ライフサイエンスコーパス: complement

1 ications of ApoE alter its interactions with complement.

2 nvolving a doubling of the entire chromosome complement.

3 the TMA disorders that involve disorders of complement.

4 from host defense mechanisms, in particular complement.

5 otoxicity is almost entirely attributable to complement.

6 into LOS maintains gonococci susceptible to complement.

7 presentative analysis of the tissue chemical complement.

8 metabolism, scavenger receptors, MERTK, and complement.

9 hose of the wild type when dksA mutation was complemented.

10 rovide the potential for either replacing or complementing (18)F-FDG PET/CT in the selection and moni

11 At this l-fucose dose, complement activation and acute post-ischemic kidney inj

12 excretion but also leads to ammonia-induced complement activation and deposition of C3 and C5b-9 tha

13 ease COVID-19 patients, we describe systemic complement activation and its association with developme

14 parasite Plasmodium berghei triggers robust complement activation and ookinete elimination upon mosq

15 an blood and plasma revealed no hemolysis or complement activation following incubation with these si

16 tection in C3-deficient mice and evidence of complement activation in humans have led to the hypothes

17 in allergic asthma and the lectin pathway of complement activation in nonallergic asthma.

18 ndicate that CFH is critical for controlling complement activation in the liver, and in its absence,

19 LRP3-independent mechanisms, and (3) whether complement activation induces inflammasome activation in

20 tabolites were associated significantly with complement activation levels, independent of AMD status.

21 Subjects with higher complement activation measured by elevated blood sC5b-9

22 We also detected in vivo classical complement activation on CD4+ T cells in 14% of the whol

23 is, platelet activation and aggregation, and complement activation or coagulation were analyzed.

24 biologically potent molecules, including the complement activation peptides, C3a and C5a.

25 Complement activation products covering the classical/le

26 ern recognition molecules that contribute to complement activation via the lectin pathway.

27 Consistently increased systemic complement activation was observed in the majority of CO

28 own regarding the role of CFH in controlling complement activation within the liver.

29 he heart proteome included vasoconstriction, complement activation, and lipoprotein metabolism enrich

30 cally-relevant radiotherapy induces aberrant complement activation, leading to brain injury.

31 ge of DAF from podocyte surfaces, leading to complement activation.

32 ck ligand binding by local CL-11 and prevent complement activation.

33 icantly correlated with disease severity and complement activation.

34 flammation revealed widespread deposition of complement-activation fragments throughout the sinusoids

35 cell activation, monocyte phagocytosis, and complement activity, all of which have been implicated i

36 e complement function, which can amplify all complement activity, during critical illness.Objectives:

37 hods: Total classical (CH50) and alternative complement (AH50) function were quantified in serum from

38 ted expression of the C3a and C5a receptors (complement anaphylatoxin C3a receptor [C3aR] and complem

39 lement anaphylatoxin C3a receptor [C3aR] and complement anaphylatoxin C5a receptor 1 [C5aR1]) on huma

40 S sialylation renders gonococci resistant to complement and cationic peptides, and down-regulates the

41 nfection results in robust engagement of the complement and coagulation pathways.

42 points to several immune pathways, including complement and coagulation, as targets of coronaviruses.

43 obtained through genetics-based approaches, complement and extend previous analyses of vIL-6 activit

44 Our findings complement and extend previous inferences from both the

45 Emerging data indicate that complement and neutrophils contribute to the maladaptive

46 ave provided an array of powerful tools that complemented and enriched biophysical insights by enabli

47 The inductions of TREM1 signaling, complement, and leukocyte extravasation with stress were

48 o determine whether novel shape measures can complement anthropometric indices when estimating waist

49 interfering with biofilm formation can thus complement antibiotics.

50 formation was not due to the ICL labeling or complement attack and was observed after injection of bo

51 deficient in sulfite assimilation, pssm2-Fd complemented bacterial growth when coexpressed with a P.

52 n the Deltabb0326 mutant and restored in the complemented bb0326+ cells, leading us to rename BB0326

53 However, the clinical relevance of complement-binding anti-HLA antibodies remains unclear.

54 e-art review of (a) current understanding of complement biology for the clinician, (b) novel insights

55 d E. coli BioC both in vivo and in vitro and complemented biotin-independent growth of the M. smegmat

56 In a nonhuman primate model, we tested complement-blockade in BD donors to prevent DGF and impr

57 Overexpression of PIC30 fully complements both picloram and chlorate insensitive pheno

58 Lyme disease spirochetes interfere with complement by producing a small arsenal of outer-surface

59 nhibition of the alternative pathway (AP) of complement by saliva from Anopheles mosquitoes facilitat

60 Humoral immunity is complemented by a cellular immune response with favourab

61 Here, we present a kinetic approach complemented by a hydrodynamic theory for agents with mi

62 (2)(OR)(2) (OR = alkoxide) diamond-like core complemented by a mu-iodo bridge between the two Ni cent

63 disease, stroke and chronic kidney disease, complemented by a systematic review of relevant observat

64 d by phylogenetically old interneuron types, complemented by an evolutionary increase in principal ne

65 and biophysical study of their interaction, complemented by an in vivo localization study.

66 d dimers on the crystal surface, where it is complemented by dimerization and expedites dimer incorpo

67 f hormone signaling components are now being complemented by genetic studies in early diverging land

68 We propose ways that such data can be complemented by genomic information and linked back to e

69 labeling and site-directed mutagenesis, and complemented by integration and interpretation of the re

70 ough an in situ circular dichroism approach, complemented by intrinsic extrinsic fluorescence analysi

71 droplet guiding and sorting experiments are complemented by modeling of the droplet motion in the ch

72 drogen/deuterium exchange mass spectrometry, complemented by molecular dynamics simulations, and bact

73 Spectroscopic techniques complemented by quantum chemical calculations aided in u

74 d gene expression in The Cancer Genome Atlas complemented by single-cell analysis of six independent

75 ileptic patient brain network models (BNMs), complemented by the analysis of the impact of interictal

76 nning tunneling microscopy and spectroscopy, complemented by theoretical calculations.

77 duced optic nerve size, the latter phenotype complemented by WT mRNA but not by SSBP1 mutant transcri

78 Possible involvement of complement (C) systems in the pathogenesis of traumatic

79 The release of complement C1q from macrophages in the inflammatory nich

80 We found significant elevations in complement C1q, C3, and TLR4 post-RT accompanied by incr

81 nized inhibitory monoclonal antibody against complement C2.

82 case of an adult with complete deficiency of complement C3 due to homozygous mutations in C3 gene: c.

83 the safety and efficacy of pegcetacoplan, a complement C3 inhibitor, for treatment of GA.

84 motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering-based mo

85 N-beta resulted in microglial activation and complement C3-dependent synapse elimination in vivo.

86 in potent and selective antagonism of human Complement C3a receptor.

87 recruited to the premetastatic lungs through complement C5a receptor 1 signaling.

88 Complement C5a-mediated chemokinesis and chemotaxis were

89 In summary, complement C5a-mediated chemotaxis requires Galpha(i2) a

90 ific mechanism of RICD involving an upstream complement cascade component, C1q.

91 The underlying alterations in CNS complement cascade proteins (C1q, C3), TLR4, and colabel

92 ollectin-11 and subsequent initiation of the complement cascade through deposition of C4.

93 This information may complement clinical judgement, support rational and shar

94 optimized a preclinical PERCIST paradigm to complement clinical standards.

95 Proteins involved in blood coagulation and complement/coagulation cascades represented a greater fr

96 CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing

97 ng with differing affinities that are either complement competent or silenced.

98 and VSM from PTH1R-VKO mice identified C1r (complement component 1, r) and C1s (complement component

99 ied C1r (complement component 1, r) and C1s (complement component 1, s), complement proteins involved

100 Known sepsis-associated genes included complement component 3; angiopoietin 2; myeloperoxidase;

101 the proteins that are found in complex with complement component C4d in pooled synovial fluid of rhe

102 ach, knob domain peptides that tightly bound Complement component C5 were obtained, at scale, using c

103 of outer-surface lipoproteins that bind host complement components and manipulate their native activi

104 ion, impairment or inadvertent activation of complement components contribute to the pathogenesis of

105 timating molecular bioactivity in silico and complements conventional empirical approaches to studyin

106 s fundamentally different contrast mechanism complements conventional imaging modes and can be acquir

107 s disease despite DAF deficiency, confirming complement dependence.

108 s to promote inflammation via elaboration of complement-dependent anaphylatoxins.

109 otoxicity (ADCC), complement deposition, and complement-dependent cytotoxicity (CDC).

110 en bead (SAB) assay-defined DSA but negative complement-dependent cytotoxicity crossmatches were enro

111 tive antibody [cPRA] class I and/or II >99%, complement-dependent cytotoxicity panel reactive antibod

112 antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity through relief of immu

113 We identified Csf2/GM-CSF as a primary complement-dependent inflammatory mediator.

114 Complement-dependent lysis of IVIg against these pig pRB

115 xpressed complement inhibitor that regulates complement-dependent synapse elimination.

116 soform-dependent inhibition of hemolysis and complement deposition at the level of sC5b-9.

117 tential of MNZ67 by significantly decreasing complement deposition on the bacterial surface.

118 capsule acquisition did not further decrease complement deposition on the relatively highly pathogeni

119 dependent cell-mediated cytotoxicity (ADCC), complement deposition, and complement-dependent cytotoxi

120 6F) resulting in glomerular inflammation and complement deposition.

121 The renaissance of complement diagnostics and therapeutics has introduced p

122 nt regulatory and inhibitory agents to treat complement dysfunction.

123 iated with aberrant innate immune signaling, complement dysregulation, Th2 skewing, and increased sec

124 e for the majority of proteins and that they complement each other, novel tools that accurately ident

125 ferent data sources show limited overlap and complement each other.

126 sents a platform of UHPLC-HRMS and LA-REIMS, complementing each other to perform salivary metabolomic

127 ric derivative of MAb 2C7 (2C7-Ximab) with a complement-enhancing E-to-G Fc mutation at position 430

128 f Lyme borreliae-host associations driven by complement evasion.

129 ferent antigens can synergistically activate complement even when each single Mab is not bactericidal

130 and argue that a "location-centric" view of complement evolution could logically justify its close c

131 n data has not been exploited to complete or complement existing inventories nor have they been used

132 To complement existing point measurements, we introduce a m

133 This can complement existing T cell-directed immunotherapy, provi

134 ditional inhibitory pathways are required to complement existing therapeutics.

135 ion with Complement Factor H (CFH) Y402H and Complement factor 3 (C3) rs2230199 (R102G) in AMD.

136 d to investigate the possible association of Complement Factor B (CFB) rs4151667 (L9H) variants and t

137 e deposited on TF1PIGAnull target cells, and complement factor Bb is increased in the supernatant fro

138 neutrophil recruitment and activation is the complement factor C5a, which signals through two recepto

139 Mice deficient in complement factor H (CFH) are a classic C3G model, with

140 variants and their possible interaction with Complement Factor H (CFH) Y402H and Complement factor 3

141 Genetic variants within complement factor H (CFH), a major alternative complemen

142 rsons with the protective genetic alleles of complement factor H (CFH), the Mediterranean diet had fu

143 ts at the chromosome 1q31.3 encompassing the complement factor H (CFH, FH) and CFH related genes (CFH

144 Complement factors are being considered as targets for t

145 ecially when the virions were opsonized with complement factors.

146 of laboratory and experimental studies have complemented field observations in the hope of achieving

147 Using self-complemented FimA variants with reversed, pseudo-palindr

148 and the reported work could be an excellent complement for industrial wastewater treatment.

149 ing extensively opsonized with prophagocytic complement fragments, we find that this cell also escape

150 nly partial function whereas all other genes complemented fully.

151 In addition to providing evidence that complement function modulates SARS-CoV-2 infection outco

152 here is limited understanding of alternative complement function, which can amplify all complement ac

153 These findings challenge the paradigm of complement gene mutations typically causing primary memb

154 ernal (factor H and C3) and one fetal (CD46) complement genes and identified a total of 9 common SNPs

155 cium channels, the dopamine D2 receptor, and complement glycoproteins.

156 In contrast, benign selection markers complement GMOs with reduced fitness.

157 eneralized to enable molecular strategies to complement heterogeneous catalysts by stabilizing interm

158 in the photorespiratory cycle of HPR1-T335D-complemented hpr1-1 rosettes compared to all other HPR1-

159 everal canonical pathways (TREM1, NF-kappaB, complement, IL-6 signaling) and upstream regulators (INF

160 tial applicability to clinical practice, (c) complement in disease across various disciplines (hemato

161 WT or near-WT levels when lon-2 mutation was complemented in cis.

162 HSV-1 that lacks gC was more sensitive to complement-independent neutralization by a panel of gB m

163 Complement inhibition was achieved using B4Crry, an inju

164 cal evidence showing that treatment with the complement inhibitor compstatin Cp40 inhibited the expre

165 main protein SRPX2 is a neuronally expressed complement inhibitor that regulates complement-dependent

166 ion of CD38 expression and overexpression of complement inhibitory proteins on MM target cells as wel

167 Here, we investigated how complement interacts with the platelet/neutrophil extrac

168 Acting as a cascade of enzymatic reactions, complement is activated through the classical (CP), the

169 Cross talk between MCs and complement is facilitated by the production of complemen

170 nated peptide antibodies, rheumatoid factor, complement levels, and cytokine levels in these 2 groups

171 Silencing components of the complement-like system through RNAi largely restores ook

172 ide polymorphisms previously assigned to the complement, lipid metabolism, or extracellular matrix (E

173 nation therapies targeting inflammasomes and complement may offer synergistic benefits to inhibit CNV

174 ARGX-117 prevents complement-mediated cytotoxicity in in vitro models for

175 ling, and proinflammatory effects in various complement-mediated diseases.

176 d precision medicine into a widened field of complement-mediated diseases.

177 d to the hypothesis that SARS-CoV-2 triggers complement-mediated endothelial damage, but the mechanis

178 athologic features with C3 glomerulopathy, a complement-mediated glomerulopathy that, unlike acute po

179 f fH-/- livers (3-24 months) for evidence of complement-mediated inflammation revealed widespread dep

180 L-17 signaling, acute inflammatory response, complement-mediated inflammation, and infection controll

181 of FH increases meningococcal resistance to complement-mediated killing.

182 ain and discuss the autoimmune mechanisms of complement-mediated myopathies, myasthenia, peripheral n

183 terferon response in neuroglia, resulting in complement-mediated synapse elimination in AD models.

184 sseminated to organs more extensively than a complemented mutant.

185 Next, by integrating the complement of a 10-23 DNAzyme into the primer pair, PCR-

186 e amount of Atoh7 needed to produce a normal complement of adult RGCs, and the secondary consequences

187 figurations of chromatin, which restrict the complement of available genes and cis-regulatory element

188 Because zebrafish harbor a full complement of cobalamin metabolic enzymes, we used genom

189 itro measurements on filaments with a sparse complement of heads detected a decrease of the cross-bri

190 ical neurons is essential to determine their complement of ion channels and to understand the functio

191 In this review, the roles of the plant complement of small GTP-binding proteins in these cellul

192 in other tissues as they express a distinct complement of transcription factors and are composed of

193 Knockout cells had a normal complement of TRPM1 at their dendritic tips, while GPR17

194 78 LG4 loci averaging >35 internal loop:loop complements of >8 bp.

195 Different animal species have different complements of AOX genes.

196 Indeed, curated microRNA complements of closely related organisms are very simila

197 tant proteins retaining partial activity can complement one another, is unclear and could affect the

198 dentify ways in which the two approaches may complement one another.

199 Upon activation by microbes, complement opsonizes bacterial surfaces, recruits profes

200 nessed in the realm of diagnostic methods to complement or replace current culture-based and molecula

201 pisode drug-naive schizophrenia, which could complement other biomarkers in the development of precis

202 s the utility of RNA-sequencing datasets and complements other tools for complete characterization an

203 We complement our data by a quantitative theory.

204 Complementing our metabolomics results, our transcriptom

205 This perspective complements our theoretical view of the human self as in

206 lidated previous reports of rare variants in complement pathway genes in AMD.

207 nction and key components of the alternative complement pathway in a series of critically ill patient

208 mplement factor H (CFH), a major alternative complement pathway regulator, are associated with the de

209 obody, hC3Nb2, inhibits C3 deposition by all complement pathways.

210 vated both the classical and the alternative complement pathways.

211 6C(lo) monocyte lineage regulates PH through complement, phagocytosis, Ag presentation, and chemokine

212 e selected and associated to coagulation and complement processes and to extracellular matrix.

213 Preclinical studies demonstrated that complement promotes tumor growth.

214 ystem to spread apoptotic factors, including complement protein C1q, to induce the membrane attack co

215 ency anemia-causing mutant (Mt2I286F) in the complement protein subcomponents C1r/C1s, urchin embryon

216 degradation of xeroderma pigmentosum group B-complementing protein (XPB), a component of human transc

217 extensive examples that implicate classical complement proteins and their receptors in CNS dysfuncti

218 Complement proteins are ancient components of innate imm

219 mplement is facilitated by the production of complement proteins by MCs and their activation by the M

220 Plasma levels of complement proteins correlated with response to immune c

221 Although the role for the cytolytic complement proteins in astrocyte destruction in NMO is w

222 t 1, r) and C1s (complement component 1, s), complement proteins involved in vascular collagen metabo

223 We describe the complex network of complement proteins that target muscle, the neuromuscula

224 dopeptidase inhibitors, coagulation factors, complement proteins, carbonic anhydrases, and redox enzy

225 To complement radio-frequency accelerator-based large-scale

226 that FPR activation leads to upregulation of complement receptors 1 and 3 as well as FCgamma receptor

227 They express various complement receptors, including those for C3a and C5a.

228 novel human lectin and PRM of importance for complement recognition and innate immunity.

229 tes produce the CspZ protein that binds to a complement regulator, factor H (FH).

230 soluble fragment of HuCR1, which retains the complement regulatory activity of the wildtype protein.

231 There is increasing interest in developing complement regulatory and inhibitory agents to treat com

232 rozygous mutations in FH are associated with complement-related diseases such as atypical hemolytic u

233 minal pathway, with possible applications in complement research, diagnostics, and therapeutics.

234 ue; its deletion led to modest reductions in complement resistance.

235 resent the fourth electrical circuit element complementing resistors, capacitors and inductors.

236 These results complement Ritz's upper bound and may turn the computati

237 iagnosis, subtyping, and treatment, where it complements routine histopathological evaluation by clar

238 available from GP databases could be used to complement screening referral decisions by identifying t

239 GSO1)/SCHENGEN3 (SGN3) chimera can partially complement sgn3 Casparian strip formation phenotypes, su

240 treat hazard rate analyses have potential to complement single-outcome analyses for the evaluation of

241 gRNAs, into separate alleles to form a trans-complementing split-gene-drive (tGD) and demonstrate its

242 In support of the hypothesis that the complement system along with neutrophils and platelets c

243 ATXN2 ASO also modified innate immunity, the complement system and lysosome/phagosome pathways.

244 The emergence and evolution of the complement system and mast cells (MCs) can be traced bac

245 These results implicate the complement system as a source of sexual dimorphism in vu

246 At a molecular level, MCs and complement system interactions are based on the producti

247 The complement system is a crucial part of innate immune def

248 The complement system is an ancient arm of the innate immune

249 The complement system is an intricate cascade of the innate

250 through DNA damage-driven apoptosis and the complement system of immunity.

251 The complement system plays a pivotal role in the pathogenes

252 et al. is one such team who report that the complement system plays a substantial role in creating t

253 The complement system serves a critical role in the modulati

254 respectively) while acute phase response and complement system were affected stronger in Cbs(-/-) mic

255 , the discovery of an intracellularly active complement system-the complosome-and its key role in the

256 effective if far-reaching lifestyle changes complement technological advancements.

257 CoV-2 (IgA) in saliva and serum is needed to complement tests that detect immunoglobulins G and M.

258 The use of dd-cfDNA may complement the Banff classification and to risk stratify

259 or faster assay for germinable endospores to complement the conventional lengthy, culture-based surfa

260 from diverse chemotypes are presented, which complement the existing structural information for the s

261 In order to complement the experimental results, the in silico metho

262 WPGD1 and WPGD2 transgenes complement the pgd3-defective kernel phenotype, indicati

263 ive cameras covering the whole soil surface, complement the rhizoboxes.

264 ssion of the full-length CpMMS19 was able to complement the thermosensitive growth of the yeast mms19

265 hat the isopeptide-N-ethylated Ub probes may complement the triazole-based probes in the study of Ub

266 f life has been proposed as the fourth 90 to complement the UNAIDS 90-90-90 targets to monitor the gl

267 By complementing the ffRF, the fbRF that we identify here c

268 e events detectably impacted the population, complementing the historical records of this culturally

269 e another and that each method is capable of complementing the limitations commonly associated with t

270 This atlas of chromatin loops complements the diverse maps of regulatory architecture

271 This finding indicated that the yeast enzyme complements the essential function of TbCAE by adding CC

272 r of electrochemical oxidations, this method complements the existing organoboron toolbox.

273 ather provides a sociotechnical adjunct that complements their use.

274 to be effective at nanomolar concentrations, complement therapy with temozolomide, and synergize stro

275 To complement these data, we have identified all orcokinin-

276 Complementing these approaches, we develop a method to e

277 Complementing these experimental tools, co-polymers theo

278 Complementing these genetic studies, we also identified

279 on E(4)(H(2),2H) formation during catalysis, complementing these results with corresponding DFT compu

280 There is an urgent need to complement this traditional approach with experiments th

281 Increasingly, omics data is being used to complement this, as it has the potential to reduce redis

282 The C1q complement/TNF-related protein superfamily (CTRPs) displ

283 This strategy represents an important complement to the conventional methods employed for the

284 -defined and operationally robust main-group complement to the current workhorse transition-metal-bas

285 of Earth observation data is evaluated as a complement to the existing historical records of natural

286 hile at the same time it offers an effective complement to the labour-intensive screening processes o

287 d-type allele of the CpRbp1 gene resulted in complemented transformants.

288 Therefore, adopting CT to complement visual core description in the ichnological a

289 y for the clinician, (b) novel insights into complement with potential applicability to clinical prac

290 vivo spinal cord slices from CX3CR1-GFP mice complemented with confocal analyses of CD68 protein.

291 transfer-based fluorescent spectrometry, was complemented with density ultracentrifugation to reveal

292 nicopathologic parameters of the tumors were complemented with DNA image cytometry profiles, enumerat

293 s, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine

294 These analyses were complemented with inactivation of FOXA1 and PTEN in inte

295 ometer-resolution coordinate estimation when complemented with multidimensional chemical mapping and

296 This ecosystem-level analysis was further complemented with published field observations of specie

297 L/6J and BALB/cJ, and deploying deep RNA-Seq complemented with quantitative RT-PCR, we found that fee

298 inary metabolites by 1H-NMR spectroscopy was complemented with targeted quantification of fecal SCFAs

299 ed surfaces providing in silico predictions, complemented with time-lapse fluorescence imaging to stu

300 tions are based on the production of several complement zymogens by MCs and their activation by MC-re