ライフサイエンスコーパス: compaction

1 al features (DSB focus size, local chromatin compaction).

2 learing, inflammatory containment and matrix compaction.

3 of nutrients and organic matter, erosion and compaction.

4 identify as a further regulator of phagosome compaction.

5 omponent of the function of HBsu in nucleoid compaction.

6 processes ranging from factor binding to DNA compaction.

7 passage via loop extrusion-driven lengthwise compaction.

8 he energy of ATP hydrolysis to promote their compaction.

9 e chromatin binding by condensin II promotes compaction.

10 perimental results of multi-cell induced ECM compaction.

11 l modification (hPTM) that fosters chromatin compaction.

12 in sister chromatid cohesion and chromosome compaction.

13 hibit defects in PC1 expression and collagen compaction.

14 op-capture mechanism for initial binding and compaction.

15 ns while most chromatin mass undergoes hyper-compaction.

16 er to enrich H4K20me1 and trigger chromosome compaction.

17 to align collagen gels using guided cellular compaction.

18 hat only the multimer shows ATP-enhanced DNA-compaction.

19 r traction, intercellular tension and tissue compaction.

20 ctive chromatin domains by promoting genomic compaction.

21 elomeric regions, which is crucial for their compaction.

22 ncluding transcription, replication, and DNA compaction.

23 This is known to mediate chromatin compaction.

24 reduced, resulting in increased chromatosome compaction.

25 genes into the cluster, so enabling cluster compaction.

26 nd Mecp2 are required to maintain chromosome compaction.

27 or by silencing transcription via chromatin compaction.

28 vealed that this relationship emerged during compaction.

29 53BP1), DSB density, and the local chromatin compaction.

30 hese molecular properties lead to chromosome compaction.

31 bases and to facilitate DNA replication and compaction.

32 hieved through massive gene loss and extreme compaction.

33 ression, but instead bookmarks promoters for compaction.

34 improved HL, nerve fiber density, and myelin compaction.

35 ft ventricle did not change during and after compaction.

36 pology by plectoneme stabilization and local compaction.

37 from colliding cells and facilitates matrix compaction.

38 bind to nucleosomes and facilitate chromatin compaction(1), although their biological functions are p

39 ncing through localized control of chromatin compaction, 3D genome organization and the epigenetic la

40 Phagosomal compaction, a crucial step in phagolysosome maturation,

41 Subsidence attributed to aquifer-system compaction accompanying groundwater extraction contribut

42 electron microscopy and show extensive soot compaction after cloud processing.

43 However, compaction alone does not account for the formation of d

44 This barrier modulates the degree of plaque compaction, amyloid fibril surface area, and insulation

45 is associated with a process of whole-embryo compaction analogous to that observed in mammals [4-7].

46 key lysine residues is to regulate nucleoid compaction, analogous to the role of histone acetylation

47 some organization is important for chromatin compaction and accessibility.

48 chromatin structure of DNA determines genome compaction and activity in the nucleus.

49 lus-end dynamicity, and motor-driven midzone compaction and alignment.

50 n 1/keratin 10 end domains to allow filament compaction and bundling, whilst also retaining extensibi

51 ains, and varies with the level of chromatin compaction and cell type.

52 removing excess cytoplasm to promote myelin compaction and development of oligodendrocytes, as well

53 Under compaction and dewatering, the size and geometry of such

54 Chromosome segregation requires both compaction and disentanglement of sister chromatids.

55 e metaphase state requires higher lengthwise compaction and drives complete topological segregation.

56 depletion, we observed significant cytosolic compaction and extensive cytoplasmic reorganization, as

57 Chromatin is critical for genome compaction and gene expression.

58 ases considerably over time during aggregate compaction and growth.

59 end at various lengths to achieve structural compaction and high packing densities.

60 shown to play an important role in chromatin compaction and large-scale chromatin organization.

61 fq-DNA interaction and a role for Hfq in DNA compaction and nucleoid architecture.

62 SUMOylation, Mer2 mediates global chromosome compaction and post-recombination chiasma development.

63 own previously to be important for chromatin compaction and proper development, raising the possibili

64 se characteristic dynamical modes facilitate compaction and rearrangement in the cell nucleus.

65 nome architectural mechanisms might regulate compaction and recombination of AgR loci.

66 o its biological function in heterochromatin compaction and regulation.

67 Rewarming reverses chromatin compaction and releases the transcripts into the cytopla

68 g transcription factor ZEB1 stimulated Golgi compaction and relieved microRNA-mediated repression of

69 R that pulls actin bundles, resulting in the compaction and removal of the cell body.

70 assay and upregulates cell-mediated collagen compaction and reorganization, whereas aggrecan, a struc

71 on in Drosophila S2 cells leads to chromatin compaction and repositioning from the nuclear envelope.

72 w this activity specifically promotes proper compaction and segregation of chromosomes during mitosis

73 prometaphase to allow for proper chromosome compaction and segregation.

74 o not significantly affect overall chromatin compaction and self-association.

75 of nucleosome arrays to undergo salt-induced compaction and self-association.

76 Experimentally, the level of compaction and shape is often determined either by small

77 B proteins regulate developmental chromatin compaction and that the timing of chromatin compaction i

78 mall RNAs are sufficient to direct chromatin compaction and that this compaction requires the small R

79 porosity near roots taking into account soil compaction and the surface effect at the root surface.

80 e complex interplay between sister chromatid compaction and their segregation during mitosis.

81 is the effect of DNA strain arising from DNA compaction and transcriptional activity on initiation co

82 ic heterochromatin that coordinate chromatin compaction and transcriptional gene silencing.

83 at the 8-cell stage and might affect embryo compaction and trophectoderm specification.

84 show that experimentally observed chromosome compaction and variance in compaction are reproduced onl

85 was associated with key regulators of Golgi compaction and vesicle transport in pull-down assays and

86 -term yearly soil productivity losses due to compaction and water erosion can amount to up to double-

87 This confirms the relevance of compaction and water erosion impacts for agricultural LC

88 er, we develop methods for the assessment of compaction and water erosion impacts within one framewor

89 s and analyte transfer without risking fiber compaction and/or damaging.

90 estigating the quasi-static avalanche angle, compaction, and dilatancy effects in different nonbuoyan

91 linked gene expression, reduces X chromosome compaction, and disrupts X chromosome conformation by di

92 enes in B. subtilis for their effects on DNA compaction, and identified five candidates that may enco

93 issues such as infrastructure damage, ground compaction, and reducing the ground capacity to store wa

94 nd that the individual contributors to chain compaction are not additive.

95 served chromosome compaction and variance in compaction are reproduced only with tandem interactions

96 eage- and developmental stage-specific locus compaction as well as broad usage of V segments.

97 We show that the extent of array compaction, as well as nucleosome positioning, dramatica

98 tubules do not show the longitudinal lattice compaction associated with EB protein binding and GTP hy

99 pecific transcription programs and chromatin compaction at high temperature.

100 pression of multiple genes through chromatin compaction at its target genes.

101 The mouse embryo undergoes compaction at the 8-cell stage, and its transition to 16

102 Yeast MTs were not observed to undergo compaction at the interdimer interface as seen for mamma

103 d a biophysical method to quantify chromatin compaction at the nucleosome level during the DNA damage

104 esses develop through cell-driven mechanical compaction at the tissue periphery, and suggest that the

105 For maximal compaction, besides dominantly interacting with parental

106 ic two-sided loop extrusion can achieve such compaction, but recent single-molecule studies (Golfier

107 ondensin complexes are involved in chromatin compaction, but the contribution of other chromatin prot

108 crucial roles in chromosome organization and compaction, but the mechanistic basis for its functions

109 eover, we found that modulation of chromatin compaction by ATP depletion, or treatment with solutions

110 DNA compaction by cohesin requires adenosine triphosphate (A

111 nding into micelleplexes, reminiscent of DNA compaction by histones in chromatin, preserves the pDNA

112 twork disassembly, expansion, and subsequent compaction by myosin motors with kinetics compatible wit

113 polyethylene glycol and blocked ATP-powered compaction by myosin-II miniature filaments.

114 rtantly, these findings imply that chromatin compaction by nucleosome stacking protects nucleosomal D

115 n, this same stress also promotes chromosome compaction by rendering the axes susceptible to the requ

116 rized condensin in driving gradual chromatin compaction by step-like and slow "creeping" dynamics con

117 Here we show that chromatin compaction by the Schizosaccharomyces pombe HP1 protein

118 High compaction can be achieved if even a small fraction of c

119 The resulting compaction can bias unfolded nucleic acids towards foldi

120 ted liquid HP1 pool; and (4) heterochromatin compaction can toggle between two "digital" states depen

121 n mice (Tet2/3-DKO) leads to ventricular non-compaction cardiomyopathy (NCC) with embryonic lethality

122 one H2B-EGFP to interrogate global chromatin compaction changes in response to localized DSBs directl

123 Loss of this patterned compaction coincides with the developmental time period

124 ukaryote cell division features a chromosome compaction-decompaction cycle that is synchronized with

125 romosome alignment leads to interchromosomal compaction defects during anaphase, abnormal organizatio

126 reproduce periodic modulations of chromatin compaction, DNA topology, and internucleosomal interacti

127 equired for gene silencing, while chromosome compaction does not appear to be an important H-NS funct

128 hromatin, which implies that heterochromatic compaction does not reduce MNase accessibility of linker

129 They reach their greatest compaction during chromosome condensation in mitosis.

130 o propose a model for its role in chromosome compaction during meiosis.

131 anning helices alpha2 and alpha3 underwent a compaction during the formation of O(L) and elongation i

132 rmation is important, yet challenging due to compaction, dynamics and scale.

133 ng that the global conformational search and compaction electrostatics are energetically independent

134 ent, reduced soil erosion, salinization, and compaction, fire management, reduced landslides and haza

135 nding of H1E enables both; others compromise compaction for bendability.

136 Following DNA compaction, further sperm maturation occurs in the epidi

137 x is presented, which illustrates how genome compaction has resulted in the smallest known eukaryotic

138 Fe1.6O4, prepared by magnetic field assisted compaction, have been reported in this study.

139 ous increases in chromatin accessibility and compaction heterogeneity.

140 tions in extracellular lipids and corneocyte compaction in all ichthyoses except epidermolytic ichthy

141 sults uncover a conservative route to genome compaction in annelids, reminiscent of that observed in

142 ke protein, are capable of driving chromatin compaction in C. elegans.

143 in the mechanism of licensing of chromosome compaction in mitosis.

144 vant features of pericentric heterochromatin compaction in mouse fibroblasts.

145 re critical for gene silencing and chromatin compaction in multiple eukaryotic systems, but the mecha

146 Chromatin compaction in mutants is delayed into developmental time

147 of occlusion in 16 (94.1%) patients and coil compaction in one (5.9%).

148 ssays and was required to reconstitute Golgi compaction in PAQR11-deficient tumor cells.

149 Finally, we show that chromatin compaction in preimplantation embryos can partially proc

150 een shown previously to eliminate nucleosome compaction in vitro and generate axial patterning defect

151 ssive exchange of histone with protamine for compaction into sperm during spermiogenesis.

152 ly organized into protein-DNA assemblies for compaction into the nucleus.

153 chemical environments and that binding site compaction is a determinant of both resting and active a

154 We propose that CBX2-driven nucleosome compaction is a key mechanism by which PcG proteins main

155 cking in condensation states once sufficient compaction is achieved.

156 The compaction is anisotropic, being higher along the long a

157 monstrate that condensin-dependent chromatin compaction is conserved in quiescent human fibroblasts.

158 Experiments suggest that ~1000-fold compaction is driven by condensin complexes that extrude

159 Chromosome compaction is essential for reliable transmission of gen

160 Gene silencing by chromatin compaction is integral to establishing and maintaining c

161 ins, histone modifications, and differential compaction is largely sufficient to reveal the locations

162 ly reduced, although no change in chromosome compaction is observed.

163 This compaction is processive over tens of kilobases at an av

164 Because the extent of compaction is small, experiments have to be accurate and

165 compaction and that the timing of chromatin compaction is temperature sensitive in both wild type an

166 r chromatid cohesion, and mitotic chromosome compaction, it appears that these complexes function via

167 d regions within the RNF4 N-terminus promote compaction, juxtaposing RING domain and SIMs to facilita

168 Extreme genome compaction led to minimal gene sizes affecting even cons

169 We further showed that the radius and compaction level of clutch-associated DNA decreased in h

170 itself, but aromatic residues lead to strong compaction, likely through pai-interactions.

171 en found in patients with left ventricle non-compaction (LVNC), we investigated members of our family

172 lex promotes genome stability as a DNA micro-compaction machine.

173 scence anisotropy-based readout of chromatin compaction may be used in the investigation of different

174 Magnetic field assisted compaction (MC) has been employed to process Zr-doped co

175 ities produce larger clutches by a chromatin compaction mechanism, while higher acetylation levels pr

176 In particular, we measured DNA compaction mediated by BsSpo0J using a recently develope

177 However, we also implicate chromatin compaction mediated by H1 as an additional, dominant rep

178 Lack of compaction might reflect slower GTP hydrolysis or a diff

179 yos at the blastomere, polyploid blastomere, compaction, morula and blastocyst-like stages by light,

180 ZIF-8 occurred by multiple processes: powder compaction, nanopore-collapse, and chemical bond-breakag

181 yriad of chromatin characteristics including compaction, nucleosome spacing, transcription regulation

182 ) T cells reveals that H1-mediated chromatin compaction occurs primarily in regions of the genome con

183 ese results suggest that the Trem2-dependent compaction of Abeta into dense plaques is a protective m

184 to its ability to self-oligomerize, causing compaction of bound template dsDNA into a higher-ordered

185 proteins in vivo, we also observe increased compaction of chromatin enriched for histone variant nuc

186 rdered region (IDR), which is the region for compaction of chromatin in vitro, promote the condensate

187 n the context of Ph, can mediate large-scale compaction of chromatin into biochemical compartments th

188 Restraining these dynamics impairs compaction of chromatin into liquid droplets by Swi6.

189 It has been proposed that lengthwise compaction of chromatin into mitotic chromosomes via loo

190 Condensin depletion prevents the compaction of chromatin within domains and leads to wide

191 neighboring nucleosomes to drive short-range compaction of chromatin, but the mechanistic details sur

192 in the nuclear periphery accompanied by the compaction of chromatin.

193 In the model, the reported compaction of chromosomal DNA caused by SYCP3 would resu

194 single-DNA magnetic tweezers assay to study compaction of DNA by yeast condensin, with the result th

195 ied and phosphorylated HP1alpha induce rapid compaction of DNA strands into puncta, although with dif

196 e nucleus, bind to chromatin, disrupt proper compaction of DNA, and are associated with a specific me

197 ctivity and promote extensive and reversible compaction of double-stranded DNA.

198 Compaction of double-tethered DNA suggests that a cohesi

199 aling and tissue development, characteristic compaction of ECM gel is induced by multiple cells that

200 Laser-induced clustered DSBs led to global compaction of even the undamaged chromatin.

201 formed in open sea by random aggregation and compaction of fibers held together by friction forces.

202 o remodel the extracellular matrix, inducing compaction of fibrin into bundled agglomerates tightly a

203 ein-DNA complexes in eukaryotes that provide compaction of genomic DNA and are implicated in regulati

204 The inversion and dense compaction of heterochromatin converts these nuclei into

205 lls; (2) the size, global accessibility, and compaction of heterochromatin foci are independent of HP

206 This response is accompanied by compaction of higher-order chromatin and hindrance of mR

207 etermine the extent of temperature-dependent compaction of individual molecules in dilute solutions.

208 ional modifications (PTMs) of histones alter compaction of interphase chromatin, but it remains poorl

209 th poly(A) tail length regulation and in the compaction of mature transcripts to facilitate nuclear e

210 hich a core mechanism, the variable physical compaction of meiotic chromosomes, generates interindivi

211 NDGA analogs induced modest, progressive compaction of monomeric alpha-synuclein, preventing aggr

212 e C-terminal dimerization domain of MUC5B in compaction of mucin chains during granular packaging via

213 Compaction of subtelomeric domains and tethering to the

214 Adding linker histone H1 further increased compaction of the A-tract arrays while maintaining struc

215 we use our approach to validate the further compaction of the already unfolded state of phosphoglyce

216 Supercoiling is able to induce some compaction of the bacterial DNA, although to a lesser ex

217 these opposite effects by promoting physical compaction of the chromatin substrate.

218 We find that the compaction of the denatured state is related to changing

219 ectivity is the magnitude of change in local compaction of the disordered chain upon phosphorylation

220 The compaction of the disordered linker depends not only on

221 ects of DNA demixing and supercoiling on the compaction of the DNA coil simply add up is shown to exi

222 lecular crowders play a dominant role in the compaction of the DNA into the nucleoid.

223 The compaction of the ENC domain was found significantly hig

224 atterning techniques to show that mechanical compaction of the extracellular matrix during mesenchyma

225 show that proton application causes a global compaction of the extracellular subunit interface, coupl

226 precisely controlled to guarantee efficient compaction of the genome and proper chromosomal segregat

227 ry, we show that both inhibitors promote the compaction of the initially formed beta2m dimer, which c

228 ist binding at the Venus flytraps leads to a compaction of the intersubunit dimer interface, thereby

229 nteractions between the termini coupled with compaction of the microtubule binding and proline- rich

230 , the proline-rich region is a requisite for compaction of the microtubule binding region upon bindin

231 either a ligand induced dimerization and/or compaction of the monomer are considered.

232 o of these mutations (A455E and L558S) delay compaction of the nascent NBD1 during a critical window

233 DNA and proteins required for the efficient compaction of the nearly 2-meter-long human genome into

234 tiply charged ions, often leading to overall compaction of the protein depending on the preferred bin

235 SAXS studies further show compaction of the protein upon complex formation.

236 of coronaviruses serves two major functions: compaction of the RNA genome in the virion and regulatio

237 The final assembly and compaction of the small subunit processome requires the

238 roscopy, we monitor the DSB dynamics and the compaction of the surrounding chromatin, visualized by f

239 tribution as originating from a shift in the compaction of the two different families of conformation

240 functions are proposed to arise in part from compaction of the underlying chromatin(2).

241 ific literatures and patents, related to the compaction of TMUPS.

242 y, interhelical contacts, and conformational compaction of Tom1 VHS, suggesting that the phosphoinosi

243 rely on experimental data, we establish that compaction of unfolded states under native conditions is

244 Re-compaction of Von Willebrand factor is accelerated by in

245 in cryo-electron microscopy, Bim1 causes the compaction of yeast microtubules and induces their rapid

246 Possible effects of the H4 tail compaction on chromatin structure are discussed within a

247 model combines the effect of segregation and compaction on chromosomal organization with the effect o

248 , therefore, has a role other than chromatin compaction or epigenetic regulation and generates biousa

249 rol gene accessibility by altering chromatin compaction or nucleosome positioning.

250 Increased soil strength due to soil compaction or soil drying is a major limitation to root

251 Further compaction over time led to clusters with highly aggrega

252 solutions for fibres of the highest possible compaction permitted by physical constraints, including

253 t requiring condensin for mitotic chromosome compaction, post-mitotic neurons express Cap-G.

254 lish that the histone-based mechanism of DNA compaction predates the nucleosome, illuminating the ori

255 of the compact is not only determined by the compaction pressure but also significantly influenced by

256 The compaction procedure is adaptive to additive manufacturi

257 ryotes, a first step towards the nuclear DNA compaction process is the formation of a nucleosome, whi

258 al signature in a form of a unique chromatin compaction profile.

259 th the goal of determining whether the total compaction ratio of the DNA is the mere sum or some more

260 ere sum or some more complex function of the compaction ratios due to each mechanism.

261 The compaction reaction involves step-like events of 200 nm

262 The compaction reactions are largely insensitive to DNA tors

263 comb repressive complex 1 (PRC1), contains a compaction region that has the biochemically defined act

264 lex role of linker histone (LH) on chromatin compaction regulation has been highlighted by recent dis

265 the mechanisms that regulate their size and compaction remain obscure.

266 , but the contributions of altered chromatin compaction remain unclear.

267 diated phase separation relates to chromatin compaction remains unclear.

268 ing, it has been hypothesized that chromatin compaction represses transcription during quiescence.

269 to direct chromatin compaction and that this compaction requires the small RNA-binding Argonaute NRDE

270 chromosomes via loop extrusion underlies the compaction-segregation/resolution process.

271 for identifying healthy embryos at the early compaction stage with 86% accuracy.

272 Compaction starts vectorially as soon as the first alpha

273 ould be modulated by modifying the chromatin compaction state and remodeling processes.

274 ns in the epigenetic sequence determines the compaction state at any particular location in the chrom

275 mmed cells have comparatively open chromatin compaction states and may be more poised to redifferenti

276 ar small RNAs initiate or maintain chromatin compaction states in C. elegans germ cells.

277 blish that heterochromatin can adopt digital compaction states that are independent of HP1 phase sepa

278 ixation and reported on underlying chromatin compaction states.

279 microscopy reveals a continuum of chromatin compaction states.

280 s underlying physical (e.g. tillage, traffic compaction, swell/shrink and freeze/thaw) and biological

281 nctions in this process to control both mRNP compaction that facilitates movement through nuclear por

282 tact domain structure, it lacks higher-order compaction that is typical of chromosomes and displays s

283 napsis, synapsis itself generates additional compaction that matures differentially according to telo

284 ed activation prevents the gradual chromatin compaction that occurs naturally in developmental progre

285 patiotemporal maps of nuclear-wide chromatin compaction that, when coupled with laser microirradiatio

286 patocytes of mice, focusing on the chromatin compaction the roles of the Polycomb repressive complex

287 ase is essential for maintaining chromosomal compaction, transcriptional programming, and genetic int

288 Direct measures of global chromatin compaction upon damage are lacking.

289 acellular physical stresses induce chromatin compaction via mechanotransductive processes.

290 Using our predictive model for chromatin compaction, we develop a methylation model to address th

291 ypermethylated dsDNA, pointing at structural compaction which may facilitate DNA packaging in vivo.

292 tive plaque encapsulation and reduced plaque compaction, which is associated with worsened axonal pat

293 , TRF2, and TIN2 mediate telomeric chromatin compaction, which was proposed to minimize access of DDR

294 Instead, they support a continuous global compaction with increasing polyQ length that derives fro

295 extrusion can maintain a level of chromosome compaction with suppressed entanglements; the transition

296 keg, a mix of partial excavation and gradual compaction with the strategic placement of filling mater

297 ty by interfering with methyl donor-acceptor compaction within the activated ground state of the wild

298 somes are incorporated into DNA loops during compaction without being displaced from the DNA, indicat

299 ges in soil chemistry correspond to the soil compaction zone as previously measured via XCT.

300 changes are colocated near the root and the compaction zone suggests that decreased permeability as