ライフサイエンスコーパス: complementarity

1 synthetic precursors to facilitate metabolic complementarity.

2 hyl transfer tunnel of NNMT with ideal shape complementarity.

3 tatic lock-and-key models based on molecular complementarity.

4 erophile elements and generating an apparent complementarity.

5 il that extends beyond general electrostatic complementarity.

6 sity and a need for physico-chemical binding complementarity.

7 The two MS approaches exhibit a degree of complementarity.

8 conserved miR159-binding sites of analogous complementarity.

9 sion post-transcriptionally through sequence complementarity.

10 posable elements (TEs) through the base-pair complementarity.

11 volving DdrB-mediated proofreading of strand complementarity.

12 very different predictions, indicating their complementarity.

13 to cross inferential scales through scaling complementarity.

14 ividual metabolisms and collective metabolic complementarity.

15 de-chain rearrangements ensure optimal shape complementarity.

16 miRNAs recognize target RNAs via sequence complementarity.

17 interactions usually involves backbone shape complementarity(1), which is less modular and hence hard

18 forms, highlighting areas of distinction and complementarity across technologies, so as to aid in the

19 t" exons in several other genes through base complementarity across the entire SNORD27 sequence, not

20 of prey heterogeneity in driving functional complementarity among predators and enhanced top-down co

21 A wide proline pocket as well as molecular complementarity and capping at the S1 substrate site of

22 th model peptides that exploit electrostatic complementarity and define a novel amyloid/nucleic acid

23 d their rationale for using mixed methods as complementarity and did not describe study priority or h

24 state model, in which it shows perfect space complementarity and forms hydrogen bonds or makes hydrop

25 domain within Cas9, REC3, recognizes target complementarity and governs the HNH nuclease to regulate

26 -31, seems to be due to better overall shape complementarity and hydrophobic interactions with S372 a

27 n-targets predicted through perfect sequence complementarity and off-targets predicted through sequen

28 RNAs that recognize target sequences by base complementarity and play a role in the regulation of tar

29 y-ecosystem functioning relationships: niche complementarity and selection effects.

30 s and adopted NoDGAT2s formulated functional complementarity and specific transcript abundance ratio

31 glycan acceptors to reveal how binding site complementarity and steric hindrance can tune substrate

32 affinity through extensive shape and charge complementarity and the unusual utilization of an antibo

33 into contributions from structural-chemical complementarity and those from changes in conformational

34 (e.g., skill substitution and human-machine complementarity), and insufficient understanding of how

35 and health and human rights, identify their complementarities, and advocate for a combined approach.

36 e seed-sequence region to scout for sequence complementarity, and (2) further unwinding of the entire

37 f-targets predicted on the basis of sequence complementarity, and identified 17 mis-splicing events f

38 function of phenotypic plasticity and niche complementarity, and set the foundation for future ecolo

39 Thirdly, causal complementarity arises when combining approaches allows

40 otprinting techniques gives insight on their complementarity as well as the robustness of FPOP to pro

41 arly superior to full-length gRNAs (20 nt of complementarity), as truncated gRNAs are generally less

42 -like domain may proceed from surface charge complementarity, as suggested by homology three-dimensio

43 Mutual exclusivity arises because of the complementarity, at the functional level, of alterations

44 econdary structure because of intramolecular complementarity/basepairing); a curvature corresponding

45 This implies potential complementarities between "top-down" regulatory interven

46 The supramolecular chemical complementarities between the gamma-CD-based ditopic cat

47 These findings illustrate the unique complementarity between cryo-EM and solution NMR for stu

48 These results show how geometric complementarity between different ligands impacts upon t

49 andard NIST mAb, we observe a high degree of complementarity between fragments generated using standa

50 The exquisite complementarity between glucuronic acid and its binding

51 s for the cross-prediction concern, dissects complementarity between predictors and demonstrates that

52 The remarkable electronic, size, and shape complementarity between primary ammonium ions and the tw

53 The complementarity between recognition sites creates a key

54 The limited complementarity between scaRNA and the endogenous DNA ta

55 In this Tutorial Review, we will detail how complementarity between static and dynamic single-molecu

56 WI-3 are primarily dictated by the degree of complementarity between target mRNAs and antisense piRNA

57 but is short-lived owing to lack of optimal complementarity between the active site cleft of proteas

58 e to the 3' end of another with little or no complementarity between the donor and acceptor templates

59 e solid-state structures reveal a size/shape complementarity between the host and the dicarboxylate a

60 termined not just by the structural-chemical complementarity between the kinase and its protein subst

61 te specificity of LplJ, determined by charge complementarity between the ligase and the lipoylable su

62 Complementarity between the template and non-template st

63 ys a paucity of salt bridges and hydrophobic complementarity between the TnT tail (TnT1) and tropomyo

64 nt pai-pai interactions resulting from shape complementarity between transition structures and cataly

65 s between interacting RNAs and high level of complementarity between two RNA sequences is a powerful

66 possible base combinations and, through base-complementarity, between all sequence positions in a dup

67 oductivity and tree abundance resulting from complementarity, but they can also be the consequence of

68 we investigate the apparent chondrule-matrix complementarity by analyzing major, minor, and trace ele

69 Sites with extensive additional complementarity can appear as more potent, but only beca

70 nstraints including composition constraints, complementarity constraints, pattern prevention constrai

71 Our simulations suggest that with sufficient complementarities, dads can emerge even in the face of h

72 Second, for translational complementarity, data from one research approach is used

73 Here, we employed de novo complementarity determining region (CDR) design to engin

74 and (iii) de novo prediction of the elusive complementarity determining region (CDR) H3 loop.

75 amely O-sulfated tyrosine in the heavy chain complementarity determining region (CDR) H3 loop.

76 When bound to HA, the heavy-chain third complementarity determining region (HCDR3) fits with an

77 The complementarity determining region 3 (CDR3) length adjus

78 served tryptophan residue in the heavy chain complementarity determining region 3 (CDR3) of mAbs A an

79 ifiers was a biophysicochemical motif in the complementarity determining region 3 (CDR3) of TCRbeta c

80 These TCRs encoded a range of V, J, and complementarity determining region 3 (CDR3) sequences on

81 or a histidine in their alpha- or beta-chain complementarity determining region 3 (CDR3) were highly

82 V5E1, by virtue of complementarity determining region 3 (CDR3), may also en

83 global changes in T cell receptor beta chain complementarity determining region 3 (CDR3beta) sequence

84 Eight Ab heavy-chain complementarity determining region 3 (HCDR3) loops from

85 encoded and immunoglobulin (Ig) heavy-chain complementarity determining region 3 (HCDR3) residues, w

86 use the biochemical features encoded by the complementarity determining region 3 of each B cell rece

87 d CD154(-) fractions revealed more than 6000 complementarity determining region 3 sequences and motif

88 nd a greater frequency of unique heavy chain complementarity determining region 3 sequences compared

89 Some complementarity determining region 3 sequences were comm

90 mmunoglobulin light chains with 5-amino acid complementarity determining region 3s, a key feature of

91 positively charged pocket formed within the complementarity determining region H2 loops that binds t

92 conewton force requires binding through both complementarity determining region loops and hydrophobic

93 n dominated the interaction and, whereas the complementarity determining region-3 (CDR3) loops exclus

94 eaminations occurring in the antigen-binding complementarity determining regions (CDR) compared to th

95 SHM was highest in the Ab complementarity determining regions (CDRs) but also surp

96 g-range rearrangements of framework (FW) and complementarity determining regions (CDRs) that increase

97 ification of the Xle site, especially in the complementarity determining regions (CDRs), can result i

98 by only three amino acids in the heavy chain complementarity determining regions (CDRs), one mAb, MED

99 The variable complementarity determining regions (CDRs), particularly

100 We estimated the evolutionary rates of the complementarity determining regions (CDRs), which are mo

101 d, a machine learning method that can design complementarity determining regions of human Immunoglobu

102 d not present, and only local changes at the complementarity determining regions were found.

103 ues in variable domains, especially in CDRs (complementarity determining regions) of an antibody, may

104 mutation frequencies, long third heavy-chain complementarity determining regions, and/or autoreactivi

105 isoelectric point values of variable domain complementarity determining regions, possibly accounting

106 Reproducibility in the output of complementarity determining three regions (CDR3 amino ac

107 -associated antibody subset featured shorter complementarity-determining (CDR3) regions relative to t

108 binds over the F'-pocket of MR1, whereby the complementarity-determining region (CDR) 3beta loop surr

109 ity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and fr

110 on the SARS-CoV-2 RBD, mainly through a long complementarity-determining region (CDR) H3, and compete

111 een the HLA surface and TCR germline-encoded complementarity-determining region (CDR) loops 1 and 2,

112 By contrast, alphabetaTCRs purpose all six complementarity-determining region (CDR) loops of their

113 E10 was derived from the parental 3B4 using complementarity-determining region (CDR)-restricted muta

114 face area; and (iv) public heavy-chain third complementarity-determining region (CDR-H3) antibodies i

115 gnatures, including shared light-chain third complementarity-determining region (CDR-L3) amino acid s

116 ne-encoded residues in the second beta-chain complementarity-determining region (CDR2beta).

117 rnary complex revealed that germline-encoded complementarity-determining region 1beta residues presen

118 , VH4 family gene utilization, a heavy chain complementarity-determining region 2 (CDRH2) insertion,

119 ng paratope interactions; the variable light complementarity-determining region 2 plays a key role by

120 Crystal structure analysis revealed that the complementarity-determining region 3 (CDR3) elements of

121 Complementarity-determining region 3 (CDR3) is the most

122 Analysis of complementarity-determining region 3 (CDR3) regions cont

123 eveloped a computational method to infer the complementarity-determining region 3 (CDR3) sequences of

124 information and ensures recovery of complete complementarity-determining region 3 (CDR3) sequences, a

125 TCR transcripts, including complementarity-determining region 3 (CDR3) sequences, w

126 th conserved motifs and global similarity of complementarity-determining region 3 (CDR3) sequences.

127 ns of V(D)J gene segments that contribute to complementarity-determining region 3 (CDR3), the region

128 as made it challenging to search through the Complementarity-determining region 3 (CDR3), which is re

129 The lineage Abs bore an anionic heavy chain complementarity-determining region 3 (CDRH3) of 25 amino

130 a strong dependence on antibody heavy chain complementarity-determining region 3 (HCDR3) is a major

131 h unusual features, such as long heavy-chain complementarity-determining region 3 (HCDR3) loops.

132 r) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mut

133 a single clonotypic expansion of the encoded complementarity-determining region 3 amino acid sequence

134 Using high-throughput and single-cell TCR-complementarity-determining region 3 beta (TCR-CDR3beta)

135 containing an Asn-Pro-Phe peptide within the complementarity-determining region 3 loop is a function-

136 h-throughput sequencing of the TCRbeta chain complementarity-determining region 3 of liver-infiltrati

137 TRUST assembled more than 30 million complementarity-determining region 3 sequences of the B

138 , characterized by their uniquely rearranged complementarity-determining region 3, were detected in d

139 lthy donors, that patients have shorter TCRB complementarity-determining region 3s (CDR3), in all cel

140 structure is largely conserved, except for a complementarity-determining region featuring six variabl

141 ficity differences are primarily mediated by complementarity-determining region H3 (CDR H3).

142 mode limits the IGHV3-53 antibodies to short complementarity-determining region H3 loops but accommod

143 Insertion of any of these motifs into the complementarity-determining region H3 of a "clean" antib

144 at generally found in more flexible antibody complementarity-determining region loops but resembles t

145 Surprisingly, crenezumab's complementarity-determining region loops can effectively

146 tralizing cyclic peptide P7 derived from the complementarity-determining region loops of human bnAbs

147 The peptide design was based on complementarity-determining region loops of human broadl

148 have unusual sequences with long heavy-chain complementarity-determining region loops, high somatic m

149 The loop is analogous to the third complementarity-determining region of immunoglobulin var

150 he buried monomeric peptide in solanezumab's complementarity-determining region, crenezumab binds the

151 low number of N nucleotide insertions in the complementarity-determining region-3 (CDR3) of their TCR

152 hips between the amino acid sequences of the complementarity-determining region-3 (CDR3) represented

153 ration of histidine residues, located in the complementarity-determining region-like proximal half of

154 Perturbations within complementarity-determining regions (CDR) induce rich be

155 tibody paratopes are formed by hypervariable complementarity-determining regions (CDRH3s) and variabl

156 ntibodies between the framework and loops of complementarity-determining regions (CDRs) 1 and 2.

157 CR) stereotypes as defined by IGHV usage and complementarity-determining regions (CDRs) classify ~30%

158 mmonly accumulate charged mutations in their complementarity-determining regions (CDRs) during affini

159 d relatively high levels of conjugation near complementarity-determining regions (CDRs) from the heav

160 recombined beneficial mutations from all six complementarity-determining regions (CDRs) in the affini

161 mer's amyloid-beta (Abeta) peptide] into the complementarity-determining regions (CDRs) of a stable a

162 ting amyloidogenic peptide segments into the complementarity-determining regions (CDRs) of single-dom

163 In addition to conformational changes in complementarity-determining regions (CDRs) of the TCR se

164 ne whether they recognize SAEs through their complementarity-determining regions (CDRs) or framework

165 Canonical forms of the antibody complementarity-determining regions (CDRs) were first de

166 mulate affinity-enhancing mutations in their complementarity-determining regions (CDRs) without compr

167 eamidation, and isomerization located in the complementarity-determining regions (CDRs), as well as N

168 poor developability: the total length of the complementarity-determining regions (CDRs), the extent a

169 ble region contains three antigen-contacting complementarity-determining regions (CDRs), with CDR1 an

170 -rich domains from bovine antibody ultralong complementarity-determining regions (CDRs).

171 ding site, located within the loops known as complementarity-determining regions (CDRs).

172 then annotated with key information such as complementarity-determining regions and potential post-t

173 low confirmation of both the sequence of the complementarity-determining regions and the payload conj

174 verlap of the IgG-Fc binding site in FcRn by complementarity-determining regions in DX-2507.

175 surface consists of residues located in four complementarity-determining regions including a major co

176 rate separation-of-function mutations in the complementarity-determining regions of 3E10 revealing th

177 It is mostly light chain complementarity-determining regions that are driving par

178 The antibody uses all six complementarity-determining regions to bind to a quatern

179 VH1-VH7 family variants of IgE with the same complementarity-determining regions were investigated wi

180 individual amino acids and motifs within the complementarity-determining regions which contribute to

181 led-coil domain that sterically occludes the complementarity-determining regions.

182 ere, we show that exome reads mapping to the complementarity-determining-region 3 (CDR3) of mature T-

183 on of numerous interactions with heavy chain complementarity domain regions (CDRs) of HM14c10, while

184 By considering the hydrophobic complementarity during the virtual screening step, we id

185 to calculate and visualize the electrostatic complementarity (EC) of protein-ligand complexes.

186 e in mixture relative to monoculture (e.g., 'complementarity effect').

187 ve overyielding suggests that positive niche complementarity effects are driving some of the response

188 Specifically: (i) complementarity effects at low and intermediate position

189 We demonstrate, however, skill complementarity enhances heterophily in the formation of

190 Unexpectedly, this complementarity extends to these proteins' synaptic func

191 r framework includes five interdisciplinary "complementarities." First, research approaches may provi

192 tes or protein scaffolds with existing shape complementarity for a target ligand.

193 erved by ligand preorganization and 3D shape complementarity for the binding pocket.

194 In plants, microRNA (miRNA)-target complementarity has long been considered the predominant

195 cular recognition, such as self-assembly and complementarity, have inspired the development of biomim

196 This result supports the complementarity hypothesis that pollination function is

197 ensing are summarized to highlight the novel complementarity in dovetailing these techniques for vast

198 The complementarity in lipid coverages between the NAPA- and

199 al extensive phenotypic plasticity and niche complementarity in oleaginous microbial populations from

200 The biological significance of charge complementarity in the M013-ASC-1 interaction was furthe

201 Although there is a clear complementarity in these behaviours, no dynamic evidence

202 In addition to complementarity, in vitro and in silico studies have sug

203 approach for estimating the competition and complementarity indices for a pair of microbial species,

204 was implemented to construct competition and complementarity indices from genome scale metabolic mode

205 Here, we differentiate complementarity into three types of species differences

206 the more global beta-sheet/beta-sheet facial complementarity is a critical determinant for amyloid nu

207 surfaces in order to optimize electrostatic complementarity is a key activity in drug design.

208 herbaceous biomass, indicating that species complementarity is especially important for understory f

209 upper end of the gradient (warmer regions), complementarity is more widespread in larger than smalle

210 Yet, complementarity is often indirectly quantified as overpe

211 Complementarity is one common explanation for these posi

212 Furthermore, the degree of skill complementarity is positively correlated with their prod

213 Fourth, contextual complementarity is realized when together research metho

214 rvival rates and immune receptor-IDH1 mutant complementarities may also, partially, explain the bette

215 This complementarity must be optimized both for functional in

216 By sensing RNA sequence complementarity near the active site, the extended prime

217 Neither the free energy of miR159-target complementarity, nor miRNA binding site accessibility, a

218 ng and opening provides a checkpoint for NTP complementarity, NTP ribo/deoxyribo identity, and NTP tr

219 ing that both positive selection effects and complementarity occur.

220 y, we examined the structural and electronic complementarities of convex 1-Zn(II), comprising functio

221 ls of skill formation that emphasize dynamic complementarities of investments in learning.

222 In contrast to previous findings, the shape complementarity of antibody-antigen interfaces resembles

223 better-known Bpin counterparts, showing the complementarity of Bcat reaction partners and expanding

224 We explain the complementarity of biological functions captured by diff

225 SCF-FBXL17 therefore probes both shape and complementarity of BTB domains, a mechanism that is well

226 Our results illustrate the complementarity of calculating the intensity of selectio

227 ing approach to classify tumors based on the complementarity of CDR3s and mutant IDH1 amino acids, re

228 Our findings offer insights into the complementarity of chiral recognition processes.

229 The complementarity of historical and contemporary processes

230 eased survival in low-grade glioma (LGG) and complementarity of IDH1 mutants to the CDR3 domain of th

231 g must be developed to take advantage of the complementarity of information available through differe

232 Considerable complementarity of molecular coverage was observed betwe

233 The described differences underline the complementarity of NISs and RCTs.

234 Dual partnerships showed complementarity of nutrient pool use and greatest photos

235 This effect relied upon the partial complementarity of OIP5-AS1 with MEF2C mRNA and the pres

236 ed to decrease the functional redundancy and complementarity of pollinator assemblages and, therefore

237 tween these two species and demonstrates the complementarity of population genetics and ecological ni

238 This demonstrates the complementarity of RNA-Seq and NanoString.

239 inical competencies in China, especially the complementarity of specialist training and general pract

240 across different cancer types, and revealed complementarity of specific mutational patterns that has

241 es thus provide a way of optimally using the complementarity of the available methods for a quantitat

242 plexed with NR-160 disclosed that the steric complementarity of the bifurcated capping group of NR-16

243 Specificity is driven by the complementarity of the enzyme active site cleft and the

244 Here, the complementarity of the invader to the single-stranded to

245 NA-like approach, the requirement of perfect complementarity of the microRNA seed region to a given t

246 The complementarity of the orthogonal separation strategy wa

247 te of C-C bond formation driven by exquisite complementarity of the reacting pai systems.

248 g to 3Q fibrils requires a precise molecular complementarity of the sulfate moieties on the GAG and c

249 The complementarity of these contrasts is experimentally val

250 phosphorylated MAPK kinase), suggesting the complementarity of these two adaptor-specific pathways.

251 We also assessed the complementarity of this panel with CA19-9 and explored t

252 Thus, we were able to highlight the complementarity of top-down and bottom-up approaches, wh

253 highly effective, by leveraging the sequence complementarity of two DNA strands.

254 ionships suggest a role of niche dimensional complementarity on the structuring of these anuran assem

255 is then attributed to the intuitive idea of complementarity or, more specifically, to species resour

256 changing linker flexibility, changing 3' end complementarity, or mutationally inducing 3' end release

257 ped bacteria, suggesting that shape and size complementarity profoundly influences the process.

258 l of amino acids or fragment ions to exploit complementarity, provides full transparency to justify v

259 Although highly stable, the steric complementarity required for their folding is surprising

260 In particular, we developed a chemical complementarity scoring approach to classify tumors base

261 The model also reveals leaf life complementarities that remained unexplained in previous

262 face from each ESX system has a unique shape complementarity that allows each EspG to discriminate am

263 mechanism constraints and required chaperone complementarity that hinder Rubisco biogenesis in altern

264 cleavage events, the tandem repeat provides complementarity that promotes realignment to a nick and

265 Through the principle of electronic complementarity, the Green Box exhibits strong recogniti

266 of 3' and 5' NTRs exhibit extensive terminal complementarity; the first 11 nucleotides are strictly c

267 ire foods enhances female-male and male-male complementarities, thus altering the fitness of dads ver

268 d to bioinformatic analysis of their reverse complementarity to 322 published RV genomic sequences.

269 s other genes, and with engineered, extended complementarity to an exogenous target, the repurposed s

270 aring a protospacer adjacent motif (PAM) and complementarity to an RNA guide.

271 vasa mRNA escapes silencing due to imperfect complementarity to AT-chX piRNAs.

272 CENP-N uses charge and space complementarity to decode the L1 loop that is unique to

273 ocatalytic nitrene transfer offers potential complementarity to metal-catalyzed methods; however ther

274 abilize interdomain interactions and improve complementarity to MMP-3.

275 cals at the middle-up level of analysis, its complementarity to reversed phase liquid chromatography,

276 ccordingly, mutations that disrupted overall complementarity to the 18S rRNA markedly reduced TriMV I

277 ating increases in contact surface and shape complementarity to the antigen.

278 These substrates provide a level of complementarity to the commonly used aryl halides and, i

279 s a viral microRNA bearing complete sequence complementarity to the mRNA for the important viral gene

280 the specificity of truncated gRNAs (18 nt of complementarity to the target) is not clearly superior t

281 e site choice is in part defined by sequence complementarity to U1 snRNA, we identify RNA secondary s

282 exhibit a coordination motive (or strategic complementarity), tolerant trigger strategies based on s

283 Our results show that molecular complementarity underlies the higher frequency and signi

284 We show here that a short-complementarity untranslated RNA (scoutRNA), together wi

285 ressive overyielding resulting from positive complementarity was only observed with the late successi

286 Due to their complementarity, we recommend taxonomists to combine phy

287 research approaches may provide comparative complementarity when they offer separate realizations of

288 ndicate that considerations of electrostatic complementarity, whether through a polar-pi or substitue

289 nity, indicating ecosystem-wide multitrophic complementarity, which is potentially an important prere

290 interaction interface should maximize their complementarity while minimizing desolvation penalties.

291 Therefore, subtle differences and complementarity will be highlighted together with emergi

292 ine core dictate binding modes and inducible-complementarity with a PARG-specific tyrosine clasp and

293 ween host and guest confirmed the high shape complementarity with fully enveloping dispersive interac

294 Its complementarity with other online resources is facilitat

295 activities and display cross-family movement complementarity with related and unrelated viruses.

296 translational repression depending on their complementarity with targets.

297 We show that depending on complementarity with the 5' tag of crRNA, the 3' anti-ta

298 This region has considerable complementarity with the 5' UTR and is predicted to form

299 y and off-targets predicted through sequence complementarity with up to two nucleotide mismatches.

300 their different levels of specialization and complementarity within long-term stable-state systems.