ライフサイエンスコーパス: compartmentalize

1 han roots and carbohydrate redistribution is compartmentalized.

2 which autophagosome biogenesis is spatially compartmentalized.

3 red exceptional and their cell plan uniquely compartmentalized.

4 organisms with problems that are not neatly compartmentalized.

5 ivo, which indicates that FCA nuclear bodies compartmentalize 3'-end processing factors to enhance po

6 We show that the highly compartmentalized 3D chromatin organization characterist

7 e majority of catabolic BMCs (metabolosomes) compartmentalize a common core of enzymes to metabolize

8 Finally, we apply these new insights to compartmentalize a two-enzyme pathway in the peroxisome

9 Within FLAgs, the lymphocytes compartmentalize according to their chemokine receptor p

10 Podosomes are compartmentalized actin-rich adhesions, defined by their

11 but the molecular mechanisms that reinforce compartmentalized activation of intracellular TLRs remai

12 TLR) 9 dysregulation, based on bypassing the compartmentalized activation of TLR9 in endosomes, and u

13 ork defines a checkpoint that reinforces the compartmentalized activation of TLR9, and provides a mec

14 However, the functional implications of compartmentalized activity for the wider neural circuit

15 Many neurons show compartmentalized activity, in which activity does not s

16 tains mitochondrial respiration by spatially compartmentalizing amino acids.

17 Metabolism in plants is compartmentalized among different tissues, cells and sub

18 FH2-DA and DCFH2 enabled the measurement and compartmentalized analysis of intra- and extracellularly

19 arallel, multigene-profiling nanoplatform to compartmentalize and analyze hundreds of single CTCs.

20 ins diverse phase-separated condensates that compartmentalize and concentrate biomolecules with disti

21 lear processes occur within condensates that compartmentalize and concentrate the protein and RNA mol

22 n summary, the data presented here show that compartmentalized and active macrophage-tropic HIV-1 var

23 proteins to generate the wide assortment of compartmentalized and cytosolic cilia observed in nature

24 has become clear that the plasma membrane is compartmentalized and highly organized at the nanometer

25 Immune mechanisms in MS are thus highly compartmentalized and indicate ongoing local T/B cell in

26 Neurons are among the most compartmentalized and interactive of all cell types.

27 Samples are compartmentalized and processed in water-in-oil droplets

28 ntrast to mice, human ILCs are less strictly compartmentalized and tissue localization selectively im

29 iplexed method that builds gene libraries by compartmentalizing and assembling microarray-derived oli

30 ng pathways modulated by ROS are complex and compartmentalized, and we are only beginning to identify

31 ol (PEG) and dextran (DEX) have been used to compartmentalize antibodies and prevent cross-talk in mu

32 ts for multiplex ELISA retain the ability to compartmentalize antibodies and prevent cross-talk, whil

33 In addition to their compartmentalized antiviral actions, these two systems a

34 paratus and depend on its highly complex and compartmentalized architecture.

35 The low-input material is compartmentalized as single molecules in millions of pic

36 Furthermore, IgA and IgG appeared compartmentalized as there was a lack of correlation bet

37 that Cul3/Inc-dependent mono-ubiquitination, compartmentalized at postsynaptic densities, gates retro

38 Selection in compartmentalized autocatalytic systems might provide a

39 The continuous growth of non-compartmentalized axonal processes provides a vesicle re

40 It reflects systemic and compartmentalized B cell accumulation and activation.

41 T function for any template chemistry called compartmentalized bead labelling and demonstrate it by t

42 Dephosphorylation compartmentalizes beta-catenin on PCREs, a specialized c

43 further enhances noncanonical Wnt signals by compartmentalizing beta-catenin.

44 es provide a general regulatory mechanism to compartmentalize biochemical reactions within cells.

45 Compartmentalized biochemical activities are essential t

46 ids are widely studied as chemical models of compartmentalized biological systems.

47 We engineered compartmentalized biomimetic colorectal tumouroids with

48 odel liquid organelles capable of reversibly compartmentalizing biomolecules.

49 However, when environments were compartmentalized by barriers, the grid-like 6-fold spat

50 calcium signals in dendrites and spines were compartmentalized by dendritic branching and clustered w

51 walk this line, immune functions are grossly compartmentalized by innate cells that act locally and a

52 By enabling the facile quantification of compartmentalized Ca(2+), CalipHluor can expand the unde

53 Furthermore, compartmentalized Ca2+ transients were also generated on

54 from neighboring keratinocytes trigger local compartmentalized Ca2+ transients within the melanocyte

55 n and activity strongly influence global and compartmentalized cAMP levels.

56 t of PKD, possibly through the regulation of compartmentalized cAMP pools that control cell prolifera

57 patial cAMP degradation so as to orchestrate compartmentalized cAMP signaling in cells.

58 es that have been successfully used to probe compartmentalized cAMP signaling in eukaryotic cells.

59 ortant implications for the understanding of compartmentalized cAMP signalling.

60 er (FRET)-based sensor, CUTie, which detects compartmentalized cAMP with unprecedented accuracy.

61 fer sensors can precisely locate and measure compartmentalized cAMP, and this allows us to estimate t

62 Compartmentalized cAMP/PKA signalling is now recognized

63 extracellular matrix from brain tissue in a compartmentalized cancer-stroma concentric-ring structur

64 Poststroke tissue remodeling results in a compartmentalized cavity that can directly accept a ther

65 t pain synapse in a novel microfluidic based compartmentalized cell culture system, which recapitulat

66 The maize endosperm consists of three major compartmentalized cell types: the starchy endosperm (SE)

67 c protocells for the implementation of multi-compartmentalized cell-like models capable of collective

68 ins to reach their destination within highly compartmentalized cells.

69 onitoring of InsPs and PP-InsPs arising from compartmentalized cellular synthesis pathways, by feedin

70 cell is the complex endomembrane system that compartmentalizes cellular functions.

71 zed into larger domains, consequently better compartmentalizing cellular functions.

72 ssed under the plasma membrane and generates compartmentalized cGMP in gut epithelia in UC.

73 cooperative effects in an extended system of compartmentalized chemical oscillators under batch and s

74 cilia, also contributes to the formation of compartmentalized cilia.

75 Such compartmentalized ciliogenesis depends on the core intra

76 ely generated by evolutionary derivations of compartmentalized ciliogenesis.

77 and ClpA hexamers collaborate with the self-compartmentalized ClpP peptidase to unfold and degrade s

78 acrophage-tropic Envs in brain tissue formed compartmentalized clusters distinct from non-macrophage-

79 The spontaneous assembly of micro-compartmentalized colloidal objects capable of controlle

80 highly-branched neuronal structures perform compartmentalized computations.

81 The compartmentalized configuration of the microfluidic devi

82 The scaffold design provides compartmentalized control for spatial separation of neur

83 s at boutons are key determinants underlying compartmentalized control of AP width in a near synapse-

84 ompartments of the dorsal striatum, allowing compartmentalized control of discrete aspects of behavio

85 We disclose compartmentalized corelease of glutamate and GABA and it

86 Peroxisomes are vital organelles that compartmentalize critical metabolic reactions, such as t

87 Using compartmentalized culture systems that isolate axons and

88 We show that in compartmentalized cultures of rat sympathetic neurons, a

89 Phosphorylation compartmentalizes Daple/beta-catenin/E-cadherin complexe

90 Founder granules mediate compartmentalized degradation of oskar during embryogene

91 d, this cholinergic sensitivity is lost, and compartmentalized dendritic responses are absent but can

92 neural plasticity-somatic disinhibition and compartmentalized dendritic spiking.

93 Conversely, the compartmentalized dichotomy was perturbed by surgical re

94 of biogeochemical processes and historically compartmentalized disciplines, ecosystem-specific concep

95 access by the surrounding Scr enhancers and compartmentalizing distinct histone modifications, and t

96 tic cells, various membrane-bound organelles compartmentalize diverse cellular activities in a spatia

97 ws their use in concentrated serum where non-compartmentalized DNA circuits cannot operate.

98 r nuclear membrane, revealing a mechanism of compartmentalized DSB repair pathway choice by sequestra

99 nic domains were progressively specified and compartmentalized during premetamorphosis, and cell subp

100 Cells routinely compartmentalize enzymes for enhanced efficiency of thei

101 their membranes to modulate the activity of compartmentalized enzymes or to convey specific cellular

102 Organelles compartmentalize eukaryotic cells, enhancing their abili

103 quent secretion of APP fragments from highly compartmentalized, euploid neurons that express APP and

104 ) signaling complex (necrosome) that we find compartmentalizes exclusively to caveolin-1-associated d

105 Thus, the compartmentalized expression of DEL-1 facilitates distin

106 C) motor neuron cell bodies and axons can be compartmentalized for independent experimental manipulat

107 Using simulations, we show that such a compartmentalized form of synaptic scaling has computati

108 n than to facilitated transport, revealing a compartmentalized functional arrangement within the NPC.

109 ltifunctional materials comprising spatially compartmentalized functions.

110 lex cytoskeletal environment of dendrites by compartmentalizing functions in an activity-dependent ma

111 ctural features of the gag-pol mRNA actively compartmentalize Gag to preferred sites within the cytop

112 Compartmentalized genome-scale metabolic models construc

113 ttability are synthesized through a one-step compartmentalized growth of a mesoporous organosilica sp

114 d to Pteronymia diversification by providing compartmentalized habitats and an array of biotic and ab

115 Yet, how this structure is compartmentalized has not been clearly elucidated.

116 r pathogens are differentially sensed by the compartmentalized host immune system.

117 nimmunologic diseases, and the importance of compartmentalized immune responses.

118 Single cells are compartmentalized in 50-pL droplets and analyzed using f

119 te and GABA, as well as their plasticity are compartmentalized in a target-dependent manner, showing

120 r, our data indicate that the ER membrane is compartmentalized in cells as diverse as budding yeast,

121 tein expression is dynamically regulated and compartmentalized in developing neurons.

122 Signal transduction by cAMP is highly compartmentalized in large part because of the formation

123 Experiments with clusters of tumor cells compartmentalized in microfluidic drops reveal that cell

124 We found that this signaling pathway is compartmentalized in myocytes, as it was distinct from a

125 Autophagy is compartmentalized in neurons, with specific stages of th

126 ude that critical substrate-enzyme pairs are compartmentalized in neutrophils and platelets during st

127 enital viruses were consistently found to be compartmentalized in only two of eight men.

128 In vertebrates, S1P is spatially compartmentalized in the blood and lymphatic circulation

129 he functions of which are characteristically compartmentalized in the cells.

130 n plants proceeds through two major pathways compartmentalized in the chloroplast and the endoplasmic

131 ansporters, chaperone-bound S1P is spatially compartmentalized in the circulatory system.

132 The gut microbiota is compartmentalized in the intestinal lumen and induces lo

133 ator of sigma(F), the phosphatase SpoIIE, is compartmentalized in the small cell by transfer from the

134 necessary for associative information to be compartmentalized in this way, but the mechanism by whic

135 Proteins encoded by those genes are compartmentalized in various subcellular locations, incl

136 We address this by using a compartmentalized in vitro system to independently alter

137 eening, in which members of enzyme libraries compartmentalized in water-in-oil emulsion droplets are

138 sition cells along the crypt-villus axis and compartmentalize incipient colorectal tumors.

139 Activation of innate immune cells and other compartmentalized inflammatory cells in the brains and s

140 The protein samples are compartmentalized inside droplets, each one acting as an

141 cells, we show that free and bound NADH are compartmentalized inside of the nucleus, and its subnucl

142 The cHL tumor microenvironment (TME) is compartmentalized into "niches" rich in programmed cell

143 Within the nucleus, chromatin is further compartmentalized into architectures that change through

144 are rapidly uptaken by the cells and become compartmentalized into different cellular regions.

145 ey are necessary for striatal learning to be compartmentalized into different states as the state of

146 t receptor tyrosine kinases are functionally compartmentalized into distinct collaborative groups dis

147 Eukaryotic plasma membranes are compartmentalized into functional lateral domains, inclu

148 rescence anisotropy measurements of reagents compartmentalized into individual nanoliter droplets are

149 oplet assays-in which biological samples are compartmentalized into millions of femtoliter-volume dro

150 Eukaryotic cells are compartmentalized into organelles by intracellular membr

151 cing techniques are used or if templates are compartmentalized into single copies prior to amplificat

152 These tissues are compartmentalized into specialized niche areas by lymph

153 argeting signal peptides, the TaFAR could be compartmentalized into the matrix of the peroxisome to h

154 The Tethys Ocean was compartmentalized into the Mediterranean Sea and Indian

155 cal modeling, we show that corpus glands are compartmentalized into two independent zones, with slow-

156 The photorespiratory pathway is highly compartmentalized, involving the chloroplast, peroxisome

157 es through liquid-liquid phase separation to compartmentalize its DNA-binding cofactor TEAD4, coactiv

158 y will ultimately displace TANGO1/cTAGE5 and compartmentalize its operation to the base of the growin

159 such as A-kinase anchoring proteins (AKAPs), compartmentalize kinase activity and ensure substrate se

160 the blood and genital tract of five men with compartmentalized lineages was determined.

161 LDs compartmentalize lipids and may help to prevent cellular

162 this central CS nanodomain, revealing a nano-compartmentalized machinery for lignin polymerization.

163 particularly useful due to their ability to compartmentalize macromolecules and chemical processes.

164 r serious.IMPORTANCE The detection of highly compartmentalized macrophage-tropic R5 Envs in the brain

165 mical analysis revealed that MSCs were found compartmentalized mainly within vasculature structures l

166 evelopment of projection neurons occurs in a compartmentalized manner in the OB; tongue-shaped, dorso

167 CFTR channel function is regulated in a compartmentalized manner through the formation of CFTR-c

168 dendrites could be regulated in a spatially compartmentalized manner.

169 nd other NAD(+) consumers are regulated in a compartmentalized manner.

170 nd dendrites can be regulated in a spatially compartmentalized manner.

171 d endosomal trafficking of PCP components to compartmentalized membrane domains.

172 intracellular stores in mediating spatially compartmentalized memory of the activity history of a ne

173 Here, we present iDC625, the first compartmentalized metabolic model of a parasitic worm.

174 s and the products from these substrates are compartmentalized metabolically.

175 The compartmentalized microchannels separated by the porous

176 Here we used compartmentalized microfluidic chambers to characterize

177 Immobilization of compartmentalized microscale objects in 3D hydrogels pro

178 ntifying unique features of the anatomically compartmentalized milk SIV populations could enhance our

179 the biochemical reactions of life, cells can compartmentalize molecular interaction partners together

180 formation of membraneless organelles, which compartmentalize molecules intracellularly in the absenc

181 egregants from RNAi suppression lines to sub-compartmentalize MSH1 effects.

182 Our studies reveal compartmentalized mucosal immune responses within the na

183 l in which yeast cells mobilize, and perhaps compartmentalize, multiple DSBs in a manner that no long

184 enzymes; however, the challenge in measuring compartmentalized NAD(+) in cells has precluded direct e

185 er discuss potential benefits to the cell of compartmentalizing NAD(+), and methods for measuring sub

186 tivity states: persistent activity, in which compartmentalized network dynamics were observed; and sl

187 same genomic regions (P < 0.05), revealing a compartmentalized network structure that may reflect net

188 Eukaryotic cells compartmentalize neutral lipids into organelles called l

189 hromatin loop extrusion, but its impact on a compartmentalized nuclear architecture, linked to nuclea

190 saccharomyces pombe provide insight into how compartmentalized nuclear pore complex disassembly allow

191 Cells on the left and right sides remain compartmentalized on their ipsilateral side throughout l

192 n of apoptotic cells can therefore spatially compartmentalize or prevent premature or ectopic activit

193 ian intestinal tract is a highly complex and compartmentalized organ with specialized functions, and

194 led that peroxisome could be engineered as a compartmentalized organelle for producing fatty acid-der

195 ature-responsive, shear-thinning hydrogel to compartmentalize organisms into polymeric hydrogels that

196 d PEX5 or PEX11 but at the same time a clear compartmentalized organization.

197 Thus, morphometric differences between compartmentalized ORNs account for highly specialized in

198 Compartmentalized oscillations of second messengers affe

199 e produced by the effective environment of a compartmentalized oscillator as the cause of the lifetim

200 rovide mechanistic insight into why barriers compartmentalize our cognitive map, indicating that boun

201 Compartmentalized partnered replication (CPR) is an emul

202 ontologically mapped to identify a spatially compartmentalized pathophysiological map of the cavity.

203 y associated with loss of peroxisomes, which compartmentalize pathways that generate reactive oxygen

204 exchange of isoprenoid intermediates between compartmentalized pathways, was assessed by a combinatio

205 However, the functional role of specific compartmentalized PDE4 isoforms has not been examined in

206 They are composed of a double-ring compartmentalized peptidase (ClpP) and a AAA+ unfoldase

207 machine consists of HslV, a double-ring self-compartmentalized peptidase, and one or two AAA+ HslU ri

208 unfoldase/translocase in complex with a self-compartmentalized peptidase.

209 metabolism, proliferation, and survival, the compartmentalized pH microenvironment favors cancer deve

210 ain behaviors, but will not map clearly into compartmentalized pieces of the brain, could represent a

211 ain behaviors, but will not map cleanly into compartmentalized pieces of the brain.

212 cal separation, whereby different subsurface compartmentalized pools of water supply either plant tra

213 Alterations of compartmentalized PPIs emanating from certain deregulate

214 the nuclear piston migration mechanism with compartmentalized pressure characteristic of nonmalignan

215 Achieving compartmentalized pressure required the nucleoskeleton-c

216 larized HT1080 and SW684 cells and generated compartmentalized pressure.

217 Metabolism is a compartmentalized process, and it is apparent in studyin

218 sought to determine how stress alters these compartmentalized processes.

219 re also found in thin dendrites which act as compartmentalized processing units and generate local ca

220 stasis and stress response is facilitated by compartmentalized proteases that couple the energy of AT

221 archaeal proteasomes are paradigms for self-compartmentalizing proteases.

222 distinct from those of known bacterial self-compartmentalizing proteases.

223 Bacteria have various types of self-compartmentalizing proteases; in addition to the proteas

224 he protein kinase A-anchoring protein dAKAP1 compartmentalizes protein kinase A (PKA) and other signa

225 RET reporter sensors have helped define more compartmentalized regulation of cAMP, PKA, and EPAC, the

226 diated inhibition, with implications for the compartmentalized regulation of dendritic signaling in t

227 These data suggest both the compartmentalized release of NO and a greater diversity

228 try and fragment the grid firing fields into compartmentalized repeating "submaps" [5].

229 pharynx, showing uniform depolarization but compartmentalized repolarization of anterior and posteri

230 As such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer mech

231 after the resolution of infection, including compartmentalized responses against epitopes within all

232 n PET-CT was safe and demonstrated spatially compartmentalized rifampin exposures in pathologically d

233 he function of MEcPP from SA, and expose the compartmentalized role of this retrograde signaling meta

234 By compartmentalizing SCs into micro-niches, tissues gain p

235 ation of plasma membrane receptors initiates compartmentalized second messenger signaling.

236 d no difference in the prevalence of diverse compartmentalized semen-derived lineages in men with or

237 ous throughout the cell, but its membrane is compartmentalized shortly before nuclear envelope breakd

238 ls and offer a new model system for studying compartmentalized signaling in dendritic structures.

239 Compartmentalized signaling in dendritic subdomains is c

240 that regulate cardiomyocyte function through compartmentalized signaling in discrete subcellular micr

241 Here, we survey different modes of compartmentalized signaling in neurons, highlighting exa

242 ently to odors, revealing their capacity for compartmentalized signaling in vivo.

243 , but mapping the dynamics and regulation of compartmentalized signaling is a challenge.

244 Compartmentalized signaling is critical for cellular org

245 icted activation of intracellular effectors, compartmentalized signaling of cyclic nucleotides confer

246 lation, biased agonism, oligomerization, and compartmentalized signaling of GPCRs that control digest

247 Compartmentalized signaling provides an opportunity for

248 Analysis of compartmentalized signaling revealed a requirement of DO

249 This review also discusses the roles of compartmentalized signaling, which is compromised in var

250 ing as a general mechanism for prolonged and compartmentalized signaling.

251 cAMP signalosomes and reveal new details of compartmentalized signaling.

252 ium is a paradigmatic organelle for studying compartmentalized signaling; however, unlike soluble pro

253 MP-sensing Gpr161:PKA complex acts as cilium-compartmentalized signalosome, a concept that now needs

254 naptic proteins involved in release are less compartmentalized.SIGNIFICANCE STATEMENT During postnata

255 y to their infants, and exhibit anatomically compartmentalized SIV populations in milk and plasma.

256 onically SIV-infected AGMs have anatomically compartmentalized SIV variants in plasma and milk, where

257 uggest that the thymidine salvage pathway is compartmentalized so that TMP kinase prefers TMP synthes

258 interior of the eukaryotic cell is a highly compartmentalized space containing both membrane-bound o

259 ing of the actin cytoskeleton in this highly compartmentalized space, but the precise mechanisms rema

260 d growth-factor-signaling, and clarifies how compartmentalized Src-kinase activity may drive cell fat

261 assigning learning in different contexts to compartmentalized "states." Though not often framed this

262 The distal domains exhibit a "trauben"-like compartmentalized structure with bulky terminal speciali

263 plication within the tumor is restricted and compartmentalized, suggesting segregation of specific vi

264 Using compartmentalized sympathetic neuronal cultures (CSCGs)

265 nd L5 dorsal root ganglia were cultured in a compartmentalized system.

266 ng of the role of compartments and designing compartmentalized systems needs reliable modelling/syste

267 offer vital clues on the behavior of simple compartmentalized systems, such as prebiotic precursors

268 antioxidant loss was more pronounced in more compartmentalized systems, which was attributed to their

269 ind that developmental domains are less well compartmentalized than constitutive domains and display

270 layers are two-dimensional cell sheets which compartmentalize the body and organs of multicellular or

271 Carboxysomes compartmentalize the enzyme ribulose-1,5-bisphosphate ca

272 that high protein concentrations kinetically compartmentalize the flagellum: Within milliseconds, cGM

273 We used a task designed to compartmentalize the visual and motor aspects of this tr

274 Patterns of co-mutation compartmentalized the cohort into 11 classes, each with

275 Multiple forms of synaptic inhibition compartmentalized the GAC dendritic tree and endowed all

276 onds of hyperosmotic stress, YAP condensates compartmentalized the YAP transcription factor TEAD1 and

277 highly convoluted contiguous inner membrane compartmentalizes the organelle, which is crucial for mi

278 ween segments may be capable of functionally compartmentalizing the body, which could explain complex

279 Compartmentalizing the network structure into interconne

280 rinciple of how cells rapidly and reversibly compartmentalize their components into membrane-less org

281 ed by the cell to sequester biomolecules and compartmentalize their function.

282 Cells compartmentalize their intracellular environment to orch

283 ls; however, how these pathogens are able to compartmentalize their life cycle to provide favorable c

284 a tunable regulator of neurogenesis via its compartmentalized thiol-oxidative function.

285 ver, it remains unclear whether the niche is compartmentalized to control stem cell self-renewal and

286 ork, the pH change underlying HC feedback is compartmentalized to individual synaptic invaginations w

287 ma-carboxylation in the ER and therefore was compartmentalized to the Trans-Golgi Network (TGN) and a

288 Liquid-liquid phase separation (LLPS) compartmentalizes transcriptional condensates for gene e

289 l (Treg) co-localization with CD8 T cells in compartmentalized tumor stroma.

290 entially conserved communication between the compartmentalized two-sector rotary ATPases.

291 ia that grow as vegetative hyphae, which are compartmentalized via cross-walls.

292 ages have evolved a specialized structure to compartmentalize viral replication.

293 nts with available sequencing data presented compartmentalized viral rebound between blood and semen

294 transmission, and the extent to which spines compartmentalize voltage, specifically excitatory postsy

295 ophes affecting a single, laggard chromosome compartmentalized within a micronucleus.

296 It is widely accepted that cAMP signaling is compartmentalized within cells.

297 s of age, consisting of naive CD4(+) T cells compartmentalized within networks of CD45(-)gp38(+)CD31(

298 ing protein, Uclacyanin1 (UCC1), that is sub-compartmentalized within the CS.

299 DNA is strictly compartmentalized within the nucleus to prevent autoimmu

300 The nucleus is highly compartmentalized yet dynamic.