ライフサイエンスコーパス: complementarity-determining region

1 ic residues in its CDR H3 (third heavy-chain complementarity-determining region).

2 ptide on their projecting, heavy-chain third complementarity determining region.

3 neation of IG V domain framework regions and complementarity determining regions.

4 g suggested a putative binding site near the complementarity-determining regions.

5 three loops that are equivalent to antibody complementarity-determining regions.

6 parent in the six hypervariable loops of the complementarity-determining regions.

7 y between two IL-18 loops and all six 125-2H complementarity-determining regions.

8 cement mutations and mutational targeting in complementarity-determining regions.

9 ns of immunoglobulin molecules outside their complementarity-determining regions.

10 led-coil domain that sterically occludes the complementarity-determining regions.

11 tified asparagine deamidation in light chain complementarity determining region 1 (CDR1) of a humaniz

12 ns containing a succinimidyl intermediate in complementarity determining region 1 (CDR1) on zero, one

13 evolved slowly and harbors highly conserved complementarity determining regions 1 and 2.

14 3 loop, with minor contacts from heavy-chain complementarity-determining region 1, and is sufficient

15 H) gene segments at conserved sites flanking complementarity-determining regions 1 and 2.

16 iffering interactions between the respective complementarity-determining region 1alpha loops and the

17 termining region 3alpha and germline-encoded complementarity determining region 1beta loops of the SB

18 rnary complex revealed that germline-encoded complementarity-determining region 1beta residues presen

19 jawed vertebrates share amino acids in their complementarity determining region 2 (CDR2).

20 ctivated an N-linked glycosylation sequon in complementarity-determining region 2 (CDR2).

21 , VH4 family gene utilization, a heavy chain complementarity-determining region 2 (CDRH2) insertion,

22 stinct alleles that use either a heavy-chain complementarity-determining region 2 (HCDR2) aspartic ac

23 ng paratope interactions; the variable light complementarity-determining region 2 plays a key role by

24 5 shows that the tip of the CH65 heavy-chain complementarity determining region 3 (CDR3) inserts into

25 The complementarity determining region 3 (CDR3) length adjus

26 served tryptophan residue in the heavy chain complementarity determining region 3 (CDR3) of mAbs A an

27 ifiers was a biophysicochemical motif in the complementarity determining region 3 (CDR3) of TCRbeta c

28 es of amino acids within the antigen binding complementarity determining region 3 (CDR3) repertoire o

29 These TCRs encoded a range of V, J, and complementarity determining region 3 (CDR3) sequences on

30 or a histidine in their alpha- or beta-chain complementarity determining region 3 (CDR3) were highly

31 V5E1, by virtue of complementarity determining region 3 (CDR3), may also en

32 global changes in T cell receptor beta chain complementarity determining region 3 (CDR3beta) sequence

33 The ultralong heavy chain complementarity determining region 3 (CDR3H) of bovine a

34 nique structure in its ultralong heavy chain complementarity determining region 3 (CDR3H) that folds

35 r unusual traits, such as a long heavy chain complementarity determining region 3 (CDRH3) and autorea

36 (BLV1H12) which has an ultralong heavy chain complementarity determining region 3 (CDRH3) provides a

37 ese, the PG9 antibody has a long heavy chain complementarity determining region 3 (HCDR3) and possess

38 Eight Ab heavy-chain complementarity determining region 3 (HCDR3) loops from

39 encoded and immunoglobulin (Ig) heavy-chain complementarity determining region 3 (HCDR3) residues, w

40 ult of stabilization of the long heavy chain complementarity determining region 3 (HCDR3).

41 e characterized by a substantial decrease in complementarity determining region 3 diversity.

42 unique and thus far not reported heavy-chain complementarity determining region 3 motifs, of which 4

43 use the biochemical features encoded by the complementarity determining region 3 of each B cell rece

44 d CD154(-) fractions revealed more than 6000 complementarity determining region 3 sequences and motif

45 nd a greater frequency of unique heavy chain complementarity determining region 3 sequences compared

46 Some complementarity determining region 3 sequences were comm

47 maturation-associated changes in heavy-chain complementarity determining region 3, a key antigen-bind

48 dominant germ line genes as well as dominant complementarity determining region 3.

49 re, increased palindromic nucleotides in the complementarity determining regions 3 and long stretches

50 Mutagenesis of M88 showed that the complementarity determining regions 3 of both gammadelta

51 Crystal structure analysis revealed that the complementarity-determining region 3 (CDR3) elements of

52 Complementarity-determining region 3 (CDR3) is the most

53 Moreover, the sequences of the complementarity-determining region 3 (CDR3) loop from to

54 ue regions" of VpreB and lambda5 replace the complementarity-determining region 3 (CDR3) loop of an a

55 result of a conformational change in the TCR complementarity-determining region 3 (CDR3) loop.

56 de centric, dominated by two residues of the complementarity-determining region 3 (CDR3) loops that a

57 structure and key amino acid residues on the complementarity-determining region 3 (CDR3) of FLCs are

58 Analysis of complementarity-determining region 3 (CDR3) regions cont

59 We performed deep sequencing of TCRbeta complementarity-determining region 3 (CDR3) regions in s

60 ng of rearranged T-cell receptor (TCR) Vbeta complementarity-determining region 3 (CDR3) regions, a p

61 eveloped a computational method to infer the complementarity-determining region 3 (CDR3) sequences of

62 information and ensures recovery of complete complementarity-determining region 3 (CDR3) sequences, a

63 TCR transcripts, including complementarity-determining region 3 (CDR3) sequences, w

64 th conserved motifs and global similarity of complementarity-determining region 3 (CDR3) sequences.

65 ns of V(D)J gene segments that contribute to complementarity-determining region 3 (CDR3), the region

66 as made it challenging to search through the Complementarity-determining region 3 (CDR3), which is re

67 variable major antigen-binding determinant, complementarity-determining region 3 (CDR3), with specif

68 igh-affinity antibodies with long human-like complementarity-determining region 3 (CDR3H), broad epit

69 that a four-residue insertion in heavy chain complementarity-determining region 3 (CDRH3) contributed

70 The lineage Abs bore an anionic heavy chain complementarity-determining region 3 (CDRH3) of 25 amino

71 However, the heavy chain complementarity-determining region 3 (H-CDR3) of most pa

72 a strong dependence on antibody heavy chain complementarity-determining region 3 (HCDR3) is a major

73 h unusual features, such as long heavy-chain complementarity-determining region 3 (HCDR3) loops.

74 unusual traits, including a long heavy chain complementarity-determining region 3 (HCDR3), polyreacti

75 r) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mut

76 a single clonotypic expansion of the encoded complementarity-determining region 3 amino acid sequence

77 Using high-throughput and single-cell TCR-complementarity-determining region 3 beta (TCR-CDR3beta)

78 ve N-region additions, Vh usage, and charged complementarity-determining region 3 consistent with aut

79 ealed an extended VH binding interface, with complementarity-determining region 3 deeply penetrating

80 ct human scFv from a library with randomized complementarity-determining region 3 domains.

81 er, neutralizing antibodies possessed longer complementarity-determining region 3 for both heavy and

82 Complementarity-determining region 3 length and amino ac

83 containing an Asn-Pro-Phe peptide within the complementarity-determining region 3 loop is a function-

84 ng site is dominated by a single heavy-chain complementarity-determining region 3 loop, with minor co

85 h-throughput sequencing of the TCRbeta chain complementarity-determining region 3 of liver-infiltrati

86 through interactions with the unusually long complementarity-determining region 3 of the HC33.1 heavy

87 and identified an A to S substitution in the complementarity-determining region 3 of the variable reg

88 We found that T-cell receptor beta (TCRbeta) complementarity-determining region 3 repertoire sequenci

89 TRUST assembled more than 30 million complementarity-determining region 3 sequences of the B

90 dentical T-cell receptor variable beta-chain complementarity-determining region 3 sequences were iden

91 with nearly identical heavy and light chain complementarity-determining region 3 sequences.

92 ow cytometry, Vbeta repertoire analysis, and complementarity-determining region 3 sequencing) were us

93 bnAbs, including a short CDRL3 (light-chain complementarity-determining region 3) and mutations that

94 variable region beta) gene usage and a CDR3 (complementarity-determining region 3) sequence to assess

95 t use, and in the length and features of the complementarity-determining region 3, a major determinan

96 , characterized by their uniquely rearranged complementarity-determining region 3, were detected in d

97 alphabeta TCR after grafting of a G8 or KN6 complementarity-determining region 3-delta (CDR3delta) l

98 but they all had very different sequences in complementarity-determining region 3.

99 hybridomas, with mutations concentrating in complementarity-determining region 3.

100 ere, we show that exome reads mapping to the complementarity-determining-region 3 (CDR3) of mature T-

101 n dominated the interaction and, whereas the complementarity determining region-3 (CDR3) loops exclus

102 low number of N nucleotide insertions in the complementarity-determining region-3 (CDR3) of their TCR

103 hips between the amino acid sequences of the complementarity-determining region-3 (CDR3) represented

104 o peptide-mediated interactions in which the complementarity determining region 3alpha and germline-e

105 TCRs feature identical, or nearly identical, complementarity-determining region 3alpha (CDR3alpha) an

106 4 complex is recognized by the TCR through a complementarity-determining region 3alpha (CDR3alpha)-me

107 hot-spot' of germline-encoded amino acids in complementarity-determining regions 3alpha, 1alpha and 2

108 harged residue in the first segment of their complementarity determining region 3beta.

109 mmunoglobulin light chains with 5-amino acid complementarity determining region 3s, a key feature of

110 lthy donors, that patients have shorter TCRB complementarity-determining region 3s (CDR3), in all cel

111 elates with high hydrophobicities of certain complementarity determining regions and with high positi

112 Six mutations (three in the complementarity-determining region and three in the fram

113 then annotated with key information such as complementarity-determining regions and potential post-t

114 low confirmation of both the sequence of the complementarity-determining regions and the payload conj

115 mutation frequencies, long third heavy-chain complementarity determining regions, and/or autoreactivi

116 The complementarity-determining regions are spatially orient

117 that the beta-subunit binds pMHC using Vbeta complementarity-determining regions as well as an expose

118 es at the tip of the m66.6 heavy-chain third complementarity-determining region, as in the case of 2F

119 produces an i-body library possessing a long complementarity determining region binding loop, and the

120 differ by small sequence alterations in the complementarity-determining region but show very large d

121 igidified the initially flexible heavy-chain complementarity determining region by two nearly indepen

122 Its crystal structure revealed a long complementarity determining region (CD3) folding over pa

123 ha TRAV5D-4 alpha-chains with many different complementarity determining region (CDR) 3 sequences, ev

124 tion with single cell analysis to define the complementarity determining region (CDR) 3alpha and CDR3

125 profile Hidden Markov Models, and translated complementarity determining region (CDR) capture-recaptu

126 Here, we employed de novo complementarity determining region (CDR) design to engin

127 using a phage-displayed framework to support complementarity determining region (CDR) diversity restr

128 ion revealed its unusually long, 28-residue, complementarity determining region (CDR) H3 forms a uniq

129 amely O-sulfated tyrosine in the heavy chain complementarity determining region (CDR) H3 loop.

130 and (iii) de novo prediction of the elusive complementarity determining region (CDR) H3 loop.

131 Complementarity determining region (CDR) loop flexibilit

132 tagenic studies reveal a requirement of five complementarity determining region (CDR) loops for CD1c

133 bodies typically accumulate mutations in the complementarity determining region (CDR) loops, which us

134 and heavy framework regions and each of the complementarity determining region (CDR) loops.

135 The Fab fragment exhibits novel complementarity determining region (CDR) structures with

136 ody trastuzumab at a crucial position in its complementarity determining region (CDR).

137 ohydrate recognition maps to a cleft between complementarity determining region (CDR)H2 and CDRH3.

138 eaminations occurring in the antigen-binding complementarity determining regions (CDR) compared to th

139 ouse Fvs, we grafted the combined KABAT/IMGT complementarity determining regions (CDR) into a human I

140 The recognition involves up to six complementarity determining regions (CDR) of the TCR.

141 ructure was dominated by a heavy-chain third-complementarity-determining region (CDR H3) of 21 residu

142 affinity maturation, and a heavy chain-third complementarity-determining region (CDR H3) that is one

143 s, individual mutation of amino acids in the complementarity-determining region (CDR) 2beta to Ala re

144 ls showing a very strong preference for N(+) complementarity-determining region (CDR) 3 compared with

145 ibodies has been developed using heavy chain complementarity-determining region (CDR) 3 grafting comb

146 binds over the F'-pocket of MR1, whereby the complementarity-determining region (CDR) 3beta loop surr

147 also prevents peptide contacts by the short complementarity-determining region (CDR) 3beta loop, and

148 nition via conformational changes within the complementarity-determining region (CDR) 3beta loop.

149 ion on a heavy chain lysine located within a complementarity-determining region (CDR) did not signifi

150 e, ultrahumanized antibodies via single-step complementarity-determining region (CDR) germ-lining.

151 ity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and fr

152 R6261 required only seven amino acids in the complementarity-determining region (CDR) H1 and framewor

153 ine-sulphated, anionic antigen-binding loop (complementarity-determining region (CDR) H3) characteris

154 on the SARS-CoV-2 RBD, mainly through a long complementarity-determining region (CDR) H3, and compete

155 nvolve interaction of its long, hydrophobic, complementarity-determining region (CDR) H3, with adjace

156 bic pockets on IL-13 that accommodate Phe32 [complementarity-determining region (CDR) L2] and Trp100a

157 een the HLA surface and TCR germline-encoded complementarity-determining region (CDR) loops 1 and 2,

158 By contrast, alphabetaTCRs purpose all six complementarity-determining region (CDR) loops of their

159 -cell receptors (TCRs) engage antigens using complementarity-determining region (CDR) loops that are

160 1d by germline Vdelta1 residues spanning all complementarity-determining region (CDR) loops, as well

161 attributed in part to the flexibility of TCR complementarity-determining region (CDR) loops, yet ther

162 bility complex (MHC) proteins using multiple complementarity-determining region (CDR) loops.

163 ecific RNA binding on a shallow surface with complementarity-determining region (CDR) sequence divers

164 Unusual complementarity-determining region (CDR) structural feat

165 ovine antibody with a well-folded, ultralong complementarity-determining region (CDR), we have develo

166 hat carried the extended, 23- to 27-residue, complementarity-determining region (CDR)-H3 segments.

167 Moreover, B7-H6 contacts NKp30 through the complementarity-determining region (CDR)-like loops of i

168 E10 was derived from the parental 3B4 using complementarity-determining region (CDR)-restricted muta

169 n interactions between the germ-line-encoded complementarity-determining region (CDR)1 and CDR2 loops

170 face area; and (iv) public heavy-chain third complementarity-determining region (CDR-H3) antibodies i

171 gnatures, including shared light-chain third complementarity-determining region (CDR-L3) amino acid s

172 Relatively conserved amino acids in the TCR complementarity-determining regions (CDR) 1 and CDR2 are

173 Perturbations within complementarity-determining regions (CDR) induce rich be

174 Abs have long (21-residue) heavy-chain third complementarity-determining regions (CDR-H3s), and m66.6

175 The role of T cell receptor (TCR) germline complementarity determining regions (CDR1 and 2) in MHC

176 49, which is located adjacent to the second complementarity-determining region (CDR2) in the light c

177 ne-encoded residues in the second beta-chain complementarity-determining region (CDR2beta).

178 e former light chain interface and the third complementarity determining region (CDR3).

179 Whether critical amino acids in the third complementarity-determining region (CDR3) of the ANA ori

180 ptor diversity is contained within the third complementarity-determining region (CDR3) of the T-cell

181 y of amino acids at positions 6 and 7 of the complementarity-determining region CDR3beta robustly pro

182 tibody paratopes are formed by hypervariable complementarity-determining regions (CDRH3s) and variabl

183 Despite a disulfide bond linking complementarity determining regions (CDRs) 1 and 3, both

184 d previously by site-directed mutagenesis of complementarity determining regions (CDRs) 1beta, 2alpha

185 typical antigen-binding cavity formed by the complementarity determining regions (CDRs) and another c

186 SHM was highest in the Ab complementarity determining regions (CDRs) but also surp

187 nd extensive coverage of the antigen-binding complementarity determining regions (CDRs) in a single L

188 Classification of the structures of the complementarity determining regions (CDRs) of antibodies

189 V-gene sequences are characterized by short complementarity determining regions (CDRs) of high diver

190 comprehensive mutagenesis of the light chain complementarity determining regions (CDRs) of HIV-1 anti

191 selective analysis of diagnostic heavy-chain complementarity determining regions (CDRs) of single-cha

192 g-range rearrangements of framework (FW) and complementarity determining regions (CDRs) that increase

193 ification of the Xle site, especially in the complementarity determining regions (CDRs), can result i

194 by only three amino acids in the heavy chain complementarity determining regions (CDRs), one mAb, MED

195 The variable complementarity determining regions (CDRs), particularly

196 We estimated the evolutionary rates of the complementarity determining regions (CDRs), which are mo

197 we turned to deep mutational scanning in the complementarity determining regions (CDRs).

198 arily by the sequence and structure of their complementarity determining regions (CDRs).

199 ntibodies between the framework and loops of complementarity-determining regions (CDRs) 1 and 2.

200 V(H) library by grafting naturally occurring complementarity-determining regions (CDRs) 2 and 3 of he

201 erate significant diversity within all three complementarity-determining regions (CDRs) and also with

202 Modifications in the complementarity-determining regions (CDRs) are especiall

203 CR) stereotypes as defined by IGHV usage and complementarity-determining regions (CDRs) classify ~30%

204 mmonly accumulate charged mutations in their complementarity-determining regions (CDRs) during affini

205 Complementarity-determining regions (CDRs) from monoclon

206 e backbone entropy change for immunoglobulin complementarity-determining regions (CDRs) from the crys

207 d relatively high levels of conjugation near complementarity-determining regions (CDRs) from the heav

208 humanized anti-CD20 monoclonal antibody with complementarity-determining regions (CDRs) identical to

209 recombined beneficial mutations from all six complementarity-determining regions (CDRs) in the affini

210 All complementarity-determining regions (CDRs) in the Fab co

211 mer's amyloid-beta (Abeta) peptide] into the complementarity-determining regions (CDRs) of a stable a

212 Previous analyses of the complementarity-determining regions (CDRs) of antibodies

213 oth containing Asp-Asp motifs and located in complementarity-determining regions (CDRs) of light chai

214 matic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic

215 ting amyloidogenic peptide segments into the complementarity-determining regions (CDRs) of single-dom

216 aspartic acid residues (Asp) present in the complementarity-determining regions (CDRs) of the light

217 In addition to conformational changes in complementarity-determining regions (CDRs) of the TCR se

218 fic, high-affinity binding of quinine to the complementarity-determining regions (CDRs) of these anti

219 y and optimised via mutagenesis of the third complementarity-determining regions (CDRs) of variable h

220 ne whether they recognize SAEs through their complementarity-determining regions (CDRs) or framework

221 in a single LC-MS run; (ii) connectivity of complementarity-determining regions (CDRs) via Sap9-prod

222 Canonical forms of the antibody complementarity-determining regions (CDRs) were first de

223 mulate affinity-enhancing mutations in their complementarity-determining regions (CDRs) without compr

224 eamidation, and isomerization located in the complementarity-determining regions (CDRs), as well as N

225 poor developability: the total length of the complementarity-determining regions (CDRs), the extent a

226 ble region contains three antigen-contacting complementarity-determining regions (CDRs), with CDR1 an

227 k with a template containing human consensus complementarity-determining regions (CDRs).

228 -rich domains from bovine antibody ultralong complementarity-determining regions (CDRs).

229 ding site, located within the loops known as complementarity-determining regions (CDRs).

230 Alanine scanning of their complementarity-determining regions, coupled with epitop

231 he buried monomeric peptide in solanezumab's complementarity-determining region, crenezumab binds the

232 The three light-chain complementarity-determining regions do not adopt canonic

233 s were influenced most by the VHH CDR3 (CDR, complementarity-determining region) elements, with the m

234 In both complexes of the unit, all the complementarity-determining regions except for L3 intera

235 utation and long, variable heavy-chain third complementarity-determining regions, factors that may li

236 structure is largely conserved, except for a complementarity-determining region featuring six variabl

237 Two metal ions bridge complementarity determining regions from the antibody li

238 ibrary with synthetic diversity in the three complementarity determining regions (H1, H2, and H3) of

239 positively charged pocket formed within the complementarity determining region H2 loops that binds t

240 ficity differences are primarily mediated by complementarity-determining region H3 (CDR H3).

241 a common epitopic focus by utilizing various complementarity-determining region H3 (CDRH3) lengths.

242 17-mer peptide of VP1 was inserted into the complementarity-determining region H3 loop of MFE-23, a

243 mode limits the IGHV3-53 antibodies to short complementarity-determining region H3 loops but accommod

244 Insertion of any of these motifs into the complementarity-determining region H3 of a "clean" antib

245 y high arginine (Arg) content in the H chain complementarity determining region (H3), suggesting that

246 espite heritable segment use, the rearranged complementarity-determining region-H3 repertoires remain

247 gglutinin stem through conserved heavy-chain complementarity determining region (HCDR) residues.

248 When bound to HA, the heavy-chain third complementarity determining region (HCDR3) fits with an

249 (motif-2) in the Ig heavy-chain (IgH) third complementarity-determining region (HCDR3) of IgH, respe

250 eals a unique epitope, where the heavy-chain complementarity determining regions (HCDRs) 1 and 2 bind

251 led the major contribution made by the first complementarity-determining region in each of sifalimuma

252 verlap of the IgG-Fc binding site in FcRn by complementarity-determining regions in DX-2507.

253 surface consists of residues located in four complementarity-determining regions including a major co

254 Their heavy-chain complementarity determining region inserts into the cons

255 ned oligonucleotide libraries encoding three complementarity-determining regions (L3 from the light c

256 libraries generated by randomizing all three complementarity-determining region -like loops of the (1

257 ration of histidine residues, located in the complementarity-determining region-like proximal half of

258 tes as well as structural properties such as complementarity determining region loop conformation and

259 conewton force requires binding through both complementarity determining region loops and hydrophobic

260 a preference for coding substitutions in the complementarity determining region loops of many of the

261 at generally found in more flexible antibody complementarity-determining region loops but resembles t

262 Surprisingly, crenezumab's complementarity-determining region loops can effectively

263 tralizing cyclic peptide P7 derived from the complementarity-determining region loops of human bnAbs

264 The peptide design was based on complementarity-determining region loops of human broadl

265 have unusual sequences with long heavy-chain complementarity-determining region loops, high somatic m

266 The variable CDR (complementarity-determining region) loops at the antigen

267 me conformations capable of fitting into the complementarity determining region of the ELDKWA-binding

268 associated with Alzheimer's disease into the complementarity determining regions of a domain (V(H)) a

269 d, a machine learning method that can design complementarity determining regions of human Immunoglobu

270 t of ligand mimicry by the third heavy-chain complementarity-determining region of 1C1.

271 The loop is analogous to the third complementarity-determining region of immunoglobulin var

272 nally alter a hydrophobic patch on the third complementarity-determining region of the heavy chain (C

273 rate separation-of-function mutations in the complementarity-determining regions of 3E10 revealing th

274 inding capability was grafted into different complementarity-determining regions of a fully human Fab

275 loidogenic peptides (6-10 residues) into the complementarity-determining regions of a single-domain (

276 ficient distance for contact by two separate complementarity-determining regions of antibody.

277 O receptor-activating peptides inserted into complementarity-determining regions of Fab (Fab 59), att

278 through a series of hydrogen bonds from the complementarity-determining regions of Gipg013 Fab to th

279 a cleft formed by residues from five of the complementarity-determining regions of the scFv.

280 ues in variable domains, especially in CDRs (complementarity determining regions) of an antibody, may

281 from the Waters antibody contains all three complementarity determining regions on the light chain.

282 isoelectric point values of variable domain complementarity determining regions, possibly accounting

283 as carried out by converting over 60% of non-complementarity-determining region residues to those of

284 Our unique complementarity-determining region sequence design optim

285 affinity maturation by mutation outside the complementarity determining region surface of the antibo

286 io of replacement to silent mutations in the complementarity determining regions than in the framewor

287 It is mostly light chain complementarity-determining regions that are driving par

288 extensive framework contacts in addition to complementarity-determining regions that has not been se

289 H91VL, and an aromatic residue in the third complementarity-determining region to recognize thymine-

290 or yeast display libraries of mutants within complementarity-determining regions to affinity mature a

291 The antibody uses all six complementarity-determining regions to bind to a quatern

292 ing was used to identify key residues in the complementarity-determining regions to guide mutagenesis

293 strong bias for replacement mutations in the complementarity determining regions was found, indicatin

294 of intrinsic ligand bias, the germ-line TCR complementarity determining regions were extensively div

295 d not present, and only local changes at the complementarity determining regions were found.

296 VH1-VH7 family variants of IgE with the same complementarity-determining regions were investigated wi

297 coverage, with incomplete sequencing of the complementarity determining regions which are fundamenta

298 individual amino acids and motifs within the complementarity-determining regions which contribute to

299 rid TCR containing TCR-gamma chain germ-line complementarity determining regions, which engaged effic

300 tching the distribution observed in antibody complementarity-determining regions without incurring th