ライフサイエンスコーパス: compensatory

1 metimes followed by mutations believed to be compensatory.

2 In particular, the compensatory activation of growth factor receptors leads

3 rved that single-agent MEK inhibition led to compensatory activation of resistance pathways, includin

4 ondary mutation causing EGFR-TKI resistance, compensatory activation of signaling pathways without in

5 on phenotypes free from secondary effects or compensatory adaptation that can confound nucleic-acid-b

6 ise that increasing wing length represents a compensatory adaptation to maintain migration as reducti

7 We uncovered a compensatory adaptation which causes global scaling with

8 ynaptic side.SIGNIFICANCE STATEMENT To date, compensatory adaptations which stabilise target cell act

9 ur models identify mutations that are likely compensatory adaptive changes that allowed for rapid exp

10 he interplay between synaptotoxic events and compensatory adhesion responses influences neuronal fate

11 timulation can be effective when paired with compensatory adjustments in other parameters.

12 RABL3(xm) displayed a large compensatory alteration in switch I, which adopted a bet

13 er, chronic fuel surfeit triggers additional compensatory and adaptive mechanisms by beta-cells to co

14 neral, effects of NRG-1 in heart failure are compensatory and beneficial, translation into therapies

15 To help minimize compensatory and experiential influences, we used an ex

16 During compensatory and maladaptive hypertrophy, mitochondria b

17 inflammatory response syndrome, followed by compensatory anti-inflammatory response syndrome (CARS).

18 systemic inflammatory response syndrome and compensatory anti-inflammatory response syndrome and mig

19 systemic inflammatory response syndrome and compensatory anti-inflammatory response syndrome develop

20 right inferior temporal volume seemed to be compensatory, as it was associated with lower levels of

21 sion and reading speed, potentially owing to compensatory attentional mechanisms.

22 alpy and entropy, which consequently exhibit compensatory behavior, DeltaDelta H degrees (R - S) = -5

23 Similar patterns emerged for compensatory behaviors (vomiting, use of laxatives, and

24 pIC neurons were modulated during the rodent compensatory behaviors of lying on belly (LOB) and Pica.

25 nsition occurs as a result of the failure of compensatory biological systems to cope with infection,

26 weeks, respectively), during which time the compensatory Ca(2+) transient effects reversed, but furt

27 eater fishery pressures but may have limited compensatory capacity to mitigate COVID-19 impacts along

28 osphere(10), which has led to suggestions of compensatory carbon fluxes(11-13) in order to preserve m

29 Compensatory cardiac hypertrophy activates ER stress and

30 Thereby, aak6 mutants exhibit compensatory cell enlargement, a phenomenon unexpected i

31 Mn for the first time for 24 h, indicating a compensatory cellular homeostatic response.

32 nce of such a host-pathogen "arms race" is a compensatory change in the host antiviral protein as it

33 gnificantly decreased gene expression and no compensatory changes in DNA methylation or chromatin acc

34 Compensatory changes in energy expenditure occur in resp

35 ed perturbed epiboly with low penetrance and compensatory changes in the expression of terpenoid/ster

36 terious effect on gene regulation, even when compensatory changes were included.

37 ns during innervation of the same muscle, or compensatory changes when the output of one motoneuron i

38 genes, suggesting stabilizing selection for compensatory changes.

39 rids, revealing genome-wide (~15%) and often compensatory cis and trans regulatory changes under dive

40 rse eukaryotic taxa supports the mitonuclear compensatory coevolution hypothesis, but the ubiquity an

41 sis, but the ubiquity and importance of such compensatory coevolution remains a topic of debate.

42 Compensatory coevolution, whereby the nuclear genome evo

43 view different proposed forms of mitonuclear compensatory coevolution.

44 These phenotypes can be rescued by compensatory CRISPR mutations that retarget mir-35 to th

45 Our findings reveal compensatory cross-talk between the ESCRT machinery, cal

46 talk and design gene circuits that introduce compensatory crosstalk at the gene network level.

47 We also identify compensatory crosstalk mechanisms between Notch and Wnt

48 uts around a homeostatic set point, caused a compensatory decrease in synaptic drive to the muscle af

49 other biophysical constraints that result in compensatory decreases in charge elsewhere on the protei

50 and some snack several times a day; however, compensatory dietary and eating behaviors associated wit

51 lethality (eg, in cancer cells with impaired compensatory DNA damage responses through ATM loss) as m

52 p in virulence during mouse infection, while compensatory double mutants restored virulence to WT lev

53 Similar to ALS patients, a compensatory downregulation of cholesterol synthesis occ

54 d that this variant causes hyperactivity and compensatory downregulation of GLS expression combined w

55 ailure of de novo Xi silencing, with partial compensatory downregulation of the active X, and also di

56 ease in synaptic strength during waking, and compensatory downsizing of (presumably less frequently u

57 As a compensatory effect, low CSE environment enhances the re

58 first, followed by larger aberrations, with compensatory effects leading to robust tumour fitness ma

59 This possibly reflects compensatory effects of selection in recovering mitonucl

60 shoot growth via strong, context-dependent, compensatory effects, with clear cascading benefits only

61 Compensatory elevation in NREM sleep EEG delta power has

62 ailed to decrease tumor progression due to a compensatory emergence of granulocytic myeloid-derived s

63 e transgene mRNA, which is homologous to the compensatory endogenous genes.

64 This demonstrates that compensatory ERK activation limits the efficacy of JAK2

65 uring the progression of the disease, robust compensatory events take place in surviving motoneurons

66 udy on the efficacy and phenotypic impact of compensatory evolution in Escherichia coli strains carry

67 is biased, producing artifactual patterns of compensatory evolution.

68 cell development, Ssb1 (-/-) cells exhibited compensatory expression of its homolog SSB2.

69 ing, which is related to Z- modules, whereas compensatory eye movement adaptation, linked to Z+ modul

70 imulus encoding is necessary to generate the compensatory eye movements found experimentally during n

71 s was linked to an unexpected CDK9-dependent compensatory feedback loop that elevated Pol II pause re

72 ng energy expenditure would naturally induce compensatory feedback mechanisms to defend body weight.

73 Instead, A. tonsa shows compensatory feeding on the alternative prey.

74 nization in larger bees and induced possible compensatory feeding.

75 found that the majority of eye movements are compensatory for head movements, thereby serving to stab

76 her exacerbated these phenotypes, suggesting compensatory function of endothelial S1PR2 and 3 in the

77 We provide evidence that the compensatory function of EZH1 is alleviated upon higher

78 Scrib in ABP has remained obscure due to the compensatory function of two other LAP proteins, Erbin a

79 tic interactions often connect genes between compensatory functional modules in a highly coherent man

80 K27me2/3) marks were globally lost without a compensatory gain in other repressive PTMs.

81 the transcription start site regions of the compensatory genes.

82 inally, defective LTbetaR signaling impaired compensatory glomerular adaptation to renal mass reducti

83 s in PBMCs whereas lack of PINK1 upregulates compensatory glycolysis in response to oxidative stress

84 duced pig placental efficiency, resulting in compensatory growth of the placentae to maintain fetal d

85 Appetite and compensatory health beliefs were measured by self-report

86 les with preserved systolic functions due to compensatory hemodynamic remodeling.

87 et of the microbiota via high-level coating, compensatory IgM in sIgAd subjects showed less specifici

88 Despite the secretion of compensatory IgM into the gut lumen, sIgAd subjects disp

89 T(R)(eg) cells contribute to compensatory immune suppression, and therapies targeting

90 e immunocompetent host, a concept defined as compensatory immune suppression.

91 esults indicate that Alox12 loss activates a compensatory increase in Alox15 that sensitizes mouse be

92 pexin deficiency in SCD is associated with a compensatory increase in alpha-1-microglobulin (A1M), re

93 an increase, 3.33 [1.27] um; P = .01), and a compensatory increase in diffusion vessel surface area (

94 Despite a compensatory increase in expression of cytoplasmic beta-

95 lactate dehydrogenase activity, indicating a compensatory increase in glycolysis for cellular energet

96 a consumptive coagulopathy, characterized by compensatory increase in prothrombotic aminophospholipid

97 This CaMKIIdelta activation caused a compensatory increase in sarcoplasmic reticulum Ca(2+) c

98 AD3 compared with ADC-TAFs, which elicited a compensatory increase in TGFbeta1/SMAD2 activation.

99 ia during acute pyelonephritis resulted in a compensatory increase in the number of monocytes and hei

100 pment of insulin resistance (IR), there is a compensatory increase in the plasma insulin response to

101 h CD8 T cell escape variants may result in a compensatory increase in the responses to other epitopes

102 tochondrial respiratory reserve capacity and compensatory increased glycolytic activity.

103 an environmental carrying capacity may cause compensatory increases in demographic parameters and pop

104 L-Them2(-/-) mice fed chow was explained by compensatory increases in rates of fatty acid oxidation

105 de CNS sympathetic control circuits prevents compensatory increases in sympathetic nerve activity, he

106 However, compensatory increases in the expression of other proteo

107 EW is impaired in HFpEF and associated with compensatory increases or pathological decreases in myoc

108 mice, and the Cyp26a1 knockout did not cause compensatory induction of lecithin:retinol acetyltransfe

109 ed that PD-1/PD-L1 expression increases as a compensatory inhibitory pathway in parallel with an ipil

110 and disfavored sequence contexts by forming compensatory interactions to the flanking residues inclu

111 MAIT cell activation potency through dynamic compensatory interactions within a MAIT TCR-MR1-AML inte

112 ult, including APAP overdose, is followed by compensatory liver regeneration, which promotes recovery

113 We did not observe compensatory long-term disengagement in the SD arm.

114 ignificantly in ventricular CM in a presumed compensatory manner but was still not detected in the AV

115 a more integrated network topology may be a compensatory mechanism associated with preserved motor f

116 ,5'-cyclic monophosphate level, suggesting a compensatory mechanism by other erythroid ABC transporte

117 ion plasticity as a potentially advantageous compensatory mechanism conferring Mytilus species a prot

118 through redox circuits provides a potential compensatory mechanism for fine-tuning energy expenditur

119 trol mice with intact Akt1 proliferated as a compensatory mechanism for metabolic overload.

120 ed that cells inhibit protein synthesis as a compensatory mechanism for mitochondrial dysfunction.

121 ory integration among CA patients suggests a compensatory mechanism for processing semantic olfactory

122 esponse to elevated cortisol might suggest a compensatory mechanism in the brain to counteract cortic

123 This compensatory mechanism is lost with acute irradiation in

124 This compensatory mechanism may be important for the maintena

125 kers seen in reduced-obese individuals are a compensatory mechanism that drives relapse or a normaliz

126 Fibrinolysis SD is a reactive, compensatory mechanism that is evident soon after injury

127 lization offers a dynamic, fast and flexible compensatory mechanism to balance otherwise unstable net

128 pheral blood mononuclear cells, as well as a compensatory mechanism to protect against several pro-de

129 xation of synaptic inhibitory events acts as compensatory mechanism to strengthen GABA/glycine inhibi

130 est that increased modulation may occur as a compensatory mechanism, helping in part to preserve work

131 We propose that this compensatory mechanism, together with Bateman's principl

132 frontal and perceptual regions and suggest a compensatory mechanism.

133 le abundance, highlighting the presence of a compensatory mechanism.

134 was increased, suggesting the existence of a compensatory mechanism.

135 Furthermore, we also identified potential compensatory mechanisms able to minimize the severe fitn

136 alertness and suggest that there are neural compensatory mechanisms at play in response to physiolog

137 euronal damage and could indicate suboptimal compensatory mechanisms at play.

138 ges observed in mitochondria could represent compensatory mechanisms by which ASD cells try to adapt

139 ls of synaptic strength, with three specific compensatory mechanisms discovered.

140 eam effects on gene expression are initially compensatory mechanisms during adaptations to the altere

141 with the costs of TB infection being met by compensatory mechanisms enabling badgers to survive for

142 We propose that despite apparent compensatory mechanisms in drug-challenged cells, the su

143 did not affect UMP levels, likely because of compensatory mechanisms in these cells.

144 Moreover, compensatory mechanisms of ICL resistance when FANCJ is

145 F-actin content, most likely as a result of compensatory mechanisms of MKL2, which is not expressed

146 llenging because some phenotypes may reflect compensatory mechanisms or normal forms of plasticity di

147 At least 2 compensatory mechanisms seem to minimize the deleterious

148 Compensatory mechanisms such as increased aqueous tear p

149 These results reveal compensatory mechanisms that balance the directional pep

150 ogical dysregulation, and allude to possible compensatory mechanisms that buffer the effects of repro

151 This suggests the existence of compensatory mechanisms that can temporarily counteract

152 in development, and its absence may activate compensatory mechanisms that counteract muscle degradati

153 These results point to unexpected compensatory mechanisms to boost immunity in neonates, p

154 latory effects are most likely a result from compensatory mechanisms to ensure adequate tissue oxygen

155 cally observed in AD, could be suggestive of compensatory mechanisms to overcome the loss of memory f

156 se.SIGNIFICANCE STATEMENT This study reveals compensatory mechanisms used by synapses to ensure stabl

157 This could reflect an inability to utilise compensatory mechanisms, and contribute to higher risk o

158 he differential regulation of set points and compensatory mechanisms, and propose a new strategy to t

159 tcomes may occur as a result of a failure in compensatory mechanisms.

160 s rarely reported, suggesting organ-specific compensatory mechanisms.

161 transport chain (ETC) complexes and exhibit compensatory metabolic activities including reductive ca

162 ata reveal that HDL NP treatment activates a compensatory metabolic response in treated cells toward

163 miR155KO mice, suggesting the induction of a compensatory miR155-independent antileishmanial pathway.

164 n tool for ecosystem service enhancement and compensatory mitigation for habitat loss.

165 ctional assays identified proteins to deduce compensatory modes of balancing proteostasis.

166 of MDC1A, demonstrating its importance as a compensatory modifier of the disease(1).

167 UU-3'OH or poly(A) sequences, and we present compensatory mutagenesis data supporting a direct intera

168 Simulation benchmarks, blind challenges, compensatory mutagenesis, cross-RNA homologies and inter

169 80X variants, this mutation did not act as a compensatory mutant but, indeed, further reduced VRC.

170 Remarkably, the Env compensatory mutants can also rescue a replication-delay

171 Reducing actin binding through a compensatory mutation in the C-terminus leads to improve

172 eering E. coli cells carrying individual and compensatory mutations at the 752 and 2609 rRNA position

173 , the cost of resistance can be mitigated by compensatory mutations elsewhere in the genome, and ther

174 al genome reverted to the wild type (WT) and compensatory mutations in NS3 gene appeared.

175 t impair Env incorporation can be rescued by compensatory mutations in the trimer interface.

176 Compensatory mutations in the V3 loop (N301D) and in the

177 ts that were obtained through acquisition of compensatory mutations near the genomic 3' terminus.

178 enic AIV may be facilitated by permissive or compensatory mutations occurring across the viral genome

179 rimerization by isolating and characterizing compensatory mutations that rescue MA trimer interface m

180 Compensatory mutations that rescue virus replication do

181 nome and describes new systems for designing compensatory mutations to test the functional relevance

182 ir experiments, the spectrum and dynamics of compensatory mutations, and the alternative molecular me

183 to survive in rich medium unless it acquires compensatory mutations.

184 t aberrant binding effects were corrected by compensatory mutations.

185 numerical DC deficiency leads to MPD through compensatory myeloid differentiation.

186 c function, demonstrating a role for ATF6 in compensatory myocyte growth.

187 hosphate pathway (PPP) inhibition depends on compensatory NADPH production through the mitochondrial

188 disease-vulnerable NMJs often fail to guide compensatory nerve terminal sprouts and to adopt a phago

189 owever, the existence of altered and perhaps compensatory neural dynamics, sub-serving auditory worki

190 e and there is a knowledge gap regarding the compensatory neural mechanisms involved in this conditio

191 IB-specific FC signature, which may point to compensatory neurofunctional mechanisms in persons at fa

192 Blockade of compensatory neuronal innervation using LOXO-101, a Trk-

193 ted in response to inflammation to mediate a compensatory neuroprotective gene expression program tha

194 No compensatory non-opioid drug use was observed during BUP

195 rats showed that locally rewired as well as compensatory NRG fibers were responsible for different a

196 nd swimming, both locally rewired as well as compensatory NRG plasticity were crucial for recovered f

197 ations were predominant and no hitch-hiking, compensatory or virulence increasing mutations were dete

198 omized projections at the lesion site versus compensatory outgrowth of spared axons, using projection

199 ce of wax esters, which was accompanied by a compensatory overproduction of cholesteryl esters.

200 Direct targeting of NT5C2 or inhibition of compensatory pathways active in NT5C2 mutant cells may a

201 Mouse models indicate distinct compensatory pathways that balance proteostasis in MLII

202 ruvate/lactate ratios), along with potential compensatory pathways that could be leveraged to amelior

203 Other studies have noted unique, possibly compensatory patterns of neural activity among adolescen

204 Compensatory pauses occurred resulting in short-long-sho

205 hand, the results indicate a possibility of compensatory phenomena, namely that spatial learning def

206 NK cell metabolism was maintained due to compensatory PKM1 expression in PKM2-null NK cells.

207 reased striatopallidal transmission and that compensatory plasticity limits STN hyperactivity and cor

208 ng possibility that endogenous mechanisms of compensatory plasticity may be impaired in some individu

209 ch as sleep apnoea, endogenous mechanisms of compensatory plasticity may be impaired, and that exogen

210 prehensively that locally rewired as well as compensatory plasticity of reticulospinal axons function

211 elevated striatopallidal transmission, while compensatory plasticity prevents STN hyperactivity and l

212 activity and hypoxia activate mechanisms of compensatory plasticity that augment inspiratory output

213 the first evidence in human participants for compensatory plasticity within nondeprived sensory areas

214 High affinity haemoglobin and compensatory polycythaemia mitigated the decline in exer

215 ed humans with high affinity haemoglobin and compensatory polycythaemia.

216 er body perturbation during standing affects compensatory postural responses.

217 ntibiotics, and unintended consequences from compensatory prescribing may occur.

218 hey also reveal stunning differences between compensatory processes operating in vivo and ex vivo.

219 ionships are causal to illness, functionally compensatory processes, or purely epiphenomena.

220 nce suggests this ancient mutation induced a compensatory program in NRF2-target genes with functions

221 at diploid cells in mosaic embryos undertake compensatory proliferation during the implantation stage

222 -) hepatocytes into GS(+) hepatocytes and by compensatory proliferation of hepatocytes across liver z

223 sis leads to cell depletion and insufficient compensatory proliferation.

224 oral control of damage-induced apoptosis and compensatory proliferation.

225 these proferroptotic phospholipids triggers compensatory prosurvival pathways, and in particular aut

226 ardiomyocyte Ca(2+) dysregulation and offers compensatory protection against cardiomyocyte mechanisms

227 ncompasses the damage induced as well as the compensatory reactions of the organism.

228 recruitment for each XRN, with a progressive compensatory recruitment of the other XRNs as the respon

229 olerance, changes in immunity and behaviour, compensatory recruitment, pathogen attenuation, environm

230 ne (AZ) number is doubled in endo mutants, a compensatory reduction in their size homeostatically adj

231 c rewiring when primed to proliferate during compensatory regeneration and in hepatocellular carcinom

232 s up-regulated in USP20-KO hearts suggesting compensatory regulation.

233 t (MU) vulnerability and potentially impairs compensatory reinnervation.

234 -vulnerable NMJs, a phenomenon essential for compensatory reinnervation.

235 , presumably due to ongoing degeneration and compensatory reorganization of dendritic systems.

236 human tcf7l2 variant can effectively provide compensatory repressor function to restore eye formation

237 nesis occurred via minority MOMP and whether compensatory resistance mechanisms prevented cell death

238 The compensatory response detected in patient fibroblasts mi

239 ion with an extinction pattern, suggesting a compensatory response in drug intake due to reduced hero

240 fibrillar collagen deposition, suggesting a compensatory response in the absence of this collagen re

241 No effective compensatory response occurred in control animals (final

242 A compensatory response of increasing inner secondary laye

243 The vestibulocollic reflex is a compensatory response that stabilizes the head in space.

244 evelopment of autophagy, which probably is a compensatory response to combat cellular injury induced

245 ar hypertrophy for human R249Q mutation is a compensatory response to decreases in heart muscle power

246 ulation of proteasome subunits, suggesting a compensatory response to diminished proteasome output.

247 Here we present an unexpected compensatory response to extensive shell dissolution in

248 k inspiratory muscles has been reported as a compensatory response to hyperinflation-related diaphrag

249 excess adiposity itself and is not simply a compensatory response to insulin resistance.

250 d with a decline in MCR(I) that represents a compensatory response to maintain normal glucose toleran

251 trol animals exhibited incomplete and slower compensatory response to respiratory acidosis (final pH

252 na increased the uptake of carbon, likely as compensatory response to the higher energetic costs face

253 nalyses pinpoint the UPR as a broad-spectrum compensatory response wherein LBS and proteotoxic stress

254 Such compensatory responses are likely to be insufficient, en

255 cognitive and social functioning and trigger compensatory responses from supporting glial cells, whic

256 Here, we describe unexpected temporal compensatory responses in biomineralization as a mechani

257 Moreover, compensatory responses leading to proper behavioral stra

258 ntitative trade-offs in biomineralization as compensatory responses to altered environments.

259 ergic basket cell axonal processes, could be compensatory responses to restore cerebellar GABAergic t

260 feedforward control are in the generation of compensatory responses.

261 ( P < 0.001], suggesting failure of earlier compensatory responses.

262 tive relevance of locally rewired as well as compensatory reticulospinal plasticity for the recovery

263 age in hemopexin-deficient states, and (2) a compensatory rise in alpha-1 microglobulin (A1M) relativ

264 levels, which were mostly attributable to a compensatory ROCK1 overactivation.

265 which suggests that binding avidity plays a compensatory role during import.

266 Taken together, this evidence implicates a compensatory role for ipsilateral (i.e. contralesional)

267 d that Bhmt2 up-regulation could carry out a compensatory role in cochlear protection against noise i

268 peripheral capillary nonperfusion may play a compensatory role in maintaining the central macular mic

269 This study highlights a compensatory role of a nonstructural regulatory protein,

270 city in the lesioned language network, and a compensatory role of the right hemisphere.

271 f) and Mafb transcription factors (TFs) have compensatory roles in repressing somatostatin (SST(+)) i

272 Molecular dynamics simulations reveal compensatory roles of the beta-hairpins, which may rende

273 s of stabilization are interspersed with non-compensatory saccades that abruptly shift gaze position.

274 hanistic insights that are consistent with a compensatory/scarring scenario for brain pathological ch

275 ression in cocultures but acquired redundant compensatory signals enabling anchorage independence via

276 ring a perturbation does influence whether a compensatory step is taken, not via a direct effect on t

277 Hence, compensatory strategies for this type of damage might ex

278 and that individuals without a diagnosis use compensatory strategies that are qualitatively similar t

279 s self-reported their use and experiences of compensatory strategies using an online platform.

280 e findings suggested that there are multiple compensatory strategies with distinct characteristics, i

281 This study aimed to investigate social compensatory strategies, and their effect on diagnosis a

282 cing autistic-like difficulties, use similar compensatory strategies, potentially enabling them to si

283 dual and environmental factors that modulate compensatory strategy use and success, positive (social

284 th, late diagnosis) outcomes associated with compensatory strategy use, and that individuals without

285 abidopsis lines with CS defects and impaired compensatory suberization, revealed that the CS and sube

286 ersistence of A156T for genotype 1 relied on compensatory substitutions increasing replication and as

287 (GI) and ZEITLUPE (ZTL), which likely act as compensatory substitutions to establish a remarkably con

288 tated transition to 156L, persisting without compensatory substitutions.

289 revise the available evidence regarding the "Compensatory Theory," which is an explanatory model of r

290 ight back to its original state: this is the Compensatory Theory.

291 gating circuit dysfunction, and hence may be compensatory to the primary pathology.

292 cult to distinguish direct from secondary or compensatory transcriptional changes by traditional meth

293 Despite a compensatory transcriptional epidermal repair response,

294 y which hyperactive IL-2R signaling promoted compensatory transcriptional events, eventually resultin

295 intake, these hypothyroid mice show signs of compensatory up-regulation of the skeletal-muscle adapti

296 VLCFA utilization, results in ER stress with compensatory UPR induction.

297 and nuclear-encoded complex I variants and a compensatory upregulation of unaffected oxidative phosph

298 e lung hypoplasia in CDH is associated with (compensatory) upregulation of miR-200b in less hypoplast

299 linked to impaired beacon discrimination and compensatory use of allocentric memory.

300 ment have led to the convergent evolution of compensatory virulence mechanisms.