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1  model and sensitizes P. aeruginosa to serum complement activity.
2  innate immune effector functions as well as complement activity.
3 independent of Fc-receptor functionality and complement activity.
4  at increasing FcgammaRIIIa/b binding and/or complement activity.
5 y is particularly vulnerable to dysregulated complement activity.
6 uman patient lacking MASP3 still retained AP complement activity.
7 There was a complete inhibition of the total complement activity.
8 th other diseases characterized by excessive complement activity.
9 nent in cartilage, as well as a regulator of complement activity.
10  in the expression of proteins essential for complement activity.
11 eminate through body fluids that are rich in complement activity.
12 ecial emphasis on their capacity to modulate complement activity.
13 ease, cobra venom factor was used to deplete complement activity.
14  architecture as MBL but lacks any intrinsic complement activity.
15 timulated robust neutrophil phagocytosis and complement activity.
16 ly in the thymus, because of low intrathymic complement activity.
17 ions and purified CP both suppress hemolytic complement activity.
18 ignificantly affect systemic levels of serum complement activity.
19 ral health was found to lack serum hemolytic complement activity.
20 eceptor 1 (CR1) is involved in regulation of complement activity.
21 zed for phagocytosis by nonimmune serum with complement activity.
22 laevis resulted in significant inhibition of complement activities.
23 devoid of CDC-activity, did not enable their complement activities.
24 ement, whereas anti-CsMAP34 antibody blocked complement activities.
25 S. aureus mechanism for modification of host complement activities.
26  buffer containing 0.4 M KCl eluted only the complementing activity.
27 itro in the absence of exogenous apobec-1 or complementing activity.
28 lone; the COG3236 domain was unnecessary for complementing activity.
29 amma-tubulin ring complex and the centrosome-complementing activity.
30 reas removing the gamma-tubulin destroys the complementing activity.
31 is indicated that only APT1 could code for a complementing activity.
32 ignificantly affect systemic levels of serum complement activity, a potential benefit for stroke pati
33 tration of eculizumab, at doses that blocked complement activity, aborted acute progressive thromboti
34 receptor 1 (HuCR1) is a pivotal regulator of complement activity, acting on all three complement path
35                 TP10 significantly inhibited complement activity after 10 to 15 minutes of CPB and th
36  cell activation, monocyte phagocytosis, and complement activity, all of which have been implicated i
37 ipients displayed > 90% inhibition of plasma complement activity and a marked reduction in tissue C3
38                                  We measured complement activity and ADAMTS13 function, and completed
39 pression of Nptx2 was sufficient to restrain complement activity and ameliorate microglia-mediated sy
40           In the present case-control study, complement activity and concentrations of complement com
41 imab to human CD20(+) cells leads to loss of complement activity and consumption of component C2.
42 that in combination have dramatic effects on complement activity and disease risk.
43 n the clinic because of the presence of high complement activity and high anti-Gal Ab titers in human
44             In the eye, this balance between complement activity and inhibition is crucial, as a low
45 ay (CP) is a potent mechanism for initiating complement activity and is a driver of pathology in many
46 her, these results show that Nptx2 regulates complement activity and microglial synapse elimination i
47 tramers are the most efficient at increasing complement activity and PGA formation.
48 njury was associated with a decline in serum complement activity and progressive intrapulmonary seque
49  deficiency reduces but does not abrogate AP complement activity and that this is explained by intrin
50 tural antibody with a lesser contribution of complement activity and the presence of neutrophils.
51 dependent, cell-autonomous and non-canonical complement activities are underappreciated contributors
52 sh peroxidase or glucose oxidase, which have complementing activities, as well as paramagnetic (gadol
53  Crry-Ig, had no significant effect on serum complement activity at minimum effective therapeutic dos
54  doses > or =1 mg/kg, significantly inhibits complement activity at the levels of C3 and C5 in patien
55 NA affinity chromatography, we show that the complementing activity binds to a 280-nucleotide apo-B R
56 ively with fibrinolysis, pexelizumab blocked complement activity but reduced neither infarct size by
57  dose-dependent manner and that Efb inhibits complement activity by blocking deposition of C3 or by p
58          Nptx2-deficient mice show increased complement activity, C1q-dependent microglial synapse en
59                                        Serum complement activity (CH(50)) in severe and mild EAMG was
60                          The highly enriched complementing activity copurified with a DNA polymerase,
61                   In contrast, pneumolysin's complement activity correlated with bacterial growth and
62                                              Complementing activity could be isolated from PICs, and
63 e complement function, which can amplify all complement activity, during critical illness.Objectives:
64  for each disease, therapeutic modulation of complement activity emerges as an attractive target for
65 usion protein, we demonstrate that enhancing complement activity enhances axonal pruning.
66 rying degrees, whereas ATPase mutants had no complementing activity, even when the mutant protein was
67 -1 immobilized on beads depleted >90% of the complementing activity from partially purified extracts.
68  the anti-donor IgM Ab level was maximal and complement activity had returned to approximately 50% of
69                     In the last two decades, complement activity has been the focus of intense invest
70 LL NUMBER REGULATOR13 (CNR13), the maize MID-COMPLEMENTING ACTIVITY homolog.
71           In this study, we have assessed AP complement activity in a Masp3-knockout mouse generated
72 nt activation in vitro, consistent with high complement activity in clinical samples.
73  patients with C3G and aHUS does not enhance complement activity in either the fluid phase or on cell
74      Cobra venom factor completely inhibited complement activity in four (group 2) and dextran sulfat
75  method for assay of lectin pathway-mediated complement activity in human serum that should be useful
76 aluated by the inhibition of total hemolytic complement activity in human serum.
77 ddition, AMD is not associated with systemic complement activity in LT patients.
78 e detected plasma concentration-dependent AP complement activity in Masp3 gene-inactivated mice.
79 atour et al describe ex vivo measurements of complement activity in paroxysmal nocturnal hemoglobinur
80               We hypothesized that exuberant complement activity in PNH results in enhanced immune ch
81  human properdin to restore LPS-dependent AP complement activity in properdin-/- mouse serum correlat
82 major complement pathways supports increased complement activity in schizophrenia and also shows that
83    Many older reports indicate altered serum complement activity in schizophrenia, though the data ar
84                                              Complement activity in the baboons was within the normal
85 n about CSMD1 including whether it regulates complement activity in the brain or otherwise plays a ro
86               Current models of pathological complement activity in the brain propose that accelerate
87            These results implicate excessive complement activity in the development of schizophrenia
88 ushi Multiple Domains 1 (CSMD1) can regulate complement activity in vitro, is expressed in the brain,
89 t the C-terminal region of Efb could inhibit complement activity in vitro.
90 ent S. aureus infections by interfering with complement activity in vivo.
91 1 were not required for interaction with the complementing activity in vitro.
92 DExx region, and the SRC region, inactivated complementing activity in vivo and clamp loading in vitr
93  of S. cerevisiae SEC65 and tested these for complementing activity in vivo and for SRP integrity in
94 utant gene, on a multicopy plasmid, retained complementing activity in vivo and the mutant gene also
95 both visual-only and audiovisual speech that complements activity in integrative brain regions like p
96 ted here can be potentially used to evaluate complement activity induced by other antigen-antibody co
97                       However, pneumolysin's complement activity inhibited killing of mutant bacteria
98  PD, resulting in a shortened period of full complement activity inhibition.
99 , a renin inhibitor, does not block abnormal complement activity introduced by nephritic factors in t
100                        However, dysregulated complement activity is associated with unwanted or non-r
101                 Finally, we demonstrate that complement activity is elevated in cd59 mutants and that
102 clusion, our data corroborate that hemolytic complement activity is essential for control of bacterem
103                           Furthermore, novel complement activity is introduced concurrently with MASP
104 hibition is crucial, as a low level of basal complement activity is necessary to support ocular immun
105 hese findings suggest that local intraocular complement activity is of greater importance in AMD path
106 ) and frontotemporal dementia (FTD), but how complement activity is regulated in the brain remains la
107                         The data reveal that complement activity is remarkably tolerant to changes in
108 nction of these additional factors, known as complementing activity, is not known.
109   Soleus macrophage number corresponded with complement activity, leading to reduced muscle degenerat
110       Thus, both pneumolysin's hemolytic and complement activities made specific contributions to the
111 tion, the observed CP-mediated inhibition of complement activity may contribute to the lack of inflam
112                 Our results suggest that the complementing activity may function as the RNA-binding s
113 geted channel mutants as well as double mid1-complementing activity (MCA) channel mutants did not aff
114                                Inhibition of complement activity, measured by CH50, was significant f
115 2 cells was expressed transiently, with peak complementing activity observed when cells were treated
116 n and a more potent anti-alternative pathway complement activity of Crry contributed to its indispens
117 poE complexes emerged as markers for ongoing complement activity of diseased ChPs, Abeta plaques, and
118            The antiserum inhibited hemolytic complement activity of Lewis (RT1(1)) rats in vivo and i
119 combinant PKF, which was shown to reduce the complement activity of normal human serum by almost 50%.
120                                          The complement activity of the perfusate was reduced by CAB-
121 ourth, aliskiren does not block dysregulated complement activity on cell surfaces.
122  elevated apoptotic threshold, modulation of complement activity or diminished cellular cytotoxicity.
123 the N-glycan structures could activate serum complement activity, possibly by the lectin pathway of c
124                                        Basal complement activity presents a potential danger for "sel
125  The ubiquitous protein CD46, a regulator of complement activity, promotes T cell activation and diff
126  cobra venom factor, which depleted serum of complement activity, protected mice from AAA development
127 ycoprotein that belongs to the regulators of complement activity (RCA) family.
128 m whether the incorporation of regulators of complement activity (RCA) into the viral envelope afford
129              Deletion analysis localized the complementing activity (Rej) to the putative Env signal
130   However, whether MASP3 is essential for AP complement activity remains uncertain.
131 absence of either pneumolysin's hemolytic or complement activities rendered mutant strains less virul
132      DNA sequence analysis revealed that the complementing activity resulted from a single point muta
133         To assess the effect of treatment on complement activity, sera from dosed subjects were analy
134  advanced the concept that subtle changes in complement activity significantly affect disease risk.
135 ic ("hemolytic") and complement-activation ("complement") activities that have been mapped to several
136 rome (aHUS) is characterized by dysregulated complement activity, the development of a thrombotic mic
137         Because C3d is deposited at sites of complement activity, this molecule localizes to tissue c
138                       SP-A may down-regulate complement activity through its association with C1q.
139                   Our results link excessive complement activity to an intracellular endo-lysosomal t
140 g and complementation analysis localized the complementing activity to a 2.8-kb B. pertussis genomic
141 e studied soluble CR1, a potent regulator of complement activity, to test whether it restores complem
142 ommunication, the induction of intracellular complement activity underlying Th1 effector cell polariz
143 te suppression of both total and alternative complement activities was maintained for 4 weeks in the
144                                     Systemic complement activity was ascertained by measuring levels
145  not measurable in 5% plasma, significant AP complement activity was detected in 20-50% plasma of Mas
146  was required to prevent plasma viremia when complement activity was eliminated.
147  to protect animals from plasma viremia when complement activity was enhanced.
148                                              Complement activity was mainly dependent on the classica
149                                Pneumolysin's complement activity was not associated with the degree o
150 n of the two polypeptides with transcription-complementing activity was confirmed with specific antib
151 ional holoenzyme containing apobec-1 and the complementing activity was eluted from the apobec-1-affi
152                                          The complementing activity was identified as HMGB1 (the high
153                                          The complementing activity was protease-sensitive and microc
154                                              Complementing activity was reduced when HumD was express
155 in the cytokine milieu, induced by a loss of complement activity, were found to alter prosurvival sig
156 hen assayed individually, were found to have complementing activity when co-expressed together.
157 rus-specific IgA levels, neutralization, and complement activity, whereas lower respiratory control w
158                         Fractionation of the complementing activity yielded HMG I(Y), a nonhistone ch
159  Isolation of the intermolecular integration-complementing activity yielded HMG I(Y), as in the HIV-1

 
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