common disease causing mutations in MECP2 are nonsense m

118 Urothelial carcinoma (UC) is a common disease causing significant morbidity and mortali

119 mimicking knock-in mouse harbouring the most common disease-causing filamin C mutation (p.W2710X).

120 the m.3243A>G mutation in MTTL1 is the most common disease-causing mtDNA mutation, with a carrier ra

121 The most common disease-causing mutation in alpha1-AT is the Z-mu

122 The most common disease-causing mutation in the cystic fibrosis t

123 Many common disease-causing mutations result in loss-of-funct

124 milies affected by probable adRP but lacking common disease-causing mutations.

125 Osteoarthritis (OA) is a common disease characterized by cartilage degeneration a

126 Hydronephrosis is a common disease characterized by dilation of the renal pe

127 gle glaucoma (POAG) is a genetically complex common disease characterized by progressive optic nerve

128 nd insulin resistance.Hepatic steatosis is a common disease closely associated with metabolic syndrom

129 y of the effects of common genetic variants (common disease-common variant hypothesis).

130 pe-phenotype relationship in humans, (2) the common-disease-common-variant hypothesis, (3) the curren

131 us studies have queried the genetic basis of common disease, contradictory hypotheses have been advoc

132 Among children, the most common diseases contributing to significant morbidity an

133 infections at magnitudes comparable to many common disease control interventions.

134 Although AD is a common disease, controlled clinical studies investigatin

135 D and those with extrinsic AD, we identified common disease-defining features of T-cell activation, p

136 Osteoporosis is a common disease diagnosed primarily by measurement of bon

137 s been implicated in the etiology of several common diseases due to the association between specific

138 A major concern in common disease epigenomics is distinguishing causal from

139 Diverticulitis is a common disease, especially in the Western world.

140 c dermatitis, and food allergy are extremely common diseases, especially among children, and are freq

141 he resulting annotations are informative for common disease, even after conditioning on a broad set o

142 ing tool for dissecting the genetic basis of common diseases, expression quantitative trait loci (eQT

143 In contrast to most other common diseases, few genetic variants have been identifi

144 Diabetes mellitus and neurodegeneration are common diseases for which shared genetic factors are sti

145 tially elevated risk of developing important common diseases.(,) For coronary artery disease, about 8

146 erse symptomatology to be quantified under a common disease framework.

147 As in other common diseases, genes at COPD GWAS loci were not differ

148 Presence of a common disease haplotype among this cohort suggests this

149 Many common diseases have an important inflammatory component

150 Genome-wide association studies of common diseases have matured over the last decade, gener

151 opulations, facilitating the illumination of common disease heritability enrichment across an array o

152 The multiple rare variant-common disease hypothesis may explain the missing herita

153 Asthma is a common disease in childhood and is often preceded by whe

154 ors, diagnosis, and treatment to manage this common disease in children.

155 onic obstructive pulmonary disease (COPD), a common disease in elderly patients, is characterized by

156 Stasis dermatitis (SD) is a common disease in the elderly population, with pruritus

157 Chronic urticaria (CU) is a common disease in which most cases were considered to be

158 Although NF1 is a relatively common disease in which routine ophthalmologic examinati

159 ICAL RELEVANCE: Although NF1 is a relatively common disease in which routine ophthalmologic examinati

160 Barrett's esophagus (BE) is a common disease in which the lining of the esophagus tran

161 Asthma is a common disease in young children and is associated with

162 Otitis media (OM), a very common disease in young children, can result in hearing

163 ion study by proxy (GWAX) and apply it to 12 common diseases in 116,196 individuals from the UK Bioba

164 Rhinitis is one of the most common diseases in childhood.

165 Atopic dermatitis and bronchial asthma are common diseases in children.

166 For many traits, including susceptibility to common diseases in humans, causal loci uncovered by gene

167 e in close proximity to SNPs associated with common diseases in large population studies.

168 e NLRP3 inflammasome is also associated with common diseases including cardiovascular disease, diabet

169 The burden of several common diseases including obesity, diabetes, hypertensio

170 a central regulator of inflammation in many common diseases, including atherosclerosis and type 2 di

171 deficiency has been associated with several common diseases, including cancer and is being investiga

172 calcium signaling and is implicated in many common diseases, including cancer and neurodegenerative,

173 le dysregulated Wnt signaling contributes to common diseases, including congenital malformations and

174 lated cardiomyopathy, and implicated in many common diseases, including dilated cardiomyopathy and is

175 hat alleles that influence susceptibility to common diseases, including schizophrenia, will frequentl

176 riasis arthritis (PsA) are poorly understood common diseases, induced by unknown environmental factor

177 t, thereby extending direct investigation of common diseases into the human evolutionary past.

178 nce, whereas it has been hypothesized that a common disease is associated primarily with common genet

179 showing that genetic susceptibility to this common disease is largely determined by common SNPs of s

180 the genetic contribution of rare variants to common diseases is a major basic and clinical science ch

181 Three common diseases, isolated cleft lip and cleft palate (CL

182 f metabolism can inform our understanding of common diseases like cancer and also considers the prosp

183 (1) Autonomic dysfunction is present in common diseases like hypertension, diabetes and heart fa

184 mTOR signaling is deregulated in common diseases, like cancer and epilepsy, and mTORC1 is

185 s, as well as between Mendelian diseases and common diseases linked by genomic location.

186 disease was higher and mortality from other common diseases lower among former Scottish professional

187 We present common disease manifestations and identify key clinical

188 Synchronizing dietary guidelines for these 2 common diseases may provide a simplified public health m

189 correctly spliced ciliopathy genes may be a common disease mechanism in retinal degenerations.

190 vide an in vitro model system to investigate common disease mechanisms and evaluate potential therapi

191 f damaged or abnormally modified protein are common disease mechanisms in many neurodegenerative diso

192 Through the identification of common disease mechanisms on which multiple ALS genes co

193 Discovering common disease mechanisms shared by tumours would provid

194 The 10th anniversary 'Genomics of Common Diseases' meeting was held in Baltimore, Septembe

195 rioritize the causal regulatory variants for common diseases, Mendelian disorders, and cancers.

196 on mitochondrial function, dysfunction, and common disease; mitochondrial receptors, targets, and su

197 ed by compound heterozygous architectures, a common disease model for recessive monogenic disorders,

198 a JNCL neuronal cell model bearing the most common disease mutation in CLN3.

199 stantially increases the informativeness for common disease of both previously uninformative and prev

200 Periodontitis is the most common disease of microbial etiology in humans.

201 Aortic valve calcification (AVC) is a common disease of the elderly.

202 Onychomycosis is the most common disease of the nail in adults.

203 gical research suggests that two of the most common diseases of aging, type 2 diabetes (T2DM) and Alz

204 ncy and both uncomplicated malaria and other common diseases of childhood in a cohort study of 752 ch

205 G6PD c.202T had no effect on other common diseases of childhood in heterozygous girls (inci

206 ading cause of otitis media, one of the most common diseases of childhood.

207 e implications for the treatment of rare and common diseases of ectopic vascular calcification.

208 The NTDs represent the most common diseases of people living in extreme poverty and

209 the underlying biology of associations with common diseases of the human retina, retinal pigment epi

210 ection in an animal model of one of the most common diseases of women worldwide, and may have signifi

211 sociated with time-to-event phenotypes of 12 common diseases, of which 38 loci would be missed within

212 and rare variants contribute to the risks of common diseases or complex traits and the cumulative eff

213 variants that function in a common variant, common disease paradigm.

214 Common diseases, particularly dementia, have large socia

215 as TH2 and regulatory T cells, indicating a common disease pathogenesis in patients with IgG4-RD.

216 nt damaged functions be linked together in a common disease pathway and which damaged function should

217 utations and connects these two genes into a common disease pathway.

218 Because these novel genes share common disease pathways with other genes implicated in A

219 vanced murine and human atherosclerosis, the common disease phenotype in clinical care.

220 he connection between the gut microbiome and common disease phenotypes might be due to underlying cha

221 , and their possible relevance to other more common disease presentations should become more clearly

222 Oral lichen planus was the most common disease presenting as DG, followed by pemphigoid.

223 Oral lichen planus was the most common disease presenting as DG, which is consistent wit

224 Fibrosis is a common disease process in which profibrotic cells distur

225 vidence is growing that dry eye represents a common disease process resulting from a number of underl

226 ings confirm our intuition that knowledge of common disease progressions results in higher predictabi

227 ence variants that underlie GWAS signals for common diseases, ranging from neuropsychiatric disorders

228 Recent emergence of the common-disease-rare-variant hypothesis has renewed inter

229 to evaluate differences in the incidence of common diseases, related hospital admissions, and relate

230 fibril formation by both wild-type TTR and a common disease-related variant, V30M TTR, as effectively

231 asis for variation in most traits, including common diseases, remains only partly understood.

232 Obstructive sleep apnea is a common disease, responsible for daytime sleepiness.

233 ility of such methods for predicting risk of common diseases responsive to early therapeutic interven

234 data to uncover a new mechanism for rare and common diseases resulting from collagen secretion defici

235 ed by the patients--to predict their risk of common diseases--revealed that they share several varian

236 -by-environment (GxE) interactions determine common disease risk factors and biomedically relevant co

237 Rolling phenotype can be modulated by common disease risk modifiers (metformin and pravastatin

238 umulate to become a substantial component of common disease risk.

239 Many common diseases show wide phenotypic variation.

240 The results on 15 common diseases showed a superior performance of the new

241 sking is due to the additional presence of a common disease-specific G170R mutation, which is encoded

242 Haplotype analysis showed a common disease-specific haplotype of the 6 families and

243 oxysmal kinesigenic dyskinesia, confirming a common disease spectrum that had previously been suggest

244 considered to represent different ends of a common disease spectrum.

245 irmly established as a major risk factor for common disease states including hypertension, type 2 dia

246 Their manifestations encompass common disease states such as idiopathic pulmonary fibro

247 rvice planning and could be applied to other common disease states within other regions of the world.

248 ore the role of elevated IL-6 levels in many common disease states, confirming the key causal role of

249 has seen great progress in mapping loci for common diseases, studying how these risk alleles lead to

250 ht thus be translated into new therapies for common diseases such as cancer and autoimmune disorders.

251 These transporters are involved in important common diseases such as cancer and diabetes.

252 associated with tissue remodeling in various common diseases such as cancer, arthritis and fibrosis.

253 erapies are potentially relevant to numerous common diseases such as cirrhosis, non-alcoholic steatoh

254 Common diseases such as coronary heart disease (CHD) are

255 and may highlight biomarkers and pathways in common diseases such as diabetes.

256 arterial calcification of infancy (GACI), to common diseases such as hardening of the arteries associ

257 where the majority of microbiota reside and common diseases such as inflammatory bowel disease, func

258 For common diseases such as VTE, biobanks provide potential

259 ogy and for obtaining critical insights into common diseases, such as those affecting oral health.

260 Emerging mechanistic links with more common diseases suggest we need to rethink our current c

261 So far, three common disease-susceptibility variants at the RET, SEMA3

262 Local allergic rhinitis (LAR) is a common disease that affects 25.7% of the rhinitis popula

263 s resulting from hair cell degeneration is a common disease that affects millions of people worldwide

264 Age-related macular degeneration (AMD) is a common disease that can result in severe visual impairme

265 tis (CRS) without nasal polyps (CRSsNP) is a common disease that is characterized by multiple inflamm

266 Periodontitis is a common disease that is characterized by resorption of th

267 Obstructive sleep apnoea is a common disease that is now more widely recognised becaus

268 Food allergy is a common disease that is rapidly increasing in prevalence

269 Barrett's esophagus is an increasingly common disease that is strongly associated with reflux o

270 rdiovascular diseases, a feature of the most common diseases that has not been elucidated by conventi

271 mortality is believed to be explained by 21 common diseases that have been formally established as c

272 There are, however, several less common diseases that present with urticarial rash, such

273 into adulthood, and play important parts in common diseases that range from obesity to psychiatric d

274 d for examining the phenotypic overlap among common diseases that share risk alleles, as well as betw

275 d microbiome homeostasis, and contributes to common diseases that show geographical disparities, such

276 ding valuable insights into genetic risks of common diseases, the genetic variants identified by GWAS

277 derlying GWAS, including the architecture of common diseases, the structure of common human genetic v

278 understanding of the genetic architecture of common diseases, they have also given rise to challenges

279 have identified many susceptibility loci for common diseases, they only explain a small portion of he

280 nent methods to imputed genotype data for 11 common diseases to partition the heritability explained

281 approach to find long-range interactions in common diseases using a standard two-locus test that con

282 identifying genetic variants associated with common diseases using genome-wide association studies (G

283 ed value in clinical risk prediction of five common diseases, using large-scale biobank data (FinnGen

284 wing intraventricular hemorrhage (IVH), is a common disease usually treated by suboptimal CSF shuntin

285 study highlights benefits of fine-mapping of common disease variants in combination with publicly ava

286 genicity scores, implying that Mendelian and common disease variants share similar properties.

287 usal mutations) if the heritability of these common diseases was explained by rare variants in the co

288 As information about the heritability of common diseases was obtained, similar efforts were direc

289 In common diseases, where multiple genetic variants within

290 Bladder cancer is a common disease whose natural history can be unpredictabl

291 and new ways of preventing and managing this common disease will become available.

292 Schizophrenia is a common disease with a complex aetiology, probably involv

293 Pulmonary thromboembolism (PTE) is a common disease with a high mortality rate that is diffic

294 Atopic dermatitis (AD) is a common disease with an increasing prevalence.

295 Abdominal aortic aneurysm (AAA) is a common disease with often life-threatening consequences.

296 Chronic rhinosinusitis (CRS) is a common disease with still unclear pathophysiologic mecha

297 Asthma is a common disease with substantial human and economic costs

298 Appendicitis is a common disease, with a lifetime risk of approximately 7%

299 Sporadic breast cancer (SBC) is a common disease without robust means of early risk predic

300 as widely expected that the genetic basis of common disease would be resolved by genome-wide associat