ライフサイエンスコーパス: common gamma chain

1 mmon beta chain and IL-2/IL-7/IL-15 receptor common gamma chain.

2 esembles the hematopoietic cytokine receptor common gamma chain.

3 mbination with the interleukin (IL)-receptor common gamma chain.

4 specific chain, and JAK3 is appended to the common gamma chain.

5 rget cells expressing the IL-15Rbeta and the common gamma-chain.

6 of Ccnd3 was dependent on expression of the common gamma-chain.

7 4, and IL-7, through engagement of the IL-2R common gamma-chain.

8 gnaling through cytokine receptors using the common gamma-chain.

9 d expression of the IL-7R alpha-chain or the common gamma-chain.

10 ans to cells bearing the IL-2Rbeta-chain and common gamma-chain.

11 sting of the IL-21 receptor (IL-21R) and the common gamma-chain.

12 ells that expressed the IL-7Ralpha-chain and common gamma-chain.

13 says with cells bearing human IL-15Rbeta and common gamma-chains.

14 alcium mobilization via association with the common gamma-chain, a subunit that transmits signals upo

15 -2 and IL-4 bind to receptors containing the common gamma chain and JAK3.

16 n an expansion of lymphocytes expressing the common gamma chain and the development of CD3(+) T lymph

17 with mutant JAK3 (M511I) for binding to the common gamma chain and thereby suppresses its oncogenic

18 But in sensitized mice lacking the Fc common gamma-chain and B cell-deficient mice, the number

19 Similar defects were present in common gamma-chain and Jak3 KO mice, but not in lambda 5

20 of FcgammaR (through an insufficiency of the common gamma-chains), and the exceptionally slow dissoci

21 vival are regulated by the cytokine receptor common gamma-chain-associated cytokines IL-2, IL-7, and

22 ished by a single amino acid mutation in the common gamma-chain binding site on IL-15.

23 Taken together, our data suggest that common gamma-chain binding-dependent activation of the s

24 The common gamma chain (CD132) is a subunit of the interleuk

25 madelta-17 cells express IL-15Ralpha and the common gamma chain (CD132), yet lack the IL-2/15Rbeta ch

26 express mRNA for IL-7R alpha (CD127) and its common gamma chain (CD132).

27 of variable speed with a few members of the common gamma-chain (CD132) family of cytokines, the spee

28 eptor composed of IL-7Ralpha (CD127) and the common gamma-chain (CD132) to transmit its signal.

29 o T cells expressing IL-2/IL-15Rbeta and the common gamma-chain (CD132), but did not block IL-15 acti

30 coexpression of MDR1 and human IL-2 receptor common gamma-chain cDNAs.

31 egulate TdT and the IL-7R alpha (but not the common gamma-chain) chain.

32 As the IL-2R shares the common gamma-chain component with IL-4, IL-7, and IL-15,

33 tently, deficiency in IL-7 receptor alone, a common gamma chain-containing receptor required for ILC

34 gnaling through T cell antigen receptors and common gamma chain cytokine receptors.

35 sion of genes associated with type I IFN and common gamma chain cytokine signaling in CD4 T cell subs

36 protein by effector T cells was dependent on common gamma-chain cytokine activation of the mTOR pathw

37 CD4 help is provided via IL-21 production, a common gamma-chain cytokine closely related to IL-2.

38 1, the most recently described member of the common gamma-chain cytokine family, is produced by activ

39 idence has indicated that CD8 T(mem) use the common gamma-chain cytokine IL-15 for their steady-state

40 e in that IL-2-mediated up-regulation of the common gamma-chain cytokine receptor and perforin, and a

41 that the need for TCR stimulation to induce common gamma-chain cytokine receptor expression, and thu

42 by demonstrating gene transfer of the human common gamma-chain cytokine receptor gene (gamma(c)), de

43 of several signaling mediators activated via common gamma-chain cytokine receptors.

44 IL-21, a common gamma-chain cytokine secreted by activated CD4+ T

45 of self ligands, whereas TCR signals impair common gamma-chain cytokine signaling and thereby decrea

46 cell cycle proteins are independent of Jak3/common gamma-chain cytokine signals.

47 IL-15 is a common gamma-chain cytokine that has been shown to be mo

48 The response is induced via IL-2 receptor common gamma chain cytokines and a Janus kinase 3 (JAK3)

49 The common gamma chain cytokines interleukin (IL)-2 and IL-7

50 T-cell activation and cellular expansion by common gamma chain cytokines such as Interleukin-2 is ne

51 For example, common gamma-chain cytokines (CGCC), such as interleukin

52 cluded bryostatin 1/ionomycin and sequential common gamma-chain cytokines (IL-7/IL-15 + IL-2).

53 The most widely recognized pathways, common gamma-chain cytokines and type I IFNs, did not co

54 The common gamma-chain cytokines IL-15 and IL-7 have been sh

55 IL-7 was not unique, because the common gamma-chain cytokines IL-2, IL-4, and IL-15, as w

56 he potential use of IGF1 in combination with common gamma-chain cytokines to drive homeostatic T cell

57 ch that signals from interleukin 7 and other common gamma-chain cytokines transcriptionally increase

58 nredundant, but IL-4, IL-7, and IL-15, other common gamma-chain cytokines, could sustain Foxp3 expres

59 chronic GVHD, caused by T cells activated by common gamma-chain cytokines, each represent therapeutic

60 Other common gamma-chain cytokines, IL-4, IL-7, or IL-15, do n

61 rgone partial differentiation in response to common gamma-chain cytokines, particularly IL-15 and IL-

62 CD25(+)Foxp3(-) cells to IL-2, but not other common gamma-chain cytokines, resulted in Stat5 phosphor

63 activation with physiologic stimuli such as common gamma-chain cytokines, Toll-like receptor (TLR) 2

64 y cognate peptide stimulation or exposure to common gamma-chain cytokines.

65 Bone marrow-cultured mast cells from common gamma-chain deficient mice, unlike mast cells cul

66 acterization of a new genetic stock of IL-2R common gamma-chain deficient NOD/LtSz-scid (NOD-scid IL2

67 In CD132 (common gamma-chain)-deficient hosts, pmel-1 CD8(+) T cel

68 (SCID/NOD) wild-type or SCID/NOD Fc receptor common gamma chain-deficient (FcRgamma(-/-)) mice.

69 -7Ralpha-chain-deficient (IL-7Ralpha-/-) and common gamma chain-deficient (gammac-/-) mice both exhib

70 s with this phenotype are highly enriched in common gamma chain-deficient mice and absent from MHC-I(

71 , whereas B cells were not eliminated in FcR common gamma chain-deficient mice.

72 ese diabetic severe combined immunodeficient common gamma chain-deficient stem cell factor (huNSG) mi

73 to control B16F10 tumor growth, but only in common gamma-chain-deficient host mice.

74 Therefore, we used alymphoid Rag- and common gamma-chain-deficient mice as recipients and obse

75 of immunoglobulin G Fc receptor (Fc(gamma)R) common gamma-chain-deficient mice revealed that the cros

76 eport, we examine in detail the role of Jak3/common gamma-chain-dependent cytokines in promoting cell

77 ental requirement for IL-2 and perhaps other common gamma-chain-dependent cytokines to promote select

78 trate a direct impact of IL-2 and IL-15, two common gamma-chain-dependent cytokines, on CD8(+) T-cell

79 ntestinal microbiota, adaptive immunity, and common-gamma chain-dependent signaling.

80 lpha-chain to the shared IL-2/IL-15Rbeta and common gamma-chains displayed on the surface of T cells

81 essed following IRI in immunodeficient RAG-2/common gamma-chain double-knockout mice, suggesting that

82 IL-2 and IL-15 are common gamma-chain family cytokines involved in regulati

83 Two common gamma-chain family cytokines, IL-2 and IL-7, alth

84 IL-7, a member of the common gamma-chain family of cytokines, is essential for

85 by interleukin-15 (IL-15), a cytokine in the common gamma-chain family.

86 MyD88 and FcR common gamma-chain (Fcer1g, FcRgamma) elicit proinflamma

87 mma RI, Fc gamma RIIb, Fc gamma RIII, or the common gamma chain (FcR gamma) had their common carotid

88 eptor tyrosine-based activation motif on the common gamma chain (FcRgamma).

89 2 and IL-15, a cytokine family that uses the common gamma-chain for signaling.

90 IL-2 receptor beta-chain CD122, forming with common gamma-chain functional high-affinity IL-2 recepto

91 like human XSCID, is due to mutations in the common gamma chain (gamma c) gene and has clinical and i

92 , a disease caused by genetic defects of the common gamma chain (gamma c) that is a shared component

93 Signaling through the common gamma chain (gamma c), a subunit of the receptors

94 consisting of the IL-4R alpha chain and the common gamma chain (gamma c), resulting in a series of p

95 a(c)-Revgen vector contains the entire human common gamma chain (gamma(c)) genomic sequence driven by

96 t mice lacking either the alpha chain or the common gamma chain (gamma(c)) of the IL-7R.

97 Here we exploited the common gamma chain (gamma(c)) receptor as a shared signa

98 this study, we examined whether Jak3 and the common gamma chain (gamma(c)) reciprocally regulate thei

99 iated with the interleukin-2 (IL-2) receptor common gamma chain (gamma(c)) that is activated by multi

100 ld not completely treat tumor in lymphopenic common gamma chain (gamma(c))-deficient hosts.

101 e models, all carrying null mutations of the common gamma chain (gamma(c)).

102 emory T cells expressing IL-15/IL-2Rbeta and common gamma chain (gamma(c)).

103 caused by a defect in the gene encoding the common gamma chain (gamma-c) of the receptor for interle

104 The common gamma-chain (gamma c) cytokines IL-2, IL-7, IL-15

105 4 signals through two receptors, IL-4R alpha/common gamma-chain (gamma(c)) and IL-4R alpha/IL-13R alp

106 erous crystal structures of complexes of the common gamma-chain (gamma(c)) cytokine receptors and the

107 intracellular domain (ICD) of receptors for common gamma-chain (gamma(c)) cytokines IL-4, IL-7, IL-9

108 The common gamma-chain (gamma(c)) cytokines signal through t

109 view focuses on the role of cytokines of the common gamma-chain (gamma(c)) family in the determinatio

110 here an unliganded receptor structure in the common gamma-chain (gamma(c)) family of receptors and cy

111 The common gamma-chain (gamma(c)) is a functional component

112 The shared common gamma-chain (gamma(c)) of IL-2R and its associate

113 28/CD40 ligand (CD40L) costimulation and the common gamma-chain (gamma(c)) signals, a shared signalin

114 The common gamma-chain (gamma(c)) that functions both in lig

115 ing through cytokine receptors utilizing the common gamma-chain (gamma(c)).

116 rough the receptor subunit IL-2Rbeta and the common gamma-chain (gamma(c)).

117 e IL-15R complex that consists of IL-2Rbeta, common gamma-chain (gamma(c)-chain), and a specific chai

118 n the X-linked gene IL2RG, which encodes the common gamma chain, gamma c, of the leukocyte receptors

119 umans and dogs results from mutations in the common gamma-chain, gamma c, which is a common component

120 a-chain that specifically binds IL-7 and the common gamma-chain, gamma(c), which is also a component

121 Cytokines that use the common gamma chain gammac are critical for lymphoid deve

122 deficient mice lacking the cytokine receptor common gamma chain (gammac(-/-)) and carrying a human st

123 combination-activating gene 2 (Rag2) and the common gamma chain (gammac) (Rag-gammac(-/-)), which lac

124 hematopoietic cells that associates with the common gamma chain (gammac) and is required for signalin

125 leukin 2 (IL-2) and IL-15 signal through the common gamma chain (gammac) and through IL-2 receptor be

126 Common gamma chain (gammac) cytokine receptors, includin

127 eficiency (XSCID) is due to mutations in the common gamma chain (gammac) gene and is identical clinic

128 Interestingly, common gamma chain (gammac) knockout mice have been show

129 The anti-common gamma chain (gammac) mAb CP.B8 is shown to inhibi

130 by mutations in the IL2RG gene encoding the common gamma chain (gammac) of receptors for interleukin

131 he alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits.

132 restricted to interleukins that recruit the common gamma chain (gammac) receptor, including IL-9.

133 odest reduction in surface expression of the common gamma chain (gammac) that associates with JAK3.

134 kinase that specifically associates with the common gamma chain (gammac), a shared subunit of recepto

135 The common gamma chain (gammac), a subunit of the interleuki

136 through cytokine receptors that utilize the common gamma chain (gammac), such as those for IL-2, IL-

137 The common gamma chain (gammac)-binding cytokine interleukin

138 However, Foxp3 lethality was prevented by common gamma chain (gammac)-dependent cytokine signals t

139 Common gamma chain (gammac)-receptor dependent cytokines

140 We show that common gamma chain (gammac)-using cytokines, namely IL-2

141 r for IL-7 is heterodimeric, consisting of a common gamma chain (gammac, encoded by Il2rg) and an alp

142 The common gamma chain (gammac; IL-2RG) is a subunit of the

143 with SCID caused by mutations affecting the common gamma-chain (gammac) cytokine signaling pathway a

144 kinase, AP-1, and NF-kappaB, as well as the common gamma-chain (gammac) cytokine-receptor-induced si

145 Tim-3 was induced by the common gamma-chain (gammac) cytokines IL-2, IL-7, IL-15,

146 resent in mice lacking both the Rag2 and the common gamma-chain (gammac) genes (Rag2(-/-)gammac(-/-))

147 R alpha-chain; IL-7Ralpha is paired with the common gamma-chain (gammac) in the IL-7 receptor complex

148 The common gamma-chain (gammac) is a key component of multip

149 The common gamma-chain (gammac) plays a central role in sign

150 LP and TGF-beta) that did not signal via the common gamma-chain (gammac) receptor but that, like IL-7

151 The common gamma-chain (gammac), a subunit of the IL-2R, is

152 ing via cytokine receptors that comprise the common gamma-chain (gammac), i.e., the receptors for IL-

153 ncies that lead to loss of signaling through common gamma-chain (gammac)-containing cytokine receptor

154 tasis of natural killer (NK) cells relies on common gamma-chain (gammac)-dependent cytokines, in part

155 by CD28/CD154 costimulatory signals and the common gamma-chain (gammac; a shared signaling element b

156 IL-4 signals through the type I (IL-4Ralpha/common gamma-chain [gammac]) and the type II (IL-4Ralpha

157 aling pathways utilizing a cytokine receptor common gamma chain, gammac, and the tyrosine kinase Jak3

158 and human XSCID are caused by defects in the common gamma chain, gammac, of receptors for interleukin

159 es share a component of their receptors, the common gamma chain, gammac.

160 ction from cytokine receptors containing the common gamma-chain, gammac.

161 ng alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors.

162 rm of human SCID, is due to mutations in the common gamma chain gene (gamma-c) that encodes an essent

163 her cytokines sharing the IL-2R beta- and/or common gamma-chains (i.e., IL-15, IL-4, and IL-7) do not

164 dditional knockout of interleukin 2 receptor common gamma chain (IL-2Rgammac) from adaptive immunity-

165 autonomously or in collaboration with other common gamma chain (IL-4 and IL-7) and IL-6/IL-12 family

166 The IL-2R common gamma-chain (IL-2Rgamma) is shared by receptors f

167 other cytokine receptor chains including the common gamma-chain, IL-2Rbeta, or the IL-2Ralpha, IL-4Ra

168 t mice bearing mutations in the IL2 receptor common gamma chain (IL2rg(null)) in the early 2000s, inv

169 utation in the interleukin 2 (IL-2) receptor common gamma chain (IL2rg(null)) into mice that were alr

170 or encoding the human interleukin 2 receptor common gamma chain (IL2RG) gene and the efficient deriva

171 ice expressing mutations in the IL2-receptor common gamma chain (IL2rg) gene, including NOD-scid IL2r

172 nterleukin-7 receptor-alpha sequestrates the common gamma chain, impairing the interleukin-2 receptor

173 ic deletion of interleukin 2 (IL-2) receptor common gamma chain in Rag-deficient mice did rescue muta

174 roduced IFN-gamma, was T cell-, B cell-, and common gamma-chain-independent, and required IL-4Ralpha

175 ich signals through receptors containing the common gamma chain, induced expression of IL-10 in the I

176 iller (NK) cells and in SCID/NOD Fc receptor common gamma chain knockout (FcRgamma-/-) mice.

177 se diabetic severe combined immunodeficiency common gamma chain knockout-bone marrow-liver-thymus hum

178 he binding of IL-13 to IL-13Ralpha1, neither common gamma-chain nor IL-13Ralpha1 contributed signific

179 opoietic cells and binds specifically to the common gamma chain of a subfamily of cytokine receptors

180 s a tyrosine kinase that associates with the common gamma chain of cytokine receptors and is recurren

181 ciency (XSCID) is caused by mutations of the common gamma chain of cytokine receptors, gamma(c).

182 In addition, we show that mice lacking the common gamma chain of Fc receptors (FcgammaRI, Fcepsilon

183 protection by infecting mice deleted for the common gamma chain of FcRs.

184 y of IL-4 and was largely independent of the common gamma chain of the IL-2, IL-4, IL-7, IL-9, and IL

185 cross-linking CD28, or signaling through the common gamma chain of the interleukin-2 receptor on T ce

186 infection of either BALB/c mice lacking the common gamma-chain of Fc receptors (FcgammaR(-/-)) or mi

187 ations of the FcgammaRIII alpha-chain or the common gamma-chain of FcepsilonRI and FcgammaRI/III, we

188 Although mice deficient in the common gamma-chain of the FcgammaR did not show clinical

189 ors, a complex of IL-4Ralpha with either the common gamma-chain or the IL-13R chain alpha1 (IL-13Ralp

190 y FcgammaRI, FcgammaRIII, FcgammaRIV, or FcR common gamma chain, or inhibitory FcgammaRIIB.

191 ubsets investigated expressed IL-4Ralpha and common gamma chain protein and mRNA, expression of IL-13

192 and SCID bearing a null mutation in the IL-2 common gamma chain receptor (NSG) mice as animal models

193 Interleukin 7 (IL-7) is a common gamma chain receptor cytokine implicated in thymo

194 nterleukin (IL) 7, a constitutively produced common gamma chain receptor cytokine, to the survival of

195 Cytokines, particularly those of the common gamma chain receptor family, provide extrinsic si

196 To identify phosphoproteins downstream of common gamma chain receptor, YT cells were radiolabeled

197 oexpressed and functions in synergy with the common-gamma chain receptor family.

198 ce IL-1R1 expression by signals via TCRs and common gamma-chain receptors was essential for naive CD4

199 tokine receptors, which can be generated for common gamma-chain receptors, interleukin-10 and -12 rec

200 Cytokine receptors that utilize the common gamma chain signal through the lymphocyte-specifi

201 cell features are induced in CTCL T cells by common gamma chain signaling cytokines such as IL-2 and

202 duction below threshold levels necessary for common gamma chain signaling.

203 IL-21 is a member of the common gamma-chain signaling family of cytokines.

204 okines are a family whose receptors share a "common-gamma-chain" signaling moiety, and play central r

205 e (Rag) 2(-/-) splenocytes but not Rag2(-/-) common gamma chain(-/-) splenocytes.

206 Cytokines that signal through the common gamma-chain suppressed T(reg) cell-induced apopto

207 CD122 forms a heterodimer with CD132 (the common gamma chain) that triggers canonical IL-2 signali

208 fs, whereas PIR-A pairs with the Fc receptor common gamma chain to form an activating receptor comple

209 iated disease and associates with either the common gamma-chain to form the type I IL-4R or with the

210 Other common gamma-chain-utilizing cytokines were unable to in

211 knocking out the immunoglobulin Fc receptor common gamma chain where the effect is greatest on chron

212 IL2RG encodes the common gamma chain, which is part of several interleukin

213 However, no cell line expressed IL-2R common gamma-chain, which is known to be shared with IL-

214 to bind with the shared IL-2/IL-15Rbeta and common gamma-chains, which activate signaling pathways o

215 CLPs express IL-7 receptors, which share the common gamma chain with IL-2 receptors, IL-7 cannot init

216 ow progenitors lacking the cytokine receptor common gamma-chain yields leukemogenic pre-B cells that