ライフサイエンスコーパス: compass

1 the H3K4-trimethylating complex of proteins (COMPASS).

2 analysis of antigen-specific T-cell subsets (COMPASS).

3 ntacts between the nucleosome, ubiquitin and COMPASS.

4 bic system implement an allocentric neuronal compass.

5 thought to provide animals with an internal compass.

6 ed by Set1, the methyltransferase subunit of COMPASS.

7 ferences are selected for the fly's internal compass.

8 and human cancers, as a key target of SET1B/COMPASS.

9 a novel catalytic-independent role of SET1B/COMPASS.

10 n a straight direction using their celestial compass.

11 entral complex, the presumed site of the sun compass.

12 ator possesses both a sun compass and a moon compass.

13 the central complex acts as an internal sky compass.

14 d no screening to orient with their magnetic compass.

15 ells signal heading direction, rather like a compass.

16 tion rely on the concept of a mental map and compass.

17 , they could not orient using their magnetic compass.

18 head orientation, thus implementing a neural compass.

19 s interaction with the Cps40/Spp1 subunit of COMPASS.

20 ons that integrate wind information into the compass.

21 histone H3 by the histone-modifying complex COMPASS.

22 g extra-personal space by functioning like a compass.

23 arginine-rich motif (ARM) that autoinhibits COMPASS.

24 n of how visual cues are integrated into the compass.

25 Of the 27 395 patients in COMPASS, 16 560 patients with a chronic coronary syndrom

26 In COMPASS, 21,111 patients had an estimated glomerular fil

27 We present COMPASS, a COmputational Model to Predict the developmen

28 ell known as a prerequisite histone mark for COMPASS activity, how H2Bub activates COMPASS remains un

29 gation rate and frequency as well as reduced COMPASS activity.

30 hipod Talitrus saltator possesses both a sun compass and a moon compass.

31 CFP-1 in mediating interaction between SET1/COMPASS and a Sin3S HDAC complex at promoters.

32 he feasibility of a radical pair based avian compass and also provide further guidelines for the desi

33 n for this task-a celestial-cue-based visual compass and an optic-flow-based visual odometer-but the

34 of ZnF on Cfp1 enables its integration into COMPASS and contributes to epigenetic signaling.

35 Cfp1 binds to COMPASS and is critical to maintain high level of H3K4me

36 Thus, COMPASS and Mediator are repurposed to promote epigeneti

37 tive interactions between the avian magnetic compass and polarized light, we developed a spatial orie

38 nctional connection, we find that mutants of COMPASS and SIN3 complex components genetically interact

39 e mental map into register with the magnetic compass and to establish the heading of the animal.

40 ing, and show how the correlated activity of compass and visual neurons drives plasticity(17-22), whi

41 loss of >=2 lines compared with best BCVA in COMPASS and worsening of visual field mean defect (VFMD)

42 ion complex Paf1, the histone methylase Set1-COMPASS, and the translation-related Trm112 dimers are a

43 d bivalent gene promoters and associate with COMPASS- and Polycomb-bound chromatin.

44 all H3K4 trimethylations implemented by MLL2/COMPASS are functionally equivalent.

45 However, the two compasses are not linked to each other, but rather seem

46 se exhibits the properties of an inclination compass as found in migratory birds.

47 Shifting the wind rightward rotates the compass as if the fly were turning leftward, and vice ve

48 Set1/COMPASS associates with the RNA polymerase II C-terminal

49 ility of this process is the use of a neural compass based on external celestial cues.

50 ot support the earlier reported polarization compass based on stimulation from a small spot above the

51 with the previously demonstrated direct sun compass based on unpolarized light stimulation.

52 ions that have previously been implicated in compass-based navigation.

53 e antennae are important for the inclination compass because they appear to contain light-sensitive m

54 ex (CX) is likely the site of the actual sun compass, because neurons in this brain region are tuned

55 onoubiquitination may not directly stimulate COMPASS but rather works in the context of the PAF and R

56 at promoters of bivalent genes, Mll2 (KMT2B)/COMPASS can also implement H3K4me3 at a subset of non-TS

57 This was a secondary analysis of the COMPASS (Cardiovascular OutcoMes for People using Antico

58 y disease or peripheral arterial disease the COMPASS (Cardiovascular Outcomes for People Using Antico

59 The COMPASS (Cardiovascular Outcomes for People Using Antico

60 The COMPASS (Cardiovascular Outcomes for People Using Antico

61 severity, and management of bleeding in the COMPASS (Cardiovascular Outcomes for People Using Antico

62 croscopy (cryo-EM) structures of an extended COMPASS catalytic module (CM) bound to the H2Bub and fre

63 The COMPASS chromatin complex, which trimethylates lysine 4

64 n by the Polycomb (Pc), Trithorax (Trx), and Compass chromatin modifier complexes.

65 lecular pathway driven by mutant p53 and the COMPASS chromatin-modifying complex that is amenable to

66 atients at intervention hospitals attended a COMPASS clinic visit.

67 The COMPASS CM clamps onto the nucleosome disk-face via an e

68 P change was similar between the HORIZON and COMPASS cohorts.

69 ates the activity of the chromatin modifying COMPASS complex (complex proteins associated with Set1)

70 ed mRNA decay pathway) and components of the COMPASS complex including wdr5 function in GCR.

71 The MLR COMPASS complex monomethylates H3K4 that serves to epige

72 alytic subunit of the highly conserved Set1C/COMPASS complex responsible for histone H3K4 methylation

73 P1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to

74 me H3K4-trimethylated through an alternative COMPASS complex.

75 CR that involves Upf3a and components of the COMPASS complex.

76 x group (TrxG) protein MLL1 found within its COMPASS (complex associated with SET1)-like complex is a

77 The COMPASS (complex of proteins associated with Set1) compl

78 ption start sites to recruit the Wdr82-Set1A/COMPASS (complex of proteins associated with Set1) compl

79 Although MLL/COMPASS (complex of proteins associated with Set1) famil

80 Mutations and translocations within the COMPASS (complex of proteins associated with Set1) famil

81 Of the six members of the COMPASS (complex of proteins associated with Set1) famil

82 Cps35/Swd2 within COMPASS (complex of proteins associated with Set1) is co

83 Here we report that yeast Set1C/COMPASS (complex of proteins associated with Set1) is di

84 and non-catalytic functions of the Trithorax-COMPASS complexes, Polycomb repressive complexes and Clr

85 rganization causes persistent changes in the compass coordinate frame.

86 suggest ways in which the performance of the compass could have been optimized by evolution, (iii) ma

87 y insects exploit skylight polarization as a compass cue for orientation and navigation.

88 We demonstrate that this mechanosensory compass cue is only used when skylight cues are difficul

89 This flexible use of compass cue preferences relative to the prevailing visua

90 lity to use the magnetic field as a map; the compass cue(s) used by eels was not investigated.

91 ol of spatial orientation, based on external compass cues and various internal needs.

92 in of insects, have been shown to encode sky compass cues.

93 e beetles use a wide repertoire of celestial compass cues.

94 persist in using a celestial body for their compass, day or night.

95 oci, generation of catalytically mutant MLL2/COMPASS demonstrated that H3K4me3 implemented by this en

96 c genealogy community, have already used DNA Compass, demonstrating its utility.

97 h butterfly possesses a time-compensated sun compass dependent upon a circadian clock in the antennae

98 Thus, COMPASS-dependent UTX stabilization is an essential nonc

99 gh addition of this limited genetic model to COMPASS did not improve prediction of progression of MCI

100 es often depart from the release site in the compass direction they were bent on before their capture

101 This whole-sky polarization compass does not support the earlier reported polarizati

102 tation mechanism uses a time-compensated sun compass during both the migration south and the remigrat

103 als), identifying such abilities as magnetic compasses, electrosensitivity, polarization vision, and

104 election criteria were applied to identify a COMPASS-eligible population (n = 16,875) from the REACH

105 the presence of >=1 enrichment criteria in "COMPASS-eligible" patients.

106 ings regarding the properties of the PcG and COMPASS families and the insight they provide into the e

107 nd its partners MLL3 and MLL4 as part of the COMPASS family during development and in oncogenesis.

108 SETD1A, a Set1/COMPASS family member maintaining histone-H3-lysine-4 (H

109 d that individual inactivation of the MLL1-4/COMPASS family members has little effect on early Hox ge

110 o how two crucial families of the TrxG - the COMPASS family of histone H3 lysine 4 methyltransferases

111 chanism controlling the activity of the KMT2/COMPASS family of lysine methyltransferases.

112 UTX and its protein interactors within the COMPASS family, including the MLL3 and MLL4 lysine methy

113 e Trithorax group (TrxG) proteins within the COMPASS family, which are highly mutated in a large numb

114 s a cytoplasmic function for a member of the COMPASS family, which could be harnessed for therapeutic

115 fashion in the central complex, but how both compasses fit together for a unified representation of e

116 o use a light-dependent inclination magnetic compass for orientation in the absence of directional da

117 head direction (HD) and provide an internal compass for spatial navigation.

118 Many migratory insects rely on a celestial compass for spatial orientation.

119 pes, providing an evolutionarily old hedonic compass for what and what not to ingest.

120 ignificance of light <420 nm for inclination compass function was not considered in previous monarch

121 we report the first evidence that nocturnal compass-guided insect migrants use a turbulence-mediated

122 delineating the spatial configuration of the COMPASS-H2Bub-nucleosome assembly, our studies establish

123 tations in WDR-5 and other components of the COMPASS H3K4 methyltransferase complex extend lifespan a

124 -Cas9 genetic knockouts, we demonstrate that COMPASS H3K4 methyltransferase family members differenti

125 Theoretical descriptions of this compass have thus far been unable to account for the hig

126 rectional sails were set and obesity was the compass heading.

127 uripotency factor NANOG to recruit the DPY30-COMPASS histone modifiers onto key developmental genes.

128 alters the recruitment of histone methylase (COMPASS)-, histone demethylase (Jmjd2a/Jmjd3)-, and SWI/

129 s of cytokine production, we demonstrate how COMPASS improves characterization of antigen-specific T

130 rized light and the light-dependent magnetic compass in an animal.

131 etoreception of the light-dependent magnetic compass in birds is suggested to be mediated by a radica

132 s the source of the light-dependent magnetic compass in migratory birds, the radical pair mechanism i

133 he HD signal plays a causal role as a neural compass in navigation.

134 pass, likely located in the brain and a moon compass in the antennae.

135 may be suited to stabilize the internal sky compass in the central complex of the locust.

136 Here, we show that the compass in the Drosophila brain is linked to the directi

137 atory birds are unable to use their magnetic compass in the presence of urban electromagnetic noise.

138 f celestial polarization are arranged like a compass in the slices of the central complex (CX).

139 Because the compass incorporates both mechanosensory and visual cues

140 ng a role of this receptor in modulating sky-compass information and/or higher sensor-motor control.

141 Here we examine how such compass information could be reliably computed by the in

142 lli of E. imperialis could provide sensitive compass information for navigation in the rainforest and

143 ract with structures that represent maps and compass information to compute and constantly control na

144 y the position of the sun, this cue provides compass information.

145 neurons can convey both map information and compass information.

146 polarized blue light suggested that the two compasses interact in a nonlinear way.SIGNIFICANCE STATE

147 COMPASS is a multi-subunit complex in which the catalyti

148 DNA Compass is a website designed to empower the public by e

149 METHODS AND Compass is an open-label randomised trial of 5-yearly HP

150 COMPASS is available as open-source software.

151 sotope shift effects in deuterated proteins, COMPASS is far more accurate for larger proteins than ex

152 Binding of Cfp1 to COMPASS is in part mediated by a new type of monovalent

153 , implying that the light-dependent magnetic compass is intrinsically polarization sensitive.

154 The use of this inclination compass is light-dependent utilizing ultraviolet-A/blue

155 t a three-dimensional, gravity-based, neural compass is likely a ubiquitous property of mammalian spe

156 However, even when Set1/COMPASS is recruited via the Nrd1 CID, histone H2B ubiqu

157 Whether H3K4 methylation by Set1A/COMPASS is required for ESC maintenance and during diffe

158 Instead, we demonstrate that SET1A/COMPASS is required for full transcriptional activation

159 Although Mll2/COMPASS is required for H3K4me3 implementation on thousa

160 We demonstrate that the compass is robust to disturbances and can be effectively

161 This light-dependent magnetic compass is thought to be mediated by cryptochrome protei

162 COMPlex ASsociating with SET1 (COMPASS) is a histone H3 Lys-4 methyltransferase that ty

163 y representation of direction that, unlike a compass, is inconsistently registered to external landma

164 This compass keeps track of their paces and turns and updates

165 mediated by key components of the Trithorax/COMPASS-like and Polycomb group complexes together with

166 and gene expression by cooperating with the COMPASS-like complex to increase H3K4 trimethylation at

167 rr and its human homologs, the MLL3 and MLL4/COMPASS-like complexes, as enhancer histone H3 lysine 4

168 Histone methyltransferase KMT2D (a COMPASS-like enzyme, also called MLL4) is among the most

169 tion of a simulated sun are represented in a compass-like fashion in the central complex, but how bot

170 the lncRNA Hottip/HOTTIP, members of the MLL/COMPASS-like H3K4 methylases, which regulate chromatin i

171 from the dorsal direction, represented in a compass-like manner across the slices of the CX.

172 ature of enhancer chromatin catalyzed by the COMPASS-like methyltransferase family, which includes Tr

173 can occur in the context of Trr or mammalian COMPASS-like proteins deficient in H3K4 monomethylation

174 desert locusts, the CX holds a topographic, compass-like representation of the plane of polarized li

175 entical paths to the same side of actin in a compass-like spinning motion demonstrating a symmetrical

176 dies have shown that neurons which fire in a compass-like way--head direction cells--are present befo

177 lunar and solar orientation apparatus; a sun compass, likely located in the brain and a moon compass

178 ropose that transcription-coupled H3K4me via COMPASS limits lifespan by encroaching upon domains of h

179 For migratory monarchs, the inclination compass may serve as an important orientation mechanism

180 We reasoned that the time-compensated compass mechanism that enables solar orientation of T. s

181 cal reference to calibrate other cues in the compass mechanism.

182 absent small or homeotic discs 1 (ASH1), and Compass member SET1 histone methyltransferases were O-Gl

183 compared with whole-gene deletions for these COMPASS members.

184 MLL2/COMPASS methylates H3K4 on many developmental genes and

185 y, we show that Cfp1 only modestly activates COMPASS methyltransferase activity in vitro.

186 Memory requires a remodeled form of the Set1/COMPASS methyltransferase lacking Spp1, which dimethylat

187 ntaining protein 5 (WDR5), a core subunit of COMPASS/MLL family histone H3 lysine 4 methyltransferase

188 icare and Medicaid Services TC policies, the COMPASS model of TC was not consistently incorporated in

189 a distance in which to move (the "clock and compass" model) [1-5].

190 hylation patterns at some loci or in certain COMPASS mutants.

191 e Earth's magnetic field for orientation and compass-navigation is fascinating and puzzling in equal

192 ts in Coronary or Peripheral Artery Disease [COMPASS]; NCT01776424).

193 dentified a protein complex that acts like a compass needle to guide magnetic orientation in animals.

194 (2020) expand our understanding of the fly "compass" network, revealing context- and experience-depe

195 Each compass neuron is inhibited only by specific visual cue

196 In the absence of visual cues, the compass neuron network estimates heading by integrating

197 Each compass neuron receives inputs from 'ring' neurons that

198 neuron overlaps with the dendrites of every compass neuron(6), raising the question of how visual cu

199 ysiology, we show that polarized-light-based compass neurons and optic-flow-based speed-encoding neur

200 visual cue can evoke synaptic inhibition in compass neurons and that R neurons mediate this inhibiti

201 ny potential connections from R neurons onto compass neurons are actually weak or silent.

202 Visual inputs to compass neurons are thought to originate from inhibitory

203 preferences are reflected in the activity of compass neurons in the brain.

204 Compass neurons in the central complex of diurnal beetle

205 ombine with the neurons' connectivity to the compass neurons to create an elegant mechanism for updat

206 depression of visually evoked inhibition in compass neurons.

207 In the fly brain, heading is represented by 'compass' neurons that innervate a ring-shaped structure

208 In the Drosophila brain, 'compass' neurons track the orientation of the body and h

209 Unexpectedly, without enhancing COMPASS-nucleosome interaction, H2Bub activates the enzy

210 lation of histone H3 lysine 4 (H3K4) by Set1/COMPASS occurs co-transcriptionally, and is important fo

211 romatin repulsion is locally encoded by Set1/COMPASS on certain actively transcribed genes and that t

212 lling the neuronal mechanisms underlying sun compass orientation and in identifying the genetic compl

213 et effective, mechanism for enabling precise compass orientation at any time of the day.

214 le and may also augment time-compensated sun compass orientation for appropriate directionality throu

215 ion of the solar disk per se is relevant for compass orientation in a migratory bat, Pipistrellus pyg

216 nce for roles in polarized light vision, sky compass orientation, and integration of spatial informat

217 in several navigational tasks including wind-compass orientation, flight control, graviception, and,

218 zed light modulated light-dependent magnetic compass orientation, i.e., how the birds perceive the ma

219 he neuronal network that underlies celestial compass orientation.

220 head polarized light near the zenith for sky compass orientation.

221 Sun compass output is time compensated by circadian clocks i

222 P bears a fundamental resemblance to the sky-compass pathway, a visual navigation circuit described i

223 COMPASS patients with vascular disease were risk stratif

224 DNA Compass presents the relevant genotypes of the user side

225 The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4)

226 We show that a large shift in the sun-compass rapidly induced by general anesthesia does not a

227 rved in ADN enhances the precision of the HD compass read-out by up to 40%.

228 her-level methylations reflect not only Set1/COMPASS recruitment but also multiple rounds of transcri

229 fects its interaction with Set1 also impairs COMPASS recruitment to chromatin and H3K4 methylation.

230 d, associated with each such snapshot, a sun-compass-referenced home vector derived from dead reckoni

231 The benefits of the dual pathway COMPASS regimen (rivaroxaban 2.5 mg bd plus aspirin), ve

232 rk for COMPASS activity, how H2Bub activates COMPASS remains unclear.

233 reen light spot, consistent with an internal compass representation of solar azimuth.

234 Such a compass representation was recently discovered in a neur

235 The stimulus responsible for compass resetting has been identified as a reduction in

236 A construct compassing residues S212-P259 and containing the TMD and

237 The chemical compass response exhibits the properties of an inclinati

238 provides insight into how best to apply the COMPASS results into practice.

239 Performing such a 'compass run' significantly increased homing efficiency.

240 n machinery and Cps35/Swd2 function to focus COMPASS's H3K4me3 activity at promoter-proximal regions

241 This ZnF interacts with the COMPASS's subunits RbBP5 and disruption of this interact

242 and the Composite Autonomic Symptoms Scale (COMPASS)-select (a measure of autonomic symptoms and aut

243 S II 26.4 (8.8) versus 25.4 (10.5; p=0.764); COMPASS-select 43.5 (18.7) versus 42.8 (19.6; p=0.835).

244 sessed by change in UMSARS I, UMSARS II, and COMPASS-select, was modest.

245 Key COMPASS selection criteria were applied to identify a CO

246 The primary detection mechanism of this compass sense is uncertain but appears to involve the qu

247 een put forward as the basis of the magnetic compass sense of migratory birds.

248 ds, endowing migratory birds with a magnetic compass sense.

249 otein thought to be responsible for magnetic compass sensing in migratory birds and a variety of magn

250 e viability of a cryptochrome-based magnetic compass sensor.

251 an provide the primary signal for a magnetic compass sensor.

252 n still be expected to be viable as magnetic compass sensors.

253 dical pairs currently postulated as magnetic compass sensors.

254 Our structure shows that COMPASS spans the face of the nucleosome, recognizing ub

255 mation to select a direction, whereas in the compass step the animal maintains that heading [3,4].

256 and potentially independent 'map step' and 'compass step' of animal navigation.

257 Inspired by natural "nano shell" and "nano compass" structures, cell nanomodification can be develo

258 Methods and Results The COMPASS study (Comprehensive Post-Acute Stroke Services)

259 atients with chronic vascular disease in the COMPASS study cohort (intention-to-treat study populatio

260 y of the Hydrus micro-stent and 619 from the COMPASS study of the Cypass micro-stent) with primary op

261 the cryo-EM structure of a six-protein core COMPASS subcomplex, which can methylate H3K4 and be stim

262 port that the Set1 N-terminal region and the COMPASS subunit Swd2, which interact with each other, ar

263 o be crucial for calibration of the magnetic-compass system in non-migratory bats [3-5].

264 dical pairs on the directional response of a compass system.

265 design and operation of exploitable chemical compass systems.

266 underlies transcriptional regulation on MLL2/COMPASS targets.

267 COMPASS-TC was patient-centered and assessed social and

268 The intervention (COMPASS-TC) was initiated at 20 hospitals, and 20 hospit

269 r, endorphins and dopamine have a much wider compass than oxytocin (whose effects are confined to rom

270 t that mRNA polarisation acts as a molecular compass that orients motile cell polarity and spatially

271 ratory birds have a light-dependent magnetic compass, the mechanism of which is thought to involve ra

272 utterflies (Danaus plexippus) use a magnetic compass to aid their fall migration has been lacking fro

273 We designed COMPASS to assess whether patients treated with aspirati

274 H2Bub acts after the initial recruitment of COMPASS to chromatin.

275 l heading, providing an animal with a neural compass to guide ongoing spatial behavior.

276 this context, a directing group serves as a compass to guide the transition metal to C-H bonds by us

277 rants indeed possess an inclination magnetic compass to help direct their flight equatorward in the f

278 navian visitors and still use their internal compass to navigate to the Basin.

279 ange in sun position over time, allowing the compass to remain fixed with respect to 'true north' dur

280 ansferase Set1/complex associated with Set1 (COMPASS) to promoter-proximal RNA polymerase II.

281 information with output from their internal compass, to compensate for the deflection.

282 sequencing (RNA-seq) analysis pipeline, RNA CoMPASS, to investigate the presence of ectopic organism

283 The COMPASS trial (Cardiovascular Outcomes for People Using

284 The COMPASS trial (Cardiovascular Outcomes for People using

285 In a prespecified analysis of the COMPASS trial (Cardiovascular Outcomes for People Using

286 ents as compared with ASA monotherapy in the COMPASS trial (Cardiovascular Outcomes for People Using

287 The primary outcome of the COMPASS trial was the occurrence of myocardial infarctio

288 This article (1) reviews the results of the COMPASS trial, (2) explains why dual pathway inhibition

289 , 2016, 27 395 patients were enrolled to the COMPASS trial, of whom 24 824 patients had stable corona

290 aucoma Patients Undergoing Cataract Surgery (COMPASS) trial who underwent Micro-Stent implantation pl

291 aucoma Patients Undergoing Cataract Surgery (COMPASS) trial who underwent Micro-Stent implantation pl

292 COMPASS uses a Bayesian hierarchical framework to model

293 ther insects use idiothetic information, sky compasses, visual cues, and odor trails.

294 In a prespecified subgroup analysis from COMPASS, we examined the outcomes of patients with chron

295 tional requirements of this complex chemical compass, we have created a family of simplified, adaptab

296 f zenithal E-vector orientation, but the two compasses were not linked to each other.

297 Here we report that SET1B/COMPASS, which is essential for cell survival, surprisin

298 ation cues at sunset to calibrate a magnetic compass, which is subsequently used for orientation duri

299 we address this by introducing the software COMPASS, which, by combining automated resonance assignm

300 he head-direction (HD) system functions as a compass, with member neurons robustly increasing their f