ライフサイエンスコーパス: complement factor H

1 most common mutation is in the gene encoding complement factor H.

2 02 protein polymorphism in the gene encoding complement factor H.

3 ed, i.e., TSG-6, chemokines IL-8 and KC, and complement factor H.

4 The purified protein was identified as human complement factor H.

5 and OPN form rapid and tight complexes with complement Factor H.

6 cells of two C' inhibitors: Vitronectin and complement factor H.

7 3G associated with the haploinsufficiency of complement factor H.

8 the complement cascade C1q, C6, and C8; and complement factor H.

9 ble proteins, such as C-reactive protein and complement factor H.

10 We have recently reported that complement factor H, a negative regulator of complement-

11 Indeed, the binding of human complement factor H, a negative regulator of the alterna

12 Genetic investigations have shown that complement factor H, a regulator of the alternative comp

13 Ten loci in 7 AMD genes [complement factor H, age-related maculopathy susceptibil

14 he BrM of apolipoprotein E, while increasing complement factor H and lowering secretion of the proang

15 Deficiency of complement factor H and mutations in CFH associate with

16 In mice deficient in complement factor H and transgenic for human CR1, solubl

17 sion in PI cells of two major C' inhibitors: complement factor H and Vitronectin.

18 The association of variants in complement factors H and B with age-related macular dege

19 g two host-derived fluid-phase regulators of complement, factor H and factor H-like protein 1 (FHL-1)

20 d with genetic complement abnormalities/anti-complement factor H antibodies, which paved the way to t

21 ession in wound fibroblasts and they uncover complement factor H as a molecular driver of skin regene

22 convalescent B1b cell-derived IgM recognizes complement factor H-binding protein (FhbA), a B. hermsii

23 xygenation and hemodynamics in aging C57 and complement factor H (CFH(-/-)) mice, proposed models of

24 ificant association was observed between the complement factor H (CFH) 402H risk variant and WACM.

25 ht to determine if rare germline variants in complement factor H (CFH) affect the PNH course, screeni

26 Genetic risk was based on Y402H in complement factor H (CFH) and A69S in age-related maculo

27 ants were genotyped for polymorphisms in the complement factor H (CFH) and age-related maculopathy su

28 cleotide polymorphisms were genotyped in the complement factor H (CFH) and ARMS2 genes using a Taqman

29 Two biologically related factors, complement factor H (CFH) and C-reactive protein (CRP),

30 suggest that defective interactions between complement factor H (CFH) and cell surface heparan sulfa

31 the relationship between local (ie, ocular) complement factor H (CFH) and choroidal neovascularizati

32 Association of variants in the complement factor H (CFH) and complement factor B (CFB)

33 tion cluster at chromosome 1q32 contains the complement factor H (CFH) and five complement factor H-r

34 s study, we investigated the associations of complement factor H (CFH) and hemicentin-1 (HMCN1) with

35 etic variants at the CFH locus, encompassing complement factor H (CFH) and the complement-factor-H-re

36 express various complement factors including complement factor H (CFH) and to promote the removal of

37 Mice deficient in complement factor H (CFH) are a classic C3G model, with

38 ctivation and genetic variants in inhibitory complement factor H (CFH) are also features of both ARMD

39 Adamts13 (-/-) or a heterozygous mutation of complement factor H (cfh) at amino acid residue of 1206

40 We previously identified an anti-complement factor H (CFH) autoantibody associated with p

41 In addition, to determine the regulation of complement factor H (CFH) by oxidative stress, in vitro

42 Genetic variations in complement factor H (CFH) confer greater risk for age-re

43 t efforts to treat C3G using exogenous human complement factor H (CFH) found limited success due to i

44 f this disease, identifying mutations in the complement factor H (CFH) gene and a locus on chromosome

45 , we found that genetic polymorphisms in the complement factor H (CFH) gene and S100A gene region are

46 Rare variants in the complement factor H (CFH) gene and their association wit

47 anding puzzle why non-coding variants in the complement factor H (CFH) gene are more strongly associa

48 Variations in the complement factor H (CFH) gene are tightly associated wi

49 S, with a focus on genetic variations in the complement Factor H (CFH) gene cluster and CFH autoantib

50 us carriers of the Y402H risk variant in the complement factor H (CFH) gene developed neovascular AMD

51 ransition at amino acid position 402) in the complement factor H (CFH) gene have a pharmacogenetics e

52 ty variants and protective haplotypes in the complement factor H (CFH) gene modulate risk for AMD.

53 mparted by carrying the Y402H variant in the complement factor H (CFH) gene on chromosome 1, recent e

54 on of a rare, high-penetrance variant in the complement factor H (CFH) gene that is also causally ass

55 Polymorphisms in the complement factor H (CFH) gene that reduce activity of C

56 A Tyr402His variant in exon 9 in the complement factor H (CFH) gene was also significantly as

57 A locus on chromosome 1q31.1 containing the complement factor H (CFH) gene was strongly associated w

58 inly been attributed to a risk allele in the complement factor H (CFH) gene.

59 underwent Sanger sequencing analysis of the complement factor H (CFH) gene.

60 ted maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) genotypes, and other factors,

61 Complement factor H (CFH) has recently been identified a

62 gh interaction with an SNP (rs380390) in the complement factor H (CFH) intron reported to be highly a

63 Complement factor H (CFH) is a central regulator of the

64 Complement factor H (CFH) is a component of the mammalia

65 Complement factor H (Cfh) is a key plasma protein in hum

66 Complement factor H (CfH) is a key regulator of the alte

67 Complement factor H (Cfh) is a key regulator of the alte

68 Complement factor H (CFH) is a major susceptibility gene

69 Complement factor H (CFH) is a negative regulator of the

70 Plasma complement factor H (Cfh) is a potent complement regulat

71 Complement factor H (CFH) is an important regulatory pro

72 Y402H and I62V substitutions in the gene for complement factor H (CFH) is strongly associated with ri

73 Complement factor H (CFH) is the major inhibitor of the

74 here is strong genetic susceptibility at the complement factor H (CFH) locus.

75 associated loci and 6 additional SNPs at the complement factor H (CFH) locus.

76 Complement factor H (CFH) negatively regulates consumpti

77 eptor 1 (CR1) on human erythrocytes (Es) and complement factor H (CFH) on rodent platelets perform im

78 This activation is efficiently suppressed by complement factor H (CFH) on self-surfaces but not on fo

79 smoking, and presence of risk alleles of the complement factor H (CFH) or age-related maculopathy sus

80 Human complement factor H (CFH) plays a central role in regula

81 plicated in the disease pathology, including complement factor H (CFH) precursor and alpha-2-macroglo

82 Complement factor H (CFH) regulates complement activatio

83 erage of 10.1 years, individuals with 1 or 2 complement factor H (CFH) risk alleles derived maximum b

84 hyperopia, and AMD-susceptibility genotypes Complement Factor H (CFH) RS1061170 and Age Related Macu

85 echanism for immune evasion by binding human complement factor H (CFH) to protect it from complement-

86 Two loci in complement factor H (CFH) were included in a risk score

87 have associated a common variant (Y402H) of complement factor H (CFH) with a highly significant incr

88 variants and their possible interaction with Complement Factor H (CFH) Y402H and Complement factor 3

89 tomegalovirus (CMV) immunoglobulin (Ig)G and complement factor H (CFH) Y402H genotype.

90 Molecular defects in complement factor H (CFH), a critical regulatory protein

91 Genetic variants within complement factor H (CFH), a major alternative complemen

92 These include complement factor H (CFH), a negative regulator of C3 ac

93 t form of HUS maps to chromosome 1q and that complement factor H (CFH), a regulatory component of the

94 ctopic treatment with one of these proteins, complement factor H (CFH), accelerated wound repair and

95 Ten genetic loci in 7 genes [complement factor H (CFH), age-related maculopathy susce

96 mplementary to the 3'-untranslated region of complement factor H (CFH), an important repressor of the

97 y complement fluid-phase regulatory protein, complement factor H (CFH), are strongly associated with

98 Genetic variants of complement factor H (CFH), C3, C2, and FB associated wit

99 ilies were filtered for rare variants in the complement factor H (CFH), complement factor I (CFI), co

100 Genetic variation across the genes encoding complement factor H (CFH), factor B (CFB) and component

101 with the physiological complement inhibitor, complement factor H (CFH), for ligand binding.

102 sm, encoding the sequence variation Y402H in complement factor H (CFH), has been strongly associated

103 tudy was to explore the relationship between complement factor H (CFH), inflammatory cytokines and an

104 Variants of the CFH gene, encoding complement factor H (CFH), show strong association with

105 rsons with the protective genetic alleles of complement factor H (CFH), the Mediterranean diet had fu

106 Two common variants in the gene encoding complement factor H (CFH), the Y402H substitution (rs106

107 that binds the negative complement regulator complement factor H (CFH), thereby inhibiting the altern

108 ponses by hijacking a host-immune regulator, complement factor H (CFH), to the bacterial surface.

109 ly it to a comparison of hemopexin (HPX) and complement factor H (CFH), two liver-secreted glycoprote

110 The fourth variant is Y402H complement factor H (CFH), which directs CFH signaling.

111 Complement factor H (CFH), which inhibits complement act

112 ificant peak was found on chromosome 1, near complement factor H (CFH), with P= 6.20 x 10(-4).

113 th age, sex, smoking status, presence of the complement factor H (CFH)-rs1061170 and age-related macu

114 oth common and rare, in the coding region of complement factor H (CFH).

115 omplement proteins or autoantibodies against complement factor H (CFH).

116 ted maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH).

117 ANGPT1) and four retinal genes interact with Complement Factor H (CFH).

118 c correlation were AMD risk-raising variants Complement Factor H (CFH):rs570618-T, CFH:rs10922109-C,

119 or age-related macular degeneration (AMD) is complement factor H (CFH); however, its impact on AMD pa

120 her [age-related macular degeneration (AMD); complement factor H (CFH)], or even three disease charac

121 ts at the chromosome 1q31.3 encompassing the complement factor H (CFH, FH) and CFH related genes (CFH

122 Genetic risk factors such as variations in complement factors H (CFH) and B (CFB) have been implica

123 the major risk variant associated with AMD (complement factor H; CFH Y402H) express increased AKT2,

124 Human complement factor H, consisting of 20 complement control

125 Human complement factor H controls spontaneous activation of c

126 model of MPGN that develops spontaneously in complement factor H-deficient mice (Cfh(-/-)).

127 ns extend freely into solution when the five complement factor H domains are bound within C3b.

128 Further, we show that complement factor H (FH) binds mCRP to dampen its proinf

129 The ability to recruit complement factor H (FH) by S. pneumoniae has been impli

130 PspC was found to bind human complement factor H (FH) by Western blot analysis of D39

131 plement control protein (CCP) modules within complement factor H (fH) encompass binding sites for C3b

132 iC3b, and C3dg and enhanced competition with complement factor H (FH) in surface plasmon resonance (S

133 Complement factor H (FH) inhibits complement activation

134 Complement factor H (fH) is a plasma protein that regula

135 The complement factor H (FH) mutation R1210C, which was desc

136 Numerous complement factor H (FH) mutations predispose patients t

137 histidine (Y402H), within the gene encoding complement factor H (FH) predisposes individuals to acqu

138 The Tyr402His polymorphism of complement factor H (FH) with 20 short complement regula

139 soluble plasma-regulatory proteins including complement factor H (fH), a 155 kDa protein composed of

140 ement-mediated innate immunity by recruiting complement factor H (FH), a complement alternative pathw

141 Complement factor H (fH), a molecule that downregulates

142 complex (TCC)), and cytoprotective elements (complement factor H (FH), as well as apolipoprotein E (A

143 cases it is associated with polymorphisms of complement factor H (FH), implicating immune vulnerabili

144 human secretory immunoglobulin A (sIgA) and complement factor H (FH).

145 pZ-YA that lacks the ability to bind to host complement factor H (FH).

146 from complement-mediated killing by binding complement factor H (FH).

147 to multiple host-derived ligands, including complement factor H (FH).

148 ve regulator of the AP is the plasma protein complement factor H (FH).

149 Alternative pathway activity is inhibited by complement factor H (FH).

150 MD (P = .03); between rs2669845 and Y402H in complement factor H for AMD (P = .04); and between rs266

151 ociations, including the top associations of complement factor H, formimidoyltransferase cyclodeamina

152 Polymorphisms in the complement factor H gene (CFH) are associated with a sig

153 A single chromosomal region around the complement factor H gene (CFH) is reported to explain ne

154 typed, an intronic and common variant in the complement factor H gene (CFH) is strongly associated wi

155 le regression models adjusted for the common complement Factor H gene (CFH) p.Y402H and age-related m

156 actors--smoking and the Y402H variant of the complement factor H gene (CFH)--we used logistic regress

157 a contiguous 358 kb region that contains the Complement Factor H gene cluster.

158 tion studies have found variation within the complement factor H gene family links to host susceptibi

159 Inherited variation in the complement factor H gene is a major risk factor for drus

160 kely caused by the Y402H polymorphism in the complement factor H gene is a recognized risk factor for

161 T-->C substitution in exon 9 (Y402H) of the complement factor H gene is strongly associated with sus

162 age, sex, and the Y402H polymorphism in the complement factor H gene on chromosome 1q) and mortality

163 DNA resequencing of the complement factor H gene within this haplotype revealed

164 Complement factor H genotype had no effect on the respon

165 Deficiency of complement factor H has long been associated with MPGN.

166 ain, antithrombin III, Fas ligand, factor V, complement factor H, IgK, and Fas.

167 work presented here demonstrates that human complement factor H is an adhesion ligand for human neut

168 und in locus 1q31.3, containing the gene for complement factor H (lead single nucleotide polymorphism

169 iated with host iron availability and higher complement factor H levels, lower expression of gametocy

170 n up to 50% of cases, caused by mutations in complement factor H, membrane cofactor protein, factor I

171 etic mutation causing aHUS, including 4 with complement factor H mutations.

172 Researchers have described autoantibodies to complement factor H of the IgG class in 10% of patients

173 fluid-phase CRP to six immobilized proteins: complement factor H, oxidized low-density lipoprotein, c

174 serine peptidase 1) (P =2.7 x 10(-72)), CFH (complement factor H) (P =2.3 x 10(-47)), C2 (complement

175 gested the protein-level contribution of the complement factor H pathway to CSC pathogenesis.

176 The complement factor H R1210C rare variant confers the stro

177 The typical phenotype of the complement factor H R1210C rare variant is associated wi

178 is revealed a novel heterozygous mutation in complement factor H (R83S) in addition to known risk pol

179 , FERM Domain Containing Kindlin-3 (FERMT3), Complement Factor H Related 1 (CFHR1), and Retinoic Acid

180 tients carrying a genetic abnormality in the complement factor H related 1 gene (CFHR1) that originat

181 nd several case-control studies for VTE, how Complement Factor H Related 5 protein (CFHR5), a regulat

182 We demonstrate that complement factor-H related 3 (CFHR3) promotes immune ac

183 Copy number variations in the complement factor H-related (CFHR) gene cluster on chrom

184 and identified a chromosomal deletion in the complement factor H-related (CFHR) gene cluster.

185 The autoimmune renal disease deficient for complement factor H-related (CFHR) genes and autoantibod

186 tains the complement factor H (CFH) and five complement factor H-related (CFHR) genes.

187 n includes genomic rearrangements within the complement factor H-related (CFHR) locus.

188 lternative, and terminal pathways, including complement factor H-related (CFHR) proteins 1, 2, 3, and

189 The role of the complement factor H-related (FHR) proteins in homeostasi

190 C3G-associated genomic mutation in the gene complement factor H-related 1 (CFHR1), which encodes FHR

191 onstrates that a duplication within the gene complement factor H-related 1 (CFHR1; encoding FHR1) lea

192 ssess the contribution of the liver-produced complement factor H-related 4 protein (FHR-4) to AMD ini

193 The human complement Factor H-related 5 protein (FHR5) antagonizes

194 ociation studies have shown that deletion of complement factor H-related genes 1 and 3 (CFHR3,1Delta)

195 e association studies identified deletion of complement factor H-related genes 1 and 3 as protective

196 Human complement factor H-related protein (CFHR) 4 belongs to

197 ing the association of rs7517126 with plasma complement factor H-related protein 1 (CFHR1) level at p

198 , Factor H, Factor H-like protein-1 (FHL-1), complement Factor H-related protein 1 (CFHR1), and plasm

199 samples revealed significant upregulation of complement factor H-related protein 2 (CFHR2) in patient

200 and endogenous nitric oxide production) and complement factor H-related protein 2 (CFHR2, related to

201 e cosegregated with the same mutation in the complement factor H-related protein 5 gene (CFHR5).

202 Complement factor H-related proteins (FHRs) are strongly

203 compassing complement factor H (CFH) and the complement-factor-H-related (CFHR) genes, but the underl

204 riants suggest decreased inhibition of C3 by complement factor H, resulting in increased activation o

205 Interactions with complement factor H (rs1061170), age-related maculopathy

206 the UK cohort included more patients with a complement factor H SCR20 mutation or hybrid gene (31% v

207 The role of complement factor H still needs to be better defined, bu

208 d, followed by the first five SCR domains of complement factor H that bind to complement C3b.

209 ly human, IgG3 monoclonal antibody targeting complement factor H that kills tumor cells and promotes

210 noncoding variant in CFH, the gene encoding complement factor H, that substantially increases the in

211 with these diseases affect the glycoprotein complement factor H, the main regulator of the alternati

212 first to a cell surface receptor and then to complement Factor H thereby blocking the lytic activity

213 are disrupted by the abundant serum protein, complement Factor H, thereby probably limiting SIBLING-m

214 characteristic of sub-RPE deposits, such as complement factor H, vitronectin, and amyloid beta, reve

215 a-2-glycoprotein and positively with afamin, complement factor H, VLDL-associated apolipoproteins, an

216 leukin-6 (IL-6), interleukin-10 (IL-10), and complement factor H was unaffected.

217 venger receptors, IgM natural antibodies and complement factor H, which bind, neutralize and/or facil

218 association of ARM with the Y402H allele of complement factor H, which has previously been reported

219 e mutant also had decreased binding of human complement Factor H, which in previous studies increased

220 Maculopathy Susceptibility 2 rs10490924 and Complement Factor H Y402H (P for trend = 4.2x10(-7)).